{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:37:12Z","timestamp":1790163432594,"version":"4.1.0"},"reference-count":55,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1107597"],"award-info":[{"award-number":["OPP1107597"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["401596\/2013-3"],"award-info":[{"award-number":["401596\/2013-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.02243","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T13:25:48Z","timestamp":1510752348000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":87,"title":["Low Microbial Diversity and Abnormal Microbial Succession Is Associated with Necrotizing Enterocolitis in Preterm Infants"],"prefix":"10.3389","volume":"8","author":[{"given":"Priscila T.","family":"Dobbler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato S.","family":"Procianoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita C.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a L.","family":"Corso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna S.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz F. W.","family":"Roesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"583","DOI":"10.4161\/gmic.21942","article-title":"Facultative to strict anaerobes ratio in the preterm infant microbiota.","volume":"3","author":"Arboleya","year":"2012","journal-title":"Gut Microbes"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090784","article-title":"Meconium microbiome analysis identifies bacteria correlated with premature birth.","volume":"9","author":"Ardissone","year":"2014","journal-title":"PLOS ONE"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1609\/icwsm.v3i1.13937","article-title":"\u201cGephi: an open source software for exploring and manipulating networks,\u201d in","author":"Bastian","year":"2009","journal-title":"Proceedings of the International AAAI Conference on Weblogs and Social Media"},{"key":"B4","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.anaerobe.2011.03.009","article-title":"Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH).","volume":"17","author":"Bezirtzoglou","year":"2011","journal-title":"Anaerobe"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad7121","article-title":"Antibiotics, birth mode, and diet shape microbiome maturation during early life.","volume":"8","author":"Bokulich","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"B6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests.","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach. Learn."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-2-1","article-title":"Microbes in the neonatal intensive care unit resemble those found in the gut of premature infants.","volume":"2","author":"Brooks","year":"2014","journal-title":"Microbiome"},{"key":"B8","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data.","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1038\/ismej.2012.8","article-title":"Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms.","volume":"6","author":"Caporaso","year":"2012","journal-title":"ISME J."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/srep23129","article-title":"Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid.","volume":"6","author":"Collado","year":"2016","journal-title":"Sci. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1126\/science.aaf1353","article-title":"Prescription drugs obscure microbiome analyses.","volume":"351","author":"Devkota","year":"2016","journal-title":"Science"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1016\/j.jpedsurg.2011.04.002","article-title":"Medical management of motility disorders in patients with intestinal failure: a focus on necrotizing enterocolitis, gastroschisis, and intestinal atresia.","volume":"46","author":"Dicken","year":"2011","journal-title":"J. Pediatr. Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads.","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"B14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1097\/MPG.0b013e3181d1b11e","article-title":"Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics.","volume":"51","author":"Fallani","year":"2010","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002687","article-title":"Inferring correlation networks from genomic survey data.","volume":"8","author":"Friedman","year":"2012","journal-title":"PLOS Comput. Biol."},{"key":"B16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/biomet\/40.3-4.237","article-title":"The population frequencies of species and the estimation of population parameters.","volume":"40","author":"Good","year":"1953","journal-title":"Biometrika"},{"key":"B17","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/ANC.0b013e31821baaf4","article-title":"Necrotizing enterocolitis in the premature infant: neonatal nursing assessment, disease pathogenesis, and clinical presentation.","volume":"11","author":"Gregory","year":"2011","journal-title":"Adv. Neonatal Care"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2015.00017","article-title":"The human neonatal gut microbiome: a brief review.","volume":"3","author":"Gritz","year":"2015","journal-title":"Front. Pediatr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1097\/ANC.0000000000000220","article-title":"Potential NICU environmental influences on the neonate\u2019s microbiome: a systematic review.","volume":"15","author":"Hartz","year":"2015","journal-title":"Adv. Neonatal Care"},{"key":"B20","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1093\/cid\/ciw016","article-title":"A necrotizing enterocolitis-associated gut microbiota is present in the meconium: results of a prospective study.","volume":"62","author":"Heida","year":"2016","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0213-y","article-title":"Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET cohort.","volume":"5","author":"Hill","year":"2017","journal-title":"Microbiome"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078257","article-title":"Diversified microbiota of meconium is affected by maternal diabetes status.","volume":"8","author":"Hu","year":"2013","journal-title":"PLOS ONE"},{"key":"B23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1093\/jac\/dkw383","article-title":"Short- and long-term effects of oral vancomycin on the human intestinal microbiota.","volume":"72","author":"Isaac","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"B24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/nrgastro.2014.153","article-title":"Diet and host-microbial crosstalk in postnatal intestinal immune homeostasis.","volume":"12","author":"Jain","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/ismej.2007.3","article-title":"Long-term ecological impacts of antibiotic administration on the human intestinal microbiota.","volume":"1","author":"Jernberg","year":"2007","journal-title":"ISME J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.resmic.2007.12.007","article-title":"Is meconium from healthy newborns actually sterile?","volume":"159","author":"Jim\u00e9nez","year":"2008","journal-title":"Res. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.tim.2016.11.008","article-title":"Disentangling interactions in the microbiome: a network perspective.","volume":"25","author":"Layeghifard","year":"2016","journal-title":"Trends Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.mimet.2011.03.014","article-title":"Rethinking microbial diversity analysis in the high throughput sequencing era.","volume":"86","author":"Lemos","year":"2011","journal-title":"J. Microbiol. Methods"},{"key":"B29","doi-asserted-by":"publisher","first-page":"F456","DOI":"10.1136\/fetalneonatal-2011-301373","article-title":"Gut microbial colonisation in premature neonates predicts neonatal sepsis.","volume":"97","author":"Madan","year":"2012","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020647","article-title":"Fecal microbiota in premature infants prior to necrotizing enterocolitis.","volume":"6","author":"Mai","year":"2011","journal-title":"PLOS ONE"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0400-1","article-title":"Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model.","volume":"15","author":"Mart\u00edn","year":"2015","journal-title":"BMC Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/ismej.2011.139","article-title":"An improved greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea.","volume":"6","author":"McDonald","year":"2012","journal-title":"ISME J."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: an R Package for reproducible interactive analysis and graphics of microbiome census data.","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLOS ONE"},{"key":"B34","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jpeds.2009.06.063","article-title":"Intestinal microbial ecology in premature infants assessed with non\u2013culture-based techniques.","volume":"156","author":"Mshvildadze","year":"2010","journal-title":"J. Pediatr."},{"key":"B35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1053\/j.semperi.2016.09.015","article-title":"Pathogenesis of NEC: impact of an altered intestinal microbiome.","volume":"41","author":"Neu","year":"2016","journal-title":"Semin. Perinatol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/nrgastro.2016.119","article-title":"Necrotizing enterocolitis: new insights into pathogenesis and mechanisms.","volume":"13","author":"Ni\u00f1o","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4172\/2167-0897.1000222","article-title":"Changes in neonatal microbiota distribution influenced by the environment of the neonatal intensive care unit in the first month of life.","volume":"5","author":"Ohoka","year":"2016","journal-title":"J. Neonatal Biol."},{"key":"B38","first-page":"2","author":"Oksanen","year":"2015"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0248-8","article-title":"Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis.","volume":"5","author":"Pammi","year":"2017","journal-title":"Microbiome"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095476","article-title":"Short-term effect of antibiotics on human gut microbiota.","volume":"9","author":"Panda","year":"2014","journal-title":"PLOS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1542\/peds.2005-2824","article-title":"Factors influencing the composition of the intestinal microbiota in early infancy.","volume":"118","author":"Penders","year":"2006","journal-title":"Pediatrics"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-6-r76","article-title":"Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition.","volume":"15","author":"Pop","year":"2014","journal-title":"Genome Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00248-016-0785-x","article-title":"BMPOS: a flexible and user-friendly tool sets for microbiome studies.","volume":"72","author":"Pylro","year":"2016","journal-title":"Microb. Ecol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.mimet.2014.08.018","article-title":"Data analysis for 16S microbial profiling from different benchtop sequencing platforms.","volume":"107","author":"Pylro","year":"2014","journal-title":"J. Microbiol. Methods"},{"key":"B45","year":"2008","journal-title":"R: A Language and Environment for Statistical Computing"},{"key":"B46","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1093\/cid\/civ137","article-title":"Determining the long-term effect of antibiotic administration on the human normal intestinal microbiota using culture and pyrosequencing methods.","volume":"60","author":"Rashid","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1007\/s00431-015-2635-0","article-title":"Richard J. Martin, Avroy A. Fanaroff and Michele C. Walsh, neonatal-perinatal medicine: diseases of the fetus and infant\u201410th Edition.","volume":"174","author":"Schoeni","year":"2015","journal-title":"Eur. J. Pediatr."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01008","article-title":"Cesarean or vaginal birth does not impact the longitudinal development of the gut microbiome in a cohort of exclusively preterm infants.","volume":"8","author":"Stewart","year":"2017","journal-title":"Front. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1111\/j.1651-2227.2012.02801.x","article-title":"The preterm gut microbiota: changes associated with necrotizing enterocolitis and infection.","volume":"101","author":"Stewart","year":"2012","journal-title":"Acta Paediatr."},{"key":"B50","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3109\/14767058.2010.482605","article-title":"Innate immunity in human newborn infants: prematurity means more than immaturity.","volume":"24","author":"Strunk","year":"2011","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.clp.2012.12.009","article-title":"The altered gut microbiome and necrotizing enterocolitis.","volume":"40","author":"Torrazza","year":"2013","journal-title":"Clin. Perinatol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1038\/ismej.2009.37","article-title":"16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis.","volume":"3","author":"Wang","year":"2009","journal-title":"ISME J."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad0917","article-title":"Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.","volume":"8","author":"Yassour","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography.","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/srep04345","article-title":"Modeling the impact of antibiotic exposure on human microbiota.","volume":"4","author":"Zhao","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02243\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T15:08:35Z","timestamp":1693235315000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02243\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":55,"alternative-id":["10.3389\/fmicb.2017.02243"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.02243","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]},"article-number":"2243"}}