{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:28:36Z","timestamp":1790778516296,"version":"4.1.0"},"reference-count":66,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.00627","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T03:42:21Z","timestamp":1491968541000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Simulating Intestinal Growth Conditions Enhances Toxin Production of Enteropathogenic Bacillus cereus"],"prefix":"10.3389","volume":"8","author":[{"given":"Nadja","family":"Je\u00dfberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Rademacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria M.","family":"Krey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Katrin","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Elisabeth","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Ehling-Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"M\u00e4rtlbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"B1","first-page":"17","article-title":"A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus","volume":"129","author":"Agata","year":"1995","journal-title":"FEMS Microbiol. Lett."},{"key":"B2","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1128\/IAI.63.11.4423-4428.1995","article-title":"Enterotoxic activity of hemolysin BL from Bacillus cereus","volume":"63","author":"Beecher","year":"1995","journal-title":"Infect. Immun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"768","DOI":"10.3389\/fmicb.2016.00768","article-title":"Comparative bioinformatics and experimental analysis of the intergenic regulatory regions of Bacillus cereus hbl and nhe enterotoxin operons and the impact of CodY on virulence heterogeneity","volume":"24","author":"B\u00f6hm","year":"2016","journal-title":"Front. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1128\/CMR.00073-09","article-title":"Bacillus cereus, a volatile human pathogen","volume":"23","author":"Bottone","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"B5","first-page":"G284","article-title":"Human gastric emptying and colonic filling of solids characterized by a new method","volume":"257","author":"Camilleri","year":"1989","journal-title":"Am. J. Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3109\/1040841X.2011.558832","article-title":"Regulation of toxin production by Bacillus cereus and its food safety implications","volume":"37","author":"Ceuppens","year":"2011","journal-title":"Crit. Rev. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"690","DOI":"10.4315\/0362-028X.JFP-11-481","article-title":"Survival of Bacillus cereus vegetative cells and spores during in vitro simulation of gastric passage","volume":"75","author":"Ceuppens","year":"2012a","journal-title":"J. Food Prot."},{"key":"B8","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ijfoodmicro.2012.02.013","article-title":"Impact of intestinal microbiota and gastrointestinal conditions on the in vitro survival and growth of Bacillus cereus","volume":"155","author":"Ceuppens","year":"2012b","journal-title":"Int. J. Food Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1074\/mcp.M000027-MCP201","article-title":"Expanding the known repertoire of virulence factors produced by Bacillus cereus through early secretome profiling in three redox conditions","volume":"9","author":"Clair","year":"2010","journal-title":"Mol. Cell Proteomics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1111\/j.1365-2672.2007.03410.x","article-title":"Effects of porcine bile on survival of Bacillus cereus vegetative cells and Haemolysin BL enterotoxin production in reconstituted human small intestine media","volume":"103","author":"Clavel","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/j.1365-2672.2004.02292.x","article-title":"Survival of Bacillus cereus spores and vegetative cells in acid media simulating human stomach","volume":"97","author":"Clavel","year":"2004","journal-title":"J. Appl. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1093\/emboj\/17.10.2894","article-title":"Induction of type III secretion in Shigella flexneri is associated with differential control of transcription of genes encoding secreted proteins","volume":"17","author":"Demers","year":"1998","journal-title":"EMBO J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.syapm.2009.01.001","article-title":"Evolution of pathogenicity in the Bacillus cereus group","volume":"32","author":"Didelot","year":"2009","journal-title":"Syst. Appl. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1128\/IAI.05681-11","article-title":"Monoclonal antibodies neutralize Bacillus cereus Nhe enterotoxin by inhibiting ordered binding of its three exoprotein components","volume":"80","author":"Didier","year":"2012","journal-title":"Infect. Immun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e0165135","DOI":"10.1371\/journal.pone.0165135","article-title":"Antibody binding studies reveal conformational flexibility of the Bacillus cereus Non-Hemolytic Enterotoxin (Nhe) a-component","volume":"11","author":"Didier","year":"2016","journal-title":"PLoS ONE"},{"key":"B16","doi-asserted-by":"publisher","first-page":"4655","DOI":"10.3390\/toxins7114655","article-title":"The mutation Glu151Asp in the B-component of the Bacillus cereus non-hemolytic enterotoxin (Nhe) leads to a diverging reactivity in antibody-based detection systems","volume":"7","author":"Didier","year":"2015","journal-title":"Toxins"},{"key":"B17","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1128\/AEM.65.10.4470-4474.1999","article-title":"Production and characterization of monoclonal antibodies against the hemolysin BL enterotoxin complex produced by Bacillus cereus","volume":"65","author":"Dietrich","year":"1999","journal-title":"Appl. Environ. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"8214","DOI":"10.1128\/AEM.71.12.8214-8220.2005","article-title":"Production and characterization of antibodies against each of the three subunits of the Bacillus cereus nonhemolytic enterotoxin complex","volume":"71","author":"Dietrich","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1128\/AEM.02317-09","article-title":"Identification of the main promoter directing cereulide biosynthesis in emetic Bacillus cereus and its application for real-time monitoring of ces gene expression in foods","volume":"76","author":"Dommel","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s00203-004-0688-y","article-title":"Anaerobiosis and low specific growth rates enhance hemolysin BL production by Bacillus cereus F4430\/73","volume":"182","author":"Duport","year":"2004","journal-title":"Arch. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"6640","DOI":"10.1128\/JB.00702-06","article-title":"Control of enterotoxin gene expression in Bacillus cereus F4430\/73 involves the redox-sensitive ResDE signal transduction system","volume":"188","author":"Duport","year":"2006","journal-title":"J. Bacteriol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"704","DOI":"10.3389\/fmicb.2015.00704","article-title":"Food-bacteria interplay: pathometabolism of emetic Bacillus cereus","volume":"6","author":"Ehling-Schulz","year":"2015","journal-title":"Front. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/mnfr.200400055","article-title":"Bacillus cereus, the causative agent of an emetic type of food-borne illness","volume":"48","author":"Ehling-Schulz","year":"2004","journal-title":"Mol. Nutr. Food Res."},{"key":"B24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1533\/9780857096937.1.63","article-title":"One pathogen but two different types of food borne outbreaks: Bacillus cereus in catering facilities in Germany","volume-title":"Case Studies in Food Safety and Quality Management: Lessons from Real-Life Situations","author":"Ehling-Schulz","year":"2012"},{"key":"B25","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fmicb.2013.00032","article-title":"Bacillus \u201cnext generation\u201ddiagnostics: moving from detection toward subtyping and risk-related strain profiling","volume":"4","author":"Ehling-Schulz","year":"2013","journal-title":"Front. Microbiol."},{"key":"B26","first-page":"275","article-title":"Bacillus cereus in milk and dairy production","volume-title":"Rapid Detection, Characterization and Enumeration of Food-Borne Pathogens","author":"Ehling-Schulz","year":"2011"},{"key":"B27","doi-asserted-by":"publisher","first-page":"4419","DOI":"10.1128\/JB.00321-09","article-title":"ResDE-dependent regulation of enterotoxin gene expression in Bacillus cereus: evidence for multiple modes of binding for ResD and interaction with Fnr","volume":"191","author":"Esbelin","year":"2009","journal-title":"J. Bacteriol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/1471-2180-12-125","article-title":"Bacillus cereus Fnr binds a [4Fe-4S] cluster and forms a ternary complex with ResD and PlcR","volume":"12","author":"Esbelin","year":"2012","journal-title":"BMC Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1186\/1471-2180-10-304","article-title":"Bacillus cereus cytotoxins Hbl, Nhe and CytK are secreted via the Sec translocation pathway","volume":"10","author":"Fagerlund","year":"2010","journal-title":"BMC Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/0092-8674(94)90510-X","article-title":"Contact with epithelial cells induces the formation of surface appendages on Salmonella typhimurium","volume":"76","author":"Ginocchio","year":"1994","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e2793","DOI":"10.1371\/journal.pone.0002793","article-title":"The PlcR virulence regulon of Bacillus cereus","volume":"3","author":"Gohar","year":"2008","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1002\/1615-9861(200206)2:6784::AID-PROT7843.0.CO;2-R","article-title":"Twodimensional electrophoresis analysis of the extracellular proteome of Bacillus cereus reveals the importance of the PlcR regulon","volume":"2","author":"Gohar","year":"2002","journal-title":"Proteomics"},{"key":"B33","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1099\/ijs.0.030627-0","article-title":"Bacillus cytotoxicus sp. nov. is a novel thermotolerant species of the Bacillus cereus group occasionally associated with food poisoning","volume":"63","author":"Guinebreti\u00e8re","year":"2013","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e63104","DOI":"10.1371\/journal.pone.0063104","article-title":"Complex formation between NheB and NheC is necessary to induce cytotoxic activity by the three-component Bacillus cereus Nhe enterotoxin","volume":"8","author":"Heilkenbrinker","year":"2013","journal-title":"PLoS ONE"},{"key":"B35","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.toxicon.2013.10.028","article-title":"Bacillus cereus enterotoxins act as major virulence factors and exhibit distinct cytotoxicity to different human cell lines","volume":"77","author":"Je\u00dfberger","year":"2014","journal-title":"Toxicon"},{"key":"B36","doi-asserted-by":"publisher","first-page":"560","DOI":"10.3389\/fmicb.2015.00560","article-title":"From genome to toxicity: a combinatory approach highlights the complexity of enterotoxin production in Bacillus cereus","volume":"6","author":"Je\u00dfberger","year":"2015","journal-title":"Front. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.3389\/fmicb.2016.01640","article-title":"Temperature exerts control of Bacillus cereus emetic toxin production on post-transcriptional levels","volume":"25","author":"Kranzler","year":"2016","journal-title":"Front. Microbiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1128\/IAI.73.2.1034-1043.2005","article-title":"Temporal expression of enteropathogenic Escherichia coli virulence genes in an in vitro model of infection","volume":"73","author":"Leverton","year":"2005","journal-title":"Infect. Immun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B40","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1099\/mic.0.024125-0","article-title":"Cereulide synthesis in emetic Bacillus cereus is controlled by the transition state regulator AbrB, but not by the virulence regulator PlcR","volume":"155","author":"L\u00fccking","year":"2009","journal-title":"Microbiology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.3389\/fmicb.2015.01101","article-title":"Ces locus embedded proteins control the non-ribosomal synthesis of the cereulide toxin in emetic Bacillus cereus on multiple levels","volume":"6","author":"L\u00fccking","year":"2015","journal-title":"Front. Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1046\/j.1365-2958.2000.02147.x","article-title":"A new cytotoxin from Bacillus cereus that may cause necrotic enteritis","volume":"38","author":"Lund","year":"2000","journal-title":"Mol. Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1574-6968.1996.tb08377.x","article-title":"Characterisation of a non-haemolytic enterotoxin complex from Bacillus cereus isolated after a foodborne outbreak","volume":"141","author":"Lund","year":"1996","journal-title":"FEMS Microbiol. Lett."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.3389\/fmicb.2016.01644","article-title":"FlhF is required for swarming motility and full pathogenicity of Bacillus cereus","volume":"19","author":"Mazzantini","year":"2016","journal-title":"Front. Microbiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.resmic.2009.11.003","article-title":"Fnr mediates carbohydrate-dependent regulation of catabolic and enterotoxin genes in Bacillus cereus F4430\/73","volume":"161","author":"Messaoudi","year":"2010","journal-title":"Res. Microbiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"465603","DOI":"10.1155\/2014\/465603","article-title":"Emetic Bacillus cereus are more volatile than thought: recent foodborne outbreaks and prevalence studies in Bavaria (2007-2013)","volume":"2014","author":"Messelh\u00e4usser","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"B47","doi-asserted-by":"publisher","first-page":"820","DOI":"10.4315\/0362-028X.JFP-12-294","article-title":"Interaction between Bacillus cereus and cultured human enterocytes: effect of calcium, cell differentiation, and bacterial extracellular factors","volume":"76","author":"Minnaard","year":"2013","journal-title":"J. Food Prot."},{"key":"B48","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0092-1157(74)90015-8","article-title":"Micro cell culture method for determination of diphtheria toxin and antitoxin titres using VERO cells. I. Studies on factors affecting the toxin and antitoxin titration","volume":"2","author":"Miyamura","year":"1974","journal-title":"J. Biol. Stand."},{"key":"B49","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/j.1574-6968.2006.00185.x","article-title":"Determination of the toxic potential of Bacillus cereus isolates by quantitative enterotoxin analyses","volume":"257","author":"Moravek","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1046\/j.1365-2958.2003.03549.x","article-title":"A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system","volume":"49","author":"Rohde","year":"2003","journal-title":"Mol. Microbiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.3390\/toxins2071690","article-title":"Production, secretion and biological activity of Bacillus cereus enterotoxins","volume":"2","author":"Senesi","year":"2010","journal-title":"Toxins"},{"key":"B53","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/j.1574-6976.2008.00112.x","article-title":"From soil to gut: Bacillus cereus and its food poisoning toxins","volume":"32","author":"Stenfors Arnesen","year":"2008","journal-title":"FEMS Microbiol. Rev."},{"key":"B54","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1471-2180-8-62","article-title":"Assessment of CcpA-mediated catabolite control of gene expression in Bacillus cereus ATCC 14579","volume":"8","author":"van der Voort","year":"2008","journal-title":"BMC Microbiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1128\/IAI.74.4.2293-2303.2006","article-title":"Efficient translocation of EspC into epithelial cells depends on enteropathogenic Escherichia coli and host cell contact","volume":"74","author":"Vidal","year":"2006","journal-title":"Infect. Immun."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/j.1462-5822.2009.01332.x","article-title":"Contact with enterocyte-like Caco-2 cells induces rapid upregulation of toxin production by Clostridium perfringens type C isolates","volume":"11","author":"Vidal","year":"2009","journal-title":"Cell Microbiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e103326","DOI":"10.1371\/journal.pone.0103326","article-title":"SecDF as part of the sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins","volume":"9","author":"V\u00f6r\u00f6s","year":"2014","journal-title":"PLoS ONE"},{"key":"B58","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1261\/rna.407707","article-title":"Ligand binding and gene control characteristics of tandem riboswitches in Bacillus anthracis","volume":"13","author":"Welz","year":"2007","journal-title":"RNA"},{"key":"B59","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1128\/AEM.02390-06","article-title":"Germination of Bacillus cereus spores is induced by germinants from differentiated Caco-2 Cells, a human cell line mimicking the epithelial cells of the small intestine","volume":"73","author":"Wijnands","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ijfoodmicro.2006.06.015","article-title":"Spores from mesophilic Bacillus cereus strains germinate better and grow faster in simulated gastro-intestinal conditions than spores from psychrotrophic strains","volume":"112","author":"Wijnands","year":"2006","journal-title":"Int. J. Food Microbiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/j.1365-2672.2008.03999.x","article-title":"Modelling the number of viable vegetative cells of Bacillus cereus passing through the stomach","volume":"106","author":"Wijnands","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"5706","DOI":"10.1093\/nar\/gks212","article-title":"Analysis of lysine recognition and specificity of the Bacillus subtilis L. box riboswitch","volume":"40","author":"Wilson-Mitchell","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0882-4010(87)90034-9","article-title":"Purification and some properties of a Vero toxin from Escherichia coli O157:H7 that is immunologically unrelated to Shiga toxin","volume":"3","author":"Yutsudo","year":"1987","journal-title":"Microb. Pathog."},{"key":"B64","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.bbrc.2015.11.126","article-title":"Formation of small transmembrane pores: an intermediate stage on the way to Bacillus cereus non-hemolytic enterotoxin (Nhe) full pores in the absence of NheA","volume":"469","author":"Zhu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s00203-006-0090-z","article-title":"Anaerobic cells of Bacillus cereus F4430\/73 respond to low oxidoreduction potential by metabolic readjustments and activation of enterotoxin expression","volume":"185","author":"Zigha","year":"2006","journal-title":"Arch. Microbiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1128\/JB.01701-06","article-title":"The redox regulator Fnr is required for fermentative growth and enterotoxin synthesis in Bacillus cereus F4430\/73","volume":"189","author":"Zigha","year":"2007","journal-title":"J. Bacteriol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00627\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T10:08:25Z","timestamp":1601892505000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00627\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":66,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.00627","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]}}}