{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:17:31Z","timestamp":1761581851219,"version":"3.41.2"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.00370","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T06:55:30Z","timestamp":1562655330000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions"],"prefix":"10.3389","volume":"10","author":[{"given":"Evangelia-Georgia","family":"Kostaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Flampouris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timokratis","family":"Karamitros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Chueca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paz","family":"Casas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen","family":"Alejos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Hatzakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Paraskevis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"CoRIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-7","article-title":"HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics.","volume":"10","author":"Abecasis","year":"2013","journal-title":"Retrovirology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.meegid.2016.05.029","article-title":"Origin and spread of HIV-1 in persons who inject drugs in Bulgaria.","volume":"46","author":"Alexiev","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.meegid.2016.06.033","article-title":"Molecular epidemiology of HIV-1 infection in Europe: an overview.","volume":"46","author":"Beloukas","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1157\/13096749","article-title":"Spanish cohort of na\u00efve HIV-infected patients (CoRIS): rationale, organization and initial results | Cohorte RIS de pacientes con infecci\u00f3n por VIH sin tratamiento antirretroviral previo (CoRIS): Metodolog\u00eda y primeros resultados.","volume":"25","author":"Caro-Murillo","year":"2007","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12977-017-0339-4","article-title":"Spatiotemporal dynamics of HIV-1 transmission in France (1999-2014) and impact of targeted prevention strategies.","volume":"14","author":"Chaillon","year":"2017","journal-title":"Retrovirology"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1217-0","article-title":"Characteristics and spread to the native population of HIV-1 non-B subtypes in two European countries with high migration rate.","volume":"15","author":"Dauwe","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.eimc.2018.06.003","article-title":"Missed opportunities within the health system for the diagnosis of HIV infection in MSM in Spain: greater commitment and action is required.","volume":"36","author":"del Amo","year":"2018","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098908","article-title":"Spatiotemporal dynamics of the HIV-1 subtype G epidemic in West and Central Africa.","volume":"9","author":"Delatorre","year":"2014","journal-title":"PLoS One"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1093\/molbev\/mss075","article-title":"Bayesian phylogenetics with BEAUti and the BEAST 1.7.","volume":"29","author":"Drummond","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"B10","article-title":"Molecular epidemiology analysis of HIV-1 epidemic in Spain","author":"Flampouris","year":"2014","journal-title":"VI Congreso National de GeSIDA"},{"key":"B11","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.meegid.2016.10.018","article-title":"Primate immunodeficiency virus classification and nomenclature: review.","volume":"46","author":"Foley","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/810617","article-title":"Circulation of HIV-1 CRF02-AG among MSM population in Central Italy: a molecular epidemiology-based study.","volume":"2013","author":"Giuliani","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1093\/molbev\/mst012","article-title":"Building phylogenetic trees from molecular data with MEGA.","volume":"30","author":"Hall","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S1473-3099(18)30647-9","article-title":"Global and regional molecular epidemiology of HIV-1, 1990\u20132015: a systematic review, global survey, and trend analysis.","volume":"19","author":"Hemelaar","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx108","article-title":"MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization.","author":"Katoh","year":"2017","journal-title":"Brief Bioinform."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1086\/651951","article-title":"Molecular epidemiology reveals long-term changes in HIV type 1 subtype B transmission in Switzerland.","volume":"201","author":"Kouyos","year":"2010","journal-title":"J. Infect. Dis."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050050","article-title":"Episodic sexual transmission of HIV revealed by molecular phylodynamics.","volume":"5","author":"Lewis","year":"2008","journal-title":"PLoS Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.meegid.2016.05.017","article-title":"Phylodynamics of the major HIV-1 CRF02_AG African lineages and its global dissemination.","volume":"46","author":"Mir","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0213-005X(18)30239-8","article-title":"Burden of HIV infection, vulnerable populations and access barriers to healthcare.","volume":"36","author":"Mor\u00e1n Arribas","year":"2018","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1241-1","article-title":"HIV-1 molecular transmission clusters in nine European countries and Canada: association with demographic and clinical factors.","volume":"17","author":"Paraskevis","year":"2019","journal-title":"BMC Med."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vew007","article-title":"Exploring the temporal structure of heterochronous sequences using TempEst (formerly Path-O-Gen).","volume":"2","author":"Rambaut","year":"2016","journal-title":"Virus Evol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1093\/bioinformatics\/btg180","article-title":"MrBayes 3: bayesian phylogenetic inference under mixed models.","volume":"19","author":"Ronquist","year":"2003","journal-title":"Bioinformatics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","article-title":"RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.","volume":"30","author":"Stamatakis","year":"2014","journal-title":"Bioinformatics"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1002\/jmv.24184","article-title":"Emergence of clusters of CRF02_AG and B human immunodeficiency viral strains among men having sex with men exhibiting HIV primary infection in Southeastern France.","volume":"87","author":"Tamalet","year":"2015","journal-title":"J. Med. Virol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1093\/infdis\/jir491","article-title":"The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland.","volume":"204","author":"Von Wyl","year":"2011","journal-title":"J. Infect. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/QAD.0000000000002034","article-title":"Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?","volume":"33","author":"Vourli","year":"2019","journal-title":"Aids"},{"key":"B27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1128\/JCM.05798-11","article-title":"Most HIV type 1 non-B infections in the spanish cohort of antiretroviral treatment-na\u00efve HIV-infected Patients (CoRIS) are due to recombinant viruses.","volume":"50","author":"Yebra","year":"2012","journal-title":"J. Clin. Microbiol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.00370\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T06:55:32Z","timestamp":1562655332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.00370\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,11]]},"references-count":27,"alternative-id":["10.3389\/fmicb.2019.00370"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.00370","relation":{},"ISSN":["1664-302X"],"issn-type":[{"type":"electronic","value":"1664-302X"}],"subject":[],"published":{"date-parts":[[2019,3,11]]},"article-number":"370"}}