{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:24:02Z","timestamp":1790616242703,"version":"4.1.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.02596","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T11:37:22Z","timestamp":1540985842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Seasonal Genetic Drift of Human Influenza A Virus Quasispecies Revealed by Deep Sequencing"],"prefix":"10.3389","volume":"9","author":[{"given":"Cyril","family":"Barbezange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Isakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gershon","family":"Celniker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Enouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Shomron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vignuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"van der Werf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1038\/nprot.2014.118","article-title":"Library preparation for highly accurate population sequencing of RNA viruses.","volume":"9","author":"Acevedo","year":"2014","journal-title":"Nat. Protoc."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.1016\/j.vaccine.2014.02.014","article-title":"WHO recommendations for the viruses used in the 2013-2014 Northern Hemisphere influenza vaccine: epidemiology, antigenic and genetic characteristics of influenza A(H1N1)pdm09, A(H3N2) and B influenza viruses collected from October 2012 to January 2013.","volume":"32","author":"Barr","year":"2014","journal-title":"Vaccine"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00329","article-title":"Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data.","volume":"3","author":"Beerenwinkel","year":"2012","journal-title":"Front. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1097\/01.aids.0000189847.98569.2d","article-title":"Hepatitis C virus in the semen of men coinfected with HIV-1: prevalence and origin.","volume":"19","author":"Briat","year":"2005","journal-title":"AIDS"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1086\/652661","article-title":"Quasispecies of the D225G substitution in the hemagglutinin of pandemic influenza A(H1N1) 2009 virus from patients with severe disease in Hong Kong, China.","volume":"201","author":"Chen","year":"2010","journal-title":"J. Infect. Dis."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006194","article-title":"Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses.","volume":"13","author":"Debbink","year":"2017","journal-title":"PLoS Pathog."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.1128\/JVI.03248-15","article-title":"Deep sequencing reveals potential antigenic variants at low frequencies in influenza A virus-infected humans.","volume":"90","author":"Dinis","year":"2016","journal-title":"J. Virol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/b137531","article-title":"Quasispecies: concept and implication for virology.","volume":"299","author":"Domingo","year":"2006","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"13910","DOI":"10.1073\/Pnas.96.24.13910","article-title":"Mutation rates among RNA viruses.","volume":"96","author":"Drake","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B10","doi-asserted-by":"publisher","first-page":"6231","DOI":"10.1128\/jvi.06541-11","article-title":"Deep sequencing reveals minor protease resistance mutations in patients failing a protease inhibitor regimen.","volume":"86","author":"Fisher","year":"2012","journal-title":"J. Virol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422x-10-116","article-title":"Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain.","volume":"10","author":"Fordyce","year":"2013","journal-title":"Virol. J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1093\/infdis\/jis571","article-title":"Presence of oseltamivir-resistant pandemic A\/H1N1 minor variants before drug therapy with subsequent selection and transmission.","volume":"206","author":"Ghedin","year":"2012","journal-title":"J. Infect. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1093\/infdis\/jiq040","article-title":"Deep sequencing reveals mixed infection with 2009 pandemic Influenza A (H1N1) virus strains and the emergence of oseltamivir resistance.","volume":"203","author":"Ghedin","year":"2011","journal-title":"J. Infect. Dis."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019075","article-title":"A comprehensive deep sequencing strategy for full-length genomes of influenza A.","volume":"6","author":"Hoper","year":"2011","journal-title":"PLoS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1093\/bioinformatics\/btv101","article-title":"Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum.","volume":"31","author":"Isakov","year":"2015","journal-title":"Bioinformatics"},{"key":"B16","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1126\/science.1222213","article-title":"An overlapping protein-coding region in influenza A virus segment 3 modulates the host response.","volume":"337","author":"Jagger","year":"2012","journal-title":"Science (80-)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jviromet.2011.09.001","article-title":"A simple method for the parallel deep sequencing of full influenza A genomes.","volume":"178","author":"Kampmann","year":"2011","journal-title":"J. Virol. Methods"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093632","article-title":"Influenza A H1N1 pandemic strain evolution\u2013divergence and the potential for antigenic drift variants.","volume":"9","author":"Klein","year":"2014","journal-title":"PLoS One"},{"key":"B19","article-title":"Spearman\u2019s Rho: Wiley StatsRef Stat. Ref. Online.","author":"Kornbrot","year":"2014"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010256","article-title":"Characterization of quasispecies of pandemic 2009 influenza A virus (A\/H1N1\/2009) by de novo sequencing using a next-generation DNA sequencer.","volume":"5","author":"Kuroda","year":"2010","journal-title":"PLoS One"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001005","article-title":"Quasispecies theory and the behavior of RNA viruses.","volume":"6","author":"Lauring","year":"2010","journal-title":"PLoS Pathog"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/srep33318","article-title":"Contamination-controlled high-throughput whole genome sequencing for influenza A viruses using the MiSeq sequencer.","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform.","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools.","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"B26","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1093\/infdis\/jis925","article-title":"Impact of minority nonnucleoside reverse transcriptase inhibitor resistance mutations on resistance genotype after virologic failure.","volume":"207","author":"Li","year":"2013","journal-title":"J. Infect. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3855\/jidc.3749","article-title":"Next-generation sequencing and bioinformatic approaches to detect and analyze influenza virus in ferrets.","volume":"8","author":"Lin","year":"2014","journal-title":"J. Infect Dev. Ctries"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.7490\/F1000RESEARCH.1114334.1","article-title":"\u201cA public Galaxy platform at Pasteur used as an execution engine for web services\u201d in","volume":"6","author":"Mareuil","year":"2017","journal-title":"Poster at the F1000Research"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1101\/176362","article-title":"Stochastic processes dominate the within and between host evolution of influenza virus.","volume":"7","author":"McCrone","year":"2017","journal-title":"Elite"},{"key":"B30","doi-asserted-by":"publisher","first-page":"552","DOI":"10.3201\/eid1504.081280","article-title":"Oseltamivir-resistant influenza Virus A (H1N1), Europe, 2007\u201308 Season.","volume":"15","author":"Meijer","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s15010-017-1091-3","article-title":"Whole genome sequencing identifies influenza A H3N2 transmission and offers superior resolution to classical typing methods.","volume":"46","author":"Meinel","year":"2018","journal-title":"Infection"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5086","DOI":"10.1016\/j.vaccine.2007.03.046","article-title":"The annual impact of seasonal influenza in the US: measuring disease burden and costs.","volume":"25","author":"Molinari","year":"2007","journal-title":"Vaccine"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078750","article-title":"A novel nonhuman primate model for influenza transmission.","volume":"8","author":"Moncla","year":"2013","journal-title":"PLoS One"},{"key":"B34","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1128\/JVI.03181-13","article-title":"Emergence of a highly pathogenic avian influenza virus from a low-pathogenic progenitor.","volume":"88","author":"Monne","year":"2014","journal-title":"J. Virol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/9781118445112.stat06898","author":"Moses","year":"2014","journal-title":"Wilcoxon-Mann-Whitney Test: Definition and Example: Wiley StatsRef Stat. Ref. Online."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030061","article-title":"Spatial, temporal, and species variation in prevalence of influenza A viruses in wild migratory birds.","volume":"3","author":"Munster","year":"2007","journal-title":"PLoS Pathog."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1128\/JVI.02656-12","article-title":"Identification of novel influenza A virus proteins translated from PA mRNA.","volume":"87","author":"Muramoto","year":"2013","journal-title":"J. Virol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr344","article-title":"Sequence-specific error profile of Illumina sequencers.","volume":"39","author":"Nakamura","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024907","article-title":"Genetic heterogeneity of hepatitis C virus in association with antiviral therapy determined by ultra-deep sequencing.","volume":"6","author":"Nasu","year":"2011","journal-title":"PLoS One"},{"key":"B40","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nature08157","article-title":"Emergence and pandemic potential of swine-origin H1N1 influenza virus.","volume":"459","author":"Neumann","year":"2009","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035052","article-title":"Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing.","volume":"7","author":"Nishijima","year":"2012","journal-title":"PLoS One"},{"key":"B42","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.1016\/j.vaccine.2012.04.057","article-title":"Indirect, out-of-pocket and medical costs from influenza-related illness in young children.","volume":"30","author":"Ortega-Sanchez","year":"2012","journal-title":"Vaccine"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1089\/088922202320886316","article-title":"Subcompartmentalization of HIV-1 quasispecies between seminal cells and seminal plasma indicates their origin in distinct genital tissues.","volume":"18","author":"Paranjpe","year":"2002","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"B44","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1128\/JVI.59.2.377-383.1986","article-title":"Measurement of the mutation rate of animal viruses: influenza A virus and poliovirus type 1.","volume":"59","author":"Parvin","year":"1986","journal-title":"J. Virol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/J.ANTIVIRAL.2017.07.021","article-title":"Characterization of oseltamivir-resistant influenza virus populations in immunosuppressed patients using digital-droplet PCR: comparison with qPCR and next generation sequencing analysis.","volume":"145","author":"Pichon","year":"2017","journal-title":"Antiviral Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"6398","DOI":"10.1128\/aac.02956-14","article-title":"Evolution of oseltamivir resistance mutations in Influenza A(H1N1) and A(H3N2) viruses during selection in experimentally infected mice.","volume":"58","author":"Pizzorno","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"B47","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/ng.3479","article-title":"Quantifying influenza virus diversity and transmission in humans.","volume":"48","author":"Poon","year":"2016","journal-title":"Nat. Genet."},{"key":"B48","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jcv.2014.06.013","article-title":"Deep sequencing: becoming a critical tool in clinical virology.","volume":"61","author":"Quinones-Mateu","year":"2014","journal-title":"J. Clin. Virol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.3201\/eid1911.130664","article-title":"Full genome of influenza A (H7N9) virus derived by direct sequencing without culture.","volume":"19","author":"Ren","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1002\/hep.26383","article-title":"Characterization of the dynamics of hepatitis B virus resistance to adefovir by ultra-deep pyrosequencing.","volume":"58","author":"Rodriguez","year":"2013","journal-title":"Hepatology"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02464-14","article-title":"Intrahost dynamics of antiviral resistance in influenza a virus reflect complex patterns of segment linkage, reassortment, and natural selection.","volume":"6","author":"Rogers","year":"2015","journal-title":"MBio"},{"key":"B52","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/J.JVIROMET.2013.07.001","article-title":"Simultaneous and complete genome sequencing of influenza A and B with high coverage by Illumina MiSeq platform.","volume":"193","author":"Rutvisuttinunt","year":"2013","journal-title":"J. Virol. Methods"},{"key":"B53","doi-asserted-by":"publisher","first-page":"9733","DOI":"10.1128\/JVI.00694-10","article-title":"Viral mutation rates.","volume":"84","author":"Sanjuan","year":"2010","journal-title":"J. Virol."},{"key":"B54","first-page":"1151","article-title":"\u201cOrthomyxoviridae,\u201d in","author":"Shaw","year":"2013","journal-title":"Fields Virology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1086\/596736","article-title":"Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes.","volume":"199","author":"Simen","year":"2009","journal-title":"J. Infect. Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.chom.2014.05.008","article-title":"Emergence and transmission of arbovirus evolutionary intermediates with epidemic potential.","volume":"15","author":"Stapleford","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B57","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1128\/JVI.63.5.2063-2071.1989","article-title":"High nucleotide substitution error frequencies in clonal pools of vesicular stomatitis virus.","volume":"63","author":"Steinhauer","year":"","journal-title":"J. Virol."},{"key":"B58","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1128\/JVI.63.5.2072-2080.1989","article-title":"Extreme heterogeneity in populations of vesicular stomatitis virus.","volume":"63","author":"Steinhauer","year":"","journal-title":"J. Virol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"6623","DOI":"10.1128\/JVI.02765-13","article-title":"Airborne transmission of highly pathogenic H7N1 influenza virus in ferrets.","volume":"88","author":"Sutton","year":"2014","journal-title":"J. Virol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1128\/jcm.00838-12","article-title":"Abundant drug-resistant NS3 mutants detected by deep sequencing in hepatitis C virus-infected patients undergoing NS3 protease inhibitor monotherapy.","volume":"50","author":"Svarovskaia","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067010","article-title":"Using high-throughput sequencing to leverage surveillance of genetic diversity and oseltamivir resistance: a pilot study during the 2009 Influenza A(H1N1) pandemic.","volume":"8","author":"T\u00e9llez-Sosa","year":"2013","journal-title":"PLoS One"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03300","article-title":"The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin.","volume":"3","author":"Thyagarajan","year":"2014","journal-title":"Elife"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003657","article-title":"New world bats harbor diverse influenza A viruses.","volume":"9","author":"Tong","year":"2013","journal-title":"PLoS Pathog."},{"key":"B64","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1172\/jci44947","article-title":"Virulence determinants of pandemic influenza viruses.","volume":"121","author":"Tscherne","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0205","article-title":"Viral population analysis and minority-variant detection using short read next-generation sequencing.","volume":"368","author":"Watson","year":"2013","journal-title":"Philos. Trans. R Soc. L B Biol. Sci."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00804","article-title":"Improved detection of artifactual viral minority variants in high-throughput sequencing data.","volume":"5","author":"Welkers","year":"2015","journal-title":"Front. Microbiol."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013564","article-title":"Development of a low bias method for characterizing viral populations using next generation sequencing technology.","volume":"5","author":"Willerth","year":"2010","journal-title":"PLoS One"},{"key":"B68","doi-asserted-by":"publisher","first-page":"11189","DOI":"10.1093\/nar\/gks918","article-title":"LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets.","volume":"40","author":"Wilm","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"7775","DOI":"10.1093\/nar\/gkr487","article-title":"Overlapping signals for translational regulation and packaging of influenza A virus segment 2.","volume":"39","author":"Wise","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/J.TIM.2018.02.007","article-title":"Within-host evolution of human influenza virus.","volume":"26","author":"Xue","year":"2018","journal-title":"Trends Microbiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1128\/jvi.02175-15","article-title":"Identification of A novel viral protein expressed from the PB2 segment of influenza A virus.","volume":"90","author":"Yamayoshi","year":"2015","journal-title":"J. Virol."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018177","article-title":"Reassortment and mutations associated with emergence and spread of oseltamivir-resistant seasonal influenza A\/H1N1 viruses in 2005-2009.","volume":"6","author":"Yang","year":"2011","journal-title":"PLoS One"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163175","article-title":"Sensitive detection and simultaneous discrimination of influenza A and B viruses in nasopharyngeal swabs in a single assay using next-generation sequencing-based diagnostics.","volume":"11","author":"Zhao","year":"2016","journal-title":"PLoS One"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.02596\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T11:20:19Z","timestamp":1605352819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.02596\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,31]]},"references-count":73,"alternative-id":["10.3389\/fmicb.2018.02596"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.02596","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,31]]},"article-number":"2596"}}