{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:52:06Z","timestamp":1740160326128,"version":"3.37.3"},"reference-count":75,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-11959 (to TM)","ICS-12398 (to TM)"],"award-info":[{"award-number":["MOP-11959 (to TM)","ICS-12398 (to TM)"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 401 (to TM)","327186 (to CC)"],"award-info":[{"award-number":["RGPIN 401 (to TM)","327186 (to CC)"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010231","name":"Banting Research Foundation","doi-asserted-by":"publisher","award":["(to TM)"],"award-info":[{"award-number":["(to TM)"]}],"id":[{"id":"10.13039\/100010231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["27881 (to TM)"],"award-info":[{"award-number":["27881 (to TM)"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-051334 (to CC)"],"award-info":[{"award-number":["AI-051334 (to CC)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.00292","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T03:59:27Z","timestamp":1487908767000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Diet-Induced Obesity Does Not Alter Tigecycline Treatment Efficacy in Murine Lyme Disease"],"prefix":"10.3389","volume":"08","author":[{"given":"Helena","family":"P\u011btro\u0161ov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azad","family":"Eshghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoha","family":"Anjum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Zlotnikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline E.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara J.","family":"Moriarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"20466","DOI":"10.1073\/pnas.0710335105","article-title":"Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge.","volume":"104","author":"Amar","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4269\/ajtmh.1992.47.249","article-title":"Carditis in Lyme disease susceptible and resistant strains of laboratory mice infected with Borrelia burgdorferi.","volume":"47","author":"Armstrong","year":"1992","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ttbdis.2009.11.004","article-title":"Comparison of in vitro activities of tigecycline, doxycycline, and tetracycline against the spirochete Borrelia burgdorferi.","volume":"1","author":"Ates","year":"2010","journal-title":"Ticks Tick Borne Dis."},{"key":"B4","first-page":"521","article-title":"Isolation and cultivation of Lyme disease spirochetes.","volume":"57","author":"Barbour","year":"1984","journal-title":"Yale J. Biol. Med."},{"key":"B5","first-page":"263","article-title":"Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice.","volume":"139","author":"Barthold","year":"1991","journal-title":"Am. J. Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/infdis\/162.1.133","article-title":"Lyme borreliosis in selected strains and ages of laboratory mice.","volume":"162","author":"Barthold","year":"1990","journal-title":"J. Infect. Dis."},{"key":"B7","first-page":"959","article-title":"Chronic Lyme borreliosis in the laboratory mouse.","volume":"143","author":"Barthold","year":"1993","journal-title":"Am. J. Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1128\/AAC.00788-09","article-title":"Ineffectiveness of tigecycline against persistent Borrelia burgdorferi.","volume":"54","author":"Barthold","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.1128\/IAI.00469-06","article-title":"Antibody-mediated disease remission in the mouse model of Lyme borreliosis.","volume":"74","author":"Barthold","year":"2006","journal-title":"Infect. Immun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1172\/JCI58813","article-title":"Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy.","volume":"122","author":"Bockenstedt","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B11","doi-asserted-by":"publisher","first-page":"5264","DOI":"10.1128\/IAI.69.9.5264-5269.2001","article-title":"CD4+ T helper 1 cells facilitate regression of murine Lyme carditis.","volume":"69","author":"Bockenstedt","year":"2001","journal-title":"Infect. Immun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1086\/345284","article-title":"Detection of attenuated, noninfectious spirochetes in Borrelia burgdorferi-infected mice after antibiotic treatment.","volume":"186","author":"Bockenstedt","year":"2002","journal-title":"J. Infect. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1093\/cid\/cit942","article-title":"Xenodiagnosis for posttreatment Lyme disease syndrome: resolving the conundrum or adding to it?","volume":"58","author":"Bockenstedt","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jaut.2014.09.004","article-title":"Lyme disease: a rigorous review of diagnostic criteria and treatment.","volume":"57","author":"Borchers","year":"2015","journal-title":"J. Autoimmun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1128\/AAC.00647-08","article-title":"Pharmacodynamics of tigecycline against phenotypically diverse Staphylococcus aureus isolates in a murine thigh model.","volume":"53","author":"Crandon","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"B16","doi-asserted-by":"publisher","first-page":"12215","DOI":"10.1073\/pnas.92.26.12215","article-title":"Early-onset multifocal inflammation in the transforming growth factor \u03b21-null mouse is lymphocyte mediated.","volume":"92","author":"Diebold","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1128\/AAC.02177-15","article-title":"Suppression of emergence of resistance in pathogenic bacteria: keeping our powder dry-Part 1.","volume":"60","author":"Drusano","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"e1004976","key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004976","article-title":"Suppression of long-lived humoral immunity following Borrelia burgdorferi infection.","volume":"11","author":"Elsner","year":"2015","journal-title":"PLoS Pathog."},{"issue":"e29914","key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029914","article-title":"Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection.","volume":"7","author":"Embers","year":"2012","journal-title":"PLoS ONE"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1128\/IAI.00427-15","article-title":"The pathogenic leptospira interrogans exoproteins are primarily involved in heterotrophic processes.","volume":"83","author":"Eshghi","year":"2015","journal-title":"Infect. Immun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1186\/2047-783X-15-12-533","article-title":"Comparison of the pharmacokinetic properties of vancomycin, linezolid, tigecyclin, and daptomycin.","volume":"15","author":"Estes","year":"2010","journal-title":"Eur. J. Med. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S0140-6736(09)60743-1","article-title":"Adjustment of dosing of antimicrobial agents for bodyweight in adults.","volume":"375","author":"Falagas","year":"2010","journal-title":"Lancet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1128\/IAI.03074-14","article-title":"A humoral immune defect distinguishes the response to Staphylococcus aureus infections in mice with obesity and type 2 diabetes from that in mice with type 1 diabetes.","volume":"83","author":"Farnsworth","year":"2015","journal-title":"Infect. Immun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S0140-6736(10)62037-5","article-title":"National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9\u22c51 million participants.","volume":"377","author":"Finucane","year":"2011","journal-title":"Lancet"},{"issue":"88","key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-9-88","article-title":"The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.","volume":"9","author":"Guh","year":"2009","journal-title":"BMC Public Health"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1128\/AAC.01050-07","article-title":"Persistence of Borrelia burgdorferi following antibiotic treatment in mice.","volume":"52","author":"Hodzic","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"issue":"e86907","key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086907","article-title":"Resurgence of persisting non-cultivable Borrelia burgdorferi following antibiotic treatment in mice.","volume":"9","author":"Hodzic","year":"2014","journal-title":"PLoS ONE"},{"key":"B28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ijo.2012.62","article-title":"Obesity and the risk and outcome of infection.","volume":"37","author":"Huttunen","year":"2013","journal-title":"Int. J. Obes."},{"key":"B29","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/labinvest.2013.81","article-title":"Dynamics of connective-tissue localization during chronic Borrelia burgdorferi infection.","volume":"93","author":"Imai","year":"2013","journal-title":"Lab. Invest."},{"issue":"e0158019","key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158019","article-title":"Hyperglycemia impairs neutrophil-mediated bacterial clearance in mice infected with the Lyme disease pathogen.","volume":"11","author":"Javid","year":"2016","journal-title":"PLoS ONE"},{"key":"B31","doi-asserted-by":"publisher","first-page":"4796","DOI":"10.1111\/j.1742-4658.2008.06619.x","article-title":"Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice.","volume":"275","author":"Karagiannides","year":"2008","journal-title":"FEBS J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1093\/jac\/dkp056","article-title":"Pharmacodynamic evaluation of tigecycline against Acinetobacter baumannii in a murine pneumonia model.","volume":"63","author":"Koomanachai","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"B33","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/cid\/cir442","article-title":"Obesity and respiratory hospitalizations during influenza seasons in Ontario, Canada: a cohort study.","volume":"53","author":"Kwong","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1128\/IAI.00369-15","article-title":"Macrophage polarization during murine Lyme borreliosis.","volume":"83","author":"Lasky","year":"2015","journal-title":"Infect. Immun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ni.1855","article-title":"An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells.","volume":"11","author":"Lee","year":"2010","journal-title":"Nat. Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1099\/jmm.0.008169-0","article-title":"Use of quantitative real-time PCR for studying the dissemination of Leptospira interrogans in the guinea pig infection model of leptospirosis.","volume":"58","author":"Lourdault","year":"2009","journal-title":"J. Med. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0561s58","article-title":"Overview of animal models of obesity.","author":"Lutz","year":"2012","journal-title":"Curr. Protoc. Pharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.idc.2015.02.010","article-title":"Epidemiology of Lyme disease.","volume":"29","author":"Mead","year":"2015","journal-title":"Infect. Dis. Clin. North Am."},{"issue":"e1000090","key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000090","article-title":"Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host.","volume":"4","author":"Moriarty","year":"2008","journal-title":"PLoS Pathog."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1111\/mmi.12045","article-title":"Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.","volume":"86","author":"Moriarty","year":"2012","journal-title":"Mol. Microbiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1056\/NEJMoa1114362","article-title":"Differentiation of reinfection from relapse in recurrent Lyme disease.","volume":"367","author":"Nadelman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1128\/CMR.00007-10","article-title":"Penetration of drugs through the blood-cerebrospinal fluid\/blood-brain barrier for treatment of central nervous system infections.","volume":"23","author":"Nau","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1128\/AAC.01678-08","article-title":"In vivo pharmacodynamic profile of tigecycline against phenotypically diverse Escherichia coli and Klebsiella pneumoniae isolates.","volume":"53","author":"Nicasio","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"B44","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1056\/NEJM199401273300401","article-title":"Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis.","volume":"330","author":"Nocton","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0002-9343(03)00308-5","article-title":"Long-term follow-up of patients with culture-confirmed Lyme disease.","volume":"115","author":"Nowakowski","year":"2003","journal-title":"Am. J. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/obr.12229","article-title":"Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies.","volume":"16","author":"O\u2019Neill","year":"2015","journal-title":"Obes. Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1093\/jac\/dkt299","article-title":"Serum and urine pharmacokinetics of tigecycline in obese class III and normal weight adults.","volume":"69","author":"Pai","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"B48","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.coph.2015.06.004","article-title":"Treatment of bacterial infections in obese adult patients: how to appropriately manage antimicrobial dosage.","volume":"24","author":"Pai","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"4422","DOI":"10.1016\/j.vaccine.2015.06.101","article-title":"The weight of obesity on the human immune response to vaccination.","volume":"33","author":"Painter","year":"2015","journal-title":"Vaccine"},{"key":"B50","doi-asserted-by":"publisher","first-page":"6701","DOI":"10.1128\/AAC.03751-14","article-title":"Culture of the entire mouse to determine whether cultivable Borrelia burgdorferi persists in infected mice treated with a five-day course of Ceftriaxone.","volume":"58","author":"Pavia","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"e61226","key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061226","article-title":"Variable VlsE is critical for host reinfection by the Lyme disease spirochete.","volume":"8","author":"Rogovskyy","year":"2013","journal-title":"PLoS ONE"},{"key":"B52","doi-asserted-by":"publisher","first-page":"5180","DOI":"10.1128\/AAC.01414-09","article-title":"Tigecycline population pharmacokinetics in patients with community- or hospital-acquired pneumonia.","volume":"54","author":"Rubino","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1128\/IAI.57.1.41-47.1989","article-title":"Demonstration of antigen-specific T cells and histopathological alterations in mice experimentally inoculated with Borrelia burgdorferi.","volume":"57","author":"Schaible","year":"1989","journal-title":"Infect. Immun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/ckj\/sfs149","article-title":"Borrelia and nephropathy: cryoglobulinaemic membranoproliferative glomerulonephritis responsive to doxycyclin in active Lyme disease.","volume":"6","author":"Schneider","year":"2013","journal-title":"Clin. Kidney J."},{"key":"B55","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.urology.2011.09.040","article-title":"The impact of obesity on urinary tract infection risk.","volume":"79","author":"Semins","year":"2012","journal-title":"Urology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/ijo.2011.208","article-title":"Obesity is associated with impaired immune response to influenza vaccination in humans.","volume":"36","author":"Sheridan","year":"2012","journal-title":"Int. J. Obes."},{"key":"B57","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance.","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. Invest."},{"key":"B58","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.amjsurg.2009.12.024","article-title":"Recurrent skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus requiring operative debridement.","volume":"201","author":"Sreeramoju","year":"2011","journal-title":"Am. J. Surg."},{"key":"B59","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/JCM.35.1.111-116.1997","article-title":"Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment.","volume":"35","author":"Straubinger","year":"1997","journal-title":"J. Clin. Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.1194\/jlr.M042457","article-title":"n-3 PUFAs enhance the frequency of murine B-cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity.","volume":"54","author":"Teague","year":"2013","journal-title":"J. Lipid Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1128\/IAI.69.5.3507-3509.2001","article-title":"Dissociation of infectivity and pathogenicity in Borrelia burgdorferi.","volume":"69","author":"Thomas","year":"2001","journal-title":"Infect. Immun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"5491","DOI":"10.1073\/pnas.1502561112","article-title":"Hypercholesterolemia and ApoE deficiency result in severe infection with Lyme disease and relapsing-fever Borrelia.","volume":"112","author":"Toledo","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B63","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jamcollsurg.2010.01.004","article-title":"Percent body fat and prediction of surgical site infection.","volume":"210","author":"Waisbren","year":"2010","journal-title":"J. Am. Coll. Surg."},{"key":"B64","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.metabol.2015.04.010","article-title":"Chronic high fat diet induces cardiac hypertrophy and fibrosis in mice.","volume":"64","author":"Wang","year":"2015","journal-title":"Metabolism"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1128\/AAC.01636-05","article-title":"Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections.","volume":"50","author":"Wart","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"journal-title":"World Health Statistics 2015.","year":"2015","author":"World Health Organization","key":"B66"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1371\/journal.ppat.1000090","article-title":"Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease.","volume":"198","author":"Wormser","year":"2008","journal-title":"J. Infect. Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1086\/508667","article-title":"The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the infectious diseases society of America.","volume":"43","author":"Wormser","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"B69","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1128\/CMR.00004-09","article-title":"Antibiotic treatment of animals infected with Borrelia burgdorferi.","volume":"22","author":"Wormser","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"B70","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1128\/IAI.62.2.492-500.1994","article-title":"Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues.","volume":"62","author":"Yang","year":"1994","journal-title":"Infect. Immun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/jac\/dkn551","article-title":"In vitro activity of tigecycline against multiple strains of Borrelia burgdorferi.","volume":"63","author":"Yang","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"B72","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1128\/IAI.00787-12","article-title":"Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice and thereby improves surgical site Staphylococcus aureus infection.","volume":"80","author":"Yano","year":"2012","journal-title":"Infect. Immun."},{"key":"B73","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/j.1600-0463.2010.02615.x","article-title":"Persistence of borrelial DNA in the joints of Borrelia burgdorferi-infected mice after ceftriaxone treatment.","volume":"118","author":"Yrj\u00e4n\u00e4inen","year":"2010","journal-title":"APMIS"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1086\/513873","article-title":"Anti-tumor necrosis factor-alpha treatment activates Borrelia burgdorferi spirochetes 4 weeks after ceftriaxone treatment in C3H\/He mice.","volume":"195","author":"Yrj\u00e4n\u00e4inen","year":"2007","journal-title":"J. Infect. Dis."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cmi.12689","article-title":"Infection with the Lyme disease pathogen suppresses innate immunity in mice with diet-induced obesity.","author":"Zlotnikov","year":"2016","journal-title":"Cell. Microbiol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00292\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T23:47:17Z","timestamp":1601682437000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00292\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,24]]},"references-count":75,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.00292","relation":{},"ISSN":["1664-302X"],"issn-type":[{"type":"electronic","value":"1664-302X"}],"subject":[],"published":{"date-parts":[[2017,2,24]]}}}