{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:22:17Z","timestamp":1757704937513,"version":"3.41.2"},"reference-count":38,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31372429"],"award-info":[{"award-number":["31372429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.02408","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T09:59:07Z","timestamp":1512381547000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Screening and Identification of the Host Proteins Interacting with Toxoplasma gondii Rhoptry Protein ROP16"],"prefix":"10.3389","volume":"8","author":[{"given":"Ming","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longjiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongle","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lun","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002992","article-title":"The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.","volume":"8","author":"Behnke","year":"2012","journal-title":"PLOS Pathog."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.355","article-title":"Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons.","volume":"5","author":"Bekdash","year":"2015","journal-title":"Brain Behav."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002236","article-title":"Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.","volume":"7","author":"Butcher","year":"2011","journal-title":"PLOS Pathog."},{"key":"B4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1124\/jpet.115.230417","article-title":"Ethanol regulation of synaptic GABAA alpha4 receptors is prevented by protein kinase a activation.","volume":"357","author":"Carlson","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1111\/cmi.12471","article-title":"Host-parasite interactions: an intimate epigenetic relationship.","volume":"17","author":"Cheeseman","year":"2015","journal-title":"Cell. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.actatropica.2012.02.001","article-title":"Interactions between the ROP18 kinase and host cell proteins that aid in the parasitism of Toxoplasma gondii.","volume":"122","author":"Cheng","year":"2012","journal-title":"Acta Trop."},{"key":"B7","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.chom.2014.04.002","article-title":"The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.","volume":"15","author":"Etheridge","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1111\/epi.12771","article-title":"Effect of spontaneous seizures on GABAA receptor alpha4 subunit expression in an animal model of temporal lobe epilepsy.","volume":"55","author":"Grabenstatter","year":"2014","journal-title":"Epilepsia"},{"key":"B9","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nrmicro2858","article-title":"Modulation of innate immunity by Toxoplasma gondii virulence effectors.","volume":"10","author":"Hunter","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1007\/s11064-013-1148-3","article-title":"GABAA-R alpha4 subunits are required for the low dose locomotor stimulatory effect of alphaxalone, but not for several other behavioral responses to alphaxalone, etomidate or propofol.","volume":"39","author":"Iyer","year":"2014","journal-title":"Neurochem. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1128\/IAI.01185-12","article-title":"Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15.","volume":"81","author":"Jensen","year":"2013","journal-title":"Infect. Immun."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002274","article-title":"The seroprevalence of Toxoplasma gondii in Chinese population with cancer: a systematic review and meta-analysis.","volume":"94","author":"Jiang","year":"2015","journal-title":"Medicine"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002825","article-title":"Toxoplasma co-opts host cells it does not invade.","volume":"8","author":"Koshy","year":"2012","journal-title":"PLOS Pathog."},{"key":"B14","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jprot.2014.03.038","article-title":"Twenty years of protein interaction studies for biological function deciphering.","volume":"107","author":"Legrain","year":"2014","journal-title":"J. Proteomics"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1943-1","article-title":"Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system.","volume":"10","author":"Liu","year":"2017","journal-title":"Parasit. Vectors"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis.","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002784","article-title":"The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.","volume":"8","author":"Niedelman","year":"2012","journal-title":"PLOS Pathog."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1084\/jem.20030275","article-title":"Constitutive expression of AID leads to tumorigenesis.","volume":"197","author":"Okazaki","year":"2003","journal-title":"J. Exp. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"28731","DOI":"10.1074\/jbc.M110.112359","article-title":"Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.","volume":"285","author":"Ong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/emboj.2011.417","article-title":"Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1.","volume":"31","author":"Orthwein","year":"2012","journal-title":"EMBO J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/ng.2007.35","article-title":"AID is required for germinal center-derived lymphomagenesis.","volume":"40","author":"Pasqualucci","year":"2008","journal-title":"Nat. Genet."},{"key":"B22","doi-asserted-by":"publisher","first-page":"9533","DOI":"10.1073\/pnas.96.17.9533","article-title":"Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL\/elongin BC\/hCUL-2 complex with the ubiquitin ligase complex SKP1\/cullin\/F-box protein.","volume":"96","author":"Pause","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1007\/s11064-013-1202-1","article-title":"Altered localization of the delta subunit of the GABAA receptor in the thalamus of alpha4 subunit knockout mice.","volume":"39","author":"Peng","year":"2014","journal-title":"Neurochem. Res."},{"key":"B24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/genetics\/138.3.609","article-title":"Protein-protein interactions in the yeast pheromone response pathway: ste5p interacts with all members of the MAP kinase cascade.","volume":"138","author":"Printen","year":"1994","journal-title":"Genetics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nature05395","article-title":"Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue.","volume":"445","author":"Saeij","year":"2007","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1021\/bi401329a","article-title":"Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer.","volume":"53","author":"Stark","year":"2014","journal-title":"Biochemistry"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2011.00110","article-title":"Subunit compensation and plasticity of synaptic GABA(A) receptors induced by ethanol in alpha4 subunit knockout mice.","volume":"5","author":"Suryanarayanan","year":"2011","journal-title":"Front. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.pt.2016.11.007","article-title":"Toxoplasma gondii: one organism, multiple models.","volume":"33","author":"Szabo","year":"2017","journal-title":"Trends Parasitol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans.","volume":"30","author":"Tenter","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-014-0543-1","article-title":"Identification of host proteins interacting with the integrin-like A domain of Toxoplasma gondii micronemal protein MIC2 by yeast-two-hybrid screening.","volume":"7","author":"Wang","year":"2014","journal-title":"Parasit. Vectors"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30005-X","article-title":"Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis.","volume":"4","author":"Wang","year":"2017","journal-title":"Lancet HIV"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1084\/jem.20091703","article-title":"A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.","volume":"206","author":"Yamamoto","year":"2009","journal-title":"J. Exp. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1128\/CVI.00312-10","article-title":"Protective immunity induced by Toxoplasma gondii rhoptry protein 16 against toxoplasmosis in mice.","volume":"18","author":"Yuan","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ajpath.2010.09.044","article-title":"Activation-induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunities.","volume":"178","author":"Zaheen","year":"2011","journal-title":"Am. J. Pathol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s13238-014-0102-8","article-title":"Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity.","volume":"6","author":"Zhang","year":"2015","journal-title":"Protein Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1586\/14760584.2015.1098539","article-title":"Recent advances in developing vaccines against Toxoplasma gondii: an update.","volume":"14","author":"Zhang","year":"2015","journal-title":"Expert Rev. Vaccines"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1128\/MCB.01154-06","article-title":"Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.","volume":"28","author":"Zhang","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-4-165","article-title":"Toxoplasma gondii infection in humans in China.","volume":"4","author":"Zhou","year":"2011","journal-title":"Parasit. Vectors"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02408\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T21:28:52Z","timestamp":1660080532000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02408\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":38,"alternative-id":["10.3389\/fmicb.2017.02408"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.02408","relation":{},"ISSN":["1664-302X"],"issn-type":[{"type":"electronic","value":"1664-302X"}],"subject":[],"published":{"date-parts":[[2017,12,4]]},"article-number":"2408"}}