{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:13:32Z","timestamp":1790820812941,"version":"4.1.0"},"reference-count":97,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI078859"],"award-info":[{"award-number":["AI078859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI074410"],"award-info":[{"award-number":["AI074410"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI127351-01"],"award-info":[{"award-number":["AI127351-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI043894"],"award-info":[{"award-number":["AI043894"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS0099029"],"award-info":[{"award-number":["NS0099029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.02147","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T07:50:22Z","timestamp":1568793022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":66,"title":["HTLV-1 Extracellular Vesicles Promote Cell-to-Cell Contact"],"prefix":"10.3389","volume":"10","author":[{"given":"Daniel O.","family":"Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"DeMarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Pleet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Branscome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Al Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Dutartre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lepene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance A.","family":"Liotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Mahieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatah","family":"Kashanchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00139","article-title":"Presence of viral RNA and proteins in exosomes from cellular clones resistant to rift valley fever virus infection.","volume":"7","author":"Ahsan","year":"2016","journal-title":"Front. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"10580","DOI":"10.1128\/JVI.01799-1715","article-title":"Viral source-independent high susceptibility of dendritic cells to human T-Cell Leukemia Virus Type 1 infection compared to that of T Lymphocytes.","volume":"89","author":"Alais","year":"2015","journal-title":"J. Virol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s11481-018-9784-9787","article-title":"Role of exosomes in human retroviral mediated disorders.","volume":"13","author":"Anderson","year":"2018","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-018-0204-207","article-title":"Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease: functional role of exosomes.","volume":"7","author":"Anderson","year":"2018","journal-title":"Clin. Transl. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s13311-016-0450-456","article-title":"Exosomes in viral disease.","volume":"13","author":"Anderson","year":"2016","journal-title":"Neurotherapeutics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/ijc.2910330202","article-title":"Location of human T-cell leukemia virus (HTLV) p19 antigen on virus-producing cells.","volume":"33","author":"Aoki","year":"1984","journal-title":"Int. J. Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1073\/pnas.95.5.2452","article-title":"Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-\u03baB site.","volume":"95","author":"Azimi","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-1-20","article-title":"Role of Tax protein in human T-cell Leukemia Virus Type-I leukemogenicity.","volume":"1","author":"Azran","year":"2004","journal-title":"Retrovirology"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.12","article-title":"HTLV-1-associated myelopathy\/tropical spastic paraparesis.","volume":"1","author":"Bangham","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02615","article-title":"HTLV-1 HBZ viral protein: a key player in HTLV-1 mediated diseases.","volume":"8","author":"Baratella","year":"2017","journal-title":"Front. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-1-4939-6872-5_5","article-title":"Isolation of Exosomes from HTLV-Infected Cells","author":"Barclay","year":"","journal-title":"Human T-Lymphotropic Viruses Methods in Molecular Biology"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.A117.793521","article-title":"Exosomes from uninfected cells activate transcription of latent HIV-1.","volume":"292","author":"Barclay","year":"","journal-title":"J. Biol. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nature03482","article-title":"DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.","volume":"434","author":"Bartkova","year":"2005","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.12469.2","article-title":"Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1.","volume":"2","author":"Billman","year":"2017","journal-title":"Wellcome Open Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1136\/sextrans-2019-053978","article-title":"Rapid onset and progression of myelopathy following an STI: a case for screening?","volume":"95","author":"Caswell","year":"2019","journal-title":"Sex Transm. Infect."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003917","article-title":"Gem-Induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission.","volume":"10","author":"Chevalier","year":"2014","journal-title":"PLoS Pathog."},{"key":"B17","doi-asserted-by":"publisher","first-page":"15525","DOI":"10.1073\/pnas.1521629112","article-title":"The discovery of HTLV-1, the first pathogenic human retrovirus.","volume":"112","author":"Coffin","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B18","doi-asserted-by":"publisher","first-page":"7270","DOI":"10.1128\/jvi.74.16.7270-7283.2000","article-title":"Overexpression of p21waf1 in Human T-Cell lymphotropic virus type 1-infected cells and its association with cyclin A\/cdk2.","volume":"74","author":"de la Fuente","year":"2000","journal-title":"J. Virol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-9946201759080","article-title":"Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil.","volume":"59","author":"de Morais","year":"2017","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"B20","doi-asserted-by":"crossref","DOI":"10.3791\/59876","article-title":"Purification of high yield extracellular vesicle preparations away from virus.","author":"DeMarino","year":"2019","journal-title":". J. Vis. Exp."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25943-25942","article-title":"Antiretroviral drugs alter the content of extracellular vesicles from HIV-1-infected cells.","volume":"8","author":"DeMarino","year":"2018","journal-title":"Sci. Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"7607","DOI":"10.1128\/JVI.00407-416","article-title":"Cell-Free versus cell-to-cell infection by human immunodeficiency Virus Type 1 and Human T-lymphotropic virus type 1: exploring the link among viral source, viral trafficking, and viral replication.","volume":"90","author":"Dutartre","year":"2016","journal-title":"J. Virol."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006281","article-title":"Human T-Lymphotropic Virus type 1c subtype proviral loads, chronic lung disease and survival in a prospective cohort of Indigenous Australians.","volume":"12","author":"Einsiedel","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"305","DOI":"10.5694\/mja16.00285","article-title":"The prevalence and clinical associations of HTLV-1 infection in a remote Indigenous community.","volume":"205","author":"Einsiedel","year":"2016","journal-title":"Med. J. Aust."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-016-0307-304","article-title":"ATL-derived exosomes modulate mesenchymal stem cells: potential role in leukemia progression.","volume":"13","author":"El-Saghir","year":"2016","journal-title":"Retrovirology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/2049-632X.12135","article-title":"The carrying pigeons of the cell: exosomes and their role in infectious diseases caused by human pathogens.","volume":"71","author":"Fleming","year":"2014","journal-title":"Pathog. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0165-0378(00)00054-1","article-title":"HTLV-I transmission from mother to child.","volume":"47","author":"Fujino","year":"2000","journal-title":"J. Reprod. Immunol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/v10010001","article-title":"HTLV-1, the other pathogenic yet neglected human retrovirus: from transmission to therapeutic treatment.","volume":"10","author":"Futsch","year":"2017","journal-title":"Viruses"},{"key":"B29","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.beha.2011.09.012","article-title":"Research and discovery of the first human cancer virus, HTLV-1.","volume":"24","author":"Gallo","year":"2011","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1182\/blood-2016-09-739433","article-title":"Screening transplant donors for HTLV-1 and -2.","volume":"128","author":"Gallo","year":"2016","journal-title":"Blood"},{"key":"B31","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/s0140-6736(85)92734-92735","article-title":"Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis.","volume":"2","author":"Gessain","year":"1985","journal-title":"Lancet"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00388","article-title":"Epidemiological aspects and world distribution of HTLV-1 infection.","volume":"3","author":"Gessain","year":"2012","journal-title":"Front. Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1056\/NEJM199506293322603","article-title":"Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine.","volume":"332","author":"Gill","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1128\/CMR.00063-69","article-title":"Epidemiology, treatment, and prevention of human T-Cell Leukemia Virus Type 1-associated diseases.","volume":"23","author":"Gon\u00e7alves","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"B35","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nature03485","article-title":"Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.","volume":"434","author":"Gorgoulis","year":"2005","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"10592","DOI":"10.1073\/pnas.1831413100","article-title":"The Trojan exosome hypothesis.","volume":"100","author":"Gould","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5976","DOI":"10.1038\/sj.onc.1208978","article-title":"Molecular mechanisms of cellular transformation by HTLV-1 Tax.","volume":"24","author":"Grassmann","year":"2005","journal-title":"Oncogene"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/v8030074","article-title":"Molecular mechanisms of HTLV-1 Cell-to-cell transmission.","volume":"8","author":"Gross","year":"2016","journal-title":"Viruses"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005916","article-title":"The tax-inducible actin-bundling protein fascin is crucial for release and cell-to-cell transmission of human T-Cell Leukemia Virus Type 1 (HTLV-1).","volume":"12","author":"Gross","year":"2016","journal-title":"PLoS Pathog."},{"key":"B40","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/sj.thj.6200195","article-title":"A prospective phase II clinical trial with the use of zidovudine and interferon-alpha in the acute and lymphoma forms of adult T-cell leukemia\/lymphoma.","volume":"3","author":"Hermine","year":"2002","journal-title":"Hematol. J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6476","DOI":"10.1073\/pnas.78.10.6476","article-title":"Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.","volume":"78","author":"Hinuma","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B42","first-page":"1737","article-title":"Transcriptional activator Tax of HTLV-1 binds to the NF-kappa B precursor p105.","volume":"7","author":"Hirai","year":"1992","journal-title":"Oncogene"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1126\/science.1080115","article-title":"Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton.","volume":"299","author":"Igakura","year":"2003","journal-title":"Science"},{"key":"B44","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1089\/AID.2016.0006","article-title":"Potential of radiation-induced cellular stress for reactivation of latent HIV-1 and killing of infected cells.","volume":"32","author":"Iordanskiy","year":"2016","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virol.2015.06.021","article-title":"Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells.","volume":"485","author":"Iordanskiy","year":"2015","journal-title":"Virology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1182\/blood-2009-12-257410","article-title":"Human T-cell Leukemia Virus Type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan.","volume":"116","author":"Iwanaga","year":"2010","journal-title":"Blood"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00322","article-title":"Adult T-Cell leukemia: a review of epidemiological evidence.","volume":"3","author":"Iwanaga","year":"2012","journal-title":"Front. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"22284","DOI":"10.1074\/jbc.M114.549659","article-title":"Human T-lymphotropic Virus Type 1-infected cells secrete exosomes that contain tax protein.","volume":"289","author":"Jaworski","year":"","journal-title":"J. Biol. Chem."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096778","article-title":"The use of nanotrap particles technology in capturing HIV-1 virions and viral proteins from infected cells.","volume":"9","author":"Jaworski","year":"","journal-title":"PLoS One"},{"key":"B50","first-page":"1096","article-title":"The risk of development of HTLV-I-associated myelopathy\/tropical spastic paraparesis among persons infected with HTLV-I.","volume":"3","author":"Kaplan","year":"1990","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"B51","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1002\/cbic.201400043","article-title":"Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes.","volume":"15","author":"Kastelowitz","year":"2014","journal-title":"Chembiochem"},{"key":"B52","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.imlet.2006.09.005","article-title":"Exosomes: from biogenesis and secretion to biological function.","volume":"107","author":"Keller","year":"2006","journal-title":"Immunol. Lett."},{"key":"B53","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1002\/jmv.21738","article-title":"Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia\/lymphoma in Nagasaki, Japan.","volume":"82","author":"Koga","year":"2010","journal-title":"J. Med. Virol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1002\/ijc.2910430618","article-title":"Age- and sex-specific cumulative rate and risk of ATLL for HTLV-I carriers.","volume":"43","author":"Kondo","year":"1989","journal-title":"Int. J. Cancer"},{"key":"B55","doi-asserted-by":"publisher","first-page":"E1269","DOI":"10.1073\/pnas.1715724115","article-title":"Sporadic on\/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.","volume":"115","author":"Mahgoub","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1089\/08892220050193137","article-title":"Inactivation of p53 by HTLV type 1 and HTLV type 2 Tax trans-activators.","volume":"16","author":"Mahieux","year":"2000","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002251","article-title":"Human T-Lymphotropic Virus-1 visualized at the virological synapse by electron tomography.","volume":"3","author":"Majorovits","year":"2008","journal-title":"PLoS One"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/S0140-6736(18)30974-30977","article-title":"Time to eradicate HTLV-1: an open letter to WHO.","volume":"391","author":"Martin","year":"2018","journal-title":"Lancet"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1128\/JVI.06993-6911","article-title":"Role of O-glycosylation and expression of CD43 and CD45 on the surfaces of effector T cells in human T cell Leukemia Virus Type 1 cell-to-cell infection.","volume":"86","author":"Mazurov","year":"2012","journal-title":"J. Virol."},{"key":"B60","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1182\/blood.V90.12.4924","article-title":"Repression of transcription from the human T-cell Leukemia Virus Type I long terminal repeat and cellular gene promoters by wild-type p53.","volume":"90","author":"Mori","year":"1997","journal-title":"Blood"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/srep20254","article-title":"Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets.","volume":"6","author":"Muller","year":"2016","journal-title":"Sci. Rep."},{"key":"B62","doi-asserted-by":"crossref","first-page":"8852","DOI":"10.1128\/JVI.72.11.8852-8860.1998","article-title":"Human T-cell lymphotropic\/Leukemia Virus Type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB\/ATF functional domain.","volume":"72","author":"Mulloy","year":"1998","journal-title":"J. Virol."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-018-0454-x","article-title":"Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM\/TSP.","volume":"15","author":"Naito","year":"2018","journal-title":"Retrovirology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"20014","DOI":"10.1074\/jbc.M112.438895","article-title":"Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA.","volume":"288","author":"Narayanan","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1182\/blood-2008-03-136770","article-title":"HTLV-1\u2013Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse.","volume":"114","author":"Nejmeddine","year":"2009","journal-title":"Blood"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29391-w","article-title":"Inhibition of Tunneling Nanotube (TNT) formation and human T-cell Leukemia Virus Type 1 (HTLV-1) transmission by cytarabine.","volume":"8","author":"Omsland","year":"2018","journal-title":"Sci. Rep."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2018.0115","article-title":"TAX-mRNA-Carrying exosomes from human T cell lymphotropic Virus Type 1-Infected cells can induce interferon-gamma production in vitro.","author":"Otaguiri","year":"2018","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"B68","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nm.2065","article-title":"Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses.","volume":"16","author":"Pais-Correia","year":"2010","journal-title":"Nat. Med."},{"key":"B69","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1128\/JVI.66.10.5879-5889.1992","article-title":"Mapping of homologous, amino-terminal neutralizing regions of human T-cell lymphotropic virus type I and II gp46 envelope glycoproteins.","volume":"66","author":"Palker","year":"1992","journal-title":"J. Virol."},{"key":"B70","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1182\/blood.V128.22.4159.4159","article-title":"A prospective, multicenter, randomized study of Anti-CCR4 monoclonal antibody mogamulizumab versus investigator\u2019s choice in the treatment of patients with relapsed\/refractory Adult T-Cell leukemia-lymphoma: overall response rate, progression-free survival, and overall survival.","volume":"128","author":"Phillips","year":"2016","journal-title":"Blood"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00378","article-title":"Pathways of cell-cell transmission of HTLV-1.","volume":"3","author":"Pique","year":"2012","journal-title":"Front. Microbiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"919","DOI":"10.2741\/1586","article-title":"Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.","volume":"10","author":"Pise-Masison","year":"2005","journal-title":"Front. Biosci."},{"key":"B73","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1128\/JVI.72.2.1165-1170.1998","article-title":"Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein.","volume":"72","author":"Pise-Masison","year":"1998","journal-title":"J. Virol."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004454","article-title":"Co-dependence of HTLV-1 p12 and p8 functions in virus persistence.","volume":"10","author":"Pise-Masison","year":"2014","journal-title":"PLoS Pathog."},{"key":"B75","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1128\/mcb.20.10.3377-3386.2000","article-title":"Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.","volume":"20","author":"Pise-Masison","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00362","article-title":"Autophagy, EVs, and infections: a perfect question for a perfect time.","volume":"8","author":"Pleet","year":"","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"S365","DOI":"10.1093\/infdis\/jiy472","article-title":"Ebola virus VP40 modulates cell cycle and biogenesis of extracellular vesicles.","volume":"218","author":"Pleet","year":"","journal-title":"J. Infect. Dis."},{"key":"B78","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1089\/dna.2017.3639","article-title":"The role of exosomal VP40 in ebola virus disease.","volume":"36","author":"Pleet","year":"2017","journal-title":"DNA Cell Biol."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01765","article-title":"Ebola VP40 in exosomes can cause immune cell dysfunction.","volume":"7","author":"Pleet","year":"2016","journal-title":"Front. Microbiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/294268a0","article-title":"Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with S\u00e9zary T-cell leukaemia.","volume":"294","author":"Poiesz","year":"1981","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends.","volume":"200","author":"Raposo","year":"2013","journal-title":"J. Cell Biol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s13365-014-0238-236","article-title":"Exosomes and their role in CNS viral infections.","volume":"20","author":"Sampey","year":"2014","journal-title":"J. Neurovirol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1074\/jbc.M115.662171","article-title":"Exosomes from HIV-1-infected cells stimulate production of Pro-inflammatory cytokines through trans-activating response (TAR) RNA.","volume":"291","author":"Sampey","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.2165\/11631090-000000000-00000","article-title":"Mogamulizumab.","volume":"72","author":"Subramaniam","year":"2012","journal-title":"Drugs"},{"key":"B85","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.chom.2013.09.009","article-title":"Host restriction factor SAMHD1 limits human T cell Leukemia Virus Type 1 infection of monocytes via STING-mediated apoptosis.","volume":"14","author":"Sze","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01425","article-title":"The exceptional oncogenicity of HTLV-1.","volume":"8","author":"Tagaya","year":"2017","journal-title":"Front. Microbiol."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01885-1817","article-title":"Control of human T-Cell Leukemia Virus Type 1 (HTLV-1) infection by eliminating envelope protein-positive cells with recombinant vesicular stomatitis viruses encoding HTLV-1 primary receptor.","volume":"92","author":"Tezuka","year":"2018","journal-title":"J. Virol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1182\/blood-2013-06-508861","article-title":"An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity.","volume":"123","author":"Tezuka","year":"2014","journal-title":"Blood"},{"key":"B89","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1200\/JCO.2008.18.2428","article-title":"Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting.","volume":"27","author":"Tsukasaki","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1111\/cas.12534","article-title":"Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways.","volume":"105","author":"Ung","year":"2014","journal-title":"Cancer Sci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.molmed.2014.03.002","article-title":"Extracellular vesicles: emerging targets for cancer therapy.","volume":"20","author":"Vader","year":"2014","journal-title":"Trends Mol. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1128\/MMBR.00063-15","article-title":"Extracellular vesicles exploit viral entry routes for cargo delivery.","volume":"80","author":"van Dongen","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B93","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles.","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.mam.2010.07.001","article-title":"Hijacking the T-cell communication network by the human T-cell leukemia\/lymphoma virus type 1 (HTLV-1) p12 and p8 proteins.","volume":"31","author":"Van Prooyen","year":"","journal-title":"Mol. Aspects Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"20738","DOI":"10.1073\/pnas.1009635107","article-title":"Human T-cell Leukemia Virus Type 1 p8 protein increases cellular conduits and virus transmission.","volume":"107","author":"Van Prooyen","year":"","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01605-1616","article-title":"Visualization of HIV T cell virological synapses and virus-containing compartments by three-dimensional correlative light and electron microscopy.","volume":"91","author":"Wang","year":"2017","journal-title":"J. Virol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1349-7006.1993.tb02775.x","article-title":"Aberrant expression of the p53 tumor suppressor gene in adult T-cell leukemia and HTLV-I-infected cells.","volume":"84","author":"Yamato","year":"1993","journal-title":"Jpn. J. Cancer Res."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.02147\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T04:42:02Z","timestamp":1611204122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.02147\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":97,"alternative-id":["10.3389\/fmicb.2019.02147"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.02147","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]},"article-number":"2147"}}