{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:16:20Z","timestamp":1768400180525,"version":"3.49.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:00:00Z","timestamp":1522886400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.00626","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T12:57:48Z","timestamp":1522933068000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Leishmania infantum Lipophosphoglycan-Deficient Mutants: A Tool to Study Host Cell-Parasite Interplay"],"prefix":"10.3389","volume":"9","author":[{"given":"Milena","family":"L\u00e1zaro-Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Matte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonilson B.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Arango Duque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziele","family":"Quintela-Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1islan","family":"de Carvalho Vivarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Moura-Pontes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udio P.","family":"Figueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio H.","family":"Jesus-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulisses","family":"Gazos Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo P.","family":"Farias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th\u00e9o","family":"Ara\u00fajo-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Descoteaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria M.","family":"Borges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1093\/infdis\/jiu299","article-title":"Role of prostaglandin F2\u03b1 production in lipid bodies from Leishmania infantum chagasi: insights on virulence","volume":"210","author":"Ara\u00fajo-Santos","year":"2014","journal-title":"J. Infect. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0166-6851(03)00160-9","article-title":"Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2","volume":"130","author":"Becker","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.plefa.2011.04.020","article-title":"Lipid body function in eicosanoid synthesis: an update","volume":"85","author":"Bozza","year":"2011","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4629","DOI":"10.1128\/IAI.00735-07","article-title":"Comparisons of mutants lacking the golgi UDP-galactose or GDP-mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania major","volume":"75","author":"Capul","year":"2007","journal-title":"Infect. Immun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.ijpara.2010.10.004","article-title":"Leishmania infantum: Lipophosphoglycan intraspecific variation and interaction with vertebrate and invertebrate hosts","volume":"41","author":"Coelho-Finamore","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1462-5822.2000.00037.x","article-title":"Leishmania promastigotes require lipophosphoglycan to actively modulate the fusion properties of phagosomes at an early step of phagocytosis","volume":"2","author":"Dermine","year":"2000","journal-title":"Cell. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4458","DOI":"10.1093\/emboj\/cdf447","article-title":"Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability","volume":"21","author":"Descoteaux","year":"2002","journal-title":"EMBO J."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1126\/science.7569927","article-title":"A specialized pathway affecting virulence glycoconjugates of Leishmania","volume":"269","author":"Descoteaux","year":"1995","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0166-6851(98)00047-4","article-title":"Leishmania donovani has distinct mannosylphosphoryltransferases for the initiation and elongation phases of lipophosphoglycan repeating unit biosynthesis","volume":"94","author":"Descoteaux","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/0169-4758(93)90105-O","article-title":"The lipophosphoglycan of Leishmania and macrophage protein kinase C","volume":"9","author":"Descoteaux","year":"1993","journal-title":"Parasitol. Today"},{"key":"B11","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.4049\/jimmunol.146.8.2747","article-title":"Leishmania donovani lipophosphoglycan selectively inhibits signal transduction in macrophages","volume":"146","author":"Descoteaux","year":"1991","journal-title":"J Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1084\/jem.185.12.2061","article-title":"Inhibition of phagolysosomal biogenesis by the Leishmania lipophosphoglycan","volume":"185","author":"Desjardins","year":"1997","journal-title":"J. Exp. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1002\/eji.200324128","article-title":"MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling","volume":"33","author":"de Veer","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3389\/fcimb.2014.00193","article-title":"Leishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?","volume":"4","author":"Forestier","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1093\/emboj\/19.9.1953","article-title":"Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana","volume":"19","author":"Ilg","year":"2000","journal-title":"EMBO J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"4988","DOI":"10.1074\/jbc.M008030200","article-title":"Phosphoglycan Repeat-deficient Leishmania mexicana parasites remain infectious to macrophages and mice","volume":"276","author":"Ilg","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"31410","DOI":"10.1074\/jbc.274.44.31410","article-title":"Molecular cloning and characterization of a novel repeat-containing Leishmania major gene, ppg1, that encodes a membrane-associated form of proteophosphoglycan with a putative glycosylphosphatidylinositol anchor","volume":"274","author":"Ilg","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0166-6851(01)00432-7","article-title":"Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor","volume":"120","author":"Joshi","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1017\/S0031182009990473","article-title":"The involvement of TLR2 in cytokine and reactive oxygen species (ROS) production by PBMCs in response to Leishmania major phosphoglycans (PGs)","volume":"136","author":"Kavoosi","year":"2009","journal-title":"Parasitology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"14321","DOI":"10.1038\/s41598-017-14229-8","article-title":"Leishmania infantum lipophosphoglycan induced-Prostaglandin E2 production in association with PPAR-\u03b3 expression via activation of Toll like receptors-1 and 2","volume":"7","author":"Lima","year":"2017","journal-title":"Sci. Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1111\/j.1462-5822.2006.00758.x","article-title":"Leishmania donovani lipophosphoglycan blocks NADPH oxidase assembly at the phagosome membrane","volume":"8","author":"Lodge","year":"2006","journal-title":"Cell. Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1042\/bj2940305","article-title":"The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes","volume":"294","author":"McConville","year":"1993","journal-title":"Biochem. J."},{"key":"B23","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fcimb.2012.00121","article-title":"Leishmania promastigotes: building a safe niche within macrophages","volume":"2","author":"Moradin","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.parint.2015.01.006","article-title":"Differential modulation of macrophage response elicited by glycoinositolphospholipids and lipophosphoglycan from Leishmania (Viannia) shawi","volume":"64","author":"Passero","year":"2015","journal-title":"Parasitol. Int."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1002\/1521-4141(2000)30:8<2235::AID-IMMU2235>3.0.CO;2-9","article-title":"Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1\/2 during infection of naive macrophages","volume":"30","author":"Priv\u00e9","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e0148640","DOI":"10.1371\/journal.pone.0148640","article-title":"Lipid droplet formation, their localization and dynamics during leishmania major macrophage infection","volume":"11","author":"Rabhi","year":"2016","journal-title":"PLoS ONE"},{"key":"B27","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1017\/S0031182013002187","article-title":"Leishmania mexicana lipophosphoglycan activates ERK and p38 MAP kinase and induces production of proinflammatory cytokines in human macrophages through TLR2 and TLR4","volume":"141","author":"Rojas-Bernab\u00e9","year":"2014","journal-title":"Parasitology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"8609","DOI":"10.1073\/pnas.90.18.8609","article-title":"Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania","volume":"90","author":"Ryan","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B29","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev.micro.55.1.453","article-title":"Molecular aspects of parasite-vector and vector-host interactions in Leishmaniasis","volume":"55","author":"Sacks","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1073\/pnas.97.1.406","article-title":"The role of phosphoglycans in Leishmania-sand fly interactions","volume":"97","author":"Sacks","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B31","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/j.1462-5822.2010.01439.x","article-title":"Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies","volume":"12","author":"Secundino","year":"2010","journal-title":"Cell. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"9258","DOI":"10.1073\/pnas.160257897","article-title":"Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major","volume":"97","author":"Sp\u00e4th","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B33","doi-asserted-by":"publisher","first-page":"9536","DOI":"10.1073\/pnas.1530604100","article-title":"The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts","volume":"100","author":"Spath","year":"2003","journal-title":"Proc. Natl. Acad. Sci.U.S.A."},{"key":"B34","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1093\/infdis\/jiu158","article-title":"Understanding the mechanisms controlling Leishmania amazonensis infection in vitro: the role of LTB4 derived from human neutrophils","volume":"210","author":"Tavares","year":"2014","journal-title":"J. Infect. Dis."},{"key":"B35","first-page":"133","article-title":"Isolation of virulence genes directing GPI synthesis by functional complementation of Leishmania","volume":"27","author":"Turco","year":"1994","journal-title":"Brazilian J. Med. Biol. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1146\/annurev.mi.46.100192.000433","article-title":"The lipophosphoglycan of leishmania parasites","volume":"46","author":"Turco","year":"1992","journal-title":"Annu. Rev. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1000628","DOI":"10.1371\/journal.ppat.1000628","article-title":"The Leishmania donovani lipophosphoglycan excludes the vesicular proton-ATPase from phagosomes by impairing the recruitment of Synaptotagmin, V","volume":"5","author":"Vinet","year":"2009","journal-title":"PLoS Pathog."},{"key":"B38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.molbiopara.2004.02.012","article-title":"The LPG1 gene family of Leishmania major","volume":"136","author":"Zhang","year":"2004","journal-title":"Mol. Biochem. Parasitol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.00626\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T23:04:58Z","timestamp":1693609498000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.00626\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,5]]},"references-count":38,"alternative-id":["10.3389\/fmicb.2018.00626"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.00626","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,5]]},"article-number":"626"}}