{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:01:03Z","timestamp":1753891263778,"version":"3.41.2"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.01628","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T04:34:02Z","timestamp":1531974842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Fimbrial Gene z3276 in Enterohemorrhagic Escherichia coli O157:H7 Contributes to Bacterial Pathogenicity"],"prefix":"10.3389","volume":"9","author":[{"given":"Bicheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kongwang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1128\/AAC.49.2.584-589.2005","article-title":"cDNA microarray nalysis of differential gene expression in Candida albicans biofilm exposed to farnesol.","volume":"49","author":"Cao","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01116-14","article-title":"Biofilms formed by gram-negative bacteria undergo increased lipid a palmitoylation, enhancing in vivo survival.","volume":"5","author":"Chalabaev","year":"2014","journal-title":"mBio"},{"key":"B3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1128\/mBio.01116-14","article-title":"Identification of pathogen-specific and conserved genes expressed in vivo by an avian pathogenic Escherichia coli strain.","volume":"100","author":"Dozois","year":"2003","journal-title":"Proc. Natl. Acid. Sci. U.S.A."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102077","article-title":"Biofilm formation by uropathogenic Escherichia coli is favored under oxygen conditions that mimic the bladder environment.","volume":"18","author":"Eberly","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-10-7757-91","article-title":"Bacterial adhesion pili.","volume":"87","author":"Epler Barbercheck","year":"2018","journal-title":"Subcell. Biochem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.5606\/ehc.2017.52507","article-title":"Effects of bone cement loaded with teicoplanin, N-acetylcysteine or their combination on Staphylococcus aureus biofilm formation: an in vitro study.","volume":"28","author":"Gocer","year":"2017","journal-title":"Eklem Hastalik. Cerrahisi"},{"key":"B7","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00284-017-1256-4","article-title":"Role of flagella in the pathogenesis of Helicobacter pylori.","volume":"74","author":"Gu","year":"2017","journal-title":"Curr. Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"Pathogenic Escherichia coli.","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.ijmm.2008.08.006","article-title":"Serine protease espP subtype alpha, but not beta or gamma, of Shiga toxin-producing Escherichia coli is associated with highly pathogenic serogroups.","volume":"299","author":"Khan","year":"2009","journal-title":"Int. J. Med. Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1017\/S0950268899004045","article-title":"The role of fimbrial and flagella in the colonization, invasion and persistence of Escherichia coli O78:K80 in the day-old-chick model.","volume":"124","author":"La Ragione","year":"2000","journal-title":"Epidemiol. Infect."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012127","article-title":"The hemorrhagic coli pilus (HCP) of Escherichia coli O157:H7 is an inducer of proinflammatory cytokine secretion in intestinal epithelial cells.","volume":"5","author":"Ledesma","year":"2010","journal-title":"PLoS One"},{"key":"B12","doi-asserted-by":"publisher","first-page":"5297","DOI":"10.1128\/AEM.00794-12","article-title":"Real-time PCR methodology for selective detection of viable Escherichia coli O157:H7 cells by targeting Z3276 as a genetic marker.","volume":"78","author":"Li","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-017-1123-1122","article-title":"Multiplex real-time PCR assay for detection of Escherichia coli O157:H7 and screening for non-O157 Shiga toxin-producing E. coli.","volume":"17","author":"Li","year":"2017","journal-title":"BMC Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1006\/mcpr.1997.0132","article-title":"Detection and characterization of the fimA gene of Escherichia coli O157:H7.","volume":"11","author":"Li","year":"1997","journal-title":"Mol. Cell. Probes"},{"key":"B15","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/328084a0","article-title":"Localization of the receptor-binding protein adhesin at the tip of the bacterial pilus.","volume":"328","author":"Lindberg","year":"1987","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"272","DOI":"10.4161\/gmic.20661","article-title":"Fimbriation and curliation in Escherichia coli O157:H7: a paradigm of intestinal and environmental colonization.","volume":"3","author":"Lloyd","year":"2012","journal-title":"Gut Microbes"},{"key":"B17","doi-asserted-by":"publisher","first-page":"6075","DOI":"10.1128\/AEM.01592-13","article-title":"Comparison of Listeria monocytogenes Exoproteomes from biofilm and planktonic state: Lmo2504, a protein associated with biofilms.","volume":"79","author":"Louren\u00e7o","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/j.1462-2920.2006.00995.x","article-title":"Analysis of fimbrial gene clusters and their expression in enterohaemorrhagic Escherichia coli O157:H7.","volume":"8","author":"Low","year":"2006","journal-title":"Environ. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1462-5822.2008.01244.x","article-title":"An investigation of the expression and adhesin function of H7 flagella in the interaction of Escherichia coli O157:H7 with bovine intestinal epithelium.","volume":"11","author":"Mahajan","year":"2009","journal-title":"Cell. Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1542\/pir.36-4-167","article-title":"Escherichia coli infections.","volume":"36","author":"Makvana","year":"2015","journal-title":"Pediatr. Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1093\/emboj\/19.12.2803","article-title":"Type 1 pilus-mediated bacterial invasion of bladder epithelial cells.","volume":"19","author":"Martinez","year":"2000","journal-title":"EMBO J."},{"key":"B22","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev.micro.56.012302.160938","article-title":"Type IV pili and twitching motility.","volume":"56","author":"Mattick","year":"2002","journal-title":"Annu. Rev. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1128\/JB.01595-09","article-title":"Longus, a type IV pilus of enterotoxigenic Escherichia coli, is involved in adherence to intestinal epithelial cells.","volume":"192","author":"Mazariego-Espinosa","year":"2010","journal-title":"J. Bacteriol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"4294","DOI":"10.1128\/IAI.00488-10","article-title":"EspP, a serine protease of enterohemorrhagic Escherichia coli, impairs complement activation by cleaving complement factors C3\/C3b and C5.","volume":"78","author":"Orth","year":"2010","journal-title":"Infect. Immun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/35054089","article-title":"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.","volume":"409","author":"Perna","year":"2001","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/s00284-015-0842-6","article-title":"Analysis of yeh fimbrial gene cluster in Escherichia coli O157:H7 in Order to find a genetic marker for this serotype.","volume":"71","author":"Ravan","year":"2015","journal-title":"Curr. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1056\/NEJM198303243081203","article-title":"Hemorrhagic colitis associated with a rare Escherichia coli serotype.","volume":"308","author":"Riley","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e746","DOI":"10.1128\/IAI.00746-17","article-title":"Context-Dependent requirements for FimH and other canonical virulence factors in gut colonization by extraintestinal pathogenic Escherichia coli.","volume":"86","author":"Russell","year":"2018","journal-title":"Infect. Immun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1099\/00221287-142-4-907","article-title":"Analyysis of the EHEC hly operon and its location in the physical map of the large plasmid of enteroheamorrhagic Escherichia coli O157:H7.","volume":"142","author":"Schmedt","year":"1996","journal-title":"Microbiology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"4312","DOI":"10.1128\/IAI.70.8.4312-4322.2002","article-title":"Streptococcus suis interactions with the murine macrophage cell line J774: adhesion and cytotoxicity.","volume":"70","author":"Segura","year":"2002","journal-title":"Infect. Immun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/0016-5085(94)90587-8","article-title":"Role of shiga-like toxin I in bacterial enteritis: comparison between isogenic Escherichia coli strains induced in rabbits.","volume":"106","author":"Sjogren","year":"1994","journal-title":"Gastro"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/S0140-6736(05)71144-2","article-title":"Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome.","volume":"365","author":"Tarr","year":"2005","journal-title":"Lancet"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1111\/j.1462-5822.2007.00952.x","article-title":"Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili.","volume":"9","author":"Wright","year":"2007","journal-title":"Cell. Microbiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1172\/JCI30727","article-title":"Intestinal adherence associated with type IV pili of enterohemorrhagic Escherichia coli O157:H7.","volume":"117","author":"Xicohtencatl-Cortes","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091632","article-title":"Immunization with H7-HCP-tir-intimin significantly reduces colonization and shedding of Escherichia coli O157:H7 in goats.","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.1016\/j.vaccine.2011.02.007","article-title":"Subcutaneous and intranasal immunization with Stx2B-Tir-Stx1B-Zot reduces colonization and shedding of Escherichia coli O157:H7 in mice.","volume":"29","author":"Zhang","year":"2011","journal-title":"Vaccine"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01628\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T04:34:07Z","timestamp":1531974847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01628\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,19]]},"references-count":36,"alternative-id":["10.3389\/fmicb.2018.01628"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.01628","relation":{},"ISSN":["1664-302X"],"issn-type":[{"type":"electronic","value":"1664-302X"}],"subject":[],"published":{"date-parts":[[2018,7,19]]},"article-number":"1628"}}