{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:21:55Z","timestamp":1771039315077,"version":"3.50.1"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.00329","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T04:19:30Z","timestamp":1551241170000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["How Does Fusarium oxysporum Sense and Respond to Nicotinaldehyde, an Inhibitor of the NAD+ Salvage Biosynthesis Pathway?"],"prefix":"10.3389","volume":"10","author":[{"given":"Gautam","family":"Anand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Waiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Vital","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Maman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shay","family":"Covo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2018.00980","article-title":"Family-four aldehyde dehydrogenases play an indispensable role in the pathogenesis of Magnaporthe oryzae.","volume":"9","author":"Abdul","year":"2018","journal-title":"Front. Plant Sci."},{"key":"B2","author":"Agrios","year":"2005","journal-title":"Plant Pathology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data.","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"B4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nature01578","article-title":"Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.","volume":"423","author":"Anderson","year":"2003","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1080\/07388550390449294","article-title":"Oxidative stress in submerged cultures of fungi.","volume":"23","author":"Bai","year":"2003","journal-title":"Crit. Rev. Biotechnol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1128\/MMBR.67.3.376-399.2003","article-title":"Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.","volume":"67","author":"Bitterman","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of micrograms quantities of proteins utilizing the principle of protein dye binding.","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1534\/genetics.108.088914","article-title":"Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.","volume":"179","author":"Celic","year":"2008","journal-title":"Genetics"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2018.01468","article-title":"Fusarium wilt of banana: current knowledge on epidemiology and research needs toward sustainable disease management.","volume":"9","author":"Dita","year":"2018","journal-title":"Front. Plant Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/microbiolspec.FUNK-0023-2016","article-title":"Plant pathogenic fungi.","volume":"5","author":"Doehlemann","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"B11","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.molmed.2017.08.001","article-title":"NAD+ in aging: molecular mechanisms and translational implications.","volume":"23","author":"Fang","year":"2017","journal-title":"Trends Mol. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"8803","DOI":"10.1021\/bi1012436","article-title":"High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes.","volume":"49","author":"French","year":"","journal-title":"Biochemistry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"10421","DOI":"10.1021\/bi1012518","article-title":"Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism.","volume":"49","author":"French","year":"","journal-title":"Biochemistry"},{"key":"B14","doi-asserted-by":"publisher","first-page":"12087","DOI":"10.1021\/ja00105a073","article-title":"2\u2032-Ribose substituent effects on the chemical and enzymatic-hydrolysis of NAD+.","volume":"116","author":"Handlon","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"B15","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1128\/AEM.02040-09","article-title":"Metabolic impact of increased NADH availability in Saccharomyces cerevisiae.","volume":"76","author":"Hou","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1365-313X.2007.03151.x","article-title":"Nicotinamidase activity is important for germination.","volume":"51","author":"Hunt","year":"2007","journal-title":"Plant J."},{"key":"B18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1469-8137.2004.01087.x","article-title":"NAD- new roles in signaling and gene regulation in plants.","volume":"163","author":"Hunt","year":"2004","journal-title":"New Phytol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1094\/Phyto-61-1213","article-title":"Symptomless carriers of the tomato Fusarium wilt pathogen.","volume":"61","author":"Katan","year":"1971","journal-title":"Phytopathology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1128\/EC.00003-13","article-title":"Fungal-specific sirtuin HstD coordinates secondary metabolism and development through control of LaeA.","volume":"12","author":"Kawauchi","year":"2013","journal-title":"Eukaryot. Cell"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/j.1567-1364.2007.00231.x","article-title":"Why do some yeast species require niacin for growth? Different modes of NAD synthesis.","volume":"7","author":"Li","year":"2007","journal-title":"FEMS Yeast Res."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1534\/genetics.108.091090","article-title":"Pnc1p-mediated nicotinamide clearance modifies the epigenetic properties of rDNA silencing in Saccharomyces cerevisiae.","volume":"180","author":"McClure","year":"2008","journal-title":"Genetics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1364-3703.2009.00538.x","article-title":"Pathogen profile update: F. oxysporum.","volume":"10","author":"Michielse","year":"2009","journal-title":"Mol. Plant Pathol."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003237","article-title":"Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid.","volume":"9","author":"Mu\u00f1oz-Galv\u00e1n","year":"2013","journal-title":"PLoS Genet."},{"key":"B27","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/BF00928468","article-title":"NAD Hydrolysis: chemical and enzymatic mechanisms.","volume":"138","author":"Oppenheimer","year":"1994","journal-title":"Mol. Cell. Biochem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1042\/BJ20061638","article-title":"The power to reduce pyridine nucleotides- small molecule with multitude of functions.","volume":"402","author":"Pollak","year":"2007","journal-title":"Biochem. J."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37623","article-title":"Temporal profiling of redox-dependent heterogeneity in single cells.","volume":"7","author":"Radzinski","year":"2018","journal-title":"eLife"},{"key":"B30","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1124\/jpet.107.120758","article-title":"NAD+ and vitamin B3: from metabolism to therapies.","volume":"324","author":"Sauve","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B31","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.fitote.2016.05.016","article-title":"Cinnamaldehyde and its derivatives, a novel class of antifungal agents.","volume":"112","author":"Shreaz","year":"2016","journal-title":"Fitoterapia"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1093\/nar\/gkv1537","article-title":"Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.","volume":"44","author":"Simoneau","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2012.11.010","article-title":"Aldehyde dehydrogenases in cellular responses to oxidative\/electrophilicstress.","volume":"56","author":"Singh","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1021\/bi2015508","article-title":"Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae.","volume":"51","author":"Smith","year":"2012","journal-title":"Biochemistry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ab.2009.07.019","article-title":"A continuous microplate assay for sirtuins and nicotinamide-producing enzymes.","volume":"394","author":"Smith","year":"2009","journal-title":"Anal. Biochem."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-1-5","article-title":"The fungus Neurospora crassa displays telomeric silencing mediated by multiple sirtuins and by methylation of histone H3 lysine 9.","volume":"1","author":"Smith","year":"2008","journal-title":"Epigenetics Chromatin"},{"key":"B37","doi-asserted-by":"publisher","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein\u2013protein association networks, made broadly accessible.","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1073\/pnas.98.2.415","article-title":"Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein SIR2: evidence for acetyl transfer from substrate to an NAD breakdown product.","volume":"98","author":"Tanny","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B39","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/ng1553","article-title":"Resurrecting ancestral alcohol dehydrogenases from yeast.","volume":"37","author":"Thomson","year":"2005","journal-title":"Nat. Genetics"},{"key":"B40","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1126\/science.aad4017","article-title":"Complementation of mitochondrial electron transport chain by manipulation of the NAD+ \/NADH ratio.","volume":"352","author":"Titov","year":"2016","journal-title":"Science"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/srep00322","article-title":"Inactivating alternative NADH dehydrogenases: enhancing fungal bioprocesses by improving growth and biomass yield.","volume":"2","author":"Voulgaris","year":"2012","journal-title":"Sci. Rep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"5872","DOI":"10.1128\/MCB.00112-09","article-title":"The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors.","volume":"29","author":"Watson","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/nm.2175","article-title":"Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy.","volume":"16","author":"Wurtele","year":"2010","journal-title":"Nat. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"42428","DOI":"10.1074\/jbc.R112.372300","article-title":"Structural basis for sirtuin activity and inhibition.","volume":"287","author":"Yuan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1126\/science.1236463","article-title":"Biochemistry. Red wine, toast of the town (again).","volume":"339","author":"Yuan","year":"2013","journal-title":"Science"},{"key":"B46","doi-asserted-by":"publisher","first-page":"8563","DOI":"10.1073\/pnas.0401057101","article-title":"Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone\/protein deacetylases.","volume":"101","author":"Zhao","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B47","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1128\/MCB.23.2.699-707.2003","article-title":"Autoregulation in the biosynthesis of ribosomes.","volume":"23","author":"Zhao","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"4561","DOI":"10.1111\/j.1742-4658.2005.04893.x","article-title":"A vital link between energy and signal transduction. Regulatory functions of NAD(P).","volume":"272","author":"Ziegler","year":"2005","journal-title":"FEBBS Lett."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.00329\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T04:19:34Z","timestamp":1551241174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.00329\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":48,"alternative-id":["10.3389\/fmicb.2019.00329"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.00329","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"article-number":"329"}}