{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:35:51Z","timestamp":1788053751737,"version":"build-2784847793"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/010.001.498\/2016"],"award-info":[{"award-number":["E-26\/010.001.498\/2016"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/110.511\/2014"],"award-info":[{"award-number":["E-26\/110.511\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.01018","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:28:53Z","timestamp":1526430533000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barr\u00e9 Syndrome and Abortion"],"prefix":"10.3389","volume":"9","author":[{"given":"K\u00edssila","family":"Rabelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz J.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia G.","family":"Salom\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson R. A.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynna de Paula","family":"Sentinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelle S.","family":"Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro B.","family":"Saraquino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando C.","family":"Rosman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Bas\u00edlio-de-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge J.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marciano V.","family":"Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1093\/brain\/aww158","article-title":"Zika virus-associated neurological disorders: a review","volume":"139","author":"Araujo","year":"2016","journal-title":"Brain"},{"key":"B2","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ajog.2014.07.060","article-title":"Human trophoblasts confer resistance to viruses implicated in perinatal infection","volume":"212","author":"Bayer","year":"2015","journal-title":"Am. J. Obs. Gynecol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0140-6736(16)00080-5","article-title":"Anticipating the international spread of Zika virus from Brazil","volume":"387","author":"Bogoch","year":"2016","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.4269\/ajtmh.17-0106","article-title":"Guillain\u2013Barr\u00e9 syndrome, acute disseminated encephalomyelitis and encephalitis associated with zika virus infection in brazil: detection of viral, RNA and isolation of virus during late infection","volume":"97","author":"Brito Ferreira","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1600-0897.2010.00908.x","article-title":"Placental viral infection sensitizes to endotoxin-induced pre-term labor: a double hit hypothesis","volume":"65","author":"Cardenas","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/1743-422X-5-165","article-title":"Molecular profiling of T-helper immune genes during dengue virus infection","volume":"5","author":"Chen","year":"2008","journal-title":"Virol. J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes birth defects in experimental models","volume":"534","author":"Cugola","year":"2016","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"6408","DOI":"10.1128\/JVI.00213-12","article-title":"Endothelial cells elicit immune-enhancing responses to dengue virus infection","volume":"86","author":"Dalrymple","year":"2012","journal-title":"J. Virol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/CMR.00072-15","article-title":"Zika virus","volume":"11","author":"Didier","year":"2016","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1126\/science.aaf6116","article-title":"Zika virus impairs growth in human neurospheres and brain organoids","volume":"352","author":"Garcez","year":"2016","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika virus targets human STAT2 to inhibit type I interferon signaling","volume":"19","author":"Grant","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e00900","DOI":"10.1128\/JVI.00900-17","article-title":"CD8 T Cell immune response in immunocompetent mice during Zika virus infection","volume":"91","author":"Huang","year":"2017","journal-title":"J. Virol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1172\/jci.insight.88461","article-title":"Zika virus productively infects primary human placenta-specific macrophages","volume":"1","author":"Jurado","year":"2016","journal-title":"JCI Insight"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1099\/jgv.0.000857","article-title":"Differences in the growth properties of Zika virus foetal brain isolate and related epidemic strains in vitro","volume":"98","author":"Kuivanen","year":"2017","journal-title":"J. Gen. Virol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"14883","DOI":"10.1038\/s41598-017-13980-2","article-title":"Zika virus infects intermediate progenitor cells and post-mitotic committed neurons in human fetal brain tissues","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep"},{"key":"B16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nrneurol.2016.30","article-title":"CNS infections: Zika virus infection could trigger Guillain-Barr\u00e9 syndrome","volume":"12","author":"Malkki","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"B17","first-page":"58","article-title":"Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye","volume":"29","author":"Medawar","year":"1948","journal-title":"Br. J. Exp. Pathol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika virus infection during pregnancy in mice causes placental damage and fetal demise","volume":"165","author":"Miner","year":"2016","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/aji.12505","article-title":"Placental inflammatory response to Zika virus may affect fetal brain development","volume":"75","author":"Mor","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1600-0897.2010.00836.x","article-title":"The immune system in pregnancy: a unique complexity","volume":"63","author":"Mor","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.chom.2016.12.010","article-title":"Mapping and role of the {CD}8 T cell response during primary Zika virus infection in mice","volume":"21","author":"Ngono","year":"2017","journal-title":"Cell Host Microbe"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e1006378","DOI":"10.1371\/journal.ppat.1006378","article-title":"Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques","volume":"13","author":"Nguyen","year":"2017","journal-title":"PLoS Pathog."},{"key":"B23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1590\/0074-02760160085","article-title":"Zika virus damages the human placental barrier and presents marked fetal neurotropism","volume":"111","author":"Noronha","year":"2016","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2807\/1560-7917.ES2014.19.9.20720","article-title":"Zika virus infection complicated by Guillain-Barr\u00e9 syndrome \u2013 case report, French Polynesia, December 2013","volume":"19","author":"Oehler","year":"2014","journal-title":"Euro Surveill."},{"key":"B25","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.placenta.2013.11.002","article-title":"Review: placenta-specific microRNAs in exosomes good things come in nano-packages","volume":"35","author":"Ouyang","year":"2014","journal-title":"Placenta"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e1006184","DOI":"10.1371\/journal.ppat.1006184","article-title":"Analysis of the T cell response to Zika virus and identification of a novel CD8 T cell epitope in immunocompetent mice","volume":"13","author":"Pardy","year":"2017","journal-title":"PLoS Pathog."},{"key":"B27","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1242\/dev.140707","article-title":"Using brain organoids to understand Zika virus-induced microcephaly","volume":"144","author":"Qian","year":"2017","journal-title":"Development"},{"key":"B28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.chom.2016.05.015","article-title":"Zika virus infects human placental macrophages","volume":"20","author":"Quicke","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.3389\/fimmu.2017.01704","article-title":"Placental histopathology and clinical presentation of severe congenital Zika syndrome in a human immunodeficiency virus-exposed uninfected infant","volume":"8","author":"Rabelo","year":"2017","journal-title":"Front. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/aji.12289","article-title":"Understanding the complexity of the immune system during pregnancy","volume":"72","author":"Racicot","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1055\/s-2006-956773","article-title":"The role of inflammation and infection in preterm birth","volume":"25","author":"Romero","year":"2007","journal-title":"Semin. Reprod. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.5858\/arpa.2016-0401-OA","article-title":"Placental pathology of Zika virus: viral infection of the placenta induces villous stromal macrophage (Hofbauer Cell) proliferation and hyperplasia","volume":"141","author":"Rosenberg","year":"2017","journal-title":"Coll. Am. Pathol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"12273","DOI":"10.1073\/pnas.1714624114","article-title":"Replication of early and recent Zika virus isolates throughout mouse brain development","volume":"114","author":"Rosenfeld","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B34","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/uog.17210","article-title":"Persistent maternal Zika viremia: a marker of fetal infection","volume":"49","author":"Schaub","year":"2017","journal-title":"Ultrasound Obs. Gynecol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/aji.12355","article-title":"Viral infections during pregnancy","volume":"73","author":"Silasi","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1080\/01652176.2016.1188333","article-title":"Zika virus \u2013 emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives \u2013 a comprehensive review","volume":"36","author":"Singh","year":"2016","journal-title":"Vet. Q."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1414-431X20165420","article-title":"Overview of Zika virus (ZIKV) infection in regards to the Brazilian epidemic","volume":"49","author":"Slavov","year":"2016","journal-title":"Brazilian J. Med. Biol. Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.chom.2016.07.002","article-title":"Zika virus targets different primary human placental cells, suggesting two routes for vertical article Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission","volume":"20","author":"Tabata","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B39","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00430-015-0445-7","article-title":"Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase","volume":"205","author":"Tappe","year":"2016","journal-title":"Med. Microbiol. Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"5555","DOI":"10.1210\/jc.2003-030528","article-title":"Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences","volume":"88","author":"Tsatsaris","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B41","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S0140-6736(16)00006-4","article-title":"Zika virus in Brazil and macular atrophy in a child with microcephaly","volume":"387","author":"Ventura","year":"2016","journal-title":"Lancet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"14575","DOI":"10.1038\/ncomms14575","article-title":"Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes","volume":"8","author":"Vermillion","year":"2017","journal-title":"Nat. Commun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"17036","DOI":"10.1038\/nmicrobiol.2017.36","article-title":"Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive {CD}8 T cells","volume":"2","author":"Wen","year":"2017","journal-title":"Nat. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/j.cell.2016.08.004","article-title":"Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection","volume":"166","author":"Yockey","year":"2016","journal-title":"Cell"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.01018\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:28:58Z","timestamp":1526430538000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2018.01018\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,16]]},"references-count":44,"alternative-id":["10.3389\/fmicb.2018.01018"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.01018","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,16]]},"article-number":"1018"}}