{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:14:18Z","timestamp":1791850458143,"version":"4.3.4"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1130250"],"award-info":[{"award-number":["1130250"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1170925"],"award-info":[{"award-number":["1170925"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["3170140"],"award-info":[{"award-number":["3170140"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1171615"],"award-info":[{"award-number":["1171615"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["3160384"],"award-info":[{"award-number":["3160384"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["15130011"],"award-info":[{"award-number":["15130011"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.00005","type":"journal-article","created":{"date-parts":[[2018,1,21]],"date-time":"2018-01-21T23:13:40Z","timestamp":1516576420000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":197,"title":["Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression"],"prefix":"10.3389","volume":"9","author":[{"given":"Paula","family":"D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Valenzuela Valderrama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimena","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F. G.","family":"Quest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e82322","DOI":"10.1371\/journal.pone.0082322","article-title":"Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis","volume":"8","author":"Akazawa","year":"2013","journal-title":"PLoS ONE"},{"key":"B2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s11739-012-0867-9","article-title":"Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma","volume":"9","author":"Amedei","year":"2014","journal-title":"Intern. Emerg. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1158\/0008-5472.CAN-12-3109","article-title":"Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity","volume":"73","author":"Atkins","year":"2013","journal-title":"Cancer Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1021\/jm300713s","article-title":"Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-p yrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)","volume":"55","author":"Axten","year":"2012","journal-title":"J. Med. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1021\/ml400228e","article-title":"Discovery of GSK2656157: an optimized PERK inhibitor selected for preclinical development","volume":"4","author":"Axten","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"B6","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1089\/ars.2008.2270","article-title":"Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment","volume":"11","author":"Azad","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"B7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1042\/bj20031208","article-title":"Oxidative-stress-related proteome changes in Helicobacter pylori-infected human gastric mucosa","volume":"379","author":"Baek","year":"2004","journal-title":"Biochem. J."},{"key":"B8","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/labinvest.2012.131","article-title":"The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner","volume":"93","author":"Baird","year":"2013","journal-title":"Lab. Invest."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1038\/onc.2010.153","article-title":"PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage","volume":"29","author":"Bobrovnikova-Marjon","year":"2010","journal-title":"Oncogene"},{"key":"B10","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.jcmgh.2017.02.002","article-title":"Oxidative stress resulting from Helicobacter pylori infection contributes to gastric carcinogenesis","volume":"3","author":"Butcher","year":"2017","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/hel.12211","article-title":"Autophagy in Helicobacter pylori infection and related gastric cancer","volume":"20","author":"Casta\u00f1o-Rodr\u00edguez","year":"2015","journal-title":"Helicobacter"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1016\/j.biocel.2010.04.015","article-title":"HSP90\u03b2 interacts with Rac1 to activate NADPH oxidase in Helicobacter pylori-infected gastric epithelial cells","volume":"42","author":"Cha","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1053\/j.gastro.2011.07.045","article-title":"Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA","volume":"141","author":"Chaturvedi","year":"2011","journal-title":"Gastroenterology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s10120-015-0462-7","article-title":"Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis","volume":"19","author":"Chen","year":"2016","journal-title":"Gastric Cancer"},{"key":"B15","doi-asserted-by":"publisher","first-page":"762514","DOI":"10.1155\/2014\/762514","article-title":"Association of Helicobacter pylori and iNOS production by macrophages and lymphocytes in the gastric mucosa in chronic gastritis","volume":"2014","author":"Cherdantseva","year":"2014","journal-title":"J. Immunol. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.3748\/wjg.v23.i9.1521","article-title":"Host pathogen interactions in Helicobacter pylori related gastric cancer","volume":"23","author":"Chmiela","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"B17","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process\u2013First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1053\/j.gastro.2007.06.026","article-title":"Carcinogenesis of Helicobacter pylori","volume":"133","author":"Correa","year":"2007","journal-title":"Gastroenterology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.1128\/IAI.00172-07","article-title":"Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells","volume":"75","author":"Ding","year":"2007","journal-title":"Infect. Immun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4186","DOI":"10.1128\/IAI.05602-11","article-title":"Localized suppression of inflammation at sites of Helicobacter pylori colonization","volume":"79","author":"Every","year":"2011","journal-title":"Infect. Immun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s12253-015-9913-z","article-title":"The role of the mediators of inflammation in cancer development","volume":"21","author":"Fernandes","year":"2015","journal-title":"Pathol. Oncol. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1053\/j.gastro.2010.03.050","article-title":"Helicobacter pylori gamma-glutamyl transpeptidase is a pathogenic factor in the development of peptic ulcer disease","volume":"139","author":"Gong","year":"2010","journal-title":"Gastroenterology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/cmi.12396","article-title":"The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response (UPR) to autophagy in gastric epithelial cells","volume":"17","author":"Halder","year":"2015","journal-title":"Cell. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1099\/mic.0.26012-0","article-title":"Catalase (KatA) and KatA-associated protein (KapA) are essential to persistent colonization in the Helicobacter pylori SS1 mouse model","volume":"149","author":"Harris","year":"2003","journal-title":"Microbiology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"B27","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1111\/j.1469-0691.2009.03031.x","article-title":"Helicobacter pylori and gastric adenocarcinoma","volume":"15","author":"Herrera","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"B28","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3978\/j.issn.2078-6891.2012.021","article-title":"Gastric cancer: Classification, histology and application of molecular pathology","volume":"3","author":"Hu","year":"2012","journal-title":"J. Gastrointest. Oncol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1016\/j.ejca.2013.03.031","article-title":"Characterization of interleukin-1\u03b2 in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout IL-1R1\u2212\/\u2212 mice","volume":"49","author":"Huang","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"B31","doi-asserted-by":"publisher","first-page":"4969","DOI":"10.1002\/cncr.27519","article-title":"Helicobacter pylori induces promoter methylation of E-cadherin via interleukin-1\u03b2 activation of nitric oxide production in gastric cancer cells","volume":"118","author":"Huang","year":"2012","journal-title":"Cancer"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.molcel.2013.01.009","article-title":"p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose","volume":"49","author":"Huber","year":"2013","journal-title":"Mol. Cell"},{"key":"B33","volume-title":"World Cancer Report 2014.","year":"2014"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e0120252","DOI":"10.1371\/journal.pone.0120252","article-title":"Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A","volume":"10","author":"Jamison","year":"2015","journal-title":"PLoS ONE"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1046\/j.1440-1746.2001.02647.x","article-title":"Reactive oxygen species activity, mucosal lipoperoxidation and glutathione in Helicobacter pylori-infected gastric mucosa","volume":"16","author":"Jung","year":"2001","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1523-5378.2008.00572.x","article-title":"CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk","volume":"13","author":"Kaise","year":"2008","journal-title":"Helicobacter"},{"key":"B37","first-page":"1093","article-title":"Role of regulatory T-cells in H. pylori-induced gastritis and gastric cancer","volume":"30","author":"Kandulski","year":"2010","journal-title":"Anticancer Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/jgh.12663","article-title":"Helicobacter pylori vacuolating cytotoxin induces apoptosis via activation of endoplasmic reticulum stress in dendritic cells","volume":"30","author":"Kim","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1158\/0008-5472.CAN-12-2464","article-title":"Chloroquine in cancer therapy: a double-edged sword of autophagy","volume":"73","author":"Kimura","year":"2013","journal-title":"Cancer Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.abb.2016.07.014","article-title":"Helicobacter pylori-induced chronic inflammation causes telomere shortening of gastric mucosa by promoting PARP-1-mediated non-homologous end joining of DNA","volume":"606","author":"Lee","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"B41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1462-5822.2009.01403.x","article-title":"Bacterial pathogens and the autophagic response","volume":"12","author":"Lerena","year":"2010","journal-title":"Cell. Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/ncb3541","article-title":"Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach","volume":"19","author":"Leushacke","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3389\/fcimb.2017.00417","article-title":"Helicobacter pylori CagA protein negatively regulates autophagy and promotes inflammatory response via c-Met-PI3K\/Akt-mTOR signaling pathway","volume":"7","author":"Li","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3389\/fcimb.2016.00203","article-title":"Statin decreases Helicobacter pylori burden in macrophages by promoting autophagy","volume":"6","author":"Liao","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1038\/cdd.2017.89","article-title":"Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-\u03baB and caspase-8-dependent apoptotic cell death","volume":"24","author":"Lim","year":"2017","journal-title":"Cell Death Differ."},{"key":"B46","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.ctrv.2014.03.002","article-title":"Unmet needs and challenges in gastric cancer: the way forward","volume":"40","author":"Lordick","year":"2014","journal-title":"Cancer Treat. Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.ccr.2014.06.025","article-title":"Tumor vessel normalization by chloroquine independent of autophagy","volume":"26","author":"Maes","year":"2014","journal-title":"Cancer Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1158\/0008-5472.CAN-13-1747","article-title":"Activated ERBB2\/HER2 licenses sensitivity to apoptosis upon endoplasmic reticulum stress through a PERK-dependent pathway","volume":"74","author":"Mart\u00edn-P\u00e9rez","year":"2014","journal-title":"Cancer Res."},{"key":"B49","first-page":"664","article-title":"Precancerous conditions after H. pylori eradication: a randomized double blind study in first degree relatives of gastric cancer patients","volume":"15","author":"Massarrat","year":"2012","journal-title":"Arch. Iran. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.1074\/jbc.M506139200","article-title":"Helicobacter pylori thioredoxin is an arginase chaperone and guardian against oxidative and nitrosative stresses","volume":"281","author":"McGee","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-3-319-50520-6_3","article-title":"Immune evasion strategies and persistence of Helicobacter pylori","volume":"400","author":"Mej\u00edas-Luque","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.cyto.2017.04.020","article-title":"Polymorphisms and haplotypes of the interleukin 2 gene are associated with an increased risk of gastric cancer. The possible involvement of Helicobacter pylori","volume":"96","author":"Melchiades","year":"2017","journal-title":"Cytokine"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1136\/gut.2005.072009","article-title":"Long term follow up of patients treated for Helicobacter pylori infection","volume":"54","author":"Mera","year":"2005","journal-title":"Gut"},{"key":"B54","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jcmgh.2017.03.006","article-title":"Metaplasia in the stomach arises from gastric chief cells","volume":"4","author":"Mills","year":"2017","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"G877","DOI":"10.1152\/ajpgi.00251.2007","article-title":"Metallothionein is a crucial protective factor against Helicobacter pylori-induced gastric erosive lesions in a mouse model","volume":"294","author":"Mita","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1046\/j.1440-1746.2000.02070.x","article-title":"Helicobacter pylori infection occurs via close contact with infected individuals in early childhood","volume":"15","author":"Miyaji","year":"2000","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1002\/ijc.30657","article-title":"Autophagy impairment by Helicobacter pylori-induced methylation silencing of MAP1LC3Av1 promotes gastric carcinogenesis","volume":"140","author":"Muhammad","year":"2017","journal-title":"Int. J. Cancer"},{"key":"B58","doi-asserted-by":"publisher","first-page":"6126","DOI":"10.1158\/1078-0432.CCR-13-0526","article-title":"Hypoxic activation of the PERK\/eIF2\u03b1 arm of the unfolded protein response promotes metastasis through induction of LAMP3","volume":"19","author":"Mujcic","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1136\/gut.2003.030684","article-title":"Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase","volume":"53","author":"Nam","year":"2004","journal-title":"Gut"},{"key":"B60","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1158\/1940-6207.CAPR-12-0369","article-title":"Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent","volume":"6","author":"Niwa","year":"2013","journal-title":"Cancer Prev. Res. (Phila)"},{"key":"B61","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.trecan.2015.07.002","article-title":"Micronutrients: a double-edged sword in microbial-induced gastric carcinogenesis","volume":"1","author":"Noto","year":"2015","journal-title":"Trends Cancer"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1093\/carcin\/21.6.1111","article-title":"Helicobacter pylori causes DNA damage in gastric epithelial cells","volume":"21","author":"Obst","year":"2000","journal-title":"Carcinogenesis"},{"key":"B63","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s12029-016-9849-x","article-title":"Helicobacter pylori peptidyl prolyl isomerase expression is associated with the severity of gastritis","volume":"47","author":"Oghalaie","year":"2016","journal-title":"J. Gastrointest. Cancer"},{"key":"B64","doi-asserted-by":"publisher","first-page":"3820","DOI":"10.1038\/onc.2013.356","article-title":"TNF-\u03b1\/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells","volume":"33","author":"Oshima","year":"2014","journal-title":"Oncogene"},{"key":"B65","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/nrc703","article-title":"Helicobacter pylori and gastrointestinal tract adenocarcinomas","volume":"2","author":"Peek","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"B66","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/path.1868","article-title":"Helicobacter infection and gastric neoplasia","volume":"208","author":"Peek","year":"2006","journal-title":"J. Pathol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1111\/j.1572-0241.2007.01284.x","article-title":"Aberrant DNA methylation in non-neoplastic gastric mucosa of H. pylori infected patients and effect of eradication","volume":"102","author":"Perri","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1111\/j.1572-0241.2001.03869.x","article-title":"Helicobacter pylori eradication attenuates oxidative stress in human gastric mucosa","volume":"96","author":"Pignatelli","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nrc2857","article-title":"Helicobacter pylori: gastric cancer and beyond","volume":"10","author":"Polk","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/onc.2015.178","article-title":"Tumor progression and the different faces of the PERK kinase","volume":"35","author":"Pytel","year":"2016","journal-title":"Oncogene"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1053\/j.gastro.2012.01.043","article-title":"Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans","volume":"142","author":"Raju","year":"2012","journal-title":"Gastroenterology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1158\/0008-5472.CAN-07-6215","article-title":"Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival","volume":"68","author":"Ranganathan","year":"2008","journal-title":"Cancer Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12885-017-3055-5","article-title":"Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells","volume":"17","author":"Rao","year":"2017","journal-title":"BMC Cancer"},{"key":"B74","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/cr.2013.166","article-title":"Autophagy regulation by nutrient signaling","volume":"24","author":"Russell","year":"2014","journal-title":"Cell Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S0891-5849(99)00124-0","article-title":"Increased expression of inducible nitric oxide synthase and peroxynitrite in Helicobacter pylori gastric ulcer","volume":"27","author":"Sakaguchi","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1128\/IAI.69.6.4034-4040.2001","article-title":"Superoxide dismutase-deficient mutants of Helicobacter pylori are hypersensitive to oxidative stress and defective in host colonization","volume":"69","author":"Seyler","year":"2001","journal-title":"Infect. Immun."},{"key":"B77","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0304-3835(01)00383-4","article-title":"Helicobacter pylori decreases gastric mucosal glutathione","volume":"164","author":"Shirin","year":"2001","journal-title":"Cancer Lett."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312888","article-title":"Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis","author":"Sierra","year":"2017","journal-title":"Gut."},{"key":"B79","doi-asserted-by":"publisher","first-page":"E119","DOI":"10.3390\/toxins9040119","article-title":"NF-\u03baB signaling in gastric cancer","volume":"9","author":"Sokolova","year":"2017","journal-title":"Toxins (Basel)"},{"key":"B80","doi-asserted-by":"publisher","first-page":"4348","DOI":"10.1002\/cncr.29644","article-title":"Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis","volume":"121","author":"Soutto","year":"2015","journal-title":"Cancer"},{"key":"B81","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1158\/0008-5472.CAN-09-2747","article-title":"Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth","volume":"70","author":"Spiotto","year":"2010","journal-title":"Cancer Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1056\/NEJMra020542","article-title":"Helicobacter pylori infection","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"370","DOI":"10.4161\/auto.5.3.7663","article-title":"Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells","volume":"5","author":"Terebiznik","year":"2009","journal-title":"Autophagy"},{"key":"B85","doi-asserted-by":"publisher","first-page":"12742","DOI":"10.3748\/wjg.v21.i45.12742","article-title":"Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis","volume":"21","author":"Valenzuela","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1093\/infdis\/jit286","article-title":"Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity","volume":"208","author":"Valenzuela","year":"2013","journal-title":"J. Infect. Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1086\/656143","article-title":"Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and death of human gastric cells","volume":"202","author":"Valenzuela","year":"2010","journal-title":"J. Infect. Dis."},{"key":"B88","doi-asserted-by":"publisher","first-page":"G852","DOI":"10.1152\/ajpgi.00175.2016","article-title":"TLR9 activation suppresses inflammation in response to Helicobacter pylori infection","volume":"311","author":"Varga","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1053\/j.gastro.2009.10.043","article-title":"Interleukin-1\u03b2 promotes gastric atrophy through suppression of Sonic Hedgehog","volume":"138","author":"Waghray","year":"2010","journal-title":"Gastroenterology"},{"key":"B90","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/j.1365-2958.2006.05302.x","article-title":"The diverse antioxidant systems of Helicobacter pylori","volume":"61","author":"Wang","year":"","journal-title":"Mol. Microbiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"6839","DOI":"10.1128\/IAI.00991-06","article-title":"Dual Roles of Helicobacter pylori NapA in inducing and combating oxidative stress","volume":"74","author":"Wang","year":"","journal-title":"Infect. Immun."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1128\/IAI.72.3.1391-1396.2004","article-title":"An NADPH quinone reductase of Helicobacter pylori plays an important role in oxidative stress resistance and host colonization","volume":"72","author":"Wang","year":"2004","journal-title":"Infect. Immun."},{"key":"B93","doi-asserted-by":"publisher","first-page":"10368","DOI":"10.3748\/wjg.v20.i30.10368","article-title":"Medicinal plant activity on Helicobacter pylori related diseases","volume":"20","author":"Wang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12964-017-0171-4","article-title":"From inflammation to gastric cancer-the importance of Hedgehog\/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases","volume":"15","author":"Wessler","year":"2017","journal-title":"Cell Commun. Signal."},{"key":"B95","doi-asserted-by":"publisher","first-page":"5081","DOI":"10.1074\/jbc.275.7.5081","article-title":"The thioredoxin system of Helicobacter pylori","volume":"275","author":"Windle","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.2174\/138161211796196945","article-title":"Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects","volume":"17","author":"Yanaka","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"B97","doi-asserted-by":"publisher","first-page":"e794","DOI":"10.1038\/cddis.2013.334","article-title":"Activation of TLR4 signaling promotes gastric cancer progression by inducing mitochondrial ROS production","volume":"4","author":"Yuan","year":"2013","journal-title":"Cell Death Dis."},{"key":"B98","doi-asserted-by":"publisher","first-page":"69136","DOI":"10.18632\/oncotarget.12049","article-title":"Native and bone marrow-derived cell mosaicism in gastric carcinoma in H. pylori-infected p27-deficient mice","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"B99","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.bbrc.2015.05.059","article-title":"Compound 13, an alpha1-selective small molecule activator of AMPK, inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis","volume":"463","author":"Zhao","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B100","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/ni.3754","article-title":"Nutrition, inflammation and cancer","volume":"18","author":"Zitvogel","year":"2017","journal-title":"Nat. Immunol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.00005\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T09:47:28Z","timestamp":1526377648000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.00005\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":100,"alternative-id":["10.3389\/fmicb.2018.00005"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.00005","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]},"article-number":"5"}}