{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:59:24Z","timestamp":1780473564429,"version":"3.54.1"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.01466","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T10:22:13Z","timestamp":1562062933000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Effect of Perillaldehyde on Prophylaxis and Treatment of Vaginal Candidiasis in a Murine Model"],"prefix":"10.3389","volume":"10","author":[{"given":"Su","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liurong","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaozhong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1128\/CMR.00076-09","article-title":"Candida infections of the genitourinary tract.","volume":"23","author":"Achkar","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24010102","article-title":"Ethnomedicinal, phytochemical and pharmacological investigations of Perilla frutescens (L.) Britt.","volume":"24","author":"Ahmed","year":"2018","journal-title":"Molecules"},{"key":"B3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS crosstalk in inflammation.","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.5114\/pdia.2013.38358","article-title":"Antifungal agents commonly used in the superficial and mucosal candidiasis treatment: mode of action and resistance development.","volume":"30","author":"Bondaryk","year":"2013","journal-title":"Postepy Dermatol. Alergol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cell.2013.06.013","article-title":"A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection.","volume":"154","author":"Brandes","year":"2013","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.bcp.2016.11.019","article-title":"Antifungals.","volume":"133","author":"Campoy","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.immuni.2009.10.003","article-title":"Never underestimate the power of a neutrophil.","volume":"31","author":"Cassatella","year":"2009","journal-title":"Immunity"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1182\/blood-2015-09-659581","article-title":"Blood at 70: its roots in the history of hematology and its birth.","volume":"126","author":"Coller","year":"2015","journal-title":"Blood"},{"key":"B9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1084\/jem.20081463","article-title":"Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis.","volume":"206","author":"Conti","year":"2009","journal-title":"J. Exp. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.it.2017.12.003","article-title":"Immune cytokines and their receptors in inflammatory pain.","volume":"39","author":"Cook","year":"2018","journal-title":"Trends Immunol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003486","article-title":"IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.","volume":"9","author":"De Luca","year":"2013","journal-title":"PLoS Pathog."},{"key":"B12","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.immuni.2017.08.013","article-title":"Developing neutrophils must eat\u2026themselves!","volume":"47","author":"Fan","year":"2017","journal-title":"Immunity"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1128\/iai.72.5.2939-2946.2004","article-title":"An intravaginal live Candida challenge in humans leads to new hypotheses for the immunopathogenesis of vulvovaginal candidiasis.","volume":"72","author":"Fidel","year":"2004","journal-title":"Infect. Immun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.trsl.2006.11.006","article-title":"Cleavage of E-cadherin: a mechanism for disruption of the intestinal epithelial barrier by Candida albicans.","volume":"149","author":"Frank","year":"2007","journal-title":"Transl. Res."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6091947","article-title":"Corrigendum to \u201cperillaldehyde inhibits AHR signaling and activates NRF2 antioxidant pathway in human keratinocytes\u201d.","volume":"2018","author":"Fuyuno","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1159\/000453134","article-title":"Quercetin assists fluconazole to inhibit biofilm formations of fluconazole-resistant candida albicans in in vitro and in vivo antifungal managements of vulvovaginal candidiasis.","volume":"40","author":"Gao","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.fct.2016.08.029","article-title":"Genotoxicity assessment of the flavouring agent, perillaldehyde.","volume":"97","author":"Hobbs","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/LGT.0b013e318287aced","article-title":"Vulvovaginal candidiasis as a chronic disease: diagnostic criteria and definition.","volume":"18","author":"Hong","year":"2014","journal-title":"J. Low. Gen. Tract Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1001\/archinte.169.4.379","article-title":"Risk factors for fluconazole-resistant Candida glabrata bloodstream infections.","volume":"169","author":"Lee","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.immuni.2009.11.002","article-title":"Interleukin-17 kick-starts T helper 1 cell differentiation.","volume":"31","author":"Malefyt Rde","year":"2009","journal-title":"Immunity"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/j.1348-0421.2007.tb04008.x","article-title":"Interleukin-17 as an effector molecule of innate and acquired immunity against infections.","volume":"51","author":"Matsuzaki","year":"2007","journal-title":"Microbiol. Immunol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00771","article-title":"Antifungal activity of the biphosphinic cyclopalladate C7a against Candida albicans yeast forms in vitro and in vivo.","volume":"8","author":"Munoz","year":"2017","journal-title":"Front. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities.","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/cid\/civ1194","article-title":"Executive summary: clinical practice guideline for the management of candidiasis: 2016 update by the infectious diseases society of America.","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003965","article-title":"Candida vaginitis: when opportunism knocks, the host responds.","volume":"10","author":"Peters","year":"2014","journal-title":"PLoS Pathog."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022770","article-title":"Th17 cells and IL-17 in protective immunity to vaginal candidiasis.","volume":"6","author":"Pietrella","year":"2011","journal-title":"PLoS One"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s10096-013-1881-1","article-title":"Antifungal activity of Ferulago capillaris essential oil against Candida, cryptococcus, aspergillus and dermatophyte species.","volume":"32","author":"Pinto","year":"2013","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nature06471","article-title":"Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.","volume":"451","author":"Romani","year":"2008","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.immuni.2018.12.001","article-title":"The biology of T regulatory type 1 cells and their therapeutic application in immune-mediated diseases.","volume":"49","author":"Roncarolo","year":"2018","journal-title":"Immunity"},{"key":"B30","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.3748\/wjg.v23.i25.4559","article-title":"Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model.","volume":"23","author":"Shin","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ajog.2015.06.067","article-title":"Recurrent vulvovaginal candidiasis.","volume":"214","author":"Sobel","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1128\/aac.47.1.34-38.2003","article-title":"Fluconazole susceptibility of vaginal isolates obtained from women with complicated Candida Vaginitis: clinical implications.","volume":"47","author":"Sobel","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"B33","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.lfs.2018.05.038","article-title":"Perilla aldehyde attenuates CUMS-induced depressive-like behaviors via regulating TXNIP\/TRX\/NLRP3 pathway in rats.","volume":"206","author":"Song","year":"2018","journal-title":"Life Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1007\/s00253-017-8217-5","article-title":"Erratum to: calcium and oxidative stress mediate perillaldehyde-induced apoptosis in Candida albicans.","volume":"101","author":"Tian","year":"","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1007\/s00253-017-8217-5","article-title":"Calcium and oxidative stress mediate perillaldehyde-induced apoptosis in Candida albicans.","volume":"101","author":"Tian","year":"","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"7404","DOI":"10.1021\/acs.jafc.6b03546","article-title":"Perillaldehyde, a promising antifungal agent used in food preservation, triggers apoptosis through a metacaspase-dependent pathway in Aspergillus flavus.","volume":"64","author":"Tian","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.lwt.2014.08.014","article-title":"Perillaldehyde, a potential preservative agent in foods: assessment of antifungal activity against microbial spoilage of cherry tomatoes.","volume":"60","author":"Tian","year":"2015","journal-title":"Lwt Food Sci. Technol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1080\/10647440400025629","article-title":"Detection of Candida species in vaginal samples in a clinical laboratory setting.","volume":"13","author":"Trama","year":"2005","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.cell.2019.02.028","article-title":"Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage.","volume":"177","author":"Uderhardt","year":"2019","journal-title":"Cell"},{"key":"B40","doi-asserted-by":"publisher","first-page":"3443","DOI":"10.1021\/acs.jafc.8b00353","article-title":"Intestinal anti-inflammatory activity of perillaldehyde.","volume":"66","author":"Uemura","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1128\/iai.00054-07","article-title":"Mucosal tissue invasion by Candida albicans is associated with E-cadherin degradation, mediated by transcription factor Rim101p and protease Sap5p.","volume":"75","author":"Villar","year":"2007","journal-title":"Infect. Immun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.cell.2016.03.009","article-title":"A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair.","volume":"165","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11046-015-9947-5","article-title":"Combination of estrogen and immunosuppressive agents to establish a mouse model of candidiasis with concurrent oral and vaginal mucosal infection.","volume":"181","author":"Wang","year":"2016","journal-title":"Mycopathologia"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bcmd.2016.01.007","article-title":"Increased Smad2\/3 phosphorylation in circulating leukocytes and platelet-leukocyte aggregates in a mouse model of aortic valve stenosis: evidence of systemic activation of platelet-derived TGF-beta1 and correlation with cardiac dysfunction.","volume":"58","author":"Wang","year":"2016","journal-title":"Blood Cells Mol. Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1093\/infdis\/jiw201","article-title":"Streptococcus oralis and Candida albicans synergistically activate mu-Calpain to degrade E-cadherin from oral epithelial junctions.","volume":"214","author":"Xu","year":"2016","journal-title":"J. Infect. Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s11046-015-9924-z","article-title":"Molecular characterization of highly susceptible Candida africana from vulvovaginal candidiasis.","volume":"180","author":"Yazdanparast","year":"2015","journal-title":"Mycopathologia"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00198","article-title":"Streptococcus agalactiae inhibits Candida albicans hyphal development and diminishes host vaginal mucosal TH17 response.","volume":"9","author":"Yu","year":"2018","journal-title":"Front. Microbiol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01466\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T10:22:15Z","timestamp":1562062935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01466\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":47,"alternative-id":["10.3389\/fmicb.2019.01466"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.01466","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]},"article-number":"1466"}}