{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:37:46Z","timestamp":1775281066070,"version":"3.50.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["AGL2013-40657-R"],"award-info":[{"award-number":["AGL2013-40657-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["AGL2015-68920-R"],"award-info":[{"award-number":["AGL2015-68920-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.01944","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T04:31:22Z","timestamp":1536294682000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Polyphosphate in Lactobacillus and Its Link to Stress Tolerance and Probiotic Properties"],"prefix":"10.3389","volume":"9","author":[{"given":"Cristina","family":"Alc\u00e1ntara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Coll-Marqu\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Jad\u00e1n-Piedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinoraz","family":"V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicenta","family":"Devesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Z\u00fa\u00f1iga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Monedero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-015-1983-2","article-title":"Inorganic polyphosphate in the microbial world. Emerging roles for a multifaceted biopolymer.","volume":"32","author":"Albi","year":"2016","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1128\/AEM.03997-13","article-title":"Accumulation of polyphosphate in Lactobacillus spp. and its involvement in stress resistance.","volume":"80","author":"Alcantara","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5107","DOI":"10.1002\/jsfa.8388","article-title":"Characterization of the binding capacity of mercurial species in Lactobacillus strains.","volume":"97","author":"Alcantara","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"B4","first-page":"256","article-title":"Isolation of polyphosphate-accumulating lactic acid bacteria from natural whey starters.","volume":"60","author":"Aprea","year":"2005","journal-title":"Milchwissenschaften"},{"key":"B5","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/0003-9861(82)90120-5","article-title":"Investigations of the state of the manganese in Lactobacillus plantarum.","volume":"215","author":"Archibald","year":"1982","journal-title":"Arch. Biochem. Biophys."},{"key":"B6","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s10895-008-0315-4","article-title":"High sensitivity, quantitative measurements of polyphosphate using a new DAPI-based approach.","volume":"18","author":"Aschar-Sobbi","year":"2008","journal-title":"J Fluoresc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0963-9969(92)90121-K","article-title":"Transformation of Lactobacillus strains used in meat and vegetable fermentations.","volume":"25","author":"Aukrust","year":"1992","journal-title":"Food Res. Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00203-005-0013-4","article-title":"Time-course development of the Cd2+ hyper-accumulating phenotype in Euglena gracilis.","volume":"184","author":"Aviles","year":"2005","journal-title":"Arch. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01580-14","article-title":"Randomized open-label pilot study of the influence of probiotics and the gut microbiome on toxic metal levels in Tanzanian pregnant women and school children.","volume":"5","author":"Bisanz","year":"2014","journal-title":"mBio"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02440-17","article-title":"Polyphosphate-accumulating bacteria: potential contributors to mineral dissolution in the oral cavity.","volume":"84","author":"Breiland","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/nrmicro2690","article-title":"Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa.","volume":"10","author":"Bron","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.1007\/s12010-015-1549-7","article-title":"Engineering tobacco to remove mercury from polluted soil.","volume":"175","author":"Chang","year":"2015","journal-title":"Appl. Biochem. Biotechnol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408398.2017.1421521","article-title":"Use of lactic acid bacteria and yeasts to reduce exposure to chemical food contaminants and toxicity.","volume":"16","author":"Chiocchetti","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179242","article-title":"Inorganic salts and intracellular polyphosphate inclusions play a role in the thermotolerance of the immunobiotic Lactobacillus rhamnosus CRL 1505.","volume":"12","author":"Correa Deza","year":"2017","journal-title":"PLoS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1128\/AEM.71.2.876-882.2005","article-title":"Metabolism of bismuth subsalicylate and intracellular accumulation of bismuth by Fusarium sp. strain BI.","volume":"71","author":"Dodge","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"6269","DOI":"10.1128\/JB.00202-06","article-title":"Regulation of ppk expression and in vivo function of Ppk in Streptomyces lividans TK24.","volume":"188","author":"Ghorbel","year":"2006","journal-title":"J. Bacteriol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"4645","DOI":"10.1073\/pnas.87.12.4645","article-title":"Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants.","volume":"87","author":"Grant","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mib.2014.12.004","article-title":"Oxidative stress protection by polyphosphate\u2013new roles for an old player.","volume":"24","author":"Gray","year":"2015","journal-title":"Curr. Opin. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-14-72","article-title":"Copper tolerance mediated by polyphosphate degradation and low-affinity inorganic phosphate transport system in Escherichia coli.","volume":"14","author":"Grillo-Puertas","year":"2014","journal-title":"BMC Microbiol."},{"key":"B20","author":"Gurr","year":"1965","journal-title":"The Rational Use of Dyes in Biology and General Staining Methods."},{"key":"B21","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.foodchem.2017.01.157","article-title":"The use of lactic acid bacteria to reduce mercury bioaccessibility.","volume":"228","author":"Jadan-Piedra","year":"2017","journal-title":"Food Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.trsl.2015.02.002","article-title":"Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis.","volume":"166","author":"Kashima","year":"2015","journal-title":"Transl. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1073\/pnas.0337704100","article-title":"Complete genome sequence of Lactobacillus plantarum WCFS1.","volume":"100","author":"Kleerebezem","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B24","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1128\/AEM.02145-09","article-title":"Requirement of the Lactobacillus casei MaeKR two-component system for L-malic acid utilization via a malic enzyme pathway.","volume":"76","author":"Landete","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"7011","DOI":"10.1128\/jb.177.24.7011-7018.1995","article-title":"A system to generate chromosomal mutations in Lactococcus lactis which allows fast analysis of targeted genes.","volume":"177","author":"Law","year":"1995","journal-title":"J. Bacteriol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.copbio.2017.10.007","article-title":"Identification of probiotic effector molecules: present state and future perspectives.","volume":"49","author":"Lebeer","year":"2018","journal-title":"Curr. Opin. Biotechnol."},{"key":"B27","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1128\/AEM.63.6.2117-2123.1997","article-title":"Single-crossover integration in the Lactobacillus sake chromosome and insertional inactivation of the ptsI and lacL genes.","volume":"63","author":"Leloup","year":"1997","journal-title":"Appl. Environ. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5633","DOI":"10.1128\/jb.174.17.5633-5638.1992","article-title":"New thermosensitive plasmid for gram-positive bacteria.","volume":"174","author":"Maguin","year":"1992","journal-title":"J. Bacteriol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1128\/JB.00076-10","article-title":"Complete genome sequence of the probiotic Lactobacillus casei strain BL23.","volume":"192","author":"Maze","year":"2010","journal-title":"J. Bacteriol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1007\/s11274-012-1094-2","article-title":"Interaction of lactic acid bacteria with metal ions: opportunities for improving food safety and quality.","volume":"28","author":"Mrvcic","year":"2012","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s00253-010-2572-9","article-title":"Development of a transgenic tobacco plant for phytoremediation of methylmercury pollution.","volume":"87","author":"Nagata","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/lam.12731","article-title":"In vitro and in vivo evaluation of Weissella cibaria and Lactobacillus plantarum for their protective effect against cadmium and lead toxicities.","volume":"64","author":"Ojekunle","year":"2017","journal-title":"Lett. Appl. Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1574-6968.2002.tb11045.x","article-title":"Polyphosphate produced in recombinant Escherichia coli confers mercury resistance.","volume":"207","author":"Pan-Hou","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"B34","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1146\/annurev.biochem.77.083007.093039","article-title":"Inorganic polyphosphate: essential for growth and survival.","volume":"78","author":"Rao","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-11-82","article-title":"Characterization of mercury bioremediation by transgenic bacteria expressing metallothionein and polyphosphate kinase.","volume":"11","author":"Ruiz","year":"2011","journal-title":"BMC Biotechnol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1080\/09168451.2015.1135041","article-title":"A Lactobacillus mutant capable of accumulating long-chain polyphosphates that enhance intestinal barrier function.","volume":"80","author":"Saiki","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B37","first-page":"591","article-title":"Polyphosphate derived from Lactobacillus brevis inhibits colon cancer progression through induction of cell apoptosis.","volume":"36","author":"Sakatani","year":"2016","journal-title":"Anticancer Res."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023278","article-title":"Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway.","volume":"6","author":"Segawa","year":"2011","journal-title":"PLoS One"},{"key":"B39","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.bbrc.2015.09.159","article-title":"Probiotic-derived polyphosphate improves the intestinal barrier function through the caveolin-dependent endocytic pathway.","volume":"467","author":"Tanaka","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/1751-7915.12368","article-title":"Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome.","volume":"9","author":"van den Nieuwboer","year":"2016","journal-title":"Microb. Biotechnol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.copbio.2012.08.001","article-title":"Phosphorus recovery from wastewater through microbial processes.","volume":"23","author":"Yuan","year":"2012","journal-title":"Curr. Opin. Biotechnol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.1128\/AEM.00762-14","article-title":"Protective effects of Lactobacillus plantarum CCFM8610 against chronic cadmium toxicity in mice indicate routes of protection besides intestinal sequestration.","volume":"80","author":"Zhai","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1021\/es00058a007","article-title":"Monitoring the cellular response of Stichococcus bacillaris to exposure of several different metals using in vivo 31P NMR and other spectroscopic techniques.","volume":"28","author":"Zhang","year":"1994","journal-title":"Environ. Sci. Technol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"84","DOI":"10.2174\/1389557513666131211105554","article-title":"Surface binding of toxins and heavy metals by probiotics.","volume":"14","author":"Zoghi","year":"2014","journal-title":"Mini Rev. Med. Chem."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01944\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T04:13:41Z","timestamp":1604895221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.01944\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":44,"alternative-id":["10.3389\/fmicb.2018.01944"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.01944","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]},"article-number":"1944"}}