{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:28:44Z","timestamp":1778891324724,"version":"3.51.4"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010011","name":"Jiangsu Postdoctoral Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.01721","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T05:13:46Z","timestamp":1565673226000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":53,"title":["Adhesive Bifidobacterium Induced Changes in Cecal Microbiome Alleviated Constipation in Mice"],"prefix":"10.3389","volume":"10","author":[{"given":"Linlin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cailing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-kun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1136\/bmj.g3174","article-title":"Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomized controlled trials.","volume":"348","author":"Alexander","year":"2014","journal-title":"BMJ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1053\/j.gastro.2012.10.028","article-title":"American gastroenterological association technical review on constipation.","volume":"144","author":"Bharucha","year":"2013","journal-title":"Gastroenterol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/j.1442-200X.2007.02397-x","article-title":"Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation.","volume":"49","author":"Bu","year":"2007","journal-title":"Pediatr. Int."},{"key":"B4","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.cmet.2015.07.026","article-title":"(2015).","volume":"22","author":"Caesar","year":"2015","journal-title":"Cell Metabol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data.","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1514","article-title":"Impact of demographics on human gut microbial diversity in a US Midwest population.","volume":"4","author":"Chen","year":"2016","journal-title":"Peer J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.5056\/jnm14142","article-title":"Alteration of gut microbiota and efficacy of probiotics in functional constipation.","volume":"21","author":"Choi","year":"2015","journal-title":"J. Neurogastroenterol. Motil."},{"key":"B8","doi-asserted-by":"publisher","first-page":"G382","DOI":"10.1152\/ajpgi.90286.2008","article-title":"High body mass alters colonic sensory-motor function and transit in humans.","volume":"295","author":"DelgadoAros","year":"2008","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.gcb.2007.06.001","article-title":"A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome.","volume":"32","author":"Drouault","year":"2008","journal-title":"Gastroenterol. Clin. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1093\/cid\/cir632","article-title":"Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent clostridium difficile infection.","volume":"53","author":"Ethan","year":"2011","journal-title":"Clin. Infect. Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity.","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/117693430600200007","article-title":"Phylogenetic diversity (PD) and biodiversity conservation: some bioinformatics challenges.","volume":"2","author":"Faith","year":"2006","journal-title":"Evol. Bioinform. Online"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00612-y","article-title":"Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility.","volume":"7","author":"Ge","year":"2017","journal-title":"Sci. Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/apt.12789","article-title":"Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation.","volume":"40","author":"Gu\u00e9rin","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1017\/S0954422410000247","article-title":"From the gut to the peripheral tissues: the multiple effects of butyrate.","volume":"23","author":"Guilloteau","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1084\/jem.20112408","article-title":"Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation.","volume":"209","author":"Jenq","year":"2012","journal-title":"J. Exp. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.tim.2016.02.015","article-title":"Oscillospira: a central, enigmatic component of the human gut microbiota.","volume":"24","author":"Konikoff","year":"2016","journal-title":"Trends Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nrgastro.2016.4","article-title":"Prevotella in the gut: choose carefully.","volume":"13","author":"Ley","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"6240","DOI":"10.1021\/acs.jafc.6b02305","article-title":"Lactulose differently modulates the composition of luminal and mucosal microbiota in C57BL\/6J Mice.","volume":"64","author":"Mao","year":"2016","journal-title":"J. Agri. Food Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nrmicro.2016.108","article-title":"Clostridium difficile colitis: pathogenesis and host defence.","volume":"14","author":"Michael","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0181-2","article-title":"Genomic characterization of the uncultured bacteroidales familys24-7 inhabiting the guts of homeothermic animals.","volume":"4","author":"Ormerod","year":"2016","journal-title":"Microbiome."},{"key":"B22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1053\/j.gastro.2015.10.005","article-title":"Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation.","volume":"150","author":"Parthasarathy","year":"2016","journal-title":"Gastroenterology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1111\/j.1572-0241.2006.00734.-x","article-title":"Efficacy of an encapsulated probiotic bifidobacterium infantis 35624 in women with irritable bowel syndrome.","volume":"101","author":"Peter","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3892\/etm.2013.1096","article-title":"Preventive effect of resistant starch on activated carbon-induced constipation in mice.","volume":"6","author":"Qian","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nrgastro.2016.53","article-title":"Diagnosis and management of chronic constipation in adults.","volume":"13","author":"Rao","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1096\/fj.14-259598\/fj.14-259598","article-title":"Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin.","volume":"29","author":"Reigstad","year":"2015","journal-title":"FASEB J."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00185","article-title":"Intestinal short chain fatty acids and their link with diet and human health.","volume":"7","author":"R\u00edos-Covi\u00e1n","year":"2016","journal-title":"Front. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/ismej.2014.3","article-title":"Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission.","volume":"8","author":"Rooks","year":"2014","journal-title":"ISME J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.pss.2014.11.011","article-title":"Preliminary study of Venus cloud layers with polarimetric data from SPICAV\/VEx.","author":"Rossi","year":"2015","journal-title":"Planet. Space Sci."},{"key":"B30","doi-asserted-by":"crossref","first-page":"A145","DOI":"10.1016\/S0016-5085(03)80717-5","article-title":"Accelerated regional bowel transit and overweight shown in idiopathic bile acid malabsorption.","volume":"124","author":"Sadik","year":"2004","journal-title":"Gastroenterol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/00365521.1997.11720717","article-title":"Lactulose, lactic acid bacteria, intestinal microecology and mucosal protection.","volume":"222","author":"Salminen","year":"1997","journal-title":"Scand. J. Gastroenterol. Suppl."},{"key":"B32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s10620-014-3285-1","article-title":"Impact of microscopic duodenitis on symptomatic response to Helicobacter pylori eradication in functional dyspepsia.","volume":"60","author":"Seyed","year":"2015","journal-title":"Digest. Dis. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"16731","DOI":"10.1073\/pnas.0804812105","article-title":"Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of crohn disease patients.","volume":"105","author":"Sokol","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B34","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/ajg.2015.98","article-title":"Peptic ulcer bleeding risk. the role of helicobacter pylori infection in nsaid\/low-dose aspirin users.","volume":"110","author":"Sostres","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-10-19","article-title":"Is bifidobacterium breve effective in the treatment of childhood constipation? results from a pilot study.","volume":"10","author":"Tabbers","year":"2011","journal-title":"Nutr. J."},{"key":"B36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.12938\/bmfh.2014-017","article-title":"Continuous consumption of fermented milk containing bifidobacterium bifidum yit 10347 improves gastrointestinal and psychological symptoms in patients with functional gastrointestinal disorders.","volume":"34","author":"Urita","year":"2015","journal-title":"Biosci. Microbiota Food Health"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/srep06328","article-title":"Changes of the human gut microbiome induced by a fermented milk product.","volume":"4","author":"Veiga","year":"2014","journal-title":"Sci Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1113\/jphysiol.2001.013056","article-title":"Effects of butyrate on active sodium and chloride transport in rat and rabbit distal colon.","volume":"539","author":"Vidyasagar","year":"2000","journal-title":"J. Physiol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020318","article-title":"Bifidobacterium adolescentis exerts strain-specific effects on constipation induced by loperamide in balb\/c mice.","volume":"18","author":"Wang","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3587","DOI":"10.1039\/C6FO01641C","article-title":"Bifidobacteria exerts species-specific effects on constipation in BALB\/c mice.","volume":"8","author":"Wang","year":"","journal-title":"Food Funct."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5461","DOI":"10.3748\/wjg.v20.i18.5461","article-title":"Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.","volume":"20","author":"Watari","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1365-2036.2008.03848.x","article-title":"Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study.","volume":"29","author":"Williams","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B43","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1113\/jphysiol.1988.sp017264","article-title":"Luminal propionate-induced secretory response in the rat distal colon in vitro.","volume":"403","author":"Yajima","year":"1988","journal-title":"J. Physiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3164\/jcbn.1514","article-title":"Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.","volume":"57","author":"Yoon","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1038\/ismej.2015.11","article-title":"A phylo-functional core of enteric microorganisms in healthy young chinese cohorts across lifestyles, geography and ethnicities.","volume":"9","author":"Zhang","year":"2015","journal-title":"ISME J."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01721\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T21:39:18Z","timestamp":1569015558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.01721\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":45,"alternative-id":["10.3389\/fmicb.2019.01721"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.01721","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,13]]},"article-number":"1721"}}