{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:31:21Z","timestamp":1790616681344,"version":"4.1.0"},"reference-count":46,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100002322","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["564243\/2010-8"],"award-info":[{"award-number":["564243\/2010-8"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406334\/2013-7"],"award-info":[{"award-number":["406334\/2013-7"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303675\/2015-2"],"award-info":[{"award-number":["303675\/2015-2"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307186\/2013-0"],"award-info":[{"award-number":["307186\/2013-0"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005285","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s","doi-asserted-by":"publisher","award":["201110267000106"],"award-info":[{"award-number":["201110267000106"]}],"id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.00273","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T22:41:43Z","timestamp":1487716903000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Non-disulfide-Bridge Peptide 5.5 from the Scorpion Hadrurus gertschi Inhibits the Growth of Mycobacterium abscessus subsp. massiliense"],"prefix":"10.3389","volume":"8","author":[{"given":"Monalisa M.","family":"Trentini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio C.","family":"das Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno de Paula Oliveira","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosevelt A.","family":"DaSilva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo C. Barros de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia R.","family":"Mortari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth F.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.","family":"Junqueira-Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5493","DOI":"10.1128\/JCM.42.12.5493-5501.2004","article-title":"Amoebal coculture of \u201cMycobacterium massiliense\u201d sp. nov. from the sputum of a patient with hemoptoic pneumonia.","volume":"42","author":"Ad\u00e9kambi","year":"2004","journal-title":"J. Clin. Microbiol."},{"issue":"e33297","key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033297","article-title":"Unique proteomic signatures distinguish macrophages and dendritic cells.","volume":"7","author":"Becker","year":"2012","journal-title":"PLoS ONE"},{"key":"B3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0010-4655(95)00042-E","article-title":"GROMACS: a message-passing parallel molecular dynamics implementation.","volume":"91","author":"Berendsen","year":"1995","journal-title":"Comput. Phys. Commun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/724635","article-title":"In vitro antimicrobial susceptibility of Mycobacterium massiliense recovered from wound samples of patients submitted to arthroscopic and laparoscopic surgeries.","volume":"2011","author":"Cardoso","year":"2011","journal-title":"Minim. Invasive Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.micinf.2008.09.008","article-title":"Emergence of nosocomial Mycobacterium massiliense infection in Goi\u00e1s, Brazil.","volume":"10","author":"Cardoso","year":"2008","journal-title":"Microbes Infect."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1128\/AAC.00925-06","article-title":"Role of peptide hydrophobicity in the mechanism of action of alfa-H = helical antimicrobial peptides.","volume":"51","author":"Chen","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1128\/AAC.00685-12","article-title":"Activities of moxifloxacin in combination with macrolides against clinical isolates of Mycobacterium abscessus and Mycobacterium massiliense.","volume":"56","author":"Choi","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1002\/jcc.20110","article-title":"Using quaternions to calculate RMSD.","volume":"25","author":"Coutsias","year":"2004","journal-title":"J. Comput. Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1016\/S0006-291X(02)00423-0","article-title":"Purification, structure\u2013function analysis, and molecular characterization of novel linear peptides from scorpion Opisthacanthus madagascariensis.","volume":"293","author":"Dai","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1006\/bbrc.2001.5472","article-title":"IsCT, a novel cytotoxic linear peptide from scorpion Opisthacanthus madagascariensis.","volume":"286","author":"Dai","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10089","key":"B11","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397","article-title":"Particle mesh Ewald: An Nlog(N) method for Ewald sums in large systems.","volume":"98","author":"Darden","year":"1993","journal-title":"J. Chem. Phys."},{"issue":"e0149729","key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149729","article-title":"Antimycobacterial activity of a new peptide polydim-I isolated from neotropical social wasp polybia dimorpha.","volume":"11","author":"das Neves","year":"2016","journal-title":"PLoS ONE"},{"key":"B13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/(SICI)1521-3773(19990115)38:1\/2236::AID-ANIE2363.0.CO;2-M","article-title":"Peptide folding: when simulation meets experiment.","volume":"38","author":"Daura","year":"1999","journal-title":"Angew. Chem. Int. Edn."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1128\/JCM.00027-09","article-title":"Epidemic of postsurgical infections caused by Mycobacterium massiliense.","volume":"47","author":"Duarte","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1096\/fj.08-122317","article-title":"Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides.","volume":"23","author":"Gao","year":"2009","journal-title":"FASEB J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2478\/s11535-007-0010-5","article-title":"Antimicrobial peptides: an overview of a promising class of therapeutics.","volume":"2","author":"Giuliani","year":"2007","journal-title":"Open Life Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1080\/02713680590968637","article-title":"A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs.","volume":"30","author":"Gordon","year":"2005","journal-title":"Curr. Eye Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/QCO.0b013e328055d9a2","article-title":"Therapy of nontuberculous mycobacterial disease.","volume":"20","author":"Griffith","year":"2007","journal-title":"Curr. Opin. Infect. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1164\/rccm.200604-571ST","article-title":"An official ATS\/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.","volume":"175","author":"Griffith","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1844","key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01844","article-title":"Activity of scorpion venom-derived antifungal peptides against planktonic cells of Candida spp. and Cryptococcus neoformans and Candida albicans Biofilms.","volume":"7","author":"Guilhelmelli","year":"2016","journal-title":"Front. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s13238-010-0004-3","article-title":"Alpha-helical cationic antimicrobial peptides: relationships of structure and function.","volume":"1","author":"Huang","year":"2010","journal-title":"Protein Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1128\/CMR.00056","article-title":"Peptide antimicrobial agents.","volume":"19","author":"Jenssen","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3384","DOI":"10.1128\/JCM.00319-08","article-title":"Proportions of Mycobacterium massiliense and Mycobacterium bolletii strains among Korean Mycobacterium chelonae-Mycobacterium abscessus group isolates.","volume":"46","author":"Kim","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and clustal X version 2.0.","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.3201\/eid2109.141634","article-title":"Mycobacterium abscessus complex infections in humans.","volume":"21","author":"Lee","year":"2015","journal-title":"Emerg. Infect. Dis."},{"issue":"8910","key":"B26","doi-asserted-by":"publisher","DOI":"10.1063\/1.481505","article-title":"A five-site model for liquid water and the reproduction of the density anomaly by rigid, nonpolarizable potential functions.","volume":"112","author":"Mahoney","year":"2000","journal-title":"J. Chem. Phys."},{"key":"B27","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tibtech.2011.05.001","article-title":"The expanding scope of antimicrobial peptide structures and their modes of action.","volume":"29","author":"Nguyen","year":"2011","journal-title":"Trends Biotechnol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.toxicon.2014.11.233","article-title":"Scorpion venom components as potential candidates for drug development.","volume":"93","author":"Ortiz","year":"2015","journal-title":"Toxicon"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.peptides.2003.08.023","article-title":"The relationship between peptide structure and antibacterial activity.","volume":"24","author":"Powers","year":"2003","journal-title":"Peptides"},{"key":"B30","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.peptides.2015.08.014","article-title":"Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity.","volume":"73","author":"Ram\u00edrez-Carreto","year":"2015","journal-title":"Peptides"},{"key":"B31","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.peptides.2012.02.002","article-title":"Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae.","volume":"34","author":"Ram\u00edrez-Carreto","year":"2012","journal-title":"Peptides"},{"key":"B32","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ijantimicag.2012.09.015","article-title":"Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6 and CP26 against Mycobacterium tuberculosis.","volume":"41","author":"Rivas-Santiago","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B33","doi-asserted-by":"publisher","first-page":"5898","DOI":"10.1128\/IAI.00014-07","article-title":"Importance of T cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower Mycobacterium abscessus in C57BL\/6 mice.","volume":"75","author":"Rottman","year":"2007","journal-title":"Infect. Immun."},{"issue":"119","key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-119","article-title":"Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones).","volume":"8","author":"Schwartz","year":"2007","journal-title":"BMC Genomics"},{"issue":"e24726","key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024726","article-title":"Increased virulence of an epidemic strain of Mycobacterium massiliense in mice.","volume":"6","author":"Shang","year":"2011","journal-title":"PLoS ONE"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1128\/IAI.00731-09","article-title":"Acute immune response to Mycobacterium massiliense in C57BL\/6 and BALB\/c mice.","volume":"78","author":"Sousa","year":"2010","journal-title":"Infect. Immun."},{"key":"B37","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3201\/eid2003.131106","article-title":"High-level relatedness among Mycobacterium abscessus subsp. massiliense strains from widely separated outbreaks.","volume":"20","author":"Tettelin","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1016\/j.peptides.2009.09.020","article-title":"Antimicrobial specificity and mechanism of action of disulfide-removed linear analogs of the plant-derived Cys-rich antimicrobial peptide Ib-AMP1.","volume":"30","author":"Wang","year":"2009","journal-title":"Peptides"},{"key":"B39","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1021\/cb1001558","article-title":"Describing the mechanism of antimicrobial peptide action with the interfacial activity model.","volume":"5","author":"Wimley","year":"2010","journal-title":"ACS Chem. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.peptides.2010.10.008","article-title":"A new natural alfa-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV.","volume":"32","author":"Yan","year":"2011","journal-title":"Peptides"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1021\/ct900604a","article-title":"Reparameterization of RNA \u03c7 torsion parameters for the AMBER force field and comparison to NMR spectra for cytidine and uridine.","volume":"6","author":"Yildirim","year":"2010","journal-title":"J. Chem. Theory Comput."},{"key":"B42","author":"Yu","year":"2012","journal-title":"Computational Modeling of Protein Dynamics with GROMACS and Java."},{"key":"B43","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms.","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"B44","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/15216540500058899","article-title":"Scorpion venom peptides without disulfide bridges.","volume":"57","author":"Zeng","year":"2005","journal-title":"IUBMB Life"},{"key":"B45","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.peptides.2003.12.003","article-title":"Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch.","volume":"25","author":"Zeng","year":"2004","journal-title":"Peptides"},{"key":"B46","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.peptides.2013.03.026","article-title":"Three new antimicrobial peptides from the scorpion Pandinus imperator.","volume":"45","author":"Zeng","year":"2013","journal-title":"Peptides"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00273\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T22:41:48Z","timestamp":1487716908000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00273\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,22]]},"references-count":46,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.00273","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,22]]}}}