{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:33:14Z","timestamp":1770676394541,"version":"3.49.0"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.01517","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T09:00:16Z","timestamp":1562317216000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["miRNA-Gene Regulatory Network in Gnotobiotic Mice Stimulated by Dysbiotic Gut Microbiota Transplanted From a Genetically Obese Child"],"prefix":"10.3389","volume":"10","author":[{"given":"Liman","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs.","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"key":"B2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data.","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1210\/jc.2002-021891","article-title":"Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level.","volume":"88","author":"Babaya","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"40649","DOI":"10.1074\/jbc.M007577200","article-title":"SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.","volume":"275","author":"Bjorbak","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"29479","DOI":"10.1074\/jbc.M501326200","article-title":"The sarcolemmal calcium pump inhibits the calcineurin\/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit.","volume":"280","author":"Buch","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.2174\/138920211795677877","article-title":"Prader-Willi syndrome: obesity due to genomic imprinting.","volume":"12","author":"Butler","year":"2011","journal-title":"Curr. Genomics"},{"key":"B7","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1128\/MCB.00719-09","article-title":"Differential effects of protein kinase B\/Akt isoforms on glucose homeostasis and islet mass.","volume":"30","author":"Buzzi","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1002\/art.10648","article-title":"Inhibition of adjuvant-induced arthritis by systemic tissue inhibitor of metalloproteinases 4 gene delivery.","volume":"46","author":"Celiker","year":"2002","journal-title":"Arthritis Rheum."},{"key":"B9","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s13679-019-00332-6","article-title":"Gastrointestinal barrier breakdown and adipose tissue inflammation.","volume":"8","author":"Cheru","year":"2019","journal-title":"Curr. Obes. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"D296","DOI":"10.1093\/nar\/gkx1067","article-title":"miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions.","volume":"46","author":"Chou","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019293","article-title":"Microbiota modulate host gene expression via microRNAs.","volume":"6","author":"Dalmasso","year":"2011","journal-title":"PLoS One"},{"key":"B12","doi-asserted-by":"publisher","first-page":"14552","DOI":"10.1073\/pnas.0904073106","article-title":"Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.","volume":"106","author":"Di Lorenzo","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B13","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1055\/s-2005-837526","article-title":"The recombinant rat glucagon-like peptide-1 receptor, expressed in an alpha-cell line, is coupled to adenylyl cyclase activation and intracellular calcium release.","volume":"113","author":"Dillon","year":"2005","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"B14","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.pharmthera.2006.11.007","article-title":"Mechanisms of action of glucagon-like peptide 1 in the pancreas.","volume":"113","author":"Doyle","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1136\/gutjnl-2011-301955","article-title":"The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation.","volume":"62","author":"El Aidy","year":"2013","journal-title":"Gut"},{"key":"B16","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/mi.2012.32","article-title":"Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice.","volume":"5","author":"El Aidy","year":"2012","journal-title":"Mucosal Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/mol.0b013e32833884bb","article-title":"Acyl-coenzyme A synthetases in metabolic control.","volume":"21","author":"Ellis","year":"","journal-title":"Curr. Opin. Lipidol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.cmet.2010.05.012","article-title":"Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis.","volume":"12","author":"Ellis","year":"","journal-title":"Cell Metab."},{"key":"B19","doi-asserted-by":"publisher","first-page":"7300","DOI":"10.1073\/pnas.89.16.7300","article-title":"Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene.","volume":"89","author":"Emens","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1517\/14728222.2012.715633","article-title":"PPARalpha as a therapeutic target in inflammation-associated diseases.","volume":"16","author":"Gervois","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/s0014-5793(02)02924-1","article-title":"The F-helix of serpins plays an essential, active role in the proteinase inhibition mechanism.","volume":"523","author":"Gettins","year":"2002","journal-title":"FEBS Lett."},{"key":"B22","doi-asserted-by":"publisher","first-page":"27849","DOI":"10.1074\/jbc.M404087200","article-title":"Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor \u03b1 (PPAR-\u03b1).","volume":"279","author":"Guzm\u00e1n","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1126\/science.1123965","article-title":"Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase.","volume":"312","author":"Haemmerle","year":"2006","journal-title":"Science"},{"key":"B24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.33549\/physiolres.930744","article-title":"PPAR-alpha and insulin sensitivity.","volume":"55","author":"Haluzik","year":"2006","journal-title":"Physiol. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation.","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.423","article-title":"Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing.","volume":"5","author":"Hsu","year":"2014","journal-title":"Cell Death Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"B28","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome.","volume":"486","year":"2012","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2337\/db12-0443","article-title":"Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity.","volume":"62","author":"Jorgensen","year":"2013","journal-title":"Diabetes"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1096\/fj.10-169219","article-title":"Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration.","volume":"25","author":"Kielbasa","year":"2011","journal-title":"FASEB J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements.","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"B32","doi-asserted-by":"publisher","first-page":"39422","DOI":"10.1074\/jbc.M305371200","article-title":"Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart.","volume":"278","author":"Kovacic","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.cyto.2014.04.001","article-title":"Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.","volume":"68","author":"Le Goff","year":"2014","journal-title":"Cytokine"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1128\/mcb.18.5.3059","article-title":"Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.","volume":"18","author":"Lee","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"17789","DOI":"10.1074\/jbc.M109.082057","article-title":"Identification of heterogeneous nuclear ribonucleoprotein K as a transactivator for human low density lipoprotein receptor gene transcription.","volume":"285","author":"Li","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"27816","DOI":"10.1074\/jbc.M109.022467","article-title":"Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.","volume":"284","author":"Li","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"49066","DOI":"10.1074\/jbc.M107250200","article-title":"Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob\/ob mouse liver.","volume":"276","author":"Liang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.nutres.2015.12.001","article-title":"Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression.","volume":"36","author":"Lim","year":"2016","journal-title":"Nutr. Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.molimm.2007.08.018","article-title":"SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1\/Smad3 signaling.","volume":"45","author":"Liu","year":"2008","journal-title":"Mol. Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.imbio.2015.02.004","article-title":"SOCS3 promotes inflammation and apoptosis via inhibiting JAK2\/STAT3 signaling pathway in 3T3-L1 adipocyte.","volume":"220","author":"Liu","year":"2015","journal-title":"Immunobiology"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease.","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"443","DOI":"10.2459\/JCM.0b013e328354e3ac","article-title":"The growing importance of PON1 in cardiovascular health: a review.","volume":"13","author":"Macharia","year":"2012","journal-title":"J. Cardiovasc. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nri1632","article-title":"NFAT proteins: key regulators of T-cell development and function.","volume":"5","author":"Macian","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/nm1195-1155","article-title":"Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects.","volume":"1","author":"Maffei","year":"1995","journal-title":"Nat. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1523\/JNEUROSCI.4587-13.2014","article-title":"Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression.","volume":"34","author":"Mathews","year":"2014","journal-title":"J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/j.1365-2443.2009.01287.x","article-title":"Intracellular galectin-9 activates inflammatory cytokines in monocytes.","volume":"14","author":"Matsuura","year":"2009","journal-title":"Genes Cells"},{"key":"B49","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/415339a","article-title":"Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.","volume":"415","author":"Minokoshi","year":"2002","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cellsig.2014.05.006","article-title":"MicroRNAs: emerging roles in adipogenesis and obesity.","volume":"26","author":"Peng","year":"2014","journal-title":"Cell Signal"},{"key":"B51","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1172\/JCI15387","article-title":"Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.","volume":"110","author":"Pullinger","year":"2002","journal-title":"J. Clin. Invest."},{"key":"B52","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1093\/bioinformatics\/bts043","article-title":"Functional microRNA targets in protein coding sequences.","volume":"28","author":"Reczko","year":"2012","journal-title":"Bioinformatics"},{"key":"B53","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1146\/annurev.nutr.21.1.193","article-title":"Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system.","volume":"21","author":"Reddy","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.2337\/diabetes.52.12.2989","article-title":"Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.","volume":"52","author":"Richter","year":"2003","journal-title":"Diabetes"},{"key":"B55","doi-asserted-by":"publisher","first-page":"42394","DOI":"10.1074\/jbc.C200444200","article-title":"SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.","volume":"277","author":"Rui","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B56","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1021\/bi00135a001","article-title":"Bile acid biosynthesis.","volume":"31","author":"Russell","year":"1992","journal-title":"Biochemistry"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1002\/hep.23861","article-title":"Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.","volume":"52","author":"Sachithanandan","year":"2010","journal-title":"Hepatology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"13740","DOI":"10.1074\/jbc.M210689200","article-title":"Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.","volume":"278","author":"Senn","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks.","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/86871","article-title":"Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism.","volume":"27","author":"Shih","year":"2001","journal-title":"Nat. Genet."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/982165","article-title":"Hexane fractions of bupleurum falcatum L. stimulates glucagon-like peptide-1 secretion through G beta gamma -mediated pathway.","volume":"2014","author":"Shin","year":"2014","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1007\/s13206-012-6202-8","article-title":"Gentiana scabra extracts stimulate glucagon-like peptide-1 secretion via G protein-coupled receptor pathway.","volume":"6","author":"Shin","year":"2012","journal-title":"BioChip J."},{"key":"B63","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.bbrc.2005.02.047","article-title":"Meg1\/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades.","volume":"329","author":"Shiura","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B64","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1136\/gut.2003.027136","article-title":"Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice.","volume":"53","author":"Siegmund","year":"2004","journal-title":"Gut"},{"key":"B65","doi-asserted-by":"publisher","first-page":"171","DOI":"10.7150\/ijbs.8.171","article-title":"The murine caecal microRNA signature depends on the presence of the endogenous microbiota.","volume":"8","author":"Singh","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.1210\/jc.2006-0638","article-title":"The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans.","volume":"91","author":"Steinberg","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1093\/glycob\/cwq214","article-title":"Galectin-9 regulates T helper cell function independently of Tim-3.","volume":"21","author":"Su","year":"2011","journal-title":"Glycobiology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.immuni.2007.02.005","article-title":"MicroRNAs and immunity: tiny players in a big field.","volume":"26","author":"Taganov","year":"2007","journal-title":"Immunity"},{"key":"B69","doi-asserted-by":"publisher","first-page":"32424","DOI":"10.1074\/jbc.M113.479527","article-title":"LMBD1 protein serves as a specific adaptor for insulin receptor internalization.","volume":"288","author":"Tseng","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"6497","DOI":"10.1128\/MCB.00679-07","article-title":"Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.","volume":"27","author":"Wang","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01602","article-title":"Genetically obese human gut microbiota induces liver steatosis in germ-free mice fed on normal diet.","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Microbiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1086\/323473","article-title":"Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.","volume":"69","author":"Waterham","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"B73","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nm.4307","article-title":"Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.","volume":"23","author":"West","year":"2017","journal-title":"Nat. Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"8460","DOI":"10.1074\/jbc.M208518200","article-title":"Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase\/Akt signaling pathway by disrupting the association of IRS-1\/IRS-2 with the insulin receptor.","volume":"278","author":"Wick","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B75","doi-asserted-by":"publisher","first-page":"D146","DOI":"10.1093\/nar\/gku1104","article-title":"miRDB: an online resource for microRNA target prediction and functional annotations.","volume":"43","author":"Wong","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.immuni.2009.04.013","article-title":"Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.","volume":"30","author":"Xu","year":"2009","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1101\/gad.552310","article-title":"Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression.","volume":"24","author":"Yamaguchi","year":"2010","journal-title":"Genes Dev."},{"key":"B78","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.4049\/jimmunol.167.8.4593","article-title":"High-dose leptin activates human leukocytes via receptor expression on monocytes.","volume":"167","author":"Zarkesh-Esfahani","year":"2001","journal-title":"J. Immunol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.ebiom.2015.07.007","article-title":"Dietary modulation of gut microbiota contributes to alleviation of both genetic and simple obesity in children.","volume":"2","author":"Zhang","year":"2015","journal-title":"EBioMedicine"},{"key":"B80","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/ismej.2009.112","article-title":"Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice.","volume":"4","author":"Zhang","year":"2010","journal-title":"ISME J."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1126\/science.1100747","article-title":"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01517\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:16:54Z","timestamp":1663892214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01517\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,5]]},"references-count":81,"alternative-id":["10.3389\/fmicb.2019.01517"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.01517","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,5]]},"article-number":"1517"}}