{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:43:49Z","timestamp":1782369829313,"version":"3.54.5"},"reference-count":46,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271867"],"award-info":[{"award-number":["81271867"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.02248","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T04:26:21Z","timestamp":1511238381000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparative Analysis of Proteome-Wide Lysine Acetylation in Juvenile and Adult Schistosoma japonicum"],"prefix":"10.3389","volume":"8","author":[{"given":"Qing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xumin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1073\/pnas.51.5.786","article-title":"Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis","volume":"51","author":"Allfrey","year":"1964","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1042\/bse0520023","article-title":"Mitochondrial protein acetylation regulates metabolism","volume":"52","author":"Anderson","year":"2012","journal-title":"Essays Biochem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"605","DOI":"10.2307\/3276242","article-title":"Mating behavior and development of schistosomes in the mouse","volume":"51","author":"Armstrong","year":"1965","journal-title":"J. Parasitol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jprot.2015.10.001","article-title":"Excretory\/secretory proteome of 14-day schistosomula, Schistosoma japonicum","volume":"130","author":"Cao","year":"2016","journal-title":"J. Proteomics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/bies.20210","article-title":"Regulatory cross-talk between lysine acetylation and ubiquitination: role in the control of protein stability","volume":"27","author":"Caron","year":"2005","journal-title":"Bioessays"},{"key":"B6","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1126\/science.1175371","article-title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions","volume":"325","author":"Choudhary","year":"2009","journal-title":"Science"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1007\/s00018-009-0252-7","article-title":"The emerging role of lysine acetylation of non-nuclear proteins","volume":"67","author":"Close","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1586\/14787210.4.2.199","article-title":"Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance","volume":"4","author":"Doenhoff","year":"2006","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"B9","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1017\/S0031182000046394","article-title":"A comparative study of the reproductive system of mature, immature and \u201cunisexual\u201d female Schistosoma mansoni","volume":"67","author":"Erasmus","year":"1973","journal-title":"Parasitology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3389\/fpls.2015.00739","article-title":"Global analysis of lysine acetylation in strawberry leaves","volume":"6","author":"Fang","year":"2015","journal-title":"Front. Plant Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/BF01022372","article-title":"Chemical communication in hermaphroditic digenetic trematodes","volume":"12","author":"Fried","year":"1986","journal-title":"J. Chem. Ecol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/BF00389899","article-title":"Praziquantel, a new board-spectrum antischistosomal agent","volume":"52","author":"Gonnert","year":"1977","journal-title":"Z. Parasitenkd."},{"key":"B13","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.tibs.2010.09.003","article-title":"Regulation of intermediary metabolism by protein acetylation","volume":"36","author":"Guan","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"10135","DOI":"10.1074\/jbc.M710277200","article-title":"HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity","volume":"283","author":"Gupta","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0166-6851(02)00031-2","article-title":"The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase","volume":"121","author":"Heather","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1074\/mcp.M112.017251","article-title":"Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in saccharomyces cerevisiae","volume":"11","author":"Henriksen","year":"2012","journal-title":"Mol. Cell Proteom."},{"key":"B17","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jprot.2016.08.008","article-title":"Proteome-wide analysis of lysine acetylation in adult Schistosoma japonicum worm","volume":"148","author":"Hong","year":"2016","journal-title":"J. Proteomics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.tibs.2016.09.006","article-title":"How myosin generates force on actin filaments","volume":"41","author":"Houdusse","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1002996","DOI":"10.1371\/journal.ppat.1002996","article-title":"Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni","volume":"8","author":"Huang","year":"2012","journal-title":"PLoS Pathog."},{"key":"B20","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1128\/EC.00088-12","article-title":"Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii","volume":"11","author":"Jeffers","year":"2012","journal-title":"Eukaryotic Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.molcel.2006.06.026","article-title":"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey","volume":"23","author":"Kim","year":"2006","journal-title":"Mol. Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1093\/emboj\/19.6.1176","article-title":"Acetylation a regulatory modification to rival phosphorylation","volume":"19","author":"Kouzarides","year":"2000","journal-title":"EMBO J."},{"key":"B23","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1007\/s00018-015-2000-5","article-title":"Tubulin acetylation: responsible enzymes, biological functions and human diseases","volume":"72","author":"Li","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0169-4758(98)01261-7","article-title":"Do antioxidants play a role in schistosome host\u2013parasite interactions","volume":"14","author":"LoVerde","year":"1998","journal-title":"Parasitol. Today"},{"key":"B25","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/0169-4758(91)90263-N","article-title":"Schistosome female reproductive development","volume":"7","author":"LoVerde","year":"1991","journal-title":"Parasitol. Today"},{"key":"B26","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nbt0303-255","article-title":"Proteomic analysis of post-translational modifications","volume":"21","author":"Mann","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/mmi.12303","article-title":"Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development","volume":"89","author":"Miao","year":"2013","journal-title":"Mol. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/0014-4894(69)90052-6","article-title":"Mating of Schistosoma mansoni in vitro","volume":"25","author":"Michaels","year":"1969","journal-title":"Exp. Parasitol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/cmi.12444","article-title":"The metabolic control of schistosome egg production","volume":"17","author":"Pearce","year":"2015","journal-title":"Cell. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1042\/bj0870258","article-title":"The presence of acetyl groups of histones","volume":"87","author":"Phillips","year":"1963","journal-title":"Biochem. J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e35033","DOI":"10.1371\/journal.pone.0035033","article-title":"Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites","volume":"7","author":"Ross","year":"2012","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.biochi.2007.06.009","article-title":"Regulation of protein turnover by acetyltransferases and deacetylases","volume":"90","author":"Sadoul","year":"2008","journal-title":"Biochimie"},{"key":"B33","doi-asserted-by":"publisher","first-page":"970382","DOI":"10.1155\/2011\/970382","article-title":"The tale of protein lysine acetylation in the cytoplasm","volume":"2011","author":"Sadoul","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"15559","DOI":"10.1074\/jbc.M115.653048","article-title":"Histone deacetylase 3 (HDAC3)-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity","volume":"290","author":"Samant","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1017\/S003118209700173X","article-title":"Identification of Ras, MAP kinases, and a GAP protein in Schistosoma mansoni by immunoblotting and their putative involvement in male-female interaction","volume":"115","author":"Schussler","year":"1997","journal-title":"Parasitology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1042\/bse0520013","article-title":"Regulation of cellular homoeostasis by reversible lysine acetylation: figure 1","volume":"52","author":"Scott","year":"2012","journal-title":"Essays Biochem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.biocel.2008.08.027","article-title":"Acetylation of non-histone proteins modulates cellular signalling at multiple levels","volume":"41","author":"Spange","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.atherosclerosis.2009.04.037","article-title":"Effects of Schistosoma mansoni worms and eggs on circulating cholesterol and liver lipids in mice","volume":"207","author":"Stanley","year":"2009","journal-title":"Atherosclerosis"},{"key":"B40","doi-asserted-by":"publisher","first-page":"14693","DOI":"10.1038\/ncomms14693","article-title":"Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1016\/S0140-6736(08)61358-6","article-title":"Schistosomiasis control: experiences and lessons from China","volume":"372","author":"Wang","year":"2008","journal-title":"Lancet"},{"key":"B41","doi-asserted-by":"publisher","first-page":"ra48","DOI":"10.1126\/scisignal.2001902","article-title":"Proteome-wide mapping of the drosophila acetylome demonstrates a high degree of conservation of lysine acetylation","volume":"4","author":"Weinert","year":"2011","journal-title":"Sci. Signal."},{"key":"B42","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.mce.2010.06.011","article-title":"Nuclear hormone receptors in parasitic helminths","volume":"334","author":"Wu","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.biocel.2014.11.010","article-title":"Proteome-wide lysine acetylation profiling of the human pathogen Mycobacterium tuberculosis","volume":"59","author":"Xie","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1083\/jcb.201202056","article-title":"Mechanistic insights into the regulation of metabolic enzymes by acetylation","volume":"198","author":"Xiong","year":"2012","journal-title":"J. Cell Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1074\/mcp.M800187-MCP200","article-title":"Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli","volume":"8","author":"Zhang","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1126\/science.1179689","article-title":"Regulation of cellular metabolism by protein lysine acetylation","volume":"327","author":"Zhao","year":"2010","journal-title":"Science"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02248\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T04:26:24Z","timestamp":1511238384000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02248\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,21]]},"references-count":46,"alternative-id":["10.3389\/fmicb.2017.02248"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.02248","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,21]]},"article-number":"2248"}}