{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:24:52Z","timestamp":1790375092082,"version":"4.1.0"},"reference-count":60,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["DFF\u20131331-00241"],"award-info":[{"award-number":["DFF\u20131331-00241"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006736","name":"Universitetssjukhuset \u00d6rebro","doi-asserted-by":"publisher","award":["OLL-547931"],"award-info":[{"award-number":["OLL-547931"]}],"id":[{"id":"10.13039\/501100006736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.02241","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T08:15:41Z","timestamp":1510820141000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Prevalence of Flp Pili-Encoding Plasmids in Cutibacterium acnes Isolates Obtained from Prostatic Tissue"],"prefix":"10.3389","volume":"8","author":[{"given":"Sabina","family":"Davidsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"M\u00f6lling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natyra","family":"Gashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ove","family":"Andr\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swen-Olof","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Brzuszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Poehlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir A.","family":"Al-Zeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Scavenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seven","family":"Nazipi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"S\u00f6derquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Br\u00fcggemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1128\/CMR.00092-13","article-title":"Propionibacterium acnes: from commensal to opportunistic biofilm-associated implant pathogen.","volume":"27","author":"Achermann","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3721","DOI":"10.1128\/JCM.01543-07","article-title":"Direct visualization of Propionibacterium acnes in prostate tissue by multicolor fluorescent in situ hybridization assay.","volume":"45","author":"Alexeyev","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-402","article-title":"BLAST ring image generator (BRIG): simple prokaryote genome comparisons.","volume":"12","author":"Alikhan","year":"2011","journal-title":"BMC Genomics"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00084","article-title":"Novel Flp pilus biogenesis-dependent natural transformation.","volume":"6","author":"Angelov","year":"2015","journal-title":"Front. Microbiol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-75","article-title":"The RAST server: rapid annotations using subsystems technology.","volume":"9","author":"Aziz","year":"2008","journal-title":"BMC Genomics"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090324","article-title":"Intracellular P. acnes infection in glandular epithelium and stromal macrophages of the prostate with or without cancer.","volume":"9","author":"Bae","year":"2014","journal-title":"PLOS ONE"},{"key":"B7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.","volume":"19","author":"Bankevich","year":"2012","journal-title":"J. Comput. Biol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107908","article-title":"Proteome analysis of human sebaceous follicle infundibula extracted from healthy and acne-affected skin.","volume":"9","author":"Bek-Thomsen","year":"2014","journal-title":"PLOS ONE"},{"key":"B9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/jdv.12224","article-title":"Propionibacterium acnes: an update on its role in the pathogenesis of acne.","volume":"28","author":"Beylot","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/9781118982907.ch12","article-title":"\u201cThe emerging role of propionibacteria in human health and disease,\u201d in","author":"Br\u00fcggemann","year":"2016","journal-title":"The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034171","article-title":"CRISPR\/cas loci of type II Propionibacterium acnes confer immunity against acquisition of mobile elements present in type I P. acnes.","volume":"7","author":"Br\u00fcggemann","year":"2012","journal-title":"PLOS ONE"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1097\/01.ju.0000158161.15277.78","article-title":"Propionibacterium acnes associated with inflammation in radical prostatectomy specimens: a possible link to cancer evolution?","volume":"173","author":"Cohen","year":"2005","journal-title":"J. Urol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-016-0074-9","article-title":"Frequency and typing of Propionibacterium acnes in prostate tissue obtained from men with and without prostate cancer.","volume":"11","author":"Davidsson","year":"2016","journal-title":"Infect. Agents Cancer"},{"key":"B14","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nrc2090","article-title":"Inflammation in prostate carcinogenesis.","volume":"7","author":"De Marzo","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"B15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ijmm.2010.08.014","article-title":"Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells.","volume":"301","author":"Fassi Fehri","year":"2011","journal-title":"Int. J. Med. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1038\/jid.2013.21","article-title":"Propionibacterium acnes strain populations in the human skin microbiome associated with acne.","volume":"133","author":"Fitz-Gibbon","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1001\/jamaoncol.2016.5688","article-title":"Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study.","volume":"3","author":"Global Burden of Disease Cancer Collaboration Fitzmaurice","year":"2017","journal-title":"JAMA Oncol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.PLAS-0004-2013","article-title":"Conjugation in gram-positive bacteria.","volume":"2","author":"Goessweiner-Mohr","year":"2014","journal-title":"Microbiol. Spectr."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06940-3","article-title":"Characterization of a Propionibacterium acnes surface protein as a fibrinogen-binding protein.","volume":"7","author":"Grange","year":"2017","journal-title":"Sci. Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1158\/1055-9965.EPI-13-1126","article-title":"Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial.","volume":"23","author":"Gurel","year":"2014","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-230","article-title":"Proteomic identification of secreted proteins of Propionibacterium acnes.","volume":"10","author":"Holland","year":"2010","journal-title":"BMC Microbiol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028919","article-title":"Identification of surprisingly diverse type IV pili, across a broad range of Gram-positive bacteria.","volume":"6","author":"Imam","year":"2011","journal-title":"PLOS ONE"},{"key":"B23","doi-asserted-by":"publisher","first-page":"6169","DOI":"10.1128\/JB.182.21.6169-6176.2000","article-title":"Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea.","volume":"182","author":"Kachlany","year":"2000","journal-title":"J. Bacteriol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169984","article-title":"Frequency of Propionibacterium acnes infection in prostate glands with negative biopsy results is an independent risk factor for prostate cancer in patients with increased serum PSA titers.","volume":"12","author":"Kakegawa","year":"2017","journal-title":"PLOS ONE"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/918320","article-title":"Analysis of complete genomes of Propionibacterium acnes reveals a novel plasmid and increased pseudogenes in an acne associated strain.","volume":"2013","author":"Kasimatis","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1128\/JCM.r06129-11","article-title":"Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnes.","volume":"50","author":"Kilian","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1046\/j.1365-2958.1999.01639.x","article-title":"Flagellar proteins and type III-exported virulence factors are the predominant proteins secreted into the culture media of Salmonella typhimurium.","volume":"34","author":"Komoriya","year":"1999","journal-title":"Mol. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003473","article-title":"A type IV pilus mediates DNA binding during natural transformation in Streptococcus pneumoniae.","volume":"9","author":"Laurenceau","year":"2013","journal-title":"PLOS Pathog."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167237","article-title":"TLR-2 recognizes Propionibacterium acnes CAMP factor 1 from highly inflammatory strains.","volume":"11","author":"Lheure","year":"2016","journal-title":"PLOS ONE"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1038\/ismej.2015.47","article-title":"The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin.","volume":"9","author":"Liu","year":"2015","journal-title":"ISME J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1016\/j.vaccine.2011.02.036","article-title":"Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris.","volume":"29","author":"Liu","year":"2011","journal-title":"Vaccine"},{"key":"B32","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1099\/mic.0.29219-0","article-title":"Variable expression of immunoreactive surface proteins of Propionibacterium acnes.","volume":"152","author":"Lodes","year":"2006","journal-title":"Microbiology"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012277","article-title":"Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne.","volume":"5","author":"Lomholt","year":"2010","journal-title":"PLOS ONE"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1111\/j.1462-5822.2012.01833.x","article-title":"Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation.","volume":"14","author":"Mak","year":"2012","journal-title":"Cell. Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1002\/pros.22621","article-title":"Multilocus sequence typing (MLST) analysis of Propionibacterium acnes isolates from radical prostatectomy specimens.","volume":"73","author":"Mak","year":"2013","journal-title":"Prostate"},{"key":"B36","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.1099\/ijsem.0.001521","article-title":"Proposal to reclassify Propionibacterium acnes type I as Propionibacterium acnes subsp. acnes subsp. nov. and Propionibacterium acnes type II as Propionibacterium acnes subsp. defendens subsp. nov.","volume":"66","author":"McDowell","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041480","article-title":"An expanded multilocus sequence typing scheme for Propionibacterium acnes: investigation of \u201cpathogenic\u201d, \u201ccommensal\u201d and antibiotic resistant strains.","volume":"7","author":"McDowell","year":"2012","journal-title":"PLOS ONE"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1099\/mic.0.049676-0","article-title":"A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens.","volume":"157","author":"McDowell","year":"2011","journal-title":"Microbiology"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070897","article-title":"The opportunistic pathogen Propionibacterium acnes: insights into typing, human disease, clonal diversification and CAMP factor evolution.","volume":"8","author":"McDowell","year":"2013","journal-title":"PLOS ONE"},{"key":"B40","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1128\/JCM.43.1.326-334.2005","article-title":"Propionibacterium acnes types I and II represent phylogenetically distinct groups.","volume":"43","author":"McDowell","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014797","article-title":"Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment.","volume":"6","author":"Nakatsuji","year":"2011","journal-title":"PLOS ONE"},{"key":"B42","doi-asserted-by":"publisher","first-page":"11217","DOI":"10.1073\/pnas.1105380108","article-title":"Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor.","volume":"108","author":"O\u2019Connell Motherway","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1586\/eri.11.137","article-title":"Propionibacterium acnes: infection beyond the skin.","volume":"9","author":"Perry","year":"2011","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"B44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1556\/1886.2016.00040","article-title":"Propionibacterium acnes phylogenetic type III is associated with progressive macular hypomelanosis.","volume":"7","author":"Petersen","year":"2017","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1365-2958.2011.07930.x","article-title":"The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria.","volume":"83","author":"Porter","year":"2012","journal-title":"Mol. Microbiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1128\/JB.185.3.1045-1058.2003","article-title":"The VirB4 family of proposed traffic nucleoside triphosphatases: common motifs in plasmid RP4 TrbE are essential for conjugation and phage adsorption.","volume":"185","author":"Rabel","year":"2003","journal-title":"J. Bacteriol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104199","article-title":"A novel high-resolution single locus sequence typing scheme for mixed populations of Propionibacterium acnes in vivo.","volume":"9","author":"Scholz","year":"2014","journal-title":"PLOS ONE"},{"key":"B48","doi-asserted-by":"publisher","first-page":"4422","DOI":"10.1099\/ijsem.0.001367","article-title":"The natural history of cutaneous propionibacteria, and reclassification of selected species within the genus Propionibacterium to the proposed novel genera Acidipropionibacterium gen. nov., Cutibacterium gen. nov. and Pseudopropionibacterium gen. nov.","volume":"66","author":"Scholz","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/srep20662","article-title":"Genome stability of Propionibacterium acnes: a comprehensive study of indels and homopolymeric tracts.","volume":"6","author":"Scholz","year":"2016","journal-title":"Sci. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"7295","DOI":"10.1073\/pnas.1237223100","article-title":"Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model.","volume":"100","author":"Schreiner","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B51","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1365-2559.2011.04033.x","article-title":"Prostate cancer and inflammation: the evidence.","volume":"60","author":"Sfanos","year":"2012","journal-title":"Histopathology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/pros.20680","article-title":"A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms.","volume":"68","author":"Sfanos","year":"2008","journal-title":"Prostate"},{"key":"B53","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.mimet.2010.09.008","article-title":"Mutagenesis of Propionibacterium acnes and analysis of two CAMP factor knock-out mutants.","volume":"83","author":"S\u00f6rensen","year":"2010","journal-title":"J. Microbiol. Methods"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: molecular evolutionary genetics analysis version 6.0.","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02559-14","article-title":"A multiprotein DNA translocation complex directs intramycelial plasmid spreading during Streptomyces conjugation.","volume":"6","author":"Thoma","year":"2015","journal-title":"mBio"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plasmid.2016.09.004","article-title":"Conjugative DNA-transfer in Streptomyces, a mycelial organism.","author":"Thoma","year":"2016","journal-title":"Plasmid"},{"key":"B57","doi-asserted-by":"publisher","first-page":"6899","DOI":"10.1128\/JB.00690-06","article-title":"The TadV protein of Actinobacillus actinomycetemcomitans is a novel aspartic acid prepilin peptidase required for maturation of the Flp1 pilin and TadE and TadF pseudopilins.","volume":"188","author":"Tomich","year":"2006","journal-title":"J. Bacteriol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nrmicro1636","article-title":"The tad locus: postcards from the widespread colonization island.","volume":"5","author":"Tomich","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00003-13","article-title":"Pan-genome and comparative genome analyses of Propionibacterium acnes reveal its genomic diversity in the healthy and diseased human skin microbiome.","volume":"4","author":"Tomida","year":"2013","journal-title":"mBio"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1016\/j.jid.2016.06.615","article-title":"Different Propionibacterium acnes phylotypes induce distinct immune responses and express unique surface and secreted proteomes.","volume":"136","author":"Yu","year":"2016","journal-title":"J. Invest. Dermatol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02241\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T08:15:46Z","timestamp":1510820146000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02241\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,16]]},"references-count":60,"alternative-id":["10.3389\/fmicb.2017.02241"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.02241","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,16]]},"article-number":"2241"}}