{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:31:54Z","timestamp":1789806714519,"version":"4.0.1"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI18C0378"],"award-info":[{"award-number":["HI18C0378"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI15C2059"],"award-info":[{"award-number":["HI15C2059"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.01122","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T04:25:04Z","timestamp":1559622304000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Blood Microbial Communities During Pregnancy Are Associated With Preterm Birth"],"prefix":"10.3389","volume":"10","author":[{"given":"Young-Ah","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008599","article-title":"The placenta harbors a unique microbiome.","volume":"6","author":"Aagaard","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"B2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data.","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"B3","doi-asserted-by":"publisher","first-page":"551","DOI":"10.2147\/IJWH.S142730","article-title":"The oral microbiome and adverse pregnancy outcomes.","volume":"9","author":"Cobb","year":"2017","journal-title":"Int. J. Womens Health"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152751","article-title":"Gut microbiome developmental patterns in early life of preterm infants: impacts of feeding and gender.","volume":"11","author":"Cong","year":"2016","journal-title":"PLoS One"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003056","article-title":"Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation.","volume":"3","author":"DiGiulio","year":"2008","journal-title":"PLoS One"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST.","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0502-8","article-title":"Increased richness and diversity of the vaginal microbiota and spontaneous preterm birth.","volume":"6","author":"Freitas","year":"2018","journal-title":"Microbiome"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3150","DOI":"10.1093\/bioinformatics\/bts565","article-title":"CD-HIT: accelerated for clustering the next-generation sequencing data.","volume":"28","author":"Fu","year":"2012","journal-title":"Bioinformatics"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1056\/NEJMe068210","article-title":"Preterm birth and periodontal disease.","volume":"355","author":"Goldenberg","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1128\/jcm.44.4.1475-1483.2006","article-title":"Transmission of an uncultivated Bergeyella strain from the oral cavity to amniotic fluid in a case of preterm birth.","volume":"44","author":"Han","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1056\/nejm199512283332604","article-title":"Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. the vaginal infections and prematurity study group.","volume":"333","author":"Hillier","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/s0029-7844(00)01146-7","article-title":"Vaginal indicators of amniotic fluid infection in preterm labor.","volume":"97","author":"Hitti","year":"2001","journal-title":"Obstet. Gynecol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"203","DOI":"10.5468\/ogs.2015.58.3.203","article-title":"Practice patterns in the management of threatened preterm labor in Korea: a multicenter retrospective study.","volume":"58","author":"Hwang","year":"2015","journal-title":"Obstet. Gynecol. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.mayocp.2013.10.011","article-title":"A clinician\u2019s primer on the role of the microbiome in human health and disease.","volume":"89","author":"Khanna","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"B15","year":"2016","journal-title":"Birth Statistics."},{"key":"B16","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy.","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1093\/infdis\/164.1.88","article-title":"Vaginal Bacteroides species are associated with an increased rate of preterm delivery among women in preterm labor.","volume":"164","author":"Krohn","year":"1991","journal-title":"J. Infect. Dis."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S6","article-title":"Born too soon: accelerating actions for prevention and care of 15 million newborns born too soon.","author":"Lawn","year":"2013","journal-title":"Reprod. Health"},{"key":"B19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5607\/en.2017.26.5.307","article-title":"Rapid assessment of microbiota changes in individuals with autism spectrum disorder using bacteria-derived membrane vesicles in urine.","volume":"26","author":"Lee","year":"2017","journal-title":"Exp. Neurobiol."},{"key":"B20","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology.","volume":"102","author":"Ley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B21","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/s0002-9378(11)80046-3","article-title":"Phospholipase C activity in microorganisms associated with reproductive tract infection.","volume":"164","author":"McGregor","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1080\/00016340802005126","article-title":"Spontaneous preterm birth, a clinical dilemma: etiologic, pathophysiologic and genetic heterogeneities and racial disparity.","volume":"87","author":"Menon","year":"2008","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"B23","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1055\/s-0033-1361830","article-title":"Microbiome in parturition and preterm birth.","volume":"32","author":"Mysorekar","year":"2014","journal-title":"Semin. Reprod. Med."},{"key":"B24","year":"2017","journal-title":"Health at a Glance 2017: OECD Indicators."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1111\/trf.13477","article-title":"Comprehensive description of blood microbiome from healthy donors assessed by 16S targeted metagenomic sequencing.","volume":"56","author":"Pa\u00efss\u00e9","year":"2016","journal-title":"Transfusion"},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7827-1-122","article-title":"Immunology of term and preterm labor.","volume":"1","author":"Peltier","year":"2003","journal-title":"Reprod. Biol. Endocrinol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"934","DOI":"10.4049\/jimmunol.1300661","article-title":"Viral infection of the pregnant cervix predisposes to ascending bacterial infection.","volume":"191","author":"Racicot","year":"2013","journal-title":"J. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/aji.12326","article-title":"Microorganisms in the female genital tract during pregnancy: tolerance versus pathogenesis.","volume":"73","author":"Ramos","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1471-0528.2006.01120.x","article-title":"The preterm parturition syndrome.","author":"Romero","year":"2006","journal-title":"BJOG"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-2-18","article-title":"The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term.","volume":"2","author":"Romero","year":"2014","journal-title":"Microbiome"},{"key":"B31","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/s0002-9378(88)80030-9","article-title":"Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes.","volume":"159","author":"Romero","year":"1988","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/0002-9378(89)90409-2","article-title":"Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes.","volume":"161","author":"Romero","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B33","author":"Ryan","year":"2004","journal-title":"Sherris Medical Microbiology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.2337\/dc13-2817","article-title":"Gut dysbiosis and detection of \u201clive gut bacteria\u201d in blood of Japanese patients with type 2 diabetes.","volume":"37","author":"Sato","year":"2014","journal-title":"Diabetes Care"},{"key":"B35","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/oby.2009.167","article-title":"Microbiota and SCFA in lean and over-weight healthy subjects.","volume":"18","author":"Schwiertz","year":"2010","journal-title":"Obesity"},{"key":"B36","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/sj.jp.7200247","article-title":"Bacteremia, meningitis, and brain abscesses in a hospitalized infant: complications of Pseudomonas aeruginosa conjunctivitis.","volume":"19","author":"Shah","year":"1999","journal-title":"J. Perinatol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111374","article-title":"Intestinal microbiota is different in women with preterm birth: results from terminal restriction fragment length polymorphism analysis.","volume":"9","author":"Shiozaki","year":"2014","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1053\/j.semperi.2010.09.005","article-title":"Preventing preterm birth and neonatal mortality: exploring the epidemiology, causes, and interventions.","volume":"34","author":"Simmons","year":"2010","journal-title":"Semin. Perinatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.anaerobe.2011.11.001","article-title":"Life-threatening clostridial infections.","volume":"18","author":"Stevens","year":"2012","journal-title":"Anaerobe"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018","article-title":"Midtrimester microbial DNA variations in maternal serum of women who experience spontaneous preterm birth.","author":"Subramaniam","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.siny.2016.02.004","article-title":"Maternal microbiome - a pathway to preterm birth.","volume":"21","author":"Vinturache","year":"2016","journal-title":"Semin. Fetal Neonatal Med."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056131","article-title":"Comparative microbial analysis of paired amniotic fluid and cord blood from pregnancies complicated by preterm birth and early-onset neonatal sepsis.","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1128\/cmr.00008-07","article-title":"Bacteroides: the good, the bad, and the nitty-gritty.","volume":"20","author":"Wexler","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.110","article-title":"16S rRNA gene-based metagenomic analysis reveals differences in bacteria-derived extracellular vesicles in the urine of pregnant and non-pregnant women.","volume":"48","author":"Yoo","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"565","DOI":"10.5468\/ogs.2018.61.5.565","article-title":"Differential expression and methylation of integrin subunit alpha 11 and thrombospondin in the amnion of preterm birth.","volume":"61","author":"Yoo","year":"2018","journal-title":"Obstet. Gynecol. Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s0029-7844(98)00122-7","article-title":"Isolation of Ureaplasma urealyticum from the amniotic cavity and adverse outcome in preterm labor.","volume":"92","author":"Yoon","year":"1998","journal-title":"Obstet. Gynecol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1099\/jmmcr.0.005021","article-title":"New insight into the analysis of amniotic fluid microflora using 16S rRNA gene sequencing.","volume":"2016","author":"You","year":"2016","journal-title":"JMM Case Rep."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01122\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T04:25:06Z","timestamp":1559622306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01122\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":47,"alternative-id":["10.3389\/fmicb.2019.01122"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.01122","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,4]]},"article-number":"1122"}}