{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:26:45Z","timestamp":1792981605904,"version":"4.5.0"},"reference-count":163,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["031A602A"],"award-info":[{"award-number":["031A602A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.01546","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T04:24:06Z","timestamp":1531283046000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":91,"title":["Mathematical Analysis of Viral Replication Dynamics and Antiviral Treatment Strategies: From Basic Models to Age-Based Multi-Scale Modeling"],"prefix":"10.3389","volume":"9","author":[{"given":"Carolin","family":"Zitzmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Kaderali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1056\/NEJMoa1316366","article-title":"Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection","volume":"370","author":"Afdhal","year":"","journal-title":"N. Engl. J. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1056\/NEJMoa1402454","article-title":"Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection","volume":"370","author":"Afdhal","year":"","journal-title":"N. Engl. J. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.cell.2017.04.008","article-title":"Zika virus persistence in the central nervous system and lymph nodes of rhesus monkeys","volume":"169","author":"Aid","year":"2017","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.3390\/v4101984","article-title":"Modelling the course of an HIV infection: insights from ecology and evolution","volume":"4","author":"Alizon","year":"2012","journal-title":"Viruses"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1097\/QAD.0000000000000843","article-title":"Early HIV RNA decay during raltegravir-containing regimens exhibits two distinct subphases (1a and 1b)","volume":"29","author":"Andrade","year":"2015","journal-title":"AIDS"},{"key":"B6","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/nature11286","article-title":"Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy","volume":"487","author":"Archin","year":"2012","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/liv.13027","article-title":"Direct-acting antivirals for the treatment of hepatitis C virus infection: optimizing current IFN-free treatment and future perspectives","volume":"36","author":"Asselah","year":"2016","journal-title":"Liver Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"7590","DOI":"10.1128\/JVI.01623-05","article-title":"Kinetics of influenza A virus infection in humans","volume":"80","author":"Baccam","year":"2006","journal-title":"J. Virol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1007\/s11538-007-9223-z","article-title":"Modeling within-host evolution of HIV: mutation, competition and strain replacement","volume":"69","author":"Ball","year":"2007","journal-title":"Bull. Math. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.tim.2010.11.005","article-title":"Assembly of infectious hepatitis C virus particles","volume":"19","author":"Bartenschlager","year":"2011","journal-title":"Trends Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/clpt.2012.202","article-title":"Prospects for treatment of latent HIV","volume":"93","author":"Barton","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.ins.2008.11.012","article-title":"Agent-based modeling of host-pathogen systems: the successes and challenges","volume":"179","author":"Bauer","year":"2009","journal-title":"Inf. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1186\/1471-2458-11-S1-S7","article-title":"A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead","volume":"11","author":"Beauchemin","year":"2011","journal-title":"BMC Public Health"},{"key":"B14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.jtbi.2008.05.031","article-title":"Modeling amantadine treatment of influenza A virus in vitro","volume":"254","author":"Beauchemin","year":"2008","journal-title":"J. Theor. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"20140886","DOI":"10.1098\/rsif.2014.0886","article-title":"Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections","volume":"12","author":"Ben-Shachar","year":"2014","journal-title":"J. R. Soc. Interface"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e1005194","DOI":"10.1371\/journal.pcbi.1005194","article-title":"Drivers of inter-individual variation in dengue viral load dynamics","volume":"12","author":"Ben-Shachar","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e1006343","DOI":"10.1371\/journal.ppat.1006343","article-title":"NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains","volume":"13","author":"Benzine","year":"2017","journal-title":"PLoS Pathog."},{"key":"B18","doi-asserted-by":"publisher","first-page":"8847","DOI":"10.1073\/pnas.1704011114","article-title":"Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies","volume":"114","author":"Best","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1003561","DOI":"10.1371\/journal.ppat.1003561","article-title":"Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle","volume":"9","author":"Binder","year":"2013","journal-title":"PLoS Pathog."},{"key":"B20","volume-title":"WHO Health in 2015: From MDGs to SDGs","author":"Boerma","year":"2015"},{"key":"B21","doi-asserted-by":"publisher","first-page":"5274","DOI":"10.3390\/v7102875","article-title":"Modeling influenza virus infection: a roadmap for influenza research","volume":"7","author":"Boianelli","year":"2015","journal-title":"Viruses"},{"key":"B22","doi-asserted-by":"publisher","first-page":"6971","DOI":"10.1073\/pnas.94.13.6971","article-title":"Virus dynamics and drug therapy","volume":"94","author":"Bonhoeffer","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B23","first-page":"214","article-title":"Adaptive immune response to viral infections","volume-title":"Fields Virology","author":"Braciale","year":"2013"},{"key":"B24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0301-4622(87)80020-0","article-title":"Computer simulation of T3 \/ T7 phage infection using lag times","volume":"26","author":"Buchholtz","year":"1987","journal-title":"Biophys. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1003568","DOI":"10.1371\/journal.pcbi.1003568","article-title":"Impact of different oseltamivir regimens on treating influenza A virus infection and resistance emergence: insights from a modelling study","volume":"10","author":"Canini","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s10928-014-9363-3","article-title":"Viral kinetic modeling: state of the art","volume":"41","author":"Canini","year":"2014","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"B27","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3389\/fimmu.2016.00611","article-title":"On the role of CD8+ T cells in determining recovery time from influenza virus infection","volume":"7","author":"Cao","year":"2016","journal-title":"Front. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e1006478","DOI":"10.1371\/journal.ppat.1006478","article-title":"Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration","volume":"13","author":"Cardozo","year":"2017","journal-title":"PLoS Pathog."},{"key":"B29","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/nm.1972","article-title":"HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation","volume":"15","author":"Chomont","year":"2009","journal-title":"Nat. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.idm.2017.04.002","article-title":"In-host modeling","volume":"2","author":"Ciupe","year":"2017","journal-title":"Infect. Dis. Model."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e1004951","DOI":"10.1371\/journal.pcbi.1004951","article-title":"Modelling virus and antibody dynamics during dengue virus infection suggests a role for antibody in virus clearance","volume":"12","author":"Clapham","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1098\/rsif.2014.0094","article-title":"Within-host viral dynamics of dengue serotype 1 infection","volume":"11","author":"Clapham","year":"2014","journal-title":"J. R. Soc. Interface"},{"key":"B33","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.virusres.2015.09.011","article-title":"Multi-scale model for hepatitis C viral load kinetics under treatment with direct acting antivirals","volume":"218","author":"Clausznitzer","year":"2015","journal-title":"Virus Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1073\/pnas.1419162112","article-title":"Post-treatment control of HIV infection","volume":"6","author":"Conway","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1056\/NEJMc1604449","article-title":"Evidence of sexual transmission of zika virus","volume":"374","author":"D'Ortenzio","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.jhep.2016.02.022","article-title":"HCV kinetic and modeling analyses indicate similar time to cure among sofosbuvir combination regimens with daclatasvir, simeprevir or ledipasvir","volume":"64","author":"Dahari","year":"2016","journal-title":"J. Hepatol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jtbi.2007.03.006","article-title":"Modeling hepatitis C virus dynamics: Liver regeneration and critical drug efficacy","volume":"247","author":"Dahari","year":"","journal-title":"J. Theor. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1053\/j.gastro.2005.01.049","article-title":"Mathematical modeling of primary hepatitis C infection: noncytolytic clearance and early blockage of virion production","volume":"128","author":"Dahari","year":"2005","journal-title":"Gastroenterology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/hep.21657","article-title":"Triphasic decline of hepatitis C virus RNA during antiviral therapy","volume":"46","author":"Dahari","year":"","journal-title":"Hepatology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1128\/JVI.01304-06","article-title":"Mathematical modeling of subgenomic hepatitis C virus replication in Huh-7 cells","volume":"81","author":"Dahari","year":"","journal-title":"J. Virol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/(SICI)1097-0290(19970605)54:5<468::AID-BIT7>3.0.CO;2-C","article-title":"A mathematical model of the trafficking of acid-dependent enveloped viruses: application to the binding, uptake, and nuclear accumulation of baculovirus","volume":"54","author":"Dee","year":"1997","journal-title":"Biotechnol. Bioeng."},{"key":"B42","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/bit.260460513","article-title":"A model of the binding, entry, uncoating, and RNA synthesis of Semliki Forest virus in baby hamster kidney (BHK-21) cells","volume":"46","author":"Dee","year":"1995","journal-title":"Biotechnol. Bioeng."},{"key":"B43","doi-asserted-by":"publisher","first-page":"11005","DOI":"10.1021\/bi00110a001","article-title":"The hypercycle. Coupling of RNA and protein biosynthesis in the infection cycle of an RNA bacteriophage","volume":"30","author":"Eigen","year":"1991","journal-title":"Biochemistry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/(SICI)1097-0290(19970720)55:2<375::AID-BIT15>3.0.CO;2-G","article-title":"Intracellular kinetics of a growing virus: a genetically structured simulation for bacteriophage T7","volume":"55","author":"Endy","year":"1997","journal-title":"Biotechnol. Bioeng."},{"key":"B45","doi-asserted-by":"publisher","first-page":"654","DOI":"10.7326\/0003-4819-124-7-199604010-00006","article-title":"Immunopathogenic mechanisms of HIV infection","volume":"124","author":"Fauci","year":"1996","journal-title":"Ann. Intern. Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3201\/eid1705.101939","article-title":"Probable non-vector-borne transmission of Zika virus, Colorado, USA","volume":"17","author":"Foy","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1056\/NEJMoa020047","article-title":"Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection","volume":"347","author":"Fried","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.antiviral.2013.09.015","article-title":"Favipiravir (T-705), a novel viral RNA polymerase inhibitor","volume":"100","author":"Furuta","year":"2013","journal-title":"Antiviral Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2147\/DDDT.S30946","article-title":"Profile of alisporivir and its potential in the treatment of hepatitis C","volume":"7","author":"Gallay","year":"2013","journal-title":"Drug Des. Devel. Ther."},{"key":"B50","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nature08960","article-title":"Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect","volume":"465","author":"Gao","year":"2010","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1006\/viro.1998.9508","article-title":"Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems","volume":"252","author":"Garcia-Sastre","year":"1998","journal-title":"Virology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.vaccine.2005.08.105","article-title":"Antibody response to influenza vaccination in the elderly: a quantitative review","volume":"24","author":"Goodwin","year":"2006","journal-title":"Vaccine"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.3851\/IMP2273","article-title":"HIV-1 control after transient antiretroviral treatment initiated in primary infection: role of patient characteristics and effect of therapy","volume":"17","author":"Goujard","year":"2012","journal-title":"Antivir. Ther."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-virology-110615-042249","article-title":"Modeling viral spread","volume":"3","author":"Graw","year":"2015","journal-title":"Annu. Rev. Virol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.coviro.2016.02.010","article-title":"Approaches to preventative and therapeutic HIV vaccines","volume":"17","author":"Gray","year":"2016","journal-title":"Curr. Opin. Virol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1073\/pnas.1203110110","article-title":"Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life","volume":"110","author":"Guedj","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1002\/hep.24788","article-title":"Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128)","volume":"55","author":"Guedj","year":"2012","journal-title":"Hepatology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3851\/IMP2733","article-title":"Analysis of the hepatitis C viral kinetics during administration of two nucleotide analogues: sofosbuvir (GS-7977) and GS-0938","volume":"19","author":"Guedj","year":"2014","journal-title":"Antivir. Ther."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1002\/hep.24272","article-title":"Second-phase hepatitis C virus RNA decline during telaprevir-based therapy increases with drug effectiveness: implications for treatment duration","volume":"53","author":"Guedj","year":"2011","journal-title":"Hepatology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1111\/j.1365-2893.2010.01348.x","article-title":"A perspective on modelling hepatitis C virus infection","volume":"17","author":"Guedj","year":"2010","journal-title":"J. Viral Hepat."},{"key":"B61","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1098\/rsif.2009.0067","article-title":"Towards a quantitative understanding of the within-host dynamics of influenza A infections","volume":"7","author":"Handel","year":"2010","journal-title":"J. R. Soc. Interface"},{"key":"B62","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nri3463","article-title":"25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end","volume":"13","author":"Heim","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e1003372","DOI":"10.1371\/journal.pcbi.1003372","article-title":"Multiscale modeling of influenza A virus infection supports the development of direct-acting antivirals","volume":"9","author":"Heldt","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0140-6736(16)32621-6","article-title":"Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola \u00c7a Suffit!)","volume":"389","author":"Henao-Restrepo","year":"2017","journal-title":"Lancet"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1053\/jhep.2003.50218","article-title":"Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon","volume":"37","author":"Herrmann","year":"2003","journal-title":"Hepatology"},{"key":"B66","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.1128\/JVI.03644-13","article-title":"Effects of aging on influenza virus infection dynamics","volume":"88","author":"Hernandez-Vargas","year":"2014","journal-title":"J. Virol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3855\/jidc.8217","article-title":"Zika virus outbreak in Brazil","volume":"10","author":"Heukelbach","year":"2016","journal-title":"J. Infect. Dev. Ctries."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1126\/science.272.5265.1124","article-title":"Viral counts count in HIV infection","volume":"272","author":"Ho","year":"1996","journal-title":"Science"},{"key":"B69","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/373123a0","article-title":"Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection","volume":"373","author":"Ho","year":"1995","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"publisher","first-page":"e14767","DOI":"10.1371\/journal.pone.0014767","article-title":"Assessing the in vitro fitness of an oseltamivir-resistant seasonal A\/H1N1 influenza strain using a mathematical model","volume":"6","author":"Holder","year":"2011","journal-title":"PLoS ONE"},{"key":"B71","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0163-7258(82)90051-1","article-title":"Kinetics of pharmacologic response","volume":"16","author":"Holford","year":"1982","journal-title":"Pharmacol. Ther."},{"key":"B72","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1053\/jhep.2002.36227","article-title":"Course and outcome of hepatitis C","volume":"36","author":"Hoofnagle","year":"2002","journal-title":"Hepatology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jhep.2012.02.024","article-title":"The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection","volume":"57","author":"Hopkins","year":"2012","journal-title":"J. Hepatol."},{"key":"B74","first-page":"189","article-title":"Innate Responses to Viral Infections","volume-title":"Fields Virology","author":"Iwasaki","year":"2013"},{"key":"B75","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/S0140-6736(16)30386-5","article-title":"Late Ebola virus relapse causing meningoencephalitis: a case report","volume":"388","author":"Jacobs","year":"2016","journal-title":"Lancet"},{"key":"B76","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1056\/NEJMoa1012912","article-title":"Telaprevir for previously untreated chronic hepatitis C virus infection","volume":"364","author":"Jacobson","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"5388","DOI":"10.1128\/AAC.00069-15","article-title":"A Drug-disease model describing the effect of oseltamivir neuraminidase inhibition on influenza virus progression","volume":"59","author":"Kamal","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B78","doi-asserted-by":"publisher","first-page":"a006916","DOI":"10.1101\/cshperspect.a006916","article-title":"Transcriptional and posttranscriptional regulation of HIV-1 gene expression","volume":"2","author":"Karn","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"e1005237","DOI":"10.1371\/journal.ppat.1005237","article-title":"Modeling the effects of vorinostat in vivo reveals both transient and delayed HIV transcriptional activation and minimal killing of latently infected cells","volume":"11","author":"Ke","year":"2015","journal-title":"PLoS Pathog."},{"key":"B80","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/hep.21781","article-title":"Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients","volume":"46","author":"Kieffer","year":"2007","journal-title":"Hepatology"},{"key":"B81","doi-asserted-by":"publisher","first-page":"e20135","DOI":"10.1371\/journal.pcbi.0020135","article-title":"Viral and latent reservoir persistence in HIV-1-infected patients on therapy","volume":"2","author":"Kim","year":"2006","journal-title":"PLoS Comput. Biol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1056\/NEJMoa1402355","article-title":"Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis","volume":"370","author":"Kowdley","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1002\/1873-3468.12095","article-title":"Multiscale modeling of virus replication and spread","volume":"590","author":"Kumberger","year":"2016","journal-title":"FEBS Lett."},{"key":"B85","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.antiviral.2011.01.003","article-title":"Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapy","volume":"89","author":"Lawitz","year":"2011","journal-title":"Antiviral Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1056\/NEJMoa013552","article-title":"Antiretroviral-drug resistance among patients recently infected with HIV","volume":"347","author":"Little","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"6554","DOI":"10.1128\/JVI.02550-08","article-title":"Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex","volume":"83","author":"Liu","year":"2009","journal-title":"J. Virol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/S0140-6736(14)60164-1","article-title":"HIV infection: epidemiology, pathogenesis, treatment, and prevention","volume":"384","author":"Maartens","year":"2014","journal-title":"Lancet"},{"key":"B89","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1128\/CMR.00045-14","article-title":"Emerging and reemerging neglected tropical diseases: a review of key characteristics, risk factors, and the policy and innovation environment","volume":"27","author":"Mackey","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"B90","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.antiviral.2015.08.015","article-title":"Ebola virus dynamics in mice treated with favipiravir","volume":"123","author":"Madelain","year":"2015","journal-title":"Antiviral Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/nbt.3179","article-title":"Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody","volume":"33","author":"Mailly","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1002\/hep.20239","article-title":"Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees","volume":"39","author":"Major","year":"2004","journal-title":"Hepatology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.biosystems.2014.02.004","article-title":"Within-host influenza dynamics: a small-scale mathematical modeling approach","volume":"118","author":"Manchanda","year":"2014","journal-title":"Biosystems"},{"key":"B94","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/S0140-6736(01)06102-5","article-title":"Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial","volume":"358","author":"Manns","year":"2001","journal-title":"Lancet"},{"key":"B95","doi-asserted-by":"publisher","first-page":"5037","DOI":"10.1128\/JVI.77.8.5037-5038.2003","article-title":"A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo","volume":"77","author":"Markowitz","year":"2003","journal-title":"J. Virol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.antiviral.2016.10.004","article-title":"Modelling Ebola virus dynamics: implications for therapy","volume":"135","author":"Martyushev","year":"2016","journal-title":"Antiviral Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"6687","DOI":"10.1128\/JVI.00266-10","article-title":"Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus","volume":"84","author":"Miao","year":"2010","journal-title":"J. Virol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/sj.icb.7100015","article-title":"Acutely dysregulated, chronically disabled by the enemy within: T-cell responses to HIV-1 infection","volume":"85","author":"Munier","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3201\/eid2102.141363","article-title":"Potential sexual transmission of Zika virus","volume":"21","author":"Musso","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"B100","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3934\/mbe.2004.1.267","article-title":"Age-structured model of HIV infection that allows for variations in the production rate of viral particles and the death rate of productively infected Cells","volume":"1","author":"Nelson","year":"2004","journal-title":"Math. Biosci. Eng."},{"key":"B101","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1126\/science.282.5386.103","article-title":"Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon- therapy","volume":"282","author":"Neumann","year":"1998","journal-title":"Science"},{"key":"B102","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3389\/fmicb.2015.00257","article-title":"Ebola virus infection modeling and identifiability problems","volume":"6","author":"Nguyen","year":"2015","journal-title":"Front. Microbiol."},{"key":"B103","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1126\/science.272.5258.74","article-title":"Population dynamics of immune responses to persistent viruses","volume":"272","author":"Nowak","year":"1996","journal-title":"Science"},{"key":"B104","doi-asserted-by":"publisher","first-page":"4398","DOI":"10.1073\/pnas.93.9.4398","article-title":"Viral dynamics in hepatitis B virus infection","volume":"93","author":"Nowak","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B105","volume-title":"Virus Dynamics: Mathematical Principles of Immunology and Virology","author":"Nowak","year":"2001"},{"key":"B106","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.tips.2009.09.005","article-title":"Elucidating the elite: mechanisms of control in HIV-1 infection","volume":"30","author":"O'Connell","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1038\/nm.4206","article-title":"Zika viral dynamics and shedding in rhesus and cynomolgus macaques","volume":"22","author":"Osuna","year":"2016","journal-title":"Nat. Med."},{"key":"B108","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1073\/pnas.0800050105","article-title":"Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy","volume":"105","author":"Palmer","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B109","doi-asserted-by":"publisher","first-page":"e1002588","DOI":"10.1371\/journal.pcbi.1002588","article-title":"Modeling within-host dynamics of influenza virus infection including immune responses","volume":"8","author":"Pawelek","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1053\/j.gastro.2016.04.003","article-title":"Hepatitis C Virus resistance to direct-acting antiviral drugs in interferon-free regimens","volume":"151","author":"Pawlotsky","year":"2016","journal-title":"Gastroenterology"},{"key":"B111","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/nri700","article-title":"Modelling viral and immune system dynamics","volume":"2","author":"Perelson","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/387188a0","article-title":"Decay characteristics of HIV-1-infected compartments during combination therapy","volume":"387","author":"Perelson","year":"1997","journal-title":"Nature"},{"key":"B113","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrgastro.2015.97","article-title":"Modelling hepatitis C therapy-predicting effects of treatment","volume":"12","author":"Perelson","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0025-5564(93)90043-A","article-title":"Dynamics of HIV infection of CD4+ T cells","volume":"114","author":"Perelson","year":"1993","journal-title":"Math. Biosci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1126\/science.271.5255.1582","article-title":"HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time","volume":"271","author":"Perelson","year":"1996","journal-title":"Science"},{"key":"B116","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/1741-7007-11-96","article-title":"Modeling the within-host dynamics of HIV infection","volume":"11","author":"Perelson","year":"2013","journal-title":"BMC Biol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1097\/QAD.0b013e32834cdaba","article-title":"Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoir","volume":"25","author":"Persaud","year":"2011","journal-title":"AIDS"},{"key":"B118","doi-asserted-by":"publisher","first-page":"10651","DOI":"10.1128\/JVI.07244-11","article-title":"The H275Y neuraminidase mutation of the pandemic A\/H1N1 influenza virus lengthens the eclipse phase and reduces viral output of infected cells, potentially compromising fitness in ferrets","volume":"86","author":"Pinilla","year":"2012","journal-title":"J. Virol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.antiviral.2014.05.015","article-title":"Update on hepatitis C virus resistance to direct-acting antiviral agents","volume":"108","author":"Poveda","year":"2014","journal-title":"Antiviral Res."},{"key":"B120","first-page":"508","article-title":"An Age-based multiscale mathematical model of the hepatitis c virus life-cycle during infection and therapy: including translation and replication","volume-title":"VII Latin American Congress on Biomedical Engineering CLAIB 2016","author":"Quintela","year":"2017"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1016\/S0140-6736(99)02035-8","article-title":"Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis","volume":"354","author":"Ramratnam","year":"1999","journal-title":"Lancet"},{"key":"B122","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1089\/088922299311457","article-title":"Quantitative intracellular kinetics of HIV type 1","volume":"15","author":"Reddy","year":"1999","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"B123","doi-asserted-by":"publisher","first-page":"7681","DOI":"10.1073\/pnas.97.14.7681","article-title":"Production of resistant HIV mutants during antiretroviral therapy","volume":"97","author":"Ribeiro","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B124","doi-asserted-by":"publisher","first-page":"6096","DOI":"10.1128\/JVI.00127-10","article-title":"Estimation of the initial viral growth rate and basic reproductive number during acute HIV-1 infection","volume":"84","author":"Ribeiro","year":"2010","journal-title":"J. Virol."},{"key":"B125","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4049\/jimmunol.123.1.365","article-title":"Virus-induced interferon production by human macrophages","volume":"123","author":"Roberts","year":"1979","journal-title":"J. Immunol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1007\/s11538-007-9203-3","article-title":"Emergence of HIV-1 drug resistance during antiretroviral treatment","volume":"69","author":"Rong","year":"","journal-title":"Bull. Math. Biol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.jtbi.2007.04.014","article-title":"Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility","volume":"247","author":"Rong","year":"","journal-title":"J. Theor. Biol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"e1002959","DOI":"10.1371\/journal.pcbi.1002959","article-title":"Analysis of hepatitis C virus decline during treatment with the protease inhibitor danoprevir using a multiscale model","volume":"9","author":"Rong","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jtbi.2009.06.011","article-title":"Modeling HIV persistence, the latent reservoir, and viral blips","volume":"260","author":"Rong","year":"2009","journal-title":"J. Theor. Biol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3389\/fmicb.2017.00706","article-title":"Impact of genetic variations in HIV-1 tat on LTR-mediated transcription via TAR RNA interaction","volume":"8","author":"Ronsard","year":"","journal-title":"Front. Microbiol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"e85452","DOI":"10.1371\/journal.pone.0085452","article-title":"Molecular and genetic characterization of natural HIV-1 tat exon-1 variants from North India and their functional implications","volume":"9","author":"Ronsard","year":"2014","journal-title":"PLoS ONE"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.3389\/fmicb.2017.01467","article-title":"In silico analyses of subtype specific HIV-1 Tat-TAR RNA interaction reveals the structural determinants for viral activity","volume":"8","author":"Ronsard","year":"","journal-title":"Front. Microbiol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.1128\/JVI.02078-09","article-title":"Dynamics of influenza virus infection and pathology","volume":"84","author":"Saenz","year":"2010","journal-title":"J. Virol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"e1003211","DOI":"10.1371\/journal.ppat.1003211","article-title":"Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study","volume":"9","author":"S\u00e1ez-Ciri\u00f3n","year":"2013","journal-title":"PLoS Pathog."},{"key":"B135","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/1742-4690-8-97","article-title":"Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy","volume":"8","author":"Salgado","year":"2011","journal-title":"Retrovirology"},{"key":"B136","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1128\/CMR.14.4.778-809.2001","article-title":"Antiviral actions of interferons","volume":"14","author":"Samuel","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"B137","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/nm.3248","article-title":"Understanding the hepatitis C virus life cycle paves the way for highly effective therapies","volume":"19","author":"Scheel","year":"2013","journal-title":"Nat. Med."},{"key":"B138","doi-asserted-by":"publisher","first-page":"e1005075","DOI":"10.1371\/journal.pcbi.1005075","article-title":"Viral RNA degradation and diffusion act as a bottleneck for the influenza A virus infection efficiency","volume":"12","author":"Schelker","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"e1005345","DOI":"10.1371\/journal.ppat.1005345","article-title":"Live cell analysis and mathematical modeling identify determinants of attenuation of dengue virus 2\u2032-O-methylation mutant","volume":"11","author":"Schmid","year":"2015","journal-title":"PLoS Pathog."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1099\/0022-1317-21-1-1","article-title":"Interferon bioassay: reduction in yield of myxovirus neuraminidases","volume":"21","author":"Sedmak","year":"1973","journal-title":"J. Gen. Virol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/S1473-3099(16)00146-8","article-title":"The global economic burden of dengue: a systematic analysis","volume":"16","author":"Shepard","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"B142","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrmicro772","article-title":"HIV-1 dynamics in vivo: implications for therapy","volume":"1","author":"Simon","year":"2003","journal-title":"Nat. Rev. Microbiol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1006\/jtbi.2000.1076","article-title":"Modeling plasma virus concentration during primary HIV infection","volume":"203","author":"Stafford","year":"2000","journal-title":"J. Theor. Biol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1056\/NEJMoa0708975","article-title":"Raltegravir with Optimized background therapy for resistant HIV-1 infection","volume":"359","author":"Steigbigel","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B145","doi-asserted-by":"crossref","first-page":"236","DOI":"10.7883\/yoken.JJID.2004.236","article-title":"Defense mechanisms against influenza virus infection in the respiratory tract mucosa","volume":"57","author":"Tamura","year":"2004","journal-title":"Jpn. J. Infect. Dis."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1084\/jem.194.10.1395","article-title":"Determinants of viral clearance and persistence during acute hepatitis C virus infection","volume":"194","author":"Thimme","year":"2001","journal-title":"J. Exp. Med."},{"key":"B147","unstructured":"A Socio-economic Impact Assessment of the Zika Virus in Latin America and the Caribbean2017"},{"key":"B148","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1056\/NEJMoa1411037","article-title":"Efficacy of a tetravalent dengue vaccine in children in Latin America","volume":"372","author":"Villar","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"B149","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.molcel.2005.05.014","article-title":"Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase","volume":"19","author":"Watashi","year":"2005","journal-title":"Mol. Cell"},{"key":"B150","doi-asserted-by":"publisher","first-page":"e837","DOI":"10.1371\/journal.pntd.0000837","article-title":"Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis","volume":"4","author":"Wauquier","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B151","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/373117a0","article-title":"Viral dynamics in human immunodeficiency virus type 1 infection","volume":"373","author":"Wei","year":"1995","journal-title":"Nature"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1098\/rspb.2003.2664","article-title":"Immune responses and the emergence of drug-resistant virus strains in vivo","volume":"271","author":"Wodarz","year":"2004","journal-title":"Proc. Biol. Sci."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1002\/bies.10196","article-title":"Mathematical models of HIV pathogenesis and treatment","volume":"24","author":"Wodarz","year":"2002","journal-title":"BioEssays"},{"key":"B154","volume-title":"Dengue and Severe Dengue","year":""},{"key":"B155","volume-title":"Guidelines for the Screening, Care and Treatment of Persons with Chronic Hepatitis C Infection","year":""},{"key":"B156","volume-title":"Ebola Virus Disease.","year":""},{"key":"B157","volume-title":"HIV\/AIDS","year":""},{"key":"B158","volume-title":"Influenza (Seasonal).","year":""},{"key":"B159","volume-title":"Zika Virus","year":""},{"key":"B160","first-page":"1186","article-title":"Orthomyxoviruses","volume-title":"Fields Virology","author":"Wright","year":"2013"},{"key":"B161","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.addr.2013.04.005","article-title":"Modeling antiretroviral drug responses for HIV-1 infected patients using differential equation models","volume":"65","author":"Xiao","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B162","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3389\/fimmu.2016.00165","article-title":"Mathematical model reveals the role of memory CD8 T cell populations in recall responses to influenza","volume":"7","author":"Zarnitsyna","year":"2016","journal-title":"Front. Immunol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jhep.2012.09.022","article-title":"Host-targeting agents for prevention and treatment of chronic hepatitis C-Perspectives and challenges","volume":"58","author":"Zeisel","year":"2013","journal-title":"J. Hepatol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01546\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T02:38:02Z","timestamp":1720406282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01546\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":163,"alternative-id":["10.3389\/fmicb.2018.01546"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.01546","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,11]]},"article-number":"1546"}}