{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:10:13Z","timestamp":1790399413612,"version":"4.1.0"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.01696","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T14:26:01Z","timestamp":1563978361000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Avian Hepatitis E Virus: With the Trend of Genotypes and Host Expansion"],"prefix":"10.3389","volume":"10","author":[{"given":"Peng","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoli","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1080\/03079450600920976","article-title":"Avian hepatitis E virus in an outbreak of hepatitis\u2013splenomegaly syndrome and fatty liver haemorrhage syndrome in two flaxseed-fed layer flocks in Ontario.","volume":"35","author":"Agunos","year":"2006","journal-title":"Avian Pathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.virusres.2011.02.011","article-title":"Molecular virology of hepatitis E virus.","volume":"161","author":"Ahmad","year":"2011","journal-title":"Virus Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3201\/eid1808.111669","article-title":"Putative novel genotype of avian hepatitis E virus, Hungary, 2010.","volume":"18","author":"B\u00e1nyai","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1099\/vir.0.007179-0","article-title":"Sequence analysis and comparison of avian hepatitis E viruses from Australia and Europe indicate the existence of different genotypes.","volume":"90","author":"Bilic","year":"2009","journal-title":"J. Gen. Virol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.1128\/jvi.79.6.3429-3437.2005","article-title":"Systematic pathogenesis and replication of avian hepatitis E virus in specific-pathogen-free adult chickens.","volume":"79","author":"Billam","year":"2005","journal-title":"J. Virol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1128\/JCM.00536-08","article-title":"Development and validation of a negative-strand-specific reverse transcription-PCR assay for detection of a chicken strain of hepatitis E Virus: identification of nonliver replication sites.","volume":"46","author":"Billam","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1099\/jgv.0.000478","article-title":"Hepatitis E virus (HEV)-1 harbouring HEV-4 non-structural protein (ORF1) replicates in transfected porcine kidney cells.","volume":"97","author":"Chatterjee","year":"2016","journal-title":"J. Gen. Virol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1637\/11070-032215-reg.1","article-title":"Avian hepatitis E virus infection in organic layers.","volume":"59","author":"Crespo","year":"2015","journal-title":"Avian Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1073\/pnas.1614955114","article-title":"Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles.","volume":"114","author":"Ding","year":"2017","journal-title":"Proc. Natl. Acad. Sci.U.S.A."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/v8100270","article-title":"Zoonotic hepatitis E virus: classification, animal reservoirs and transmission routes.","volume":"8","author":"Doceul","year":"2016","journal-title":"Viruses"},{"key":"B11","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.jviromet.2010.11.025","article-title":"Analysis of epitopes in the capsid protein of avian hepatitis E virus by using monoclonal antibodies.","volume":"171","author":"Dong","year":"2011","journal-title":"J. Virol. Methods"},{"key":"B12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/rmv.384","article-title":"Hepatitis E virus.","volume":"13","author":"Emerson","year":"2003","journal-title":"Rev. Med. Virol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1080\/03079457.2014.935755","article-title":"Identification and characterization of avian hepatitis E virus in 2013 outbreaks of hepatitis-splenomegaly syndrome in two US layer operations.","volume":"43","author":"Gerber","year":"2014","journal-title":"Avian Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1099\/vir.0.82689-0","article-title":"Egg whites from eggs of chickens infected experimentally with avian hepatitis E virus contain infectious virus, but evidence of complete vertical transmission is lacking.","volume":"88","author":"Guo","year":"2007","journal-title":"J. Gen. Virol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2307\/1590997","article-title":"An egg drop associated with splenomegaly in broiler breeders.","volume":"32","author":"Handlinger","year":"1988","journal-title":"Avian Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1099\/0022-1317-83-9-2201","article-title":"The putative capsid protein of the newly identified avian hepatitis E virus shares antigenic epitopes with that of swine and human hepatitis E viruses and chicken big liver and spleen disease virus.","volume":"83","author":"Haqshenas","year":"2002","journal-title":"J. Gen. Virol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1099\/0022-1317-82-10-2449","article-title":"Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis\u2013splenomegaly syndrome in the United States.","volume":"82","author":"Haqshenas","year":"2001","journal-title":"J. Gen. Virol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3201\/eid2001.131224","article-title":"Avian hepatitis E virus in chickens, Taiwan, 2013.","volume":"20","author":"Hsu","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4197","DOI":"10.1128\/jcm.40.11.4197-4202.2002","article-title":"Heterogeneity and seroprevalence of a newly identified avian hepatitis E virus from chickens in the United States.","volume":"40","author":"Huang","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1099\/vir.0.79841-0","article-title":"Determination and analysis of the complete genomic sequence of avian hepatitis E virus (avian HEV) and attempts to infect rhesus monkeys with avian HEV.","volume":"85","author":"Huang","year":"2004","journal-title":"J. Gen. Virol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1128\/jvi.02259-06","article-title":"Initiation at the third in-frame AUG codon of open reading frame 3 of the hepatitis E virus is essential for viral infectivity in vivo.","volume":"81","author":"Huang","year":"2007","journal-title":"J. Virol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.3201\/eid1808.120057","article-title":"Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans, France.","volume":"18","author":"Izopet","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"B23","doi-asserted-by":"crossref","first-page":"8848","DOI":"10.1128\/JVI.73.10.8848-8850.1999","article-title":"Evidence that the genomic RNA of hepatitis E virus is capped.","volume":"73","author":"Kabrane-Lazizi","year":"1999","journal-title":"J. Virol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jcv.2010.11.005","article-title":"The first case of genotype 4 hepatitis E related to wild boar in South Korea.","volume":"50","author":"Kim","year":"2011","journal-title":"J. Clin. Virol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"850","DOI":"10.7589\/2016-02-038","article-title":"Detection of zoonotic pathogens in wild birds in the cross-border region Austria\u2013Czech Republic.","volume":"52","author":"Konicek","year":"2016","journal-title":"J. Wildlife Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s11262-012-0761-6","article-title":"Serological prevalence, genetic identification, and characterization of the first strains of avian hepatitis E virus from chickens in Korea.","volume":"45","author":"Kwon","year":"2012","journal-title":"Virus Genes"},{"key":"B27","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1053\/j.gastro.2015.10.048","article-title":"Chronic infection with camelid hepatitis E virus in a liver transplant recipient who regularly consumes camel meat and milk.","volume":"150","author":"Lee","year":"2016","journal-title":"Gastroenterology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.3201\/eid1112.051041","article-title":"Hepatitis E virus transmission from wild boar meat.","volume":"11","author":"Li","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"B29","doi-asserted-by":"crossref","DOI":"10.1038\/s41426-018-0075-4","article-title":"Avian hepatitis E virus infection of duck, goose, and rabbit in northwest China.","volume":"7","author":"Liu","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1203-4","article-title":"Effect of housing arrangement on fecal-oral transmission of avian hepatitis E virus in chicken flocks.","volume":"13","author":"Liu","year":"2017","journal-title":"BMC Vet. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jviromet.2014.03.023","article-title":"Development of a blocking ELISA for detection of antibodies against avian hepatitis E virus.","volume":"204","author":"Liu","year":"2014","journal-title":"J. Virol. Methods"},{"key":"B32","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.vetmic.2010.03.014","article-title":"Phylogenetic analysis of avian hepatitis E virus samples from European and Australian chicken flocks supports the existence of a different genus within the Hepeviridae comprising at least three different genotypes.","volume":"145","author":"Marek","year":"2010","journal-title":"Vet. Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00705-018-4089-y","article-title":"Avian hepatitis E virus is widespread among chickens in Poland and belongs to genotype 2.","volume":"164","author":"Matczuk","year":"2019","journal-title":"Arch. Virol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1006\/viro.2001.1093","article-title":"Identification and characterization of the neutralization epitope (s) of the hepatitis E virus.","volume":"288","author":"Meng","year":"2001","journal-title":"Virology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.virusres.2011.01.016","article-title":"From barnyard to food table: the omnipresence of hepatitis E virus and risk for zoonotic infection and food safety.","volume":"161","author":"Meng","year":"2011","journal-title":"Virus Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"041","DOI":"10.1055\/s-0033-1338113","article-title":"Zoonotic and foodborne transmission of hepatitis E virus.","volume":"33","author":"Meng","year":"2013","journal-title":"Semin. Liver Dis."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005695","article-title":"Expanding host range and cross-species infection of hepatitis E virus.","volume":"12","author":"Meng","year":"2016","journal-title":"PLoS Pathog."},{"key":"B38","first-page":"377","author":"Meng","year":"2008","journal-title":"Hepatitis E virus (hepevirus). Encyclopedia of Virology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.vetmic.2009.03.017","article-title":"Hepatitis E virus: animal reservoirs and zoonotic risk.","volume":"140","author":"Meng","year":"2010","journal-title":"Vet. Microbiol."},{"key":"B40","first-page":"443","article-title":"Hepatitis E virus infections.","volume":"12","author":"Meng","year":"2008","journal-title":"Dis. Poul."},{"key":"B41","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3201\/eid1203.051004","article-title":"Host feeding patterns of Culex mosquitoes and West Nile virus transmission, Northeastern United States.","volume":"12","author":"Molaei","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1007\/s11262-016-1351-9","article-title":"Identification and characterization of avian hepatitis E virus genotype 2 from chickens with hepatitis-splenomegaly syndrome in Korea.","volume":"52","author":"Moon","year":"2016","journal-title":"Virus Genes"},{"key":"B43","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1080\/03079450802356946","article-title":"Avian hepatitis E virus infection and possible associated clinical disease in broiler breeder flocks in Hungary.","volume":"37","author":"Morrow","year":"2008","journal-title":"Avian Pathol."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12581","article-title":"First detection of Hepatitis E virus (Orthohepevirus C) in wild brown rats (Rattus norvegicus) from Great Britain.","author":"Murphy","year":"2019","journal-title":"Zoonoses and Public Health."},{"key":"B45","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/jmv.21116","article-title":"Hepatitis E virus: molecular virology, clinical features, diagnosis, transmission, epidemiology, and prevention.","volume":"80","author":"Mushahwar","year":"2008","journal-title":"J. Med. Virol."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00266","article-title":"Vaccine development against zoonotic hepatitis E virus: open questions and remaining challenges.","volume":"9","author":"Nan","year":"2018","journal-title":"Front. Microbiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1080\/03079457.2012.711464","article-title":"Avian hepatitis E virus identified in Russian chicken flocks exhibits high genetic divergence based on the ORF2 capsid gene AU - Sprygin, A. V.","volume":"41","author":"Nikonova","year":"2012","journal-title":"Avian Pathol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nrgastro.2017.150","article-title":"Hepatitis E virus: advances and challenges.","volume":"15","author":"Nimgaonkar","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1099\/vir.0.000045","article-title":"Construction of an infectious cDNA clone of genotype 1 avian hepatitis E virus: characterization of its pathogenicity in broiler breeders and demonstration of its utility in studying the role of the hypervariable region in virus replication.","volume":"96","author":"Park","year":"2015","journal-title":"J. Gen. Virol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/s0378-1135(99)00067-x","article-title":"Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus.","volume":"68","author":"Payne","year":"1999","journal-title":"Vet. Microbiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.vetmic.2008.12.010","article-title":"Evidence of widespread infection of avian hepatitis E virus (avian HEV) in chickens from Spain.","volume":"137","author":"Peralta","year":"2009","journal-title":"Vet. Microbiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.jhep.2007.12.008","article-title":"Hepatitis E: an emerging awareness of an old disease.","volume":"48","author":"Purcell","year":"2008","journal-title":"J. Hepatol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.meegid.2016.10.026","article-title":"A novel avian-like hepatitis E virus in wild aquatic bird, little egret (Egretta garzetta), in Hungary.","volume":"46","author":"Reuter","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"B54","first-page":"1041","author":"Riddell","year":"1997","journal-title":"Hepatitis-splenomegaly syndrome. Diseases of poultry"},{"key":"B55","first-page":"500","article-title":"British Columbia.\u201cHepatitis-splenomegaly\u201d syndrome in commercial egg laying hens.","volume":"32","author":"Ritchie","year":"1991","journal-title":"Can. Vet. J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1099\/0022-1317-81-6-1413","article-title":"Cellular receptors for viruses: links to tropism and pathogenesis.","volume":"81","author":"Schneider-Schaulies","year":"2000","journal-title":"J. Gen. Virol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"5548","DOI":"10.1128\/jvi.74.12.5548-5555.2000","article-title":"Identification by phage display and characterization of two neutralizing chimpanzee monoclonal antibodies to the hepatitis E virus capsid protein.","volume":"74","author":"Schofield","year":"2000","journal-title":"J. Virol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1099\/vir.0.068429-0","article-title":"Consensus proposals for classification of the family Hepeviridae.","volume":"95","author":"Smith","year":"2014","journal-title":"J. Gen. Virol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/zph.12405","article-title":"Hepatitis E virus and related viruses in wild, domestic and zoo animals: a review.","volume":"65","author":"Spahr","year":"2018","journal-title":"Zoonoses Public Health"},{"key":"B60","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1080\/03079457.2012.711464","article-title":"Avian hepatitis E virus identified in Russian chicken flocks exhibits high genetic divergence based on the ORF2 capsid gene.","volume":"41","author":"Sprygin","year":"2012","journal-title":"Avian Pathol."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040869","article-title":"Hepatitis E virus genotypes and evolution: emergence of camel hepatitis E variants.","volume":"18","author":"Sridhar","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.vetmic.2018.06.019","article-title":"Hepatic rupture hemorrhage syndrome in chickens caused by a novel genotype avian hepatitis E virus.","volume":"222","author":"Su","year":"","journal-title":"Vet. Microbiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1111\/tbed.12987","article-title":"Characterization of the novel genotype avian hepatitis E viruses from outbreaks of hepatic rupture haemorrhage syndrome in different geographical regions of China.","volume":"65","author":"Su","year":"","journal-title":"Transbound. Emerg. Dis."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-016-0892-4","article-title":"Seroprevalence of avian hepatitis E virus and avian leucosis virus subgroup J in chicken flocks with hepatitis syndrome, China.","volume":"12","author":"Sun","year":"2016","journal-title":"BMC Vet. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1128\/jcm.42.6.2658-2662.2004","article-title":"Generation and infectivity titration of an infectious stock of avian hepatitis E virus (HEV) in chickens and cross-species infection of turkeys with avian HEV.","volume":"42","author":"Sun","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1016\/j.vaccine.2017.05.030","article-title":"Evaluation of recombinant Chinese avian hepatitis E virus (CaHEV) ORF2 and ORF3 proteins for protection of chickens against CaHEV infection.","volume":"35","author":"Syed","year":"2017","journal-title":"Vaccine"},{"key":"B67","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1080\/03079459408419041","article-title":"Necrotic, haemorrhagic, hepatomegalic hepatitis associated with vasculitis and amyloidosis in commercial laying hens.","volume":"23","author":"Tablante","year":"1994","journal-title":"Avian Pathol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1099\/vir.0.029470-0","article-title":"Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype.","volume":"92","author":"Takahashi","year":"2011","journal-title":"J. Gen. Virol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1128\/JCM.01626-10","article-title":"TaqMan real-time reverse transcription-PCR assay for universal detection and quantification of avian hepatitis E virus from clinical samples in the presence of a heterologous internal control RNA.","volume":"49","author":"Troxler","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1080\/03079457.2014.924616","article-title":"Subclinical circulation of avian hepatitis E virus within a multiple-age rearing and broiler breeder farm indicates persistence and vertical transmission of the virus.","volume":"43","author":"Troxler","year":"2014","journal-title":"Avian Pathol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1590\/s0074-02762005000200003","article-title":"Serological evidence of hepatitis E virus infection in different animal species from the Southeast of Brazil.","volume":"100","author":"Vitral","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.vaccine.2018.01.003","article-title":"Live recombinant Lactococcuslactis expressing avian hepatitis virus ORF2 protein: immunoprotection against homologous virus challenge in chickens.","volume":"36","author":"Wang","year":"2018","journal-title":"Vaccine"},{"key":"B73","doi-asserted-by":"publisher","first-page":"2710","DOI":"10.1099\/vir.0.069021-0","article-title":"Identification of an antigenic domain in the N-terminal region of avian hepatitis E virus (HEV) capsid protein that is not common to swine and human HEVs.","volume":"95","author":"Wang","year":"2014","journal-title":"J. Gen. Virol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"5491","DOI":"10.1128\/JVI.00107-15","article-title":"Characterization of two novel linear B-cell epitopes in the capsid protein of avian hepatitis E virus (HEV) that are common to avian, swine, and human HEVs.","volume":"89","author":"Wang","year":"2015","journal-title":"J. Virol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.3201\/eid2006.140140","article-title":"New hepatitis E virus genotype in camels, the Middle East.","volume":"20","author":"Woo","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1007\/s00705-018-3925-4","article-title":"Detection and genomic characterization of new avian-like hepatitis E virus in a sparrow in the United States.","volume":"163","author":"Yang","year":"2018","journal-title":"Arch. Virol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1637\/11386-013016-Reg.1","article-title":"Natural infection with avian hepatitis E virus and marek\u2019s disease virus in brown layer chickens in China.","volume":"60","author":"Yang","year":"2016","journal-title":"Avian Dis."},{"key":"B78","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1637\/11229-070515-Review.1","article-title":"Hepatitis virus infections in poultry.","volume":"60","author":"Yugo","year":"2016","journal-title":"Avian Dis."},{"key":"B79","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.3390\/ijerph10104507","article-title":"Hepatitis E virus: foodborne, waterborne and zoonotic transmission.","volume":"10","author":"Yugo","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153723","article-title":"C-Terminal amino acids 471-507 of avian hepatitis E virus capsid protein are crucial for binding to avian and human cells.","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"B81","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.virusres.2016.11.028","article-title":"Evidence of genotypes 1 and 3 of avian hepatitis E virus in wild birds.","volume":"228","author":"Zhang","year":"2017","journal-title":"Virus Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.vetmic.2017.03.005","article-title":"Decreased egg production in laying hens associated with infection with genotype 3 avian hepatitis E virus strain from China.","volume":"203","author":"Zhao","year":"2017","journal-title":"Vet. Microbiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.jviromet.2012.08.026","article-title":"Development and application of an indirect ELISA for detection of antibodies against avian hepatitis E virus.","volume":"187","author":"Zhao","year":"","journal-title":"J. Virol. Methods"},{"key":"B84","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.vetmic.2013.08.006","article-title":"Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus.","volume":"167","author":"Zhao","year":"","journal-title":"Vet. Microbiol."},{"key":"B85","first-page":"103","article-title":"Antigenic domains of avian HEV: bases for serological diagnosis of HEV in avian, swine and human.","volume":"1","author":"Zhao","year":"2014","journal-title":"Br. J. Virol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.vetmic.2015.08.016","article-title":"Antigenic properties of avian hepatitis E virus capsid protein.","volume":"180","author":"Zhao","year":"2015","journal-title":"Vet. Microbiol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.3201\/eid1609.100626","article-title":"Analysis of avian hepatitis E virus from chickens, China.","volume":"16","author":"Zhao","year":"2010","journal-title":"Emerg. Infect. Dis."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01696\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T05:45:29Z","timestamp":1610603129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01696\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,24]]},"references-count":87,"alternative-id":["10.3389\/fmicb.2019.01696"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.01696","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,24]]},"article-number":"1696"}}