{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:02:18Z","timestamp":1790625738457,"version":"4.1.0"},"reference-count":64,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["203591"],"award-info":[{"award-number":["203591"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["IRCPJ 499946-15"],"award-info":[{"award-number":["IRCPJ 499946-15"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.00865","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T12:06:02Z","timestamp":1495109162000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":64,"title":["Bacteriocin-Producing Enterococcus faecium LCW 44: A High Potential Probiotic Candidate from Raw Camel Milk"],"prefix":"10.3389","volume":"8","author":[{"given":"Allison","family":"Vimont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riadh","family":"Hammami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlem","family":"Ababsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hocine","family":"Daba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isma\u00efl","family":"Fliss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nrmicro2761","article-title":"The rise of the Enterococcus: beyond vancomycin resistance.","volume":"10","author":"Arias","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.ijfoodmicro.2008.04.011","article-title":"Antimicrobial activity of Enterococcus faecium L50, a strain producing enterocins L50 (L50A and L50B), P and Q, against beer-spoilage lactic acid bacteria in broth, wort (hopped and unhopped), and alcoholic and non-alcoholic lager beers.","volume":"125","author":"Basanta","year":"2008","journal-title":"Int. J. Food Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nrmicro3439","article-title":"Tackling antibiotic resistance: the environmental framework.","volume":"13","author":"Berendonk","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ijfoodmicro.2010.05.001","article-title":"Safety assessment and evaluation of probiotic potential of bacteriocinogenic Enterococcus faecium KH 24 strain under in vitro and in vivo conditions.","volume":"141","author":"Bhardwaj","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ijfoodmicro.2008.10.010","article-title":"Comparison of susceptibility to opsonic killing by in vitro human immune response of Enterococcus strains isolated from dairy products, clinical samples and probiotic preparation.","volume":"128","author":"Bhardwaj","year":"2009","journal-title":"Int. J. Food Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.ijfoodmicro.2004.04.011","article-title":"Enterococcus species dominating in fresh modified-atmosphere-packaged, marinated broiler legs are overgrown by Carnobacterium and Lactobacillus species during storage at 6\u00b0C.","volume":"97","author":"Bj\u00f6rkroth","year":"2005","journal-title":"Int. J. Food Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.fm.2011.12.002","article-title":"Characterization of functional, safety, and probiotic properties of Enterococcus faecalis UGRA10, a new AS-48-producer strain.","volume":"30","author":"Cebri\u00e1n","year":"2012","journal-title":"Food Microbiol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1128\/JB.180.8.1988-1994.1998","article-title":"Enterocins L50A and L50B, two novel bacteriocins from Enterococcus faecium L50, are related to staphylococcal hemolysins.","volume":"180","author":"Cintas","year":"1998","journal-title":"J. Bacteriol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.foodres.2006.11.007","article-title":"In vitro analysis of probiotic strain combinations to inhibit pathogen adhesion to human intestinal mucus.","volume":"40","author":"Collado","year":"2007","journal-title":"Food Res. Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1093\/infdis\/171.5.1223","article-title":"Incidence of hemolysin, gelatinase, and aggregation substance among enterococci isolated from patients with endocarditis and other infections and from feces of hospitalized and community-based persons.","volume":"171","author":"Coque","year":"1995","journal-title":"J. Infect. Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.1073\/pnas.0700440104","article-title":"Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118.","volume":"104","author":"Corr","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B12","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/nrmicro1273","article-title":"Bacteriocins: developing innate immunity for food.","volume":"3","author":"Cotter","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"6653","DOI":"10.1128\/aem.00859-06","article-title":"Complete sequence of the enterocin Q-encoding plasmid pCIZ2 from the multiple bacteriocin producer Enterococcus faecium L50 and genetic characterization of enterocin Q production and immunity.","volume":"72","author":"Criado","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ijfoodmicro.2009.05.005","article-title":"In vivo study on the effectiveness of pediocin PA-1 and Pediococcus acidilactici UL5 at inhibiting Listeria monocytogenes.","volume":"133","author":"Dabour","year":"2009","journal-title":"Int. J. Food Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1080\/08910600701538240","article-title":"Purification and characterization of enterocin 62-6, a two-peptide bacteriocin produced by a vaginal strain of Enterococcus faecium: potential significance in bacterial vaginosis.","volume":"19","author":"Dezwaan","year":"2007","journal-title":"Microb. Ecol. Health Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/aem.05576-11","article-title":"Bacteriocin production: A probiotic trait?","volume":"78","author":"Dobson","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/j.1574-6941.2011.01069.x","article-title":"Fate and efficacy of lacticin 3147-producing Lactococcus lactis in the mammalian gastrointestinal tract.","volume":"76","author":"Dobson","year":"2011","journal-title":"FEMS Microbiol. Ecol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1128\/aem.67.4.1628-1635.2001","article-title":"Molecular screening of Enterococcus virulence determinants and potential for genetic exchange between food and medical isolates.","volume":"67","author":"Eaton","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1017\/S0022029900027953","article-title":"Composition and characteristics of camel milk.","volume":"60","author":"Farah","year":"1993","journal-title":"J. Dairy Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/jam.12391","article-title":"Pediococcus acidilactici UL5 and Lactococcus lactis ATCC 11454 are able to survive and express their bacteriocin genes under simulated gastrointestinal conditions.","volume":"116","author":"Fernandez","year":"2014","journal-title":"J. Appl. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/jam.12081","article-title":"Growth, acid production and bacteriocin production by probiotic candidates under simulated colonic conditions.","volume":"114","author":"Fernandez","year":"2013","journal-title":"J. Appl. Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00248-015-0645-0","article-title":"Survival and metabolic activity of pediocin producer Pediococcus acidilactici UL5: its impact on intestinal microbiota and Listeria monocytogenes in a model of the human terminal ileum.","volume":"72","author":"Fernandez","year":"2015","journal-title":"Microb. Ecol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ijfoodmicro.2011.08.014","article-title":"Enterococci as probiotics and their implications in food safety.","volume":"151","author":"Franz","year":"2011","journal-title":"Int. J. Food Microbiol."},{"key":"B24","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1128\/IAI.64.4.1299-1308.1996","article-title":"Effect of cell polarization and differentiation on entry of Listeria monocytogenes into the enterocyte-like Caco-2 cell line.","volume":"64","author":"Gaillard","year":"1996","journal-title":"Infect. Immun."},{"key":"B25","author":"Gerosa","year":"2012","journal-title":"ESA Working Paper No. 12-01: Milk Availability \u2013 Trends in Production and Demand and Medium-Term Outlook"},{"key":"B26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0168-1605(03)00183-1","article-title":"Functionality of enterococci in dairy products.","volume":"88","author":"Giraffa","year":"2003","journal-title":"Int. J. Food Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.foodres.2005.10.003","article-title":"Adhesion and competitive inhibition and displacement of human enteropathogens by selected lactobacilli.","volume":"39","author":"Gueimonde","year":"2006","journal-title":"Food Res. Int."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1099\/13500872-142-1-3","article-title":"New approaches to typing and identification of bacteria using the 16S-23S rDNA spacer region.","volume":"142","author":"G\u00fcrtler","year":"1996","journal-title":"Microbiology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3584","DOI":"10.1021\/acs.jafc.6b00700","article-title":"Simultaneous production of formylated and non-formylated enterocins L50A and L50B, and 61A, a new glycosylated durancin, by Enterococcus durans 61A, a strain isolated from artisanal fermented milk in Tunisia.","volume":"64","author":"Hanchi","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s00203-014-0978-y","article-title":"Bacteriocinogenic properties and in vitro probiotic potential of enterococci from Tunisian dairy products.","volume":"196","author":"Hanchi","year":"2014","journal-title":"Arch. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1099\/mic.0.25949-0","article-title":"Production of enterolysin A by a raw milk enterococcal isolate exhibiting multiple virulence factors.","volume":"149","author":"Hickey","year":"2003","journal-title":"Microbiology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-1-4419-7692-5_13","article-title":"Class IId or linear and non-pediocin-like bacteriocins","author":"Iwatani","year":"2011","journal-title":"Prokaryotic Antimicrobial Peptides"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1128\/aac.01409-07","article-title":"Production of enterocins L50A, L50B, and IT, a new enterocin, by Enterococcus faecium IT62, a strain isolated from Italian ryegrass in Japan.","volume":"52","author":"Izquierdo","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"B34","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1128\/AEM.65.11.4949-4956.1999","article-title":"Screening of probiotic activities of forty-seven strains of Lactobacillus spp. by in vitro techniques and evaluation of the colonization ability of five selected strains in humans.","volume":"65","author":"Jacobsen","year":"1999","journal-title":"Appl. Environ. Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s10482-015-0579-z","article-title":"Enterococcus bulliens sp. nov., a novel lactic acid bacterium isolated from camel milk.","volume":"108","author":"Kadri","year":"2015","journal-title":"Antonie van Leeuwenhoek"},{"key":"B36","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0168-1605(03)00188-0","article-title":"Safety aspects of enterococci from the medical point of view.","volume":"88","author":"Kayser","year":"2003","journal-title":"Int. J. Food Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nature15524","article-title":"Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract.","volume":"526","author":"Kommineni","year":"2015","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3168\/jds.S0022-0302(07)72606-1","article-title":"Lactoferrin and immunoglobulin contents in camel\u2019s milk (Camelus bactrianus, Camelus dromedarius, and hybrids) from Kazakhstan.","volume":"90","author":"Konuspayeva","year":"2007","journal-title":"J. Dairy Sci."},{"key":"B39","article-title":"Enterococcus diversity, origins in nature, and gut colonization","author":"Lebreton","year":"2014","journal-title":"Enterococci: From Commensals to Leading Causes of Drug Resistant Infection [Internet]"},{"key":"B40","first-page":"967","article-title":"Biological properties of SF 68, a new approach for the treatment of diarrheal diseases.","volume":"26","author":"Lewenstein","year":"1979","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5602","DOI":"10.1021\/jf104751v","article-title":"Identification of an N-terminal formylated, two-peptide bacteriocin from Enterococcus faecalis 710C.","volume":"59","author":"Liu","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"B42","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s002489900072","article-title":"Validation of a three-stage compound continuous culture system for investigating the effect of retention time on the ecology and metabolism of bacteria in the human colon.","volume":"35","author":"Macfarlane","year":"1998","journal-title":"Microb. Ecol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000582","article-title":"Genetic diversity among Enterococcus faecalis.","volume":"2","author":"McBride","year":"2007","journal-title":"PLoS ONE"},{"key":"B44","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s13213-011-0363-x","article-title":"Technological, functional and safety aspects of enterococci in fermented vegetable products: a mini-review.","volume":"62","author":"M\u2019hir","year":"2011","journal-title":"Ann. Microbiol."},{"key":"B45","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/026119299502300205","article-title":"A multicompartmental dynamic computer-controlled model simulating the stomach and small intestine.","volume":"23","author":"Minekus","year":"1995","journal-title":"Altern. Lab. Anim."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijfoodmicro.2005.06.026","article-title":"The role and application of enterococci in food and health.","volume":"106","author":"Moreno","year":"2006","journal-title":"Int. J. Food Microbiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"6894","DOI":"10.1128\/aem.00928-06","article-title":"Inactivation of adhesion and invasion of food-borne Listeria monocytogenes by bacteriocin-producing Bifidobacterium strains of human origin.","volume":"72","author":"Moroni","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1128\/JB.01254-06","article-title":"Bacteriocin diversity in Streptococcus and Enterococcus.","volume":"189","author":"Nes","year":"2007","journal-title":"J. Bacteriol."},{"key":"B49","article-title":"Enterococcal bacteriocins and antimicrobial proteins that contribute to niche control","author":"Nes","year":"2014","journal-title":"Enterococci: From Commensals to Leading Causes of Drug Resistant Infection"},{"key":"B50","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.ijfoodmicro.2010.12.029","article-title":"Probiotic assessment of Enterococcus faecalis CP58 isolated from human gut.","volume":"145","author":"Nueno-Palop","year":"2011","journal-title":"Int. J. Food Microbiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1745-4514.1998.tb00234.x","article-title":"Characterization of whey proteins from Mongolian yak, khainak, and bactrian camel.","volume":"22","author":"Ochirkhuyag","year":"1998","journal-title":"J. Food Biochem."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/175285","article-title":"Probiotic bacteria influence the composition and function of the intestinal microbiota.","volume":"2008","author":"O\u2019Toole","year":"2008","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"B53","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/1574-6976.12030","article-title":"The complex microbiota of raw milk.","volume":"37","author":"Quigley","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"key":"B54","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1089\/fpd.2011.0972","article-title":"Enterocin CRL35 inhibits Listeria monocytogenes in a murine model.","volume":"9","author":"Salvucci","year":"2011","journal-title":"Foodborne Pathog. Dis."},{"key":"B55","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1201\/b17297-5","article-title":"Biopreservation by lactic acid bacteria","author":"Saris","year":"2014","journal-title":"Dairy Microbiology and Biochemistry: Recent Developments"},{"key":"B56","doi-asserted-by":"publisher","first-page":"6044","DOI":"10.1128\/iai.68.10.6044-6047.2000","article-title":"Aggregation substance increases adherence and internalization, but not translocation, of Enterococcus faecalis through different intestinal epithelial cells in vitro.","volume":"68","author":"Sartingen","year":"2000","journal-title":"Infect. Immun."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1128\/jcm.41.6.2569-2576.2003","article-title":"Comparative study using type strains and clinical and food isolates to examine hemolytic activity and occurrence of the cyl operon in enterococci.","volume":"41","author":"Semedo","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/0966-842X(96)81501-0","article-title":"M cells and the pathogenesis of mucosal and systemic infections.","volume":"4","author":"Siebers","year":"1996","journal-title":"Trends Microbiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4473","DOI":"10.1128\/jcm.42.10.4473-4479.2004","article-title":"Development of a multiplex PCR for the detection of asa1, gelE, cylA, esp, and hyl genes in enterococci and survey for virulence determinants among european hospital isolates of Enterococcus faecium.","volume":"42","author":"Vankerckhoven","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1128\/cmr.14.3.584-640.2001","article-title":"Listeria pathogenesis and molecular virulence determinants.","volume":"14","author":"V\u00e1zquez-Boland","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1099\/00221287-148-6-1863","article-title":"Enterococcus faecalis surface proteins determine its adhesion mechanism to bile drain materials.","volume":"148","author":"Waar","year":"2002","journal-title":"Microbiology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1146\/annurev-micro-090110-102830","article-title":"The human gut microbiome: ecology and recent evolutionary changes.","volume":"65","author":"Walter","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1128\/aem.01416-08","article-title":"Development of chemically defined media supporting high-cell-density growth of lactococci, enterococci, and streptococci.","volume":"75","author":"Zhang","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"B64","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1128\/AEM.62.12.4504-4513.1996","article-title":"Characterization of universal small-subunit rRNA hybridization probes for quantitative molecular microbial ecology studies.","volume":"62","author":"Zheng","year":"1996","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00865\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T01:36:21Z","timestamp":1602120981000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00865\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,18]]},"references-count":64,"alternative-id":["10.3389\/fmicb.2017.00865"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.00865","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,18]]},"article-number":"865"}}