{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:09:22Z","timestamp":1790284162680,"version":"4.1.0"},"reference-count":42,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007378","name":"Universidade Federal de Juiz de Fora","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.02419","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T12:50:56Z","timestamp":1512651056000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Eugenol Induces Phenotypic Alterations and Increases the Oxidative Burst in Cryptococcus"],"prefix":"10.3389","volume":"8","author":[{"given":"J\u00fania C. O.","family":"Alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella F.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julliana R.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds C. N.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o F. S.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallace R. N.","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanueli I.","family":"Farah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1quila R. C.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda S.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourimar V. N. F.","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera L.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago R. L.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngelo M. L.","family":"Denadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana S.","family":"Guzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1021\/bi048077d","article-title":"Isothermal titration calorimetry studies of the binding of a rationally designed analogue of the antimicrobial peptide gramicidin s to phospholipid bilayer membranes.","volume":"44","author":"Abraham","year":"2005","journal-title":"Biochemistry"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029561","article-title":"Capsules from pathogenic and non-pathogenic Cryptococcus spp. manifest significant differences in structure and ability to protect against phagocytic cells.","volume":"7","author":"Araujo Gde","year":"2012","journal-title":"PLOS ONE"},{"key":"B3","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1515\/revneuro-2015-0009","article-title":"Phytochemical constituents as future antidepressants: a comprehensive review.","volume":"26","author":"Bahramsoltani","year":"2015","journal-title":"Rev. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/570521","article-title":"Antioxidant and antimycotic activities of two native Lavandula species from Portugal.","volume":"2015","author":"Baptista","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B5","author":"Berg","year":"2002","journal-title":"Biochemistry: Section 1.3 Chemical Bonds in Biochemistry"},{"key":"B6","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1021\/jf60075a005","article-title":"Spectrophotometric semi-microdetermination of ergosterol in yeast.","volume":"5","author":"Breivik","year":"1957","journal-title":"J. Agric. Food Chem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/13693780701675797","article-title":"Disseminated cryptococcosis with necrotizing fasciitis in an apparently immunocompetent host: a case report.","volume":"46","author":"Capoor","year":"2008","journal-title":"Med. Mycol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.3390\/molecules17011002","article-title":"Antifungal activity of eugenol analogues. Influence of different substituents and studies on mechanism of action.","volume":"17","author":"Carrasco","year":"2012","journal-title":"Molecules"},{"key":"B9","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/jac\/dkh436","article-title":"Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model.","volume":"54","author":"Chami","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"B10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.idc.2006.07.001","article-title":"Cryptococcosis.","volume":"20","author":"Chayakulkeeree","year":"2006","journal-title":"Infect. Dis. Clin. North Am."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076028","article-title":"The antifungal eugenol perturbs dual aromatic and branched-chain amino acid permeases in the cytoplasmic membrane of yeast.","volume":"8","author":"Darvishi","year":"2013","journal-title":"PLOS ONE"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1093\/jac\/dkt114","article-title":"The role of oxidative and nitrosative bursts caused by azoles and amphotericin B against the fungal pathogen Cryptococcus gattii.","volume":"68","author":"Ferreira","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"B13","doi-asserted-by":"publisher","first-page":"4600","DOI":"10.1128\/aac.00466-15","article-title":"Heteroresistance to itraconazole alters the morphology and increases the virulence of Cryptococcus gattii.","volume":"59","author":"Ferreira","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B14","doi-asserted-by":"publisher","first-page":"5478","DOI":"10.1128\/AAC.02287-12","article-title":"Azole resistance in Cryptococcus gattii from the Pacific Northwest: investigation of the role of ERG11.","volume":"57","author":"Gast","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B15","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3390\/molecules19010514","article-title":"New natural diterpene-type abietane from Tetradenia riparia essential oil with cytotoxic and antioxidant activities.","volume":"19","author":"Gazim","year":"2014","journal-title":"Molecules"},{"key":"B16","doi-asserted-by":"publisher","first-page":"5750","DOI":"10.1128\/AEM.70.10.5750-5755.2004","article-title":"Mechanisms of bactericidal action of cinnamaldehyde against Listeria monocytogenes and of eugenol against L. monocytogenes and Lactobacillus sakei.","volume":"70","author":"Gill","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1590\/S0074-02762012000500003","article-title":"Terbinafine inhibits Cryptococcus neoformans growth and modulates fungal morphology.","volume":"107","author":"Guerra","year":"2012","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.fgb.2015.02.009","article-title":"Recognition of seven species in the Cryptococcus gattii\/Cryptococcus neoformans species complex.","volume":"78","author":"Hagen","year":"2015","journal-title":"Fungal Genet. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000360978","article-title":"Disseminated cryptococcosis-induced skin ulcers in a patient with autoimmune hepatitis.","volume":"6","author":"Ikeda","year":"2014","journal-title":"Case Rep. Dermatol."},{"key":"B20","year":"2008","journal-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standard M27-A3"},{"key":"B21","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/j.1567-1364.2010.00697.x","article-title":"Induction of oxidative stress as a possible mechanism of the antifungal action of three phenylpropanoids.","volume":"11","author":"Khan","year":"2011","journal-title":"FEMS Yeast Res."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/2191-0855-3-54","article-title":"Phenyl aldehyde and propanoids exert multiple sites of action towards cell membrane and cell wall targeting ergosterol in Candida albicans.","volume":"3","author":"Khan","year":"2013","journal-title":"AMB Express"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089122","article-title":"A vanillin derivative causes mitochondrial dysfunction and triggers oxidative stress in Cryptococcus neoformans.","volume":"9","author":"Kim","year":"2014","journal-title":"PLOS ONE"},{"key":"B24","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1128\/iai.39.3.1214-1219.1983","article-title":"Dissociation of a hydrophobic surface from phagocytosis of encapsulated and non-encapsulated Cryptococcus neoformans.","volume":"39","author":"Kozel","year":"1983","journal-title":"Infect. Immun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrmicro2522","article-title":"Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box.","volume":"9","author":"Kronstad","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1248\/bpb.30.184","article-title":"Antifungal effect of eugenol and nerolidol against Microsporum gypseum in a guinea pig model.","volume":"30","author":"Lee","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"B27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1590\/S0074-02762005000100011","article-title":"Antifungal activity from Ocimum gratissimum L. towards Cryptococcus neoformans.","volume":"100","author":"Lemos","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000993","article-title":"Structure and reaction mechanism of basil eugenol synthase.","volume":"2","author":"Louie","year":"2007","journal-title":"PLOS ONE"},{"key":"B29","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/lam.12086","article-title":"Hydroxyaldimines as potent in vitro anticryptococcal agents.","volume":"57","author":"Magalh\u00e3es","year":"2013","journal-title":"Lett. Appl. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.fgb.2006.07.010","article-title":"The volume and hydration of the Cryptococcus neoformans polysaccharide capsule.","volume":"44","author":"Maxson","year":"2007","journal-title":"Fungal Genet. Biol."},{"key":"B31","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1128\/AAC.43.8.1856","article-title":"Heteroresistance to fluconazole and voriconazole in Cryptococcus neoformans.","volume":"43","author":"Mondon","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"B32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1128\/AAC.43.2.233","article-title":"Amphotericin B and fluconazole affect cellular charge, macrophage phagocytosis, and cellular morphology of Cryptococcus neoformans at subinhibitory concentrations.","volume":"43","author":"Nosanchuk","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them.","volume":"52","author":"Odds","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"B34","first-page":"159","article-title":"Flow cytofluorometry of lysosomal acridine orange uptake by living cultured cells. Effect of trypsinization and starvation.","volume":"95","author":"Olsson","year":"1987","journal-title":"Acta Pathol. Microbiol. Immunol. Scand. A"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/861497","article-title":"Effect of eugenol against Streptococcus agalactiae and synergistic interaction with biologically produced silver nanoparticles.","volume":"2015","author":"Perugini Biasi-Garbin","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.4161\/cc.9.12.12052","article-title":"Connecting Hsp70, sphingolipid metabolism and lysosomal stability.","volume":"9","author":"Petersen","year":"2010","journal-title":"Cell Cycle"},{"key":"B37","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4103\/0975-7406.76462","article-title":"The thermodynamics of simple biomembrane mimetic systems.","volume":"3","author":"Raudino","year":"2011","journal-title":"J. Pharm. Bioallied Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1768-322X.1986.tb00458.x","article-title":"Mitochondrial analysis in living cells: the use of rhodamine 123 and flow cytometry.","volume":"57","author":"Ronot","year":"1986","journal-title":"Biol. Cell"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1128\/AAC.06098-11","article-title":"Dynamic interaction between fluconazole and amphotericin B against Cryptococcus gattii.","volume":"56","author":"Santos","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112669","article-title":"Fluconazole alters the polysaccharide capsule of Cryptococcus gattii and leads to distinct behaviors in murine Cryptococcosis.","volume":"9","author":"Santos","year":"2014","journal-title":"PLOS ONE"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00036","article-title":"Antifungal therapy: new advances in the understanding and treatment of mycosis.","volume":"8","author":"Scorzoni","year":"2017","journal-title":"Front. Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"k2683","DOI":"10.3390\/molecules17032683","article-title":"Chemical and antimicrobial evaluation of supercritical and conventional Sideritis scardica Griseb., Lamiaceae extracts.","volume":"17","author":"Tadi\u0107","year":"2012","journal-title":"Molecules"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02419\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T01:07:57Z","timestamp":1660093677000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.02419\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":42,"alternative-id":["10.3389\/fmicb.2017.02419"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.02419","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,7]]},"article-number":"2419"}}