{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:23:32Z","timestamp":1789741412626,"version":"4.0.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.01237","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T07:23:36Z","timestamp":1528442616000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Comparative Transcriptome Analysis Between a Spontaneous Albino Mutant and Its Sibling Strain of Cordyceps militaris in Response to Light Stress"],"prefix":"10.3389","volume":"9","author":[{"given":"Fen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuanbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/978-1-4939-1191-2_8","article-title":"\u201cCarotenoids,\u201d in","author":"\u00c1valos","year":"2014","journal-title":"Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites"},{"key":"B2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/978-1-61779-918-1_18","article-title":"Neurosporaxanthin production by Neurospora and Fusarium.","volume":"898","author":"Avalos","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrmicro2916","article-title":"Regulation of fungal secondary metabolism.","volume":"11","author":"Brakhage","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"B4","first-page":"36","article-title":"Chemical composition analysis of cultured Cordyceps militaris.","volume":"34","author":"Chen","year":"2013","journal-title":"Food Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1021\/acs.jafc.5b05931","article-title":"Anti-inflammatory cerebrosides from cultivated Cordyceps militaris.","volume":"64","author":"Chiu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s11101-005-3748-2","article-title":"Taxol biosynthesis and molecular genetics.","volume":"5","author":"Croteau","year":"2006","journal-title":"Phytochem. Rev."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111988","article-title":"HemI: a toolkit for illustrating heatmaps.","volume":"9","author":"Deng","year":"2014","journal-title":"PLoS One"},{"key":"B8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1615\/IntJMedMushr.v12.i3.80","article-title":"Comparison of some metabolites among cultured mycelia of medicinal fungus, Ophiocordyceps sinensis (Ascomycetes) from different geographical regions.","volume":"12","author":"Dong","year":"2010","journal-title":"Int. J. Med. Mushrooms"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1016\/j.jff.2013.06.002","article-title":"Composition and characterization of cordyxanthins from Cordyceps militaris fruiting bodies.","volume":"5","author":"Dong","year":"2013","journal-title":"J. Funct. Foods"},{"key":"B10","first-page":"11","article-title":"A rapid DNA isolation procedure for small quantities of fresh leaf tissue.","volume":"19","author":"Doyle","year":"1987","journal-title":"Phytochem. Bull."},{"key":"B11","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.fgb.2007.12.003","article-title":"The white collar protein WcoA of Fusarium fujikuroi is not essential for photocarotenogenesis, but is involved in the regulation of secondary metabolism and conidiation.","volume":"45","author":"Estrada","year":"2008","journal-title":"Fungal Genet. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1104\/pp.68.3.745","article-title":"Photoregulation of the carotenoid biosynthesis pathway in albino and white collar mutants of Neurospora crassa.","volume":"68","author":"Harding","year":"1981","journal-title":"Plant Physiol."},{"key":"B13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5109\/1685879","article-title":"Performance of vegetative growth and artificial fruit body formation of Hypsizygus marmoreus in Bangladesh.","volume":"61","author":"Imtiaj","year":"2016","journal-title":"J. Fac. Agric. Kyushu Univ."},{"key":"B14","first-page":"62","article-title":"The antioxidation activity of albino mutant strain of Cordyceps militaris.","volume":"18","author":"Jiang","year":"2011","journal-title":"J. Edible Fungi"},{"key":"B15","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1523\/jneurosci.2538-06.2006","article-title":"SMURF: genomic mapping of fungal secondary metabolite clusters.","volume":"47","author":"Khaldi","year":"2010","journal-title":"Fungal Genet. Biol."},{"key":"B16","first-page":"65","article-title":"\u201cProduction of a novel white Flammulina velutipes by breeding,\u201d in","author":"Kitamoto","year":"1993","journal-title":"Genetics and Breeding of Edible Mushrooms"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00445-9","article-title":"Transcriptome analysis of genes involved in dendrobine biosynthesis in Dendrobium nobile Lindl. infected with mycorrhizal fungus MF23 (Mycena sp.).","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"B18","first-page":"230","article-title":"A review of the advances of the research on a white variant strain in Genus Auricularia.","volume":"24","author":"Li","year":"2016","journal-title":"Edible Med. Mushrooms"},{"key":"B19","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.ijbiomac.2017.02.064","article-title":"The preparation of three selenium-containing Cordyceps militaris polysaccharides: characterization and anti-tumor activities.","volume":"99","author":"Liu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B22","first-page":"1","author":"Ma","year":"2014","journal-title":"Mutation and Screening of Qinba Cordyceps militaris and Biological Charactistics of an Albino Strain."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1093\/bioinformatics\/bti430","article-title":"Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary.","volume":"21","author":"Mao","year":"2005","journal-title":"Bioinformatics"},{"key":"B24","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1104\/pp.106.094854","article-title":"The structure of two N-Methyltransferases from the caffeine biosynthetic pathway.","volume":"144","author":"McCarthy","year":"2007","journal-title":"Plant Physiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"W339","DOI":"10.1093\/nar\/gkr466","article-title":"AntiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.","volume":"39","author":"Medema","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jphotobiol.2009.02.006","article-title":"Photoprotective role of carotenoids in yeasts: response to UV-B of pigmented and naturally-occurring albino strains.","volume":"95","author":"Molin\u00e9","year":"2009","journal-title":"J. Photochem. Photobiol. B"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1093\/bioinformatics\/btn058","article-title":"FTFD: an informatics pipeline supporting phylogenomic analysis of fungal transcription factors.","volume":"24","author":"Park","year":"2008","journal-title":"Bioinformatics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.fct.2013.08.033","article-title":"The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties.","volume":"62","author":"Reis","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4489\/myco.2005.33.3.125","article-title":"Genetic analysis of pigmentation in Cordyceps militaris.","volume":"33","author":"Shrestha","year":"2005","journal-title":"Mycobiology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s11557-012-0825-y","article-title":"The medicinal fungus Cordyceps militaris: research and development.","volume":"11","author":"Shrestha","year":"2012","journal-title":"Mycol. Prog."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: molecular evolutionary genetics analysis version 6.0.","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq.","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"B33","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1159\/000088453","article-title":"Immunohistochemical and microarray analyses of a mouse model for the smith-lemli-opitz syndrome.","volume":"27","author":"Waage-Baudet","year":"2005","journal-title":"Dev. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"4645","DOI":"10.1007\/s00253-017-8276-7","article-title":"DASH-type cryptochromes regulate fruiting body development and secondary metabolism differently than CmWC-1 in the fungus Cordyceps militaris.","volume":"101","author":"Wang","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B35","first-page":"777","article-title":"Isolation and identification of one natural pigment from cultured Cordyceps militaris.","volume":"5","author":"Yan","year":"2010","journal-title":"Mycosystema"},{"key":"B36","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/1574-6968.12393","article-title":"Photo morphogenesis and photo response of the blue-light receptor gene Cmwc-1 in different strains of Cordyceps militaris.","volume":"352","author":"Yang","year":"2014","journal-title":"FEMS Microbiol. Lett."},{"key":"B37","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00253-015-7047-6","article-title":"The blue light receptor CmWC-1 mediates fruit body development and secondary metabolism in Cordyceps militaris.","volume":"100","author":"Yang","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1615\/IntJMedMushr.v16.i2.30","article-title":"Process optimization for extraction of carotenoids from medicinal caterpillar fungus, Cordyceps militaris (Ascomycetes).","volume":"16","author":"Yang","year":"2014","journal-title":"Int. J. Med. Mushrooms"},{"key":"B39","doi-asserted-by":"publisher","first-page":"477","DOI":"10.4103\/0973-1296.160454","article-title":"A direct protein kinase B-targeted anti-inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris.","volume":"11","author":"Yoon","year":"2015","journal-title":"Pharmacogn. Mag."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias.","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1111\/j.1744-7909.2006.00345.x","article-title":"Antioxidant activities of aqueous extract from cultivated fruiting-bodies of Cordyceps militaris in vitro.","volume":"48","author":"Zhan","year":"2006","journal-title":"J. Integr. Plant Biol."},{"key":"B42","first-page":"585","article-title":"Analysis of active components and antioxidant activity of albino Cordyceps militaris.","volume":"39","author":"Zhang","year":"2017","journal-title":"J. Jilin Agric. Univ."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-11-r116","article-title":"Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional Chinese medicine.","volume":"12","author":"Zheng","year":"2011","journal-title":"Genome Biol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01237\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T07:38:03Z","timestamp":1661413083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01237\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,8]]},"references-count":43,"alternative-id":["10.3389\/fmicb.2018.01237"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.01237","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,8]]},"article-number":"1237"}}