{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:24:53Z","timestamp":1760955893972,"version":"3.41.2"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.02465","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:54:01Z","timestamp":1539651241000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Jejunal Metabolic Responses to Escherichia coli Infection in Piglets"],"prefix":"10.3389","volume":"9","author":[{"given":"Hucong","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Bin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1177\/0148607115587330","article-title":"Glutamine restores tight junction protein Claudin-1 expression in colonic mucosa of patients with diarrhea-predominant irritable bowel syndrome.","volume":"40","author":"Bertrand","year":"2015","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"B2","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.micinf.2013.12.003","article-title":"The contribution of the glycine cleavage system to the pathogenesis of Francisella tularensis.","volume":"16","author":"Brown","year":"2014","journal-title":"Microbes Infect."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3109\/14767058.2014.956403","article-title":"Urinary metabolomics of pregnant women at term: a combined GC\/MS and NMR approach.","volume":"27","author":"Caboni","year":"2014","journal-title":"J. Mater. Fetal Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ejphar.2015.03.002","article-title":"Magnolol and honokiol regulate the calcium-activated potassium channels signaling pathway in Enterotoxigenic Escherichia coli-induced diarrhea mice.","volume":"755","author":"Deng","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.jss.2014.06.016","article-title":"Glycine selectively reduces intestinal injury during endotoxemia.","volume":"192","author":"Effenberger-Neidnicht","year":"2014","journal-title":"J. Surg. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.micinf.2009.10.002","article-title":"Molecular mechanisms of enterotoxigenic Escherichia coli infection.","volume":"12","author":"Fleckenstein","year":"2010","journal-title":"Microbes Infect."},{"key":"B7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1089\/jmf.2016.3837","article-title":"Time course effect of R-alpha-lipoic acid on cellular metabolomics in cultured hepatoma cells.","volume":"20","author":"Ikuta","year":"2017","journal-title":"J. Med. Food"},{"key":"B8","doi-asserted-by":"publisher","first-page":"36012","DOI":"10.1074\/jbc.M606895200","article-title":"A novel function of ionotropic gamma-aminobutyric acid receptors involving alveolar fluid homeostasis.","volume":"281","author":"Jin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1089\/jmf.2017.3928","article-title":"Effect of feeding high gamma-aminobutyric acid-containing giant embryo black sticky rice (Oryza sativa L.) on Anxiety-Related Behavior of C57BL\/6 Mice.","volume":"20","author":"Jung","year":"2017","journal-title":"J. Med. Food"},{"key":"B10","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1089\/jmf.2016.3874","article-title":"Investigation of the hepatoprotective effect of Prunus mume Sieb. et Zucc extract in a mouse model of alcoholic liver injury through high-resolution metabolomics.","volume":"20","author":"Khan","year":"2017","journal-title":"J. Med. Food"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00520-012-1627-0","article-title":"The protective effects of glutamine on radiation-induced diarrhea.","volume":"21","author":"Kucuktulu","year":"2013","journal-title":"Support. Care Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"G453","DOI":"10.1152\/ajpgi.00497.2011","article-title":"A novel role of intestine epithelial GABAergic signaling in regulating intestinal fluid secretion.","volume":"303","author":"Li","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1007\/s00726-017-2410-9","article-title":"L-Glutamine and L-arginine protect against enterotoxigenic Escherichia coli infection via intestinal innate immunity in mice.","volume":"49","author":"Liu","year":"2017","journal-title":"Amino Acids"},{"key":"B14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.5114\/fn.2015.56552","article-title":"Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men.","volume":"53","author":"Mikulski","year":"2015","journal-title":"Folia Neuropathol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.jnutbio.2013.12.006","article-title":"Dietary supplementation of aspartate enhances intestinal integrity and energy status in weanling piglets after lipopolysaccharide challenge.","volume":"25","author":"Pi","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.vetimm.2013.02.006","article-title":"The effects of natural and modified clinoptilolite on intestinal barrier function and immune response to LPS in broiler chickens.","volume":"153","author":"Qiu","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/srep25640","article-title":"Proteome analysis for the global proteins in the jejunum tissues of enterotoxigenic Escherichia coli -infected piglets.","volume":"6","author":"Ren","year":"","journal-title":"Sci. Rep."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00685","article-title":"Intestinal microbiota-derived GABA mediates interleukin-17 expression during enterotoxigenic Escherichia coli infection.","volume":"7","author":"Ren","year":"","journal-title":"Front. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"59550","DOI":"10.1039\/C5RA09513A","article-title":"Metabolomics study of metabolic variations in enterotoxigenic Escherichia coli-infected piglets.","volume":"5","author":"Ren","year":"2015","journal-title":"RSC Adv."},{"key":"B20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00726-011-1068-y","article-title":"Glycine and its N-methylated analogues cause pH-dependent membrane damage to enterotoxigenic Escherichia coli.","volume":"43","author":"Vanhauteghem","year":"2012","journal-title":"Amino Acids"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3608","DOI":"10.3748\/wjg.v10.i24.3608","article-title":"Characteristic expression of gamma-aminobutyric acid and glutamate decarboxylase in rat jejunum and its relation to differentiation of epithelial cells.","volume":"10","author":"Wang","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00726-009-0269-0","article-title":"Amino acids: metabolism, functions, and nutrition.","volume":"37","author":"Wu","year":"2009","journal-title":"Amino Acids"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.2527\/jas.2013-6619","article-title":"Effect of Lactobacillus plantarum on diarrhea and intestinal barrier function of young piglets challenged with enterotoxigenic Escherichia coli K88.","volume":"92","author":"Yang","year":"2014","journal-title":"J. Anim. Sci."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122893","article-title":"Effects of dietary supplementation with glutamate and aspartate on diquat-induced oxidative stress in piglets.","volume":"10","author":"Yin","year":"2015","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/mnfr.201500031","article-title":"l-Cysteine metabolism and its nutritional implications.","volume":"60","author":"Yin","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"8502","DOI":"10.3390\/ijms12128502","article-title":"Effects of soybean agglutinin on intestinal barrier permeability and tight junction protein expression in weaned piglets.","volume":"12","author":"Zhao","year":"2011","journal-title":"Int. J. Mol. Sci."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.02465\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:54:03Z","timestamp":1539651243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.02465\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":26,"alternative-id":["10.3389\/fmicb.2018.02465"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.02465","relation":{},"ISSN":["1664-302X"],"issn-type":[{"type":"electronic","value":"1664-302X"}],"subject":[],"published":{"date-parts":[[2018,10,16]]},"article-number":"2465"}}