{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:41:44Z","timestamp":1790494904553,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1A2A1A10055961"],"award-info":[{"award-number":["2015R1A2A1A10055961"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.01735","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T04:11:46Z","timestamp":1533615106000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Sepsis-Like Systemic Inflammation Induced by Nano-Sized Extracellular Vesicles From Feces"],"prefix":"10.3389","volume":"9","author":[{"given":"Kyong-Su","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaewook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Taek","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Youn","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae Rom","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"R\u00e5dinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoe-Yune","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaesung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"L\u00f6tvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Song","family":"Gho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7692","DOI":"10.4049\/jimmunol.179.11.7692","article-title":"Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo.","volume":"179","author":"Alaniz","year":"2007","journal-title":"J. Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nri2316","article-title":"Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut.","volume":"8","author":"Artis","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1089\/vim.2009.0113","article-title":"Membrane vesicles released by intestinal epithelial cells infected with rotavirus inhibit T-cell function.","volume":"23","author":"Barreto","year":"2010","journal-title":"Viral Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1177\/09680519000060060501","article-title":"Cellular activating properties and morphology of membrane-bound and purified meningococcal lipopolysaccharide.","volume":"6","author":"Bjerre","year":"2000","journal-title":"J. Endotoxin Res."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000382","article-title":"Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles.","volume":"5","author":"Bomberger","year":"2009","journal-title":"PLoS Pathog."},{"key":"B6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1046\/j.1442-200X.2003.01701.x","article-title":"Microbiology and management of intra-abdominal infections in children.","volume":"45","author":"Brook","year":"2003","journal-title":"Pediatr. Int."},{"key":"B7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/00000658-199208000-00002","article-title":"Multiple organ failure. Pathophysiology and potential future therapy.","volume":"216","author":"Deitch","year":"1992","journal-title":"Ann. Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.1128\/IAI.00433-10","article-title":"Naturally produced outer membrane vesicles from Pseudomonas aeruginosa elicit a potent innate immune response via combined sensing of both lipopolysaccharide and protein components.","volume":"78","author":"Ellis","year":"2010","journal-title":"Infect. Immun."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1182\/blood-2006-06-032961","article-title":"Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria.","volume":"109","author":"Elson","year":"2007","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.mib.2011.12.011","article-title":"Coordinate regulation of Gram-positive cell surface components.","volume":"15","author":"Hanson","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrd3203","article-title":"Targeting Toll-like receptors: emerging therapeutics?","volume":"9","author":"Hennessy","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"B12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.cyto.2004.05.008","article-title":"Gram-positive and Gram-negative bacteria elicit different patterns of pro-inflammatory cytokines in human monocytes.","volume":"30","author":"Hessle","year":"2005","journal-title":"Cytokine"},{"key":"B13","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1113\/jphysiol.2011.220822","article-title":"Interspecies communication in the gut, from bacterial delivery to host-cell response.","volume":"590","author":"Hodges","year":"2012","journal-title":"J. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/j.1398-9995.2010.02483.x","article-title":"Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation.","volume":"66","author":"Hong","year":"2011","journal-title":"Allergy"},{"key":"B15","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1093\/femsre\/fuw047","article-title":"Forgotten fungi-the gut mycobiome in human health and disease.","volume":"41","author":"Huseyin","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.1128\/IAI.71.10.5670-5675.2003","article-title":"Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells.","volume":"71","author":"Ismail","year":"2003","journal-title":"Infect. Immun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/smll.201401803","article-title":"In vivo kinetic biodistribution of nano-sized outer membrane vesicles derived from bacteria.","volume":"11","author":"Jang","year":"2015","journal-title":"Small"},{"key":"B18","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1093\/bioinformatics\/btu741","article-title":"EVpedia: a community web portal for extracellular vesicles research.","volume":"31","author":"Kim","year":"2015","journal-title":"Bioinformatics"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059276","article-title":"Outer membrane vesicles derived from Escherichia coli up-regulate expression of endothelial cell adhesion molecules in vitro and in vivo.","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.4049\/jimmunol.1200742","article-title":"Immunization of Escherichia coli outer membrane vesicles protects bacteria-induced lethality via Th1 and Th17 cell responses.","volume":"190","author":"Kim","year":"2013","journal-title":"J. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1101\/gad.1299905","article-title":"Bacterial outer membrane vesicles and the host-pathogen interaction.","volume":"19","author":"Kuehn","year":"2005","journal-title":"Genes Dev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1002\/pmic.200700196","article-title":"Global proteomic profiling of native outer membrane vesicles derived from Escherichia coli.","volume":"7","author":"Lee","year":"2007","journal-title":"Proteomics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/mas.20175","article-title":"Proteomics in Gram-negative bacterial outer membrane vesicles.","volume":"27","author":"Lee","year":"2008","journal-title":"Mass Spectrom. Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5425","DOI":"10.1002\/pmic.200900338","article-title":"Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles.","volume":"9","author":"Lee","year":"2009","journal-title":"Proteomics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/ki.1987.188","article-title":"Role of peritoneal cavity lymphatic absorption in peritoneal dialysis.","volume":"32","author":"Mactier","year":"1987","journal-title":"Kidney Int."},{"key":"B26","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1080\/00365540310016259","article-title":"Proinflammatory activity of cell-wall constituents from Gram-positive bacteria.","volume":"35","author":"Moreillon","year":"2003","journal-title":"Scand. J. Infect. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1146\/annurev.pathol.1.110304.100200","article-title":"Severe sepsis and septic shock: the role of Gram-negative bacteremia.","volume":"1","author":"Munford","year":"2006","journal-title":"Annu. Rev. Pathol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11721-1","article-title":"Fatal meningococcal septicaemia with \u201dblebbing\u201d meningococcus.","volume":"360","author":"Namork","year":"2002","journal-title":"Lancet"},{"key":"B29","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/sj.embor.7400731","article-title":"The gut flora as a forgotten organ.","volume":"7","author":"O\u2019Hara","year":"2006","journal-title":"EMBO Rep."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00830","article-title":"Microfluidic PCR amplification and MiSeq amplicon sequencing techniques for high-throughput detection and genotyping of human pathogenic RNA viruses in human feces, sewage, and oysters.","volume":"9","author":"Oshiki","year":"2018","journal-title":"Front. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011334","article-title":"Outer membrane vesicles derived from Escherichia coli induce systemic inflammatory response syndrome.","volume":"5","author":"Park","year":"2010","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1165\/rcmb.2012-0370OC","article-title":"Pulmonary inflammation induced by bacteria-free outer membrane vesicles from Pseudomonas aeruginosa.","volume":"49","author":"Park","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/145749690709600302","article-title":"Management of severe sepsis of abdominal origin.","volume":"96","author":"Pieracci","year":"2007","journal-title":"Scand. J. Surg."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1172\/JCI44261","article-title":"Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.","volume":"121","author":"Prados-Rosales","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B35","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.clnu.2006.10.006","article-title":"Commensal bacteria do translocate across the intestinal barrier in surgical patients.","volume":"26","author":"Reddy","year":"2007","journal-title":"Clin. Nutr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/j.1462-5822.2010.01546.x","article-title":"Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells.","volume":"13","author":"Schaar","year":"2011","journal-title":"Cell. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/bjs.1800840236","article-title":"Abdominal contamination, infection and sepsis: a continuum.","volume":"84","author":"Schein","year":"1997","journal-title":"Br. J. Surg."},{"key":"B38","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/SHK.0b013e318250de5d","article-title":"Circulating bacterial membrane vesicles cause sepsis in rats.","volume":"37","author":"Shah","year":"2012","journal-title":"Shock"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1111\/j.1462-2920.2011.02632.x","article-title":"Multifunctional membrane vesicles in Pseudomonas aeruginosa.","volume":"14","author":"Tashiro","year":"2012","journal-title":"Environ. Microbiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1021\/pr200872s","article-title":"Vesicle and vesicle-free extracellular proteome of Paracoccidioides brasiliensis: comparative analysis with other pathogenic fungi.","volume":"11","author":"Vallejo","year":"2012","journal-title":"J. Proteome Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1034\/j.1399-3003.2000.01516.x","article-title":"Neutrophils released from the bone marrow by granulocyte colony-stimulating factor sequester in lung microvessels but are slow to migrate.","volume":"15","author":"van Eeden","year":"2000","journal-title":"Eur. Respir. J."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01735\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T04:11:49Z","timestamp":1533615109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01735\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":41,"alternative-id":["10.3389\/fmicb.2018.01735"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.01735","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,7]]},"article-number":"1735"}}