{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T12:30:14Z","timestamp":1753360214563},"reference-count":52,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.00655","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T03:31:59Z","timestamp":1492572719000},"update-policy":"http:\/\/dx.doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["N2 Gas Flushing Limits the Rise of Antibiotic-Resistant Bacteria in Bovine Raw Milk during Cold Storage"],"prefix":"10.3389","volume":"8","author":[{"given":"Patricia","family":"Munsch-Alatossava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapani","family":"Alatossava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierrre","family":"Gauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2471\/BLT.15.030415","article-title":"What to do about resistant bacteria in the food chain?","volume":"93","author":"Andremont","year":"2015","journal-title":"Bull. World Health Organ."},{"key":"B2","article-title":"Regulation (EC) No 853\/2004 of the European parliament and of the council of 29 April 2004 laying down specific hygiene rules for on the hygiene of foodstuffs","volume-title":"Official J. Eur. Union","author":"Anonymous","year":"2004"},{"key":"B3","doi-asserted-by":"publisher","first-page":"557","DOI":"10.4315\/0362-028X-70.3.557","article-title":"Isolation and molecular characterization of antibiotic-resistant lactic acid bacteria from poultry and swine meat products","volume":"70","author":"Aquilanti","year":"2007","journal-title":"J. Food Prot."},{"key":"B4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3329\/jesnr.v8i1.24662","article-title":"Adulteration of raw milk in selected regions of Tangail district of Bangladesh","volume":"8","author":"Bari","year":"2015","journal-title":"J. Environ. Sci."},{"key":"B5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/AEM.30.2.199-204.1975","article-title":"Antibacterial activity of the lactoperoxidase system in milk against Pseudomonads and other Gram-negative bacteria","volume":"30","author":"Bj\u00f6rck","year":"1975","journal-title":"App. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1086\/504477","article-title":"Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa","volume":"43","author":"Bonomo","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.foodchem.2015.02.077","article-title":"Development and analytical validation of a screening method for simultaneous detection of five adulterants in raw milk using mid-infrared spectroscopy and PLS-DA","volume":"181","author":"Botelho","year":"2015","journal-title":"Food Chem."},{"key":"B8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/0471723959.ch2","article-title":"The microbiology of raw milk","volume-title":"Dairy Microbiology Handbook","author":"Chambers","year":"2002"},{"key":"B9","doi-asserted-by":"publisher","first-page":"172","DOI":"10.4315\/0362-028X-45.2.172","article-title":"Presence and activity of psychrotrophic microorganisms in milk and dairy products: a review","volume":"45","author":"Cousin","year":"1982","journal-title":"J. Food Prot."},{"key":"B10","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/elsc.200520082","article-title":"Effect of modified atmospheres on the growth and extracellular enzymes of psychrotrophs in raw milk","volume":"5","author":"Dechemi","year":"2005","journal-title":"Eng. Life Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1046\/j.1469-0691.2000.00142.x","article-title":"European Committee on Antimicrobial Susceptibility Testing. Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by agar dilution","volume":"6","author":"EUCAST","year":"2000","journal-title":"Clin. Microbiol. Infect."},{"key":"B12","author":"EUCAST","year":"2010","journal-title":"AST of Bacteria: EUCAST Breakpoint Tables v1.1"},{"key":"B13","first-page":"4006","volume-title":"ECDC\/EFSA\/EMA First Joint Report on the Integrated Analysis of the Consumption of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Bacteria from Humans and Food-Producing Animals","author":"ECDC (European Centre for Disease Prevention Control) EFSA (European Food Safety Authority), EMA (European Medicines Agency)","year":"2015"},{"key":"B14","volume-title":"Guidelines for the Preservation of Raw Milk by the Use of the Lactoperoxidase System","author":"FAO","year":"1991"},{"key":"B15","author":"FAO","year":"2016","journal-title":"Antimicrobial Resistance. FAO"},{"key":"B16","article-title":"Benefits and potential risks of the lactoperoxidase system of raw milk preservation","volume-title":"Report of an FAO\/WHO Technical Meeting.","author":"FAO","year":"2005"},{"key":"B17","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/bies.201300143","article-title":"Metagenomic insights into the human gut resistome and the forces that shape it","volume":"36","author":"Forslund","year":"2014","journal-title":"Bioessays"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1016\/B0-12-227235-8\/00305-9","article-title":"Microorganisms associated with milk","volume-title":"Encyclopedia of Dairy Sciences","author":"Frank","year":"2002"},{"key":"B19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijfoodmicro.2006.07.015","article-title":"Direct detection of antibiotic resistance genes in specimens of chicken and pork meat","volume":"113","author":"Garofalo","year":"2007","journal-title":"Int. J. Food Microbiol."},{"key":"B20","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1128\/AEM.57.11.3355-3360.1991","article-title":"Effect of the lactoperoxidase system on Listeria monocytogenes behavior in raw milk at refrigeration temperatures","volume":"57","author":"Gaya","year":"1991","journal-title":"Appl. Environ. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e0146015","DOI":"10.1371\/journal.pone.0146015","article-title":"N2 gas flushing alleviates the loss of bacterial diversity and inhibits psychrotrophic Pseudomonas during the cold storage of bovine raw milk","volume":"11","author":"Gschwendtner","year":"2016","journal-title":"PLoS ONE"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-7180-7","volume-title":"Multiple Comparisons: Theory and Methods.","author":"Hsu","year":"1996"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1128\/AEM.66.4.1328-1333.2000","article-title":"rRNA operon copy number reflects ecological strategies of bacteria","volume":"66","author":"Klappenbach","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.yrtph.2007.06.003","article-title":"Estimating the use of veterinary medicines in the European Union","volume":"50","author":"Kools","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"5644","DOI":"10.1128\/AEM.70.9.5644-5650.2004","article-title":"Raw cow milk bacterial populations shifts attributable to refrigeration","volume":"70","author":"Lafarge","year":"2004","journal-title":"App. Environ. Microbiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1099\/00207713-48-4-1373","article-title":"Bacillus weihenstephanensis sp. nov. is a new psychrotolerant species of the Bacillus cereus group","volume":"48","author":"Lechner","year":"1998","journal-title":"Int. J. Syst. Bacteriol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.micres.2005.12.004","article-title":"Phenotypic characterization of raw-milk associated psychrotrophic bacteria","volume":"161","author":"Munsch-Alatossava","year":"2006","journal-title":"Microbiol. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.micres.2006.01.015","article-title":"Antibiotic resistance of raw-milk associated psychrotrophic bacteria","volume":"162","author":"Munsch-Alatossava","year":"2007","journal-title":"Microbiol. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3389\/fmicb.2014.00619","article-title":"Nitrogen gas flushing can be bactericidal: the temperature-dependent destiny of Bacillus weihenstephanensis KBAB4 under a pure N2 atmosphere","volume":"5","author":"Munsch-Alatossava","year":"2014","journal-title":"Front. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"918208","DOI":"10.5402\/2012\/918208","article-title":"Trends of antibiotic resistance in mesophilic and psychrotrophic bacterial populations during cold storage of raw milk","volume":"2012","author":"Munsch-Alatossava","year":"2012a","journal-title":"ISRN Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"5668","DOI":"10.3390\/ijms14035668","article-title":"Potential of nitrogen gas (N2) flushing to extend the shelf life of cold stored pasteurised milk","volume":"14","author":"Munsch-Alatossava","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.micres.2009.02.002","article-title":"Potential of nitrogen gas (N2) to control psychrotrophs and mesophiles in raw milk","volume":"165","author":"Munsch-Alatossava","year":"2010a","journal-title":"Microbiol. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.micres.2008.07.001","article-title":"Exclusion of phospholipases (PLs)-producing bacteria in raw milk flushed with nitrogen gas (N2)","volume":"165","author":"Munsch-Alatossava","year":"2010b","journal-title":"Microbiol. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"105","DOI":"10.5772\/29994","article-title":"Trends of antibiotic resistance (AR) in mesophilic and psychrotrophic bacterial populations during cold storage of raw milk, produced by organic and conventional farming systems","volume-title":"Antibiotic Resistant Bacteria, A Continuous Challenge in the New Millenium","author":"Munsch-Alatossava","year":"2012b"},{"key":"B35","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3389\/fmicb.2016.00839","article-title":"Efficiency of N2 gas flushing compared to the lactoperoxidase system at controlling bacterial growth in bovine raw milk stored at mild temperatures","volume":"7","author":"Munsch-Alatossava","year":"2016","journal-title":"Front. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1111\/j.1365-2621.1983.tb09183.x","article-title":"Effect of nitrogen flushing on the production of proteinase by psychrotrophic bacteria in raw milk","volume":"48","author":"Murray","year":"1983","journal-title":"J. Food Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s40168-016-0199-5","article-title":"The structure and diversity of human, animal and environmental resistomes","volume":"4","author":"Pal","year":"2016","journal-title":"Microbiome"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e115223","DOI":"10.1371\/journal.pone.0115223","article-title":"In vivo selection of resistant E. coli after ingestion of milk with added drug residues","volume":"9","author":"Pereira","year":"2014","journal-title":"PLoS ONE"},{"key":"B39","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/39767","article-title":"Antibiotic resistance spread in food","volume":"389","author":"Perreten","year":"1997","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.fm.2010.10.009","article-title":"Molecular analysis of bacterial communities in raw cow milk and the impact of refrigeration on its structure and dynamics","volume":"28","author":"Raats","year":"2011","journal-title":"Food Microbiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ijfoodmicro.2010.01.008","article-title":"Molecular analysis of bacterial population structure and dynamics during cold storage of untreated and treated milk","volume":"138","author":"Rasolofo","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3389\/fmicb.2013.00173","article-title":"Food and human gut as reservoirs of transferable antibiotic resistance encoding genes","volume":"4","author":"Rolain","year":"2013","journal-title":"Front. Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.tifs.2004.11.002","article-title":"Significance of the lactoperoxidase system in the dairy industry and its potential applications: a review","volume":"16","author":"Seifu","year":"2005","journal-title":"Trends Food Sci. Technol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0168-1605(02)00241-6","article-title":"Antibiotic resistance in food-related bacteria- a result of interfering with the global web of bacterial genetics","volume":"78","author":"S\u00d8rum","year":"2002","journal-title":"Int. J. Food Microbiol."},{"key":"B45","volume-title":"Dairy Processing Handbook, 2nd Revised Edn.","author":"Tetra Pak","year":"2003"},{"key":"B46","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s000180050022","article-title":"Spread of antibiotic resistance with food-borne pathogens","volume":"56","author":"Teuber","year":"1999","journal-title":"Cell Mol. Life Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e557923","DOI":"10.1371\/journal.pone.0057923","article-title":"The variability of the 16S rRNA gene in bacterial genomes and its consequences for bacterial community analyses","volume":"8","author":"V\u011btrovsky","year":"2013","journal-title":"PLoS ONE"},{"key":"B48","doi-asserted-by":"publisher","first-page":"249","DOI":"10.20506\/rst.31.1.2117","article-title":"The transfer of antibiotic resistance from food to humans: facts, implications and future directions","volume":"31","author":"Wang","year":"2012","journal-title":"Rev. Sci. Tech."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e01017","DOI":"10.1128\/mBio.01017-13","article-title":"Diverse antibiotic resistance genes in dairy cow manure","volume":"5","author":"Wichmann","year":"2014","journal-title":"mBio"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1128\/AEM.66.5.2085-2095.2000","article-title":"Molecular and phenotypic characterization of Pseudomonas spp. isolated from milk","volume":"66","author":"Wiedmann","year":"2000","journal-title":"App. Environ. Microbiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"887","DOI":"10.4315\/0362-028X-56.10.887","article-title":"Antibacterial activity of the lactoperoxidase system: a review","volume":"56","author":"Wolfson","year":"1993","journal-title":"J. Food Prot."},{"key":"B52","volume-title":"Global Action Plan on Antimicrobial Resistance","author":"WHO","year":"2015"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00655\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T05:21:10Z","timestamp":1692768070000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00655\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,19]]},"references-count":52,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.00655","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,19]]}}}