{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:44:18Z","timestamp":1790628258000,"version":"4.1.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["BIO2013-46266"],"award-info":[{"award-number":["BIO2013-46266"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011941","name":"Gobierno del Principado de Asturias","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2018.02654","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T04:36:27Z","timestamp":1541392587000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Adaptive Evolution of Industrial Lactococcus lactis Under Cell Envelope Stress Provides Phenotypic Diversity"],"prefix":"10.3389","volume":"9","author":[{"given":"Mar\u00eda Jes\u00fas","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Escobedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Rute","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Janzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e880","DOI":"10.1128\/mBio.00880-14","article-title":"Differences in lactococcal cell wall polysaccharide structure are major determining factors in bacteriophage sensitivity.","volume":"5","author":"Ainsworth","year":"","journal-title":"mBio"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1111\/1574-6976.12074","article-title":"The Lactococcus lactis plasmidome: much learnt, yet still lots to discover.","volume":"38","author":"Ainsworth","year":"","journal-title":"FEMS Microbiol. Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1007\/s00253-016-7343-9","article-title":"Bacteriocins of lactic acid bacteria: extending the family.","volume":"100","author":"\u00c1lvarez-Sieiro","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrmicro3270","article-title":"Microbiological effects of sublethal levels of antibiotics.","volume":"12","author":"Andersson","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"W147","DOI":"10.1093\/nar\/gkw419","article-title":"Heatmapper: web-enabled heat mapping for all.","volume":"44","author":"Babicki","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"S201","DOI":"10.1093\/femsre\/fux024","article-title":"Experimental evolution and the adjustment of metabolic strategies in lactic acid bacteria.","volume":"41","author":"Bachmann","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1101\/gr.121285.111","article-title":"Microbial domestication signatures of Lactococcus lactis can be reproduced by experimental evolution.","volume":"22","author":"Bachmann","year":"2012","journal-title":"Genome Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1099\/mic.0.082289-0","article-title":"Resistance to bacteriocins produced by Gram-positive bacteria.","volume":"161","author":"Bastos","year":"2015","journal-title":"Microbiology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1128\/AAC.01485-08","article-title":"An ABC transporter of Streptococcus pneumoniae involved in susceptibility to vancoresmycin and bacitracin.","volume":"53","author":"Becker","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/srep08365","article-title":"RASTtk: a modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes.","volume":"5","author":"Brettin","year":"2015","journal-title":"Sci. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s10295-018-2052-2","article-title":"The increase of O-acetylation and N-deacetylation in cell wall promotes acid resistance and nisin production through improving cell wall integrity in Lactococcus lactis.","volume":"45","author":"Cao","year":"2018","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s002170000157","article-title":"Comparative performance of a mixed strain starter in cow\u2019s milk, ewe\u2019s milk and mixtures of these milks.","volume":"211","author":"C\u00e1rcoba","year":"2000","journal-title":"Eur. Food Res. Technol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1128\/AEM.04092-14","article-title":"Evaluation of Lactococcus lactis isolates from nondairy sources with potential dairy applications reveals extensive phenotype-genotype disparity and implications for a revised species.","volume":"81","author":"Cavanagh","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-13-S1-S9","article-title":"Cell wall structure and function in lactic acid bacteria.","author":"Chapot-Chartier","year":"2014","journal-title":"Microb. Cell Fact."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/srep14199","article-title":"Adaptation of Lactococcus lactis to high growth temperature leads to a dramatic increase in acidification rate.","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1017\/S0022029997002185","article-title":"Characterization of the lactic acid bacteria in artisanal dairy products.","volume":"64","author":"Cogan","year":"1997","journal-title":"J. Dairy Res."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-13-S1-S5","article-title":"The art of strain improvement of industrial lactic acid bacteria without the use of recombinant DNA technology.","author":"Derkx","year":"2014","journal-title":"Microb. Cell Fact."},{"key":"B18","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/S0147-619X(02)00156-7","article-title":"Molecular organization of exopolysaccharide (EPS) encoding genes on the lactococcal bacteriophage adsorption blocking plasmid, pCI658.","volume":"49","author":"Forde","year":"2003","journal-title":"Plasmid"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-10-S1-S20","article-title":"Bacteriophages of lactic acid bacteria and their impact on milk fermentations.","author":"Garneau","year":"2011","journal-title":"Microb. Cell Fact."},{"key":"B20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1574-6968.2006.00302.x","article-title":"Spontaneous resistance in Lactococcus lactis IL1403 to the lantibiotic lacticin 3147.","volume":"260","author":"Guinane","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2607","article-title":"beta-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity.","volume":"4","author":"Gutierrez","year":"2013","journal-title":"Nat. Commun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"6137","DOI":"10.1007\/s00253-017-8365-7","article-title":"Promoting acid resistance and nisin yield of Lactococcus lactis F44 by genetically increasing D-Asp amidation level inside cell wall.","volume":"101","author":"Hao","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1146\/annurev-food-030117-012450","article-title":"Use of natural selection and evolution to develop new starter cultures for fermented foods.","volume":"9","author":"Johansen","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"B24","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/B978-1-78242-015-6.00010-4","article-title":"\u201c10 - Modern approaches for isolation, selection, and improvement of bacterial strains for fermentation applications,\u201d in","author":"Johansen","year":"2015","journal-title":"Advances in Fermented Foods and Beverages"},{"key":"B25","doi-asserted-by":"publisher","first-page":"9952","DOI":"10.3168\/jds.2017-12979","article-title":"A 100-year review: cheese production and quality.","volume":"100","author":"Johnson","year":"2017","journal-title":"J. Dairy Sci."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3650-5","article-title":"Comparative and functional genomics of the Lactococcus lactis taxon; insights into evolution and niche adaptation.","volume":"18","author":"Kelleher","year":"2017","journal-title":"BMC Genomics"},{"key":"B27","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1128\/JB.180.15.3907-3916.1998","article-title":"A transcriptional activator, homologous to the Bacillus subtilis PurR repressor, is required for expression of purine biosynthetic genes in Lactococcus lactis.","volume":"180","author":"Kilstrup","year":"1998","journal-title":"J. Bacteriol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1111\/mmi.12632","article-title":"Sensitivity to the two-peptide bacteriocin lactococcin G is dependent on UppP, an enzyme involved in cell-wall synthesis.","volume":"92","author":"Kjos","year":"2014","journal-title":"Mol. Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1099\/mic.0.2007\/015412-0","article-title":"Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis.","volume":"154","author":"Kramer","year":"2008","journal-title":"Microbiology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1128\/AAC.50.5.1753-1761.2006","article-title":"Transcriptome analysis reveals mechanisms by which Lactococcus lactis acquires nisin resistance.","volume":"50","author":"Kramer","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"B31","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0308-8146(03)00126-2","article-title":"Modelling of the acidification process and rheological properties of milk fermented with a yogurt starter culture using response surface methodology.","volume":"83","author":"Kristo","year":"2003","journal-title":"Food Chem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nrmicro2315","article-title":"Bacteriophage resistance mechanisms.","volume":"8","author":"Labrie","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-018-1222-8","article-title":"Resistance to bacteriocin Lcn972 improves oxygen tolerance of Lactococcus lactis IPLA947 without compromising its performance as a dairy starter.","volume":"18","author":"L\u00f3pez-Gonz\u00e1lez","year":"2018","journal-title":"BMC Microbiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.idairyj.2004.08.024","article-title":"Role, mechanisms and control of lactic acid bacteria lysis in cheese.","volume":"15","author":"Lortal","year":"2005","journal-title":"Int. Dairy J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ijfoodmicro.2008.11.004","article-title":"Prophage induction in Lactococcus lactis by the bacteriocin Lactococcin 972.","volume":"129","author":"Madera","year":"2009","journal-title":"Int. J. Food Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"4666","DOI":"10.1128\/AEM.00092-08","article-title":"Specific interaction of the unmodified bacteriocin Lactococcin 972 with the cell wall precursor lipid II.","volume":"74","author":"Mart\u00ednez","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.4315\/0362-028X-58.10.1118","article-title":"Antimicrobials produced by wild lactococcal strains isolated from homemade cheeses.","volume":"58","author":"Mart\u00ednez","year":"1995","journal-title":"J. Food Protect."},{"key":"B38","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1365-2958.2007.05668.x","article-title":"Cell envelope stress induced by the bacteriocin Lcn972 is sensed by the lactococcal two-component system CesSR.","volume":"64","author":"Mart\u00ednez","year":"2007","journal-title":"Mol. Microbiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.3168\/jds.2017-13331","article-title":"Symposium review: Lactococcus lactis from nondairy sources: their genetic and metabolic diversity and potential applications in cheese.","volume":"101","author":"McAuliffe","year":"2018","journal-title":"J. Dairy Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1099\/mic.0.2007\/005835-0","article-title":"Peptidoglycan N-acetylglucosamine deacetylation decreases autolysis in Lactococcus lactis.","volume":"153","author":"Meyrand","year":"2007","journal-title":"Microbiology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.1128\/AEM.01293-16","article-title":"LsbB bacteriocin interacts with the third transmembrane domain of the YvjB receptor.","volume":"82","author":"Miljkovic","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3168\/jds.S0022-0302(97)75906-X","article-title":"Increasing starter cell lysis in Cheddar cheese using a bacteriocin-producing adjunct.","volume":"80","author":"Morgan","year":"1997","journal-title":"J. Dairy Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1046\/j.1365-2958.2003.03653.x","article-title":"The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.","volume":"49","author":"Ohki","year":"2003","journal-title":"Mol. Microbiol."},{"key":"B44","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1128\/AEM.59.8.2730-2733.1993","article-title":"Rapid mini-prep isolation of high-quality plasmid DNA from Lactococcus and Lactobacillus spp.","volume":"59","author":"O\u2019sullivan","year":"1993","journal-title":"Appl. Environ. Microbiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1128\/AEM.00795-12","article-title":"Isolation of Lactococcus lactis mutants simultaneously resistant to the cell wall-active bacteriocin Lcn972, lysozyme, nisin and bacteriophage c2.","volume":"78","author":"Roces","year":"","journal-title":"Appl. Environ. Microbiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"5520","DOI":"10.1128\/AAC.01206-12","article-title":"The putative lactococcal extracytoplasmic function anti-sigma factor llmg2447 determines resistance to the cell wall-active bacteriocin lcn972.","volume":"56","author":"Roces","year":"","journal-title":"Antimicrob. Agents Chemother."},{"key":"B47","first-page":"31","article-title":"\u201cDairy starter cultures,\u201d in","author":"Rodr\u00edguez","year":"2012","journal-title":"Handbook of Animal- Based Fermented Food and Beverages"},{"key":"B48","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1099\/mic.0.082586-0","article-title":"Multi-stress resistance in Lactococcus lactis is actually escape from purine-induced stress sensitivity.","volume":"160","author":"Ryssel","year":"2014","journal-title":"Microbiology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"11323","DOI":"10.1074\/jbc.M116.714303","article-title":"Regulation of cell wall plasticity by nucleotide metabolism in Lactococcus lactis.","volume":"291","author":"Solopova","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1128\/AEM.00462-16","article-title":"Enhancing the sweetness of yoghurt through metabolic remodeling of carbohydrate metabolism in Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus.","volume":"82","author":"S\u00f8rensen","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1128\/JB.187.1.114-124.2005","article-title":"Autolysis of Lactococcus lactis is increased upon D-alanine depletion of peptidoglycan and lipoteichoic acids.","volume":"187","author":"Steen","year":"2005","journal-title":"J. Bacteriol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/1751-7915.13278","article-title":"Altering textural properties of fermented milk by using surface-engineered Lactococcus lactis.","volume":"11","author":"Tarazanova","year":"2018","journal-title":"Microb. Biotechnol."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016192","article-title":"Global transcriptional analysis of spontaneous sakacin P-resistant mutant strains of Listeria monocytogenes during growth on different sugars.","volume":"6","author":"Tessema","year":"2011","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1099\/mic.0.062554-0","article-title":"Molecular characterization and structural instability of the industrially important composite metabolic plasmid pLP712.","volume":"158","author":"Wegmann","year":"2012","journal-title":"Microbiology"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.02654\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T17:21:09Z","timestamp":1605374469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2018.02654\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":54,"alternative-id":["10.3389\/fmicb.2018.02654"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2018.02654","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,5]]},"article-number":"2654"}}