{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:52:52Z","timestamp":1787313172908,"version":"build-2736575974"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-OD010978-26"],"award-info":[{"award-number":["T32-OD010978-26"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-ES002109"],"award-info":[{"award-number":["P30-ES002109"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.00311","type":"journal-article","created":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T23:26:45Z","timestamp":1520206005000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Plasmid-Mediated Quinolone Resistance in Shigella flexneri Isolated From Macaques"],"prefix":"10.3389","volume":"9","author":[{"given":"Anthony J.","family":"Mannion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeli","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn L.","family":"Dzink-Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Marini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1128\/AAC.01615-12","article-title":"Differential distribution of plasmid-mediated quinolone resistance genes in clinical enterobacteria with unusual phenotypes of quinolone susceptibility from Argentina","volume":"57","author":"Andres","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1600-0765.1982.tb01139.x","article-title":"Periodontal disease associated with Shigella flexneri in rhesus monkeys. Clinical, microbiologic and histopathologic findings","volume":"17","author":"Armitage","year":"1982","journal-title":"J. Periodontal Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"142","DOI":"10.4056\/sigs.541628","article-title":"Standard operating procedure for calculating genome-to-genome distances based on high-scoring segment pairs","volume":"2","author":"Auch","year":"2010","journal-title":"Stand. Genomic Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1471-2164-9-75","article-title":"The RAST Server: rapid annotations using subsystems technology","volume":"9","author":"Aziz","year":"2008","journal-title":"BMC Genomics"},{"key":"B5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2460\/javma.1993.203.01.126","article-title":"Prevalence of shigellosis and other enteric pathogens in a zoologic collection of primates","volume":"203","author":"Banish","year":"1993","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"B6","first-page":"318","article-title":"Importation and domestic transmission of Shigella sonnei resistant to ciprofloxacin - United States, May 2014-February 2015","volume":"64","author":"Bowen","year":"2015","journal-title":"Morbid. Mortal. Week. Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3895","DOI":"10.1128\/AAC.02412-14","article-title":"In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing","volume":"58","author":"Carattoli","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"B8","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1093\/jac\/dkl547","article-title":"Prevalence of qnr genes in Salmonella in France","volume":"59","author":"Cattoir","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"B9","volume-title":"CDC Recommendations for Diagnosing and Managing Shigella Strains with Possible Reduced Susceptibility to Ciprofloxacin","year":"2017"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3390\/toxins2061179","article-title":"Serine protease autotransporters of enterobacteriaceae (SPATEs): biogenesis and function","volume":"2","author":"Dautin","year":"2010","journal-title":"Toxins"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e49980","DOI":"10.1371\/journal.pone.0049980","article-title":"Chromosomal and plasmid-encoded factors of Shigella flexneri induce secretogenic activity ex vivo","volume":"7","author":"Faherty","year":"2012","journal-title":"PLoS ONE"},{"key":"B12","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1574-695X.2011.00778.x","article-title":"Shigella enterotoxin-2 is a type III effector that participates in Shigella-induced interleukin 8 secretion by epithelial cells","volume":"61","author":"Farfan","year":"2011","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000459850","article-title":"Transmissible drug resistance in Shigella and Salmonella isolated from pet monkeys and their owners","volume":"4","author":"Fox","year":"1975","journal-title":"J. Med. Primatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"W181","DOI":"10.1093\/nar\/gkn179","article-title":"The CGView Server: a comparative genomics tool for circular genomes","volume":"36","author":"Grant","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"B15","article-title":"Shigella","volume-title":"Medical Microbiology, 4th edn","author":"Hale","year":"1996"},{"key":"B16","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1128\/AAC.49.2.801-803.2005","article-title":"Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b","volume":"49","author":"Hata","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"B17","doi-asserted-by":"publisher","first-page":"4432","DOI":"10.1093\/nar\/gkf566","article-title":"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157","volume":"30","author":"Jin","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1128\/JCM.03617-13","article-title":"Real-time whole-genome sequencing for routine typing, surveillance, and outbreak detection of verotoxigenic Escherichia coli","volume":"52","author":"Joensen","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1093\/jac\/dks158","article-title":"Complete nucleotide sequence of pVQS1 containing a quinolone resistance determinant from Salmonella enterica serovar Virchow associated with foreign travel","volume":"67","author":"Karczmarczyk","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"B20","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1017\/S0950268800068163","article-title":"Shigellosis due to occupational contact with non-human primates","volume":"110","author":"Kennedy","year":"1993","journal-title":"Epidemiol. Infect."},{"key":"B21","first-page":"79","article-title":"Antimicrobial use for and resistance of zoonotic bacteria recovered from nonhuman primates","volume":"67","author":"Kim","year":"2017","journal-title":"Comp. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1128\/JCM.06094-11","article-title":"Multilocus sequence typing of total-genome-sequenced bacteria","volume":"50","author":"Larsen","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1099\/ijsem.0.000760","article-title":"OrthoANI: an improved algorithm and software for calculating average nucleotide identity","volume":"66","author":"Lee","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B24","first-page":"240","article-title":"Enrofloxacin treatment of long-tailed macaques with acute bacillary dysentery due to multiresistant Shigella flexneri IV","volume":"42","author":"Line","year":"1992","journal-title":"Lab. Anim. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1128\/AAC.49.1.71-76.2005","article-title":"Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe","volume":"49","author":"Mammeri","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"B26","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0140-6736(97)07322-4","article-title":"Quinolone resistance from a transferable plasmid","volume":"351","author":"Martinez-Martinez","year":"1998","journal-title":"Lancet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fcimb.2017.00064","article-title":"How do the virulence factors of shigella work together to cause disease?","volume":"7","author":"Mattock","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"938","DOI":"10.2460\/javma.1976.169.09.938","article-title":"Nonenteric Shigella infections in nonhuman primates","volume":"169","author":"McClure","year":"1976","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"B29","volume-title":"National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS): Human Isolates Surveillance Report for 2014.","year":"2016"},{"key":"B30","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fmicb.2012.00024","article-title":"Plasmid-mediated quinolone resistance; interactions between human, animal, and environmental ecologies","volume":"3","author":"Poirel","year":"2012","journal-title":"Front. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1159\/000459732","article-title":"Elimination of the Shigella carrier state in rhesus monkeys (Macaca mulatta) by trimethoprim-sulfamethoxazole","volume":"6","author":"Pucak","year":"1977","journal-title":"J. Med. Primatol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.tim.2014.04.007","article-title":"Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success","volume":"22","author":"Redgrave","year":"2014","journal-title":"Trends Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1128\/AAC.01647-05","article-title":"qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States","volume":"50","author":"Robicsek","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"B34","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1093\/jac\/dks377","article-title":"Contribution of OqxAB efflux pumps to quinolone resistance in extended-spectrum-\u03b2-lactamase-producing Klebsiella pneumoniae","volume":"68","author":"Rodriguez-Martinez","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"B35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3201\/eid1701.P11101","article-title":"Foodborne illness acquired in the United States\u2013major pathogens","volume":"17","author":"Scallan","year":"2011","journal-title":"Emerging Infect. Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12941-017-0212-2","article-title":"Genome sequence of Shigella flexneri strain SP1, a diarrheal isolate that encodes an extended-spectrum \u03b2-lactamase (ESBL)","volume":"16","author":"Shen","year":"2017","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"B37","first-page":"54","article-title":"A challenge model for Shigella dysenteriae 1 in cynomolgus monkeys (Macaca fascicularis)","volume":"60","author":"Shipley","year":"2010","journal-title":"Comp. Med."},{"key":"B38","volume-title":"Performance Standards for Antimicrobial Disk Susceptibility Tests, Approved Standard, 10th Edn","year":"2010"},{"key":"B39","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, Approved Standard, 9th Edn","year":"2012"},{"key":"B40","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fourth Informational Supplement (M100-S24).","year":"2014"},{"key":"B41","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1128\/CMR.00016-09","article-title":"Plasmid-mediated quinolone resistance: a multifaceted threat","volume":"22","author":"Strahilevitz","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"B42","doi-asserted-by":"publisher","first-page":"5638","DOI":"10.1073\/pnas.082092899","article-title":"Mechanism of plasmid-mediated quinolone resistance","volume":"99","author":"Tran","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B43","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1128\/AAC.49.1.118-125.2005","article-title":"Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase","volume":"49","author":"Tran","year":"","journal-title":"Antimicrob. Agents Chemother."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1128\/AAC.49.7.3050-3052.2005","article-title":"Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV","volume":"49","author":"Tran","year":"","journal-title":"Antimicrob. Agents Chemother."},{"key":"B45","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1258\/002367783781070957","article-title":"Biphasic enteritis in imported cynomolgus (Macaca fascicularis) monkeys infected with Shigella, Salmonella and Campylobacter species","volume":"17","author":"Tribe","year":"1983","journal-title":"Lab. Anim."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1128\/AAC.48.4.1295-1299.2004","article-title":"Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States","volume":"48","author":"Wang","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"B47","doi-asserted-by":"publisher","first-page":"D581","DOI":"10.1093\/nar\/gkt1099","article-title":"PATRIC, the bacterial bioinformatics database and analysis resource","volume":"42","author":"Wattam","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"D535","DOI":"10.1093\/nar\/gkw1017","article-title":"Improvements to PATRIC, the all-bacterial bioinformatics database and analysis resource center","volume":"45","author":"Wattam","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1128\/IAI.71.5.2775-2786.2003","article-title":"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T","volume":"71","author":"Wei","year":"2003","journal-title":"Infect. Immun."},{"key":"B50","volume-title":"Critically Important Antimicrobials for Human Medicine, 5th Edn","year":"2017"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1093\/jac\/dks261","article-title":"Identification of acquired antimicrobial resistance genes","volume":"67","author":"Zankari","year":"2012","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.00311\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:46:18Z","timestamp":1751435178000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.00311\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":51,"alternative-id":["10.3389\/fmicb.2018.00311"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.00311","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,5]]},"article-number":"311"}}