{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:35:50Z","timestamp":1773250550405,"version":"3.50.1"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq 400328\/2014-3"],"award-info":[{"award-number":["CNPq 400328\/2014-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["475525\/2013-2"],"award-info":[{"award-number":["475525\/2013-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.00086","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T04:58:14Z","timestamp":1517893094000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Polymorphism in Mitochondrial Group I Introns among Cryptococcus neoformans and Cryptococcus gattii Genotypes and Its Association with Drug Susceptibility"],"prefix":"10.3389","volume":"9","author":[{"given":"Felipe E. E. S.","family":"Gomes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thales D.","family":"Arantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A. L.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo C.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M. G.","family":"Bosco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T. B.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilda M. B.","family":"Del Negro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel C.","family":"Theodoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"30237","DOI":"10.1074\/jbc.270.51.30237","article-title":"Mechanisms of intron mobility","volume":"270","author":"Belfort","year":"1995","journal-title":"J. Biol. Chem"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1093\/nar\/25.17.3379","article-title":"Homing endonucleases: keeping the house in order","volume":"25","author":"Belfort","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1471-2148-5-68","article-title":"Phylogenetic analyses suggest reverse splicing spread of group I introns in fungal ribosomal DNA","volume":"5","author":"Bhattacharya","year":"2005","journal-title":"BMC Evol. Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1093\/nar\/gki341","article-title":"Site-specific reverse splicing of a HEG-containing group I intron in ribosomal RNA","volume":"33","author":"Birgisdottir","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1099\/00221287-147-4-891","article-title":"Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans","volume":"147","author":"Boekhout","year":"2001","journal-title":"Microbiology"},{"key":"B7","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1128\/JCM.33.7.1890-1895.1995","article-title":"Comparison of multilocus enzyme electrophoresis and random amplified polymorphic DNA analysis for molecular subtyping of Cryptococcus neoformans. the cryplococcal disease active surveillance group","volume":"33","author":"Brandt","year":"1995","journal-title":"J. Clin. Microbiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1000850","DOI":"10.1371\/journal.ppat.1000850","article-title":"Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States","volume":"6","author":"Byrnes","year":"2010","journal-title":"PLoS Pathog"},{"key":"B9","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standard, 3rd Edn","year":""},{"key":"B10","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Fourth Informational Supplement.","year":""},{"key":"B11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2105-3-2","article-title":"The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs","volume":"3","author":"Cannone","year":"2002","journal-title":"BMC Bioinformatics"},{"key":"B12","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nsb0594-273","article-title":"Representation of the secondary and tertiary structure of group I introns","volume":"1","author":"Cech","year":"1994","journal-title":"Nat. Struct. Biol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1128\/CMR.00126-13","article-title":"Cryptococcus gattii infections","volume":"27","author":"Chen","year":"2014","journal-title":"Clin. Microbiol. Rev"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.1128\/J.C.M.01271-10","article-title":"In vitro susceptibility of the yeast pathogen cryptococcus to fluconazole and other azoles varies with molecular genotype","volume":"48","author":"Chong","year":"2010","journal-title":"J. Clin. Microbiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"a019752","DOI":"10.1101\/cshperspect.a019752","article-title":"Mechanisms of antifungal drug resistance","volume":"5","author":"Cowen","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1086\/313748","article-title":"Introduction to Antifungal Drugs","volume":"30","author":"Dismukes","year":"2000","journal-title":"Clin. Infect. Dis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"6520","DOI":"10.1021\/bi002009j","article-title":"Binding enhancement by tertiary interactions and suicide inhibition of a Candida albicans group I intron by phosphoramidate and 2'-O-methyl hexanucleotides","volume":"40","author":"Disney","year":"2001","journal-title":"Biochemistry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e00342-10","DOI":"10.1128\/mBio.00342-10","article-title":"Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts","volume":"2","author":"D'Souza","year":"2011","journal-title":"MBio"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.00868-15","article-title":"Genome evolution and innovation across the four major lineages of Cryptococcus gattii.","author":"Farrer","year":"2015"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3855\/jidc.4446","article-title":"Molecular typing and in vitro antifungal susceptibility of Cryptococcus spp from patients in midwest Brazil","volume":"8","author":"Favalessa","year":"2014","journal-title":"J. Infect. Dev. Ctries"},{"key":"B21","doi-asserted-by":"publisher","first-page":"13880","DOI":"10.1073\/pnas.96.24.13880","article-title":"Recurrent invasion and extinction of a selfish gene","volume":"96","author":"Goddard","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s10096-013-1915-8","article-title":"Cryptococcosis: epidemiology, fungal resistance, and new alternatives for treatment","volume":"32","author":"Gullo","year":"2013","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"5139","DOI":"10.1128\/AAC.00746-10","article-title":"In vitro antifungal susceptibilities and amplified fragment length polymorphism genotyping of a worldwide collection of 350 clinical, veterinary, and environmental Cryptococcus gattii isolates","volume":"54","author":"Hagen","year":"2010","journal-title":"Antimicrob. Agents Chemother"},{"key":"B24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.fgb.2015.02.009","article-title":"Recognition of seven species in the Cryptococcus gattii\/ Cryptococcus neoformans species complex","volume":"78","author":"Hagen","year":"2015","journal-title":"Fungal Genet. Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1261\/rna.5202704","article-title":"Long-term evolution of the S788 fungal nuclear small subunit rRNA group I introns long-term evolution of the S788 fungal nuclear small subunit rRNA group I introns","volume":"10","author":"Haugen","year":"2004","journal-title":"RNA"},{"key":"B26","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.tig.2004.12.007","article-title":"The natural history of group I introns","volume":"21","author":"Haugen","year":"2005","journal-title":"Trends Genet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1759-8753-5-8","article-title":"Bacterial group I introns: mobile RNA catalysts","volume":"5","author":"Hausner","year":"2014","journal-title":"Mob. DNA"},{"key":"B28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1759-8753-4-17","article-title":"Nuclear group I introns in self-splicing and beyond","volume":"4","author":"Hedberg","year":"2013","journal-title":"Mob. DNA"},{"key":"B29","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1128\/JCM.01505-09","article-title":"Correlation of genotype and in vitro susceptibilities of Cryptococcus gattii strains from the pacific northwest of the United States","volume":"48","author":"Iqbal","year":"2010","journal-title":"J. Clin. Microbiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11033-006-9002-1","article-title":"Group I intron renders differential susceptibility of Candida albicans to Bleomycin","volume":"34","author":"Jayaguru","year":"2007","journal-title":"Mol. Biol. Rep"},{"key":"B31","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1017\/S1355838201010500","article-title":"A new nomenclature of group I introns in ribosomal DNA","volume":"7","author":"Johansen","year":"2001","journal-title":"RNA"},{"key":"B32","doi-asserted-by":"publisher","first-page":"17258","DOI":"10.1073\/pnas.0402981101","article-title":"A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada).","volume":"101","author":"Kidd","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/A:1025561706522","article-title":"Inhibition of the group I ribozyme splicing by NADP+","volume":"252","author":"Kim","year":"2003","journal-title":"Mol. Cell Biochem"},{"key":"B34","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1745-6150-1-22","article-title":"The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate?","volume":"1","author":"Koonin","year":"2006","journal-title":"Biol. Direct"},{"key":"B35","doi-asserted-by":"publisher","first-page":"a019760","DOI":"10.1101\/cshperspect.a019760","article-title":"Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis","volume":"4","author":"Kwon-chung","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B36","unstructured":"LambowitzA. CapraraM. Group I and Group II Ribozymes as RNPs: Clues to the Past and Guides to the Future1999"},{"key":"B37","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.riam.2009.06.003","article-title":"Amphotericin B: side effects and toxicity","volume":"26","author":"Laniado-Labor\u00edn","year":"2009","journal-title":"Rev. Iberoam. Micol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1080\/13693780701824429","article-title":"Cryptococcus species identification by multiplex PCR","volume":"46","author":"Leal","year":"2008","journal-title":"Med. Mycol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1093\/nar\/gki517","article-title":"Predicting the secondary structures and tertiary interactions of 211 group I introns in IE subgroup","volume":"33","author":"Li","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s10482-005-8544-x","article-title":"Differences in mitochondrial genome organization of Cryptococcus neoformans strains. Antonie van Leeuwenhoek","volume":"88","author":"Litter","year":"2005","journal-title":"Int. J. Gen. Mol. Microbiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1186\/1471-2105-11-579","article-title":"webPRANK: a phylogeny-aware multiple sequence aligner with interactive alignment browser","volume":"11","author":"L\u00f6ytynoja","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1469-0691.2010.03222.x","article-title":"outbreak on Vancouver Island","author":"Ma","year":"2010","journal-title":"J. Infect. Dis"},{"key":"B43","doi-asserted-by":"publisher","first-page":"12980","DOI":"10.1073\/pnas.0902963106","article-title":"The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation","volume":"106","author":"Ma","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B44","doi-asserted-by":"publisher","first-page":"D222","DOI":"10.1093\/nar\/gku1221","article-title":"CDD: NCBI's conserved domain database","volume":"43","author":"Marchler-Bauer","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s10096-011-1488-3","article-title":"Microbiological characteristics of clinical isolates of Cryptococcus spp. in Bahia, Brazil: molecular types and antifungal susceptibilities.","volume":"31","author":"Matos","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/nar\/25.2.431","article-title":"Expression of a reporter gene interrupted by the Candida albicans group I intron is inhibited by base analogs","volume":"25","author":"Mercure","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"B47","doi-asserted-by":"publisher","first-page":"6020","DOI":"10.1093\/nar\/21.25.6020","article-title":"Correlation between the presence of a self-splicing intron in the 25S rDNA of C.albicans and strains susceptibility to 5-fluorocytosine","volume":"21","author":"Mercure","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1080\/13693780902953886","article-title":"Consensus multi-locus sequence typing scheme for Cryptococcus neoformans and Cryptococcus gattii","volume":"47","author":"Meyer","year":"2009","journal-title":"Med. Mycol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3201\/eid0902.020246","article-title":"Molecular typing of IberoAmerican Cryptococcus neoformans isolates","volume":"9","author":"Meyer","year":"2003","journal-title":"Emerg. Infect. Dis"},{"key":"B50","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0022-2836(90)90386-Z","article-title":"Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis","volume":"216","author":"Michel","year":"1990","journal-title":"J. Mol. Biol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1128\/AAC.44.4.958-966.2000","article-title":"Pentamidine inhibition of group I intron splicing in Candida albicans correlates with growth inhibition","volume":"44","author":"Miletti","year":"2000","journal-title":"Antimicrob. Agents Chemother"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1093\/bioinformatics\/btt509","article-title":"Infernal 1.1: 100-fold faster RNA homology searches","volume":"29","author":"Nawrocki","year":"2013","journal-title":"Bioinformatics"},{"key":"B53","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1093\/nar\/gku1063","article-title":"Rfam 12. 0 : updates to the RNA families database","volume":"43","author":"Nawrocki","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1006\/bbrc.2001.4314","article-title":"NAD+ Inhibits the self-splicing of the group I intron","volume":"281","author":"Park","year":"2001","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B55","author":"Rambaut","year":"2009"},{"key":"B56","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cub.2011.01.008","article-title":"Redox-responsive zinc finger fidelity switch in homing endonuclease and intron promiscuity in oxidative stress","volume":"21","author":"Robbins","year":"2011","journal-title":"Curr. Biol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1745-6150-7-11","article-title":"Origin and evolution of spliceosomal introns","volume":"7","author":"Rogozin","year":"2012","journal-title":"Biol. Direct"},{"key":"B58","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/sysbio\/sys029","article-title":"Mrbayes 3.2: efficient bayesian phylogenetic inference and model choice across a large model space","volume":"61","author":"Ronquist","year":"2012","journal-title":"Syst. Biol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1590\/S0074-02762008000800012","article-title":"Primary endemic Cryptococcosis gattii by molecular type VGII in the state of Par\u00e1, Brazil","volume":"103","author":"Santos","year":"2008","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1086\/323895","article-title":"Trends in the epidemiology of opportunistic fungal infections: predisposing factors and the impact of antimicrobial use practices","volume":"33","author":"Singh","year":"2001","journal-title":"Clin. Infect. Dis"},{"key":"B61","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/mmy.39.2.155.168","article-title":"Cryptococcus neoformans variety gattii","volume":"39","author":"Sorrell","year":"2001","journal-title":"Med. Mycol"},{"key":"B62","volume-title":"Stata Statistical Software: Release 15","year":"2017"},{"key":"B63","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.str.2010.12.003","article-title":"Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification","volume":"19","author":"Stoddard","year":"2011","journal-title":"Structure"},{"key":"B64","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1590\/S0074-02762008000500008","article-title":"Regional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil","volume":"103","author":"Trilles","year":"2008","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"B65","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3109\/13693786.2011.602126","article-title":"Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans\/C. gattii species complex","volume":"50","author":"Trilles","year":"2012","journal-title":"Med. Mycol"},{"key":"B66","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1128\/JCM.33.12.3328-3332.1995","article-title":"Random amplified polymorphic DNA analysis of clinically and environmentally isolated Cryptococcus neoformans in Nagasaki","volume":"33","author":"Yamamoto","year":"1995","journal-title":"J. Clin. Microbiol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1093\/nar\/gkf394","article-title":"Pentamidine inhibits catalytic activity of group I intron Ca.LSU by altering RNA folding","volume":"30","author":"Zhang","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1093\/nar\/gkg595","article-title":"Mfold web server for nucleic acid folding and hybridization prediction","volume":"31","author":"Zuker","year":"2003","journal-title":"Nucleic Acids Res"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.00086\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T15:32:22Z","timestamp":1603812742000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.00086\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,6]]},"references-count":68,"alternative-id":["10.3389\/fmicb.2018.00086"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.00086","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,6]]},"article-number":"86"}}