{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:56:01Z","timestamp":1790607361174,"version":"4.1.0"},"reference-count":33,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.00985","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T03:50:55Z","timestamp":1496375455000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Proteomic Differences between Developmental Stages of Toxoplasma gondii Revealed by iTRAQ-Based Quantitative Proteomics"],"prefix":"10.3389","volume":"8","author":[{"given":"Ze-Xiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Xue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany M.","family":"Elsheikha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Quan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"52300","DOI":"10.1074\/jbc.M409175200","article-title":"The expression of lactate dehydrogenase is important for the cell cycle of Toxoplasma gondii","volume":"279","author":"Al-Anouti","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/1471-2164-15-350","article-title":"Toxoplasma gondii merozoite gene expression analysis with comparison to the life cycle discloses a unique expression state during enteric development","volume":"15","author":"Behnke","year":"2014","journal-title":"BMC Genomics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1146\/annurev-micro-091014-104100","article-title":"Lytic cycle of Toxoplasma gondii: 15 years later","volume":"69","author":"Blader","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S0171-2985(99)80065-5","article-title":"Stage differentiation of the protozoan parasite Toxoplasma gondii","volume":"201","author":"Bohne","year":"1999","journal-title":"Immunobiology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1128\/EC.1.3.329-340.2002","article-title":"Toxoplasma gondii asexual development: identification of developmentally regulated genes and distinct patterns of gene expression","volume":"1","author":"Cleary","year":"2002","journal-title":"Eukaryotic Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0020-7519(01)00308-3","article-title":"Characterisation of global protein expression by two-dimensional electrophoresis and mass spectrometry: proteomics of Toxoplasma gondii","volume":"32","author":"Cohen","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ymeth.2013.04.008","article-title":"Recent advances in quantitative neuroproteomics","volume":"61","author":"Craft","year":"2013","journal-title":"Methods"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1645\/GE-2836.1","article-title":"Oocyst ingestion as an important transmission route of Toxoplasma gondii in Brazilian urban children","volume":"97","author":"Dattoli","year":"2011","journal-title":"J. Parasitol."},{"key":"B9","volume-title":"Toxoplasmosis of Animals and Humans, 2nd Edn","author":"Dubey","year":"2010"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e29955","DOI":"10.1371\/journal.pone.0029955","article-title":"Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance","volume":"7","author":"Fritz","year":"2012","journal-title":"PLoS ONE"},{"key":"B11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12864-015-1225-x","article-title":"Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes","volume":"16","author":"Hehl","year":"2015","journal-title":"BMC Genomics"},{"key":"B12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1297-9716-43-39","article-title":"Toxoplasma gondii sexual cross in a single naturally infected feline host: generation of highly mouse-virulent and avirulent clones, genotypically different from clonal types I, II and III","volume":"43","author":"Herrmann","year":"2012","journal-title":"Vet. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e1405","DOI":"10.1371\/journal.pone.0014057","article-title":"T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest","volume":"5","author":"Hutson","year":"2010","journal-title":"PLoS ONE"},{"key":"B14","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/yea.320100203","article-title":"Ribosome synthesis during the growth cycle of Saccharomyces cerevisiae","volume":"10","author":"Ju","year":"1994","journal-title":"Yeast"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/j.ijpara.2008.06.002","article-title":"Control of the risk of human toxoplasmosis transmitted by meat","volume":"38","author":"Kijlstra","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/01.inf.0000202070.59190.9a","article-title":"Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis","volume":"25","author":"McLeod","year":"2006","journal-title":"Pediatr. Infect. Dis. J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"6321","DOI":"10.1046\/j.1432-1327.2000.01719.x","article-title":"Synthesis of the translational apparatus is regulated at the translational level","volume":"267","author":"Meyuhas","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"key":"B19","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1128\/JB.143.3.1411-1419.1980","article-title":"Changes in regulation of ribosomal protein synthesis during vegetative growth and sporulation of Saccharomyces cerevisiae","volume":"143","author":"Pearson","year":"1980","journal-title":"J. Bacteriol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1074\/mcp.M700251-MCP200","article-title":"Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases","volume":"7","author":"Pierce","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/1471-2164-14-183","article-title":"Global proteomic analysis of the oocyst\/sporozoite of Toxoplasma gondii reveals commitment to a host- independent lifestyle","volume":"14","author":"Possenti","year":"2013","journal-title":"BMC Genomics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.molbiopara.2004.11.011","article-title":"De novo ribosome biosynthesis is transcriptionally regulated in Eimeria tenella, dependent on its life cycle stage","volume":"139","author":"Schaap","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3791\/1420","article-title":"Obtaining highly purified Toxoplasma gondii oocysts by a discontinuous cesium chloride gradient","volume":"3","author":"Staggs","year":"2009","journal-title":"J. Vis. Exp."},{"key":"B24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/infdis\/173.1.265","article-title":"Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients","volume":"173","author":"Suzuki","year":"1996","journal-title":"J. Infect. Dis."},{"key":"B25","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1128\/IAI.65.11.4598-4605.1997","article-title":"Toxoplasma gondii sporozoites form a transient parasitophorous vacuole that is impermeable and contains only a subset of dense-granule proteins","volume":"65","author":"Tilley","year":"1997","journal-title":"Infect. Immun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.pt.2013.06.001","article-title":"Toxoplasma oocysts as a public health problem","volume":"29","author":"Torrey","year":"2013","journal-title":"Trends Parasitol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1017\/S0031182006009954","article-title":"The complete set of Toxoplasma gondii ribosomal protein genes contains two conserved promoter elements","volume":"133","author":"Van Poppel","year":"2006","journal-title":"Parasitology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/cmi.12267","article-title":"Toxoplasma gondii development - turn the switch on or off?","volume":"16","author":"White","year":"2014","journal-title":"Cell. Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1021\/pr050405o","article-title":"Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D gel- or LC-MALDI TOF\/TOF","volume":"5","author":"Wu","year":"2006","journal-title":"J. Proteome Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1128\/EC.00296-12","article-title":"Translational control in Plasmodium and Toxoplasma parasites","volume":"12","author":"Zhang","year":"2013","journal-title":"Eukaryotic Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jprot.2016.07.010","article-title":"Global iTRAQ-based proteomic profiling of Toxoplasma gondii oocysts during sporulation","volume":"148","author":"Zhou","year":"2016","journal-title":"J. Proteomics"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1007\/s00436-011-2435-z","article-title":"Modulation of mouse macrophage proteome induced by Toxoplasma gondii tachyzoites in vivo","volume":"109","author":"Zhou","year":"2011","journal-title":"Parasitol. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1002\/elps.201300044","article-title":"Comparative proteomic analysis of different Toxoplasma gondii genotypes by two-dimensional fluorescence difference gel electrophoresis combined with mass spectrometry","volume":"35","author":"Zhou","year":"2014","journal-title":"Electrophoresis"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00985\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T06:53:29Z","timestamp":1602226409000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00985\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":33,"alternative-id":["10.3389\/fmicb.2017.00985"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.00985","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]},"article-number":"985"}}