{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:50:14Z","timestamp":1790815814827,"version":"4.1.0"},"reference-count":140,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.01612","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T04:13:24Z","timestamp":1532492004000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":61,"title":["Immunomodulation as Therapy for Fungal Infection: Are We Closer?"],"prefix":"10.3389","volume":"9","author":[{"given":"Qi Hui","family":"Sam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Shan","family":"Yew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaminda J.","family":"Seneviratne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Wook","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis Yi Ann","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.2217\/imt.15.92","article-title":"Immunomodulatory effects of Lactobacillus strains: emphasis on their effects on cancer cells.","volume":"7","author":"Abedin-Do","year":"2015","journal-title":"Immunotherapy"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1210\/jc.2011-0090","article-title":"Clinical review: the 2011 report on dietary reference intake for vitamin D: where do we go from here?","volume":"96","author":"Aloia","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1111\/j.1600-6143.2010.03094.x","article-title":"Exogenous interferon-\u03b3 immunotherapy for invasive fungal infections in kidney transplant patients.","volume":"10","author":"Armstrong-James","year":"2010","journal-title":"Am. J. Transplant."},{"key":"B4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.fob.2014.01.002","article-title":"Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target.","volume":"4","author":"Azad","year":"2014","journal-title":"FEBS Open Bio"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1016\/j.jcyt.2015.05.011","article-title":"Clinical-scale isolation of the total Aspergillus fumigatus\u2013reactive T\u2013helper cell repertoire for adoptive transfer.","volume":"17","author":"Bacher","year":"2015","journal-title":"Cytotherapy"},{"key":"B6","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s15010-008-7378-7","article-title":"Interferon-\u03b3 and granulocyte-macrophage colony stimulating factor therapy in three patients with pulmonary aspergillosis.","volume":"36","author":"Bandera","year":"2008","journal-title":"Infection"},{"key":"B7","first-page":"125","article-title":"Anti-Candida activity of the anti-cancer drug tamoxifen.","volume":"80","author":"Beggs","year":"1993","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"6332","DOI":"10.4049\/jimmunol.169.11.6332","article-title":"Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1.","volume":"169","author":"Berclaz","year":"2002","journal-title":"J. Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1093\/infdis\/168.5.1314","article-title":"Inhibition of candida albicans translocation from the gastrointestinal tract of mice by oral administration of Saccharomyces boulardii.","volume":"168","author":"Berg","year":"1993","journal-title":"J. Infect. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1182\/blood-2012-08-448977","article-title":"Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation.","volume":"121","author":"Blyth","year":"2013","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.4049\/jimmunol.1003593","article-title":"Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-\u03b3 release.","volume":"187","author":"Bouzani","year":"2011","journal-title":"J. Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1074\/jbc.M116.767582","article-title":"A monoclonal antibody to Cryptococcus neoformans glucuronoxylomannan manifests hydrolytic activity for both peptides and polysaccharides.","volume":"292","author":"Bowen","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.4049\/jimmunol.1400814","article-title":"PTX3 binds MD-2 and promotes TRIF-dependent immune protection in Aspergillosis.","volume":"193","author":"Bozza","year":"2014","journal-title":"J. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.4049\/jimmunol.0900961","article-title":"Immune sensing of Aspergillus fumigatus proteins, glycolipids, and polysaccharides and the impact on th immunity and vaccination.","volume":"183","author":"Bozza","year":"2009","journal-title":"J. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/S1286-4579(02)00007-2","article-title":"Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants.","volume":"4","author":"Bozza","year":"2002","journal-title":"Microbes Infect."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections.","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.2217\/fmb.13.79","article-title":"Radioimmunotherapy of Cryptococcus neoformans spares bystander mammalian cells.","volume":"8","author":"Bryan","year":"2013","journal-title":"Fut. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1097\/INF.0000000000000909","article-title":"Interferon-gamma immunotherapy in a patient with refractory disseminated candidiasis.","volume":"34","author":"Buddingh","year":"2015","journal-title":"Pediatr. Infect. Dis. J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF01536771","article-title":"Stimulation of secretory IgA and secretory component of immunoglobulins in small intestine of rats treated with Saccharomyces boulardii.","volume":"35","author":"Buts","year":"1990","journal-title":"Dig. Dis. Sci."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00765-13","article-title":"Estrogen receptor antagonists are anti-cryptococcal agents that directly bind ef hand proteins and synergize with fluconazole in vivo.","volume":"5","author":"Butts","year":"2014","journal-title":"mBio"},{"key":"B21","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1128\/AAC.42.6.1437","article-title":"Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies.","volume":"42","author":"Casadevall","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"B22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2217\/fmb.10.158","article-title":"Immune response to Aspergillus fumigatus in compromised hosts: from bedside to bench.","volume":"6","author":"Chai","year":"2011","journal-title":"Fut. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/mmy\/myw118","article-title":"Successful treatment of Aspergillus ventriculitis through voriconazole adaptive pharmacotherapy, immunomodulation, and therapeutic monitoring of cerebrospinal fluid (1rightarrow3)-\u03b2-D-glucan.","volume":"55","author":"Chen","year":"2017","journal-title":"Med. Mycol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/ppul.21234","article-title":"Voriconazole inhibition of vitamin A metabolism: are adverse events increased in cystic fibrosis patients?","volume":"45","author":"Cheng","year":"2010","journal-title":"Pediatr. Pulmonol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4198","DOI":"10.1200\/JCO.2005.05.645","article-title":"Colony-stimulating factors for chemotherapy-induced febrile neutropenia: a meta-analysis of randomized controlled trials.","volume":"23","author":"Clark","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1056\/NEJMoa1211161","article-title":"Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation.","volume":"370","author":"Cunha","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00605","article-title":"Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity.","volume":"6","author":"Dahlberg","year":"2015","journal-title":"Front. Immunol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00345","article-title":"The efficacy of humanized antibody against the Sporothrix antigen, gp70, in promoting phagocytosis and reducing disease burden.","volume":"8","author":"de Almeida","year":"2017","journal-title":"Front. Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1093\/cid\/ciu168","article-title":"Topical application of imiquimod as a treatment for chromoblastomycosis.","volume":"58","author":"de Sousa","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-166","article-title":"Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series.","volume":"14","author":"Delsing","year":"2014","journal-title":"BMC Infect. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1007\/s00431-013-2041-4","article-title":"Prophylactic Saccharomyces boulardii versus nystatin for the prevention of fungal colonization and invasive fungal infection in premature infants.","volume":"172","author":"Demirel","year":"2013","journal-title":"Eur. J. Pediatr."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1128\/AAC.01564-08","article-title":"Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization.","volume":"53","author":"Dolan","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"B33","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/jac\/dkr540","article-title":"Deferasirox as adjunctive therapy for mucormycosis.","volume":"67","author":"Donnelly","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"B34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s10096-013-1944-3","article-title":"Clinical and economic burden of invasive fungal diseases in Europe: focus on pre-emptive and empirical treatment of Aspergillus and Candida species.","volume":"33","author":"Drgona","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B35","author":"Drks","year":"2017","journal-title":"Tansfusion of Granulocytes for Patients with Febrile Neutropenia (GRANITE). Deutsches Register Klinischer Studien."},{"key":"B36","first-page":"491","article-title":"Comparative effect of a single or continuous administration of \u201cSaccharomyces boulardii\u201d on the establishment of various strains of \u201ccandida\u201d in the digestive tract of gnotobiotic mice.","volume":"133","author":"Ducluzeau","year":"1982","journal-title":"Ann. Microbiol."},{"key":"B37","year":"2007","journal-title":"Refusal CHMP Assessment Report for Mycograb."},{"key":"B38","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s11046-005-5260-z","article-title":"Successful treatment of antifungal- and cryotherapy-resistant subcutaneous hyalohyphomycosis in an immunocompetent case with topical 5% imiquimod cream.","volume":"159","author":"Erbagci","year":"2005","journal-title":"Mycopathologia"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005341.pub3","article-title":"Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction.","volume":"6","author":"Estcourt","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005339.pub2","article-title":"Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction.","volume":"4","author":"Estcourt","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/493758","article-title":"Invasive aspergillosis in a renal transplant recipient successfully treated with interferon-gamma.","volume":"2012","author":"Estrada","year":"2012","journal-title":"Case Rep. Transplant."},{"key":"B42","year":"2000","journal-title":"FDA Approved Drug Products."},{"key":"B43","year":"","journal-title":"FDA Approves CAR-T Cell Therapy to Treat Adults with Certain Types of Large B-cell Lymphoma."},{"key":"B44","year":"","journal-title":"FDA Approves Tisagenlecleucel for B-cell ALL and Tocilizumab for Cytokine Release Syndrome. U.S. Food & Drug Administration."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3950","article-title":"Efficacy and safety of Saccharomyces boulardii for acute diarrhea.","volume":"134","author":"Feizizadeh","year":"2014","journal-title":"Pediatrics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nature01195","article-title":"Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response.","volume":"420","author":"Garlanda","year":"2002","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004827.pub4","article-title":"Probiotics for the prevention of pediatric antibiotic-associated diarrhea.","volume":"12","author":"Goldenberg","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"B48","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.mmcr.2016.04.005","article-title":"Scedosporium apiospermum infections and the role of combination antifungal therapy and GM-CSF: a case report and review of the literature.","volume":"11","author":"Goldman","year":"2016","journal-title":"Med. Mycol. Case Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nrmicro2711","article-title":"Candida albicans morphogenesis and host defence: discriminating invasion from colonization.","volume":"10","author":"Gow","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1111\/j.1445-5994.1996.tb00630.x","article-title":"G-CSF stimulated donor granulocyte collections for prophylaxis and therapy of neutropenic sepsis.","volume":"26","author":"Grigg","year":"1996","journal-title":"Aust. N. Z. J. Med."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nri2356","article-title":"Colony-stimulating factors in inflammation and autoimmunity.","volume":"8","author":"Hamilton","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1038\/sj.bmt.1702654","article-title":"Invasive fungal infections in pediatric bone marrow transplant recipients: single center experience of 10 years.","volume":"26","author":"Hovi","year":"2000","journal-title":"Bone Marrow Transplant."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1182\/blood-2011-09-379214","article-title":"Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling.","volume":"119","author":"Hume","year":"2012","journal-title":"Blood"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1172\/JCI32338","article-title":"The iron chelator deferasirox protects mice from mucormycosis through iron starvation.","volume":"117","author":"Ibrahim","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1126\/science.1221789","article-title":"Interactions between commensal fungi and the C-Type lectin receptor Dectin-1 influence colitis.","volume":"336","author":"Iliev","year":"2012","journal-title":"Science"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1097\/QAD.0b013e3283536a93","article-title":"Adjunctive Interferon-\u03b3 immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial.","volume":"26","author":"Jarvis","year":"2012","journal-title":"AIDS"},{"key":"B57","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1080\/13693780701523013","article-title":"Saccharomyces boulardii decreases inflammation and intestinal colonization by Candida albicans in a mouse model of chemically-induced colitis.","volume":"45","author":"Jawhara","year":"2007","journal-title":"Med. Mycol."},{"key":"B58","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1128\/IAI.46.2.552-558.1984","article-title":"In vitro effects of natural killer cells against Paracoccidioides brasiliensis yeast phase.","volume":"46","author":"Jimenez","year":"1984","journal-title":"Infect. Immun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1084\/jem.20151975","article-title":"M-CSF improves protection against bacterial and fungal infections after hematopoietic stem\/progenitor cell transplantation.","volume":"213","author":"Kandalla","year":"2016","journal-title":"J. Exp. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1183\/09031936.06.00021705","article-title":"Interferon-\u03b3 therapy in two patients with progressive chronic pulmonary aspergillosis.","volume":"27","author":"Kelleher","year":"2006","journal-title":"Eur. Respir. J."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1182\/blood-2010-12-322610","article-title":"Generation of a multipathogen-specific T-cell product for adoptive immunotherapy based on activation-dependent expression of CD154.","volume":"118","author":"Khanna","year":"2011","journal-title":"Blood"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/srep40599","article-title":"Differential effects of vitamins A and D on the transcriptional landscape of human monocytes during infection.","volume":"7","author":"Klassert","year":"2017","journal-title":"Sci. Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00430-014-0351-4","article-title":"Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes.","volume":"203","author":"Klassert","year":"2014","journal-title":"Med. Microbiol. Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1002\/art.21754","article-title":"Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis.","volume":"54","author":"Kobayashi","year":"2006","journal-title":"Arthritis Rheum."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1111\/j.1567-1364.2009.00559.x","article-title":"The antagonistic effect of Saccharomyces boulardii on Candida albicans filamentation, adhesion and biofilm formation.","volume":"9","author":"Krasowska","year":"2009","journal-title":"FEMS Yeast Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"10660","DOI":"10.1073\/pnas.1312789111","article-title":"Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection.","volume":"111","author":"Kumaresan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B67","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1128\/AAC.49.3.952-958.2005","article-title":"Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis.","volume":"49","author":"Larsen","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"B68","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1172\/JCI5212","article-title":"GM-CSF\u2013deficient mice are susceptible to pulmonary group B streptococcal infection.","volume":"103","author":"LeVine","year":"1999","journal-title":"J. Clin. Invest."},{"key":"B69","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1093\/infdis\/152.1.33","article-title":"Mechanisms of resistance of Aspergillus fumigatus conidia to killing by neutrophils in vitro.","volume":"152","author":"Levitz","year":"1985","journal-title":"J. Infect. Dis."},{"key":"B70","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1128\/IAI.62.1.194-202.1994","article-title":"Direct activity of human T lymphocytes and natural killer cells against Cryptococcus neoformans.","volume":"62","author":"Levitz","year":"1994","journal-title":"Infect. Immun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/jat\/bkt014","article-title":"Analysis of sertraline in postmortem fluids and tissues in 11 aviation accident victims.","volume":"37","author":"Lewis","year":"2013","journal-title":"J. Anal. Toxicol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1093\/infdis\/jiv033","article-title":"Bimodal influence of Vitamin D in host response to systemic candida infection\u2014vitamin D dose matters.","volume":"212","author":"Lim","year":"2015","journal-title":"J. Infect. Dis."},{"key":"B73","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.1128\/AAC.00674-10","article-title":"Efficacy of PTX3 in a rat model of invasive aspergillosis.","volume":"54","author":"Lo Giudice","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B74","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1128\/AAC.01324-10","article-title":"Dose range evaluation of mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein 90, in combination with amphotericin B-desoxycholate for treatment of murine systemic candidiasis.","volume":"55","author":"Louie","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B75","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3324\/haematol.2012.061952","article-title":"The role of antifungal treatment in hematology.","volume":"97","author":"Maertens","year":"2012","journal-title":"Haematologica"},{"key":"B76","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.1182\/blood-2002-05-1496","article-title":"Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors.","volume":"100","author":"Marr","year":"2002","journal-title":"Blood"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1093\/cid\/ciw038","article-title":"Probiotics as antifungals in mucosal candidiasis.","volume":"62","author":"Matsubara","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1128\/AAC.47.7.2208-2216.2003","article-title":"Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90.","volume":"47","author":"Matthews","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00336","article-title":"Repurposing Auranofin, Ebselen, and PX-12 as antimicrobial agents targeting the thioredoxin system.","volume":"9","author":"May","year":"2018","journal-title":"Front. Microbiol."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.4161\/onci.28398","article-title":"Myeloid-derived cells are key targets of tumor immunotherapy.","volume":"3","author":"Medina-Echeverz","year":"2014","journal-title":"Oncoimmunology"},{"key":"B81","first-page":"1359","article-title":"Interferon gamma in association with immunosuppressive drugs withdrawal and antifungal combination as a rescue therapy for cerebral invasive Aspergillosis in a liver transplant recipient.","volume":"80","author":"Mezidi","year":"2014","journal-title":"Minerva Anestesiol."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003039.pub2","article-title":"Colony-stimulating factors for chemotherapy-induced febrile neutropenia.","volume":"10","author":"Mhaskar","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"B83","doi-asserted-by":"publisher","first-page":"361","DOI":"10.2165\/00003088-200342040-00004","article-title":"Pharmacokinetics of selective estrogen receptor modulators.","volume":"42","author":"Morello","year":"2003","journal-title":"Clin. Pharmacokinet."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1056\/NEJMoa1707447","article-title":"Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma.","volume":"377","author":"Neelapu","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"B85","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1182\/blood.V82.5.1422.1422","article-title":"Long-term follow-up of patients with invasive fungal disease who received adjunctive therapy with recombinant human macrophage colony- stimulating factor.","volume":"82","author":"Nemunaitis","year":"1993","journal-title":"Blood"},{"key":"B86","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1086\/595846","article-title":"Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of multicenter prospective antifungal therapy (PATH) alliance registry.","volume":"48","author":"Neofytos","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1002\/cmdc.201600236","article-title":"Identification of ebsulfur analogues with broad-spectrum antifungal activity.","volume":"11","author":"Ngo","year":"2016","journal-title":"ChemMedChem"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-015-0003-5","article-title":"Vitamin D supplementation decreases Aspergillus fumigatus specific Th2 responses in CF patients with aspergillus sensitization: a phase one open-label study.","volume":"1","author":"Nguyen","year":"2015","journal-title":"Asthma Res. Pract."},{"key":"B89","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/sj.embor.7400731","article-title":"The gut flora as a forgotten organ.","volume":"7","author":"O\u2019Hara","year":"2006","journal-title":"EMBO Rep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nrd3074","article-title":"An insight into the antifungal pipeline: selected new molecules and beyond.","volume":"9","author":"Ostrosky-Zeichner","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1086\/503428","article-title":"A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis.","volume":"42","author":"Pachl","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.4049\/jimmunol.164.5.2602","article-title":"Granulocyte-Macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice.","volume":"164","author":"Paine","year":"2000","journal-title":"J. Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.critrevonc.2015.10.005","article-title":"Adoptive transfer of aspergillus-specific T cells as a novel anti-fungal therapy for hematopoietic stem cell transplant recipients: progress and challenges.","volume":"98","author":"Papadopoulou","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1086\/420829","article-title":"Recombinant Interferon-\u03b3lb as adjunctive therapy for AIDS-related acute cryptococcal meningitis.","volume":"189","author":"Pappas","year":"2004","journal-title":"J. Infect. Dis."},{"key":"B95","doi-asserted-by":"publisher","first-page":"4306","DOI":"10.4049\/jimmunol.0803462","article-title":"Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis.","volume":"182","author":"Park","year":"2009","journal-title":"J. Immunol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"4397","DOI":"10.1182\/blood-2005-05-1775","article-title":"Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation.","volume":"106","author":"Perruccio","year":"2005","journal-title":"Blood"},{"key":"B97","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1111\/j.1365-2036.2009.04102.x","article-title":"Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii.","volume":"30","author":"Pothoulakis","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1182\/blood-2015-05-645986","article-title":"Efficacy of transfusion with granulocytes from G-CSF\/dexamethasone\u2013treated donors in neutropenic patients with infection.","volume":"126","author":"Price","year":"2015","journal-title":"Blood"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1128\/IAI.69.4.2762-2765.2001","article-title":"Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to clostridium difficile toxin A in mice.","volume":"69","author":"Qamar","year":"2001","journal-title":"Infect. Immun."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1093\/annonc\/mdt110","article-title":"Granulocyte transfusions in hematologic malignancy patients with invasive pulmonary aspergillosis: outcomes and complications.","volume":"24","author":"Raad","year":"2013","journal-title":"Ann. Oncol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01322","article-title":"Optimizing outcomes in immunocompromised hosts: understanding the role of immunotherapy in invasive fungal diseases.","volume":"6","author":"Ravikumar","year":"2015","journal-title":"Front. Microbiol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S1473-3099(16)00074-8","article-title":"Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study.","volume":"16","author":"Rhein","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"B104","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.1128\/AAC.00435-12","article-title":"The non-specific effect of mycograb on amphotericin B minimum inhibitory concentration.","volume":"56","author":"Richie","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/srep40598","article-title":"Massive effect on LncRNAs in human monocytes during fungal and bacterial infections and in response to vitamins A and D.","volume":"7","author":"Riege","year":"2017","journal-title":"Sci. Rep."},{"key":"B106","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1046\/j.1365-2672.2000.01128.x","article-title":"Saccharomyces boulardii stimulates sIgA production and the phagocytic system of gnotobiotic mice.","volume":"89","author":"Rodrigues","year":"2000","journal-title":"J. Appl. Microbiol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections.","volume":"11","author":"Romani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1111\/j.1537-2995.2006.00996.x","article-title":"Safety and efficacy of therapeutic early onset granulocyte transfusions in pediatric patients with neutropenia and severe infections.","volume":"46","author":"Sachs","year":"2006","journal-title":"Transfusion"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020330","article-title":"The fungal mycobiome and its interaction with gut bacteria in the host.","volume":"18","author":"Sam","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/myc.12431","article-title":"Natural killer cell-mediated damage of clinical isolates of mucormycetes.","volume":"59","author":"Schmidt","year":"2016","journal-title":"Mycoses"},{"key":"B111","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.imbio.2012.10.013","article-title":"Rhizopus oryzae hyphae are damaged by human natural killer (NK) cells, but suppress NK cell mediated immunity.","volume":"218","author":"Schmidt","year":"2013","journal-title":"Immunobiology"},{"key":"B112","doi-asserted-by":"publisher","first-page":"71062","DOI":"10.18632\/oncotarget.12616","article-title":"Aspergillus fumigatus responds to natural killer (NK) cells with upregulation of stress related genes and inhibits the immunoregulatory function of NK cells.","volume":"7","author":"Schneider","year":"2016","journal-title":"Oncotarget"},{"key":"B113","doi-asserted-by":"publisher","first-page":"S373","DOI":"10.1016\/j.clml.2017.07.213","article-title":"Global pivotal phase 2 trial of the CD19-targeted therapy CTL019 in adult patients with relapsed or refractory (R\/R) diffuse large B-cell lymphoma (DLBCL)\u2014an interim analysis.","volume":"17","author":"Schuster","year":"2017","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"B114","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.mib.2017.10.018","article-title":"Modulating host immune responses to fight invasive fungal infections.","volume":"40","author":"Scriven","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/bmt.2008.237","article-title":"Randomized phase III study of granulocyte transfusions in neutropenic patients.","volume":"42","author":"Seidel","year":"2008","journal-title":"Bone Marrow Transplant."},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/568543","article-title":"Pivotal roles of GM-CSF in autoimmunity and inflammation.","volume":"2015","author":"Shiomi","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B117","doi-asserted-by":"publisher","first-page":"3187","DOI":"10.1200\/JCO.2006.06.4451","article-title":"2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline.","volume":"24","author":"Smith","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1093\/jac\/dkr529","article-title":"Deferasirox in mucormycosis: hopefully, not defeated.","volume":"67","author":"Soman","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"B119","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1093\/jac\/dkr375","article-title":"The Deferasirox\u2013AmBisome therapy for mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial.","volume":"67","author":"Spellberg","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.31","article-title":"Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole.","volume":"7","author":"Spitzer","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/bmt.2012.162","article-title":"Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT: a prospective phase II study in two centers.","volume":"48","author":"Stern","year":"2012","journal-title":"Bone Marrow Transplant."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1093\/infdis\/jiu607","article-title":"Multispecific aspergillus T cells selected by CD137 or CD154 induce protective immune responses against the most relevant mold infections.","volume":"211","author":"Stuehler","year":"2015","journal-title":"J. Infect. Dis."},{"key":"B123","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1007\/s10096-012-1670-2","article-title":"Adoptive immunity mediated by HLA-A\u22170201 restricted Asp f16 peptides-specific CD8 + T cells against Aspergillus fumigatus infection.","volume":"31","author":"Sun","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.jcyt.2017.07.012","article-title":"Cellular therapy for multiple pathogen infections after hematopoietic stem cell transplant.","volume":"19","author":"Sutrave","year":"2017","journal-title":"Cytotherapy"},{"key":"B125","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/bmt.2008.271","article-title":"Clinical-scale generation of human anti-Aspergillus T cells for adoptive immunotherapy.","volume":"43","author":"Tramsen","year":"2008","journal-title":"Bone Marrow Transplant."},{"key":"B126","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jcyt.2012.11.014","article-title":"Clinical-scale generation of multi-specific anti-fungal T cells targeting Candida, Aspergillus and mucormycetes.","volume":"15","author":"Tramsen","year":"2013","journal-title":"Cytotherapy"},{"key":"B127","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1128\/IAI.01700-14","article-title":"Immunosuppressive compounds exhibit particular effects on functional properties of human anti-aspergillus TH1 cells.","volume":"82","author":"Tramsen","year":"2014","journal-title":"Infect. Immun."},{"key":"B128","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1093\/mmy\/myv109","article-title":"Activity of sertraline against Cryptococcus neoformans: in vitro and in vivo assays.","volume":"54","author":"Trevino-Rangel Rde","year":"2016","journal-title":"Med. Mycol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1200\/JCO.2017.73.0655","article-title":"Off-the-shelf virus-specific T cells to treat BK virus, human herpesvirus 6, cytomegalovirus, epstein-barr virus, and adenovirus infections after allogeneic hematopoietic stem-cell transplantation.","volume":"35","author":"Tzannou","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1016\/j.bbmt.2017.07.029","article-title":"Granulocyte transfusions: a critical reappraisal.","volume":"23","author":"Valentini","year":"2017","journal-title":"Biol. Blood Marrow Transplant."},{"key":"B131","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/j.1469-0691.2011.03676.x","article-title":"Adjunctive immunotherapy with recombinant cytokines for the treatment of disseminated candidiasis.","volume":"18","author":"van de Veerdonk","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"B132","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1056\/NEJMoa1205037","article-title":"Duodenal infusion of donor feces for recurrent Clostridium difficile.","volume":"368","author":"van Nood","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1093\/infdis\/jit574","article-title":"Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity.","volume":"209","author":"Voigt","year":"2014","journal-title":"J. Infect. Dis."},{"key":"B134","doi-asserted-by":"publisher","first-page":"3999","DOI":"10.1200\/JCO.2014.60.5121","article-title":"Effect of granulocyte-macrophage colony-stimulating factor on prevention and treatment of invasive fungal disease in recipients of allogeneic stem-cell transplantation: a prospective multicenter randomized phase IV trial.","volume":"33","author":"Wan","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/bjh.14597","article-title":"Granulocyte transfusions in the management of invasive fungal infections.","volume":"177","author":"West","year":"2017","journal-title":"Br. J. Haematol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/21505594.2016.1196301","article-title":"Repurposing auranofin as an antifungal: in vitro activity against a variety of medically important fungi.","volume":"8","author":"Wiederhold","year":"2017","journal-title":"Virulence"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1042\/bst0171038","article-title":"Observation and significance of growth inhibition of Saccharomyces cerevisiae (A224A) by the antioestrogen drug tamoxifen.","volume":"17","author":"Wiseman","year":"1989","journal-title":"Biochem. Soc. Trans."},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7517350","article-title":"Granulocyte colony-stimulating factor and its potential application for skeletal muscle repair and regeneration.","volume":"2017","author":"Wright","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"B139","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1146\/annurev-immunol-020711-074958","article-title":"Adaptive immunity to fungi.","volume":"30","author":"W\u00fcthrich","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1128\/AAC.00212-12","article-title":"The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections.","volume":"56","author":"Zhai","year":"2012","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01612\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T16:54:16Z","timestamp":1604681656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01612\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,25]]},"references-count":140,"alternative-id":["10.3389\/fmicb.2018.01612"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.01612","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,25]]},"article-number":"1612"}}