{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T21:04:42Z","timestamp":1786741482375,"version":"build-2736575974"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3332018108"],"award-info":[{"award-number":["3332018108"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.02482","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T04:38:35Z","timestamp":1572410315000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Interleukin-37 Ameliorates Influenza Pneumonia by Attenuating Macrophage Cytokine Production in a MAPK-Dependent Manner"],"prefix":"10.3389","volume":"10","author":[{"given":"Feifei","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengdi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuran","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7123.","DOI":"10.1038\/s41598-019-42808-4","article-title":"Association between IL-37 gene polymorphisms and risk of HBV-related liver disease in a Saudi Arabian population","volume":"9","author":"Al-Anazi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/FJC.0000000000000476","article-title":"Interleukin-37 ameliorates coxsackievirus B3-induced viral myocarditis by modulating the Th17\/regulatory T cell immune response","volume":"69","author":"An","year":"2017","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.3389\/fimmu.2019.02014","article-title":"Interleukin-1 family cytokines: keystones in liver inflammatory diseases","volume":"10","author":"Barbier","year":"2019","journal-title":"Front. Immunol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1684\/ecn.2011.0288","article-title":"IL-37: a new anti-inflammatory cytokine of the IL-1 family","volume":"22","author":"Boraschi","year":"2011","journal-title":"Eur. Cytokine Netw."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.smim.2013.10.023","article-title":"The interleukin-1 receptor family","volume":"25","author":"Boraschi","year":"2013","journal-title":"Semin. Immunol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1080\/00325481.2019.1592400","article-title":"Pulmonary complications of influenza infection: a targeted narrative review","volume":"131","author":"Daoud","year":"2019","journal-title":"Postgrad. Med."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbscr.2016.11.005","article-title":"Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection","volume":"3","author":"Davis","year":"2017","journal-title":"Neurobiol. Sleep Circadian Rhythms"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.smim.2013.10.004","article-title":"Interleukin-37","volume":"25","author":"Dinarello","year":"2013","journal-title":"Semin. Immunol."},{"key":"ref9","first-page":"1","article-title":"Interleukin-1 family cytokines and mast cells: activation and inhibition","volume":"33","author":"Gallenga","year":"2019","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/s41467-017-00928-3","article-title":"Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice","volume":"8","author":"He","year":"2017","journal-title":"Nat Commun."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s10096-016-2833-3","article-title":"Influenza virus infections in patients with malignancies \u2013 characteristics and outcome of the season 2014\/15. A survey conducted by the infectious diseases working party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO)","volume":"36","author":"Hermann","year":"2017","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/sji.12326","article-title":"IL-37 expression is upregulated in patients with tuberculosis and induces macrophages towards an M2-like phenotype","volume":"82","author":"Huang","year":"2015","journal-title":"Scand. J. Immunol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3058640","DOI":"10.1155\/2018\/3058640","article-title":"Reviews of Interleukin-37: functions, receptors, and roles in diseases","volume":"2018","author":"Jia","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1006\/cyto.2002.0873","article-title":"Interleukin-1F7B (IL-1H4\/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production","volume":"18","author":"Kumar","year":"2002","journal-title":"Cytokine"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1016\/S0140-6736(16)31593-8","article-title":"Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/all.12566","article-title":"IL-37 requires IL-18Ralpha and SIGIRR\/IL-1R8 to diminish allergic airway inflammation in mice","volume":"70","author":"Lunding","year":"2015","journal-title":"Allergy"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1111\/all.13395","article-title":"IL-37 inhibits IL-4\/IL-13-induced CCL11 production and lung eosinophilia in murine allergic asthma","volume":"73","author":"Lv","year":"2018","journal-title":"Allergy"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3604","DOI":"10.4049\/jimmunol.1601907","article-title":"Macrophage-specific expression of IL-37 in hyperlipidemic mice attenuates","volume":"199","author":"McCurdy","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e1004462","DOI":"10.1371\/journal.ppat.1004462","article-title":"IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis","volume":"10","author":"Moretti","year":"2014","journal-title":"PLoS Pathog."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.cell.2013.02.027","article-title":"The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza","volume":"153","author":"Morita","year":"2013","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/ni.1944","article-title":"IL-37 is a fundamental inhibitor of innate immunity","volume":"11","author":"Nold","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/ni.3103","article-title":"IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction","volume":"16","author":"Nold-Petry","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1056\/NEJMoa0904252","article-title":"Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico","volume":"361","author":"Perez-Padilla","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.ccc.2013.06.003","article-title":"Influenza and endemic viral pneumonia","volume":"29","author":"Ramsey","year":"2013","journal-title":"Crit. Care Clin."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"R148","DOI":"10.1186\/cc8044","article-title":"Intensive care adult patients with severe respiratory failure caused by influenza a (H1N1)v in Spain","volume":"13","author":"Rello","year":"2009","journal-title":"Crit. Care"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1097\/CCM.0b013e3182416f23","article-title":"Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States","volume":"40","author":"Rice","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"fj201901265R","DOI":"10.1096\/fj.201901265R","article-title":"The annexin A1\/FPR2 signaling axis expands alveolar macrophages, limits viral replication, and attenuates pathogenesis in the murine influenza A virus infection model","volume":"33","author":"Schloer","year":"2019","journal-title":"FASEB J."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"7569","DOI":"10.1128\/JVI.00291-10","article-title":"Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice","volume":"84","author":"Tate","year":"2010","journal-title":"J. Virol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.4049\/jimmunol.1300047","article-title":"IL-37 ameliorates the inflammatory process in psoriasis by suppressing proinflammatory cytokine production","volume":"192","author":"Teng","year":"2014","journal-title":"J. Immunol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.3390\/ijms20153701","article-title":"Mast cells may regulate the anti-inflammatory activity of IL-37","volume":"20","author":"Theoharides","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3604","DOI":"10.4049\/jimmunol.1601907","article-title":"Macrophage-specific expression of IL-37 in hyperlipidemic mice attenuates atherosclerosis","volume":"199","author":"Toulmin","year":"2017","journal-title":"J. Immunol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"17577","DOI":"10.1038\/srep17577","article-title":"Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity","volume":"5","author":"Uematsu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"4711","DOI":"10.3892\/ol.2018.7982","article-title":"Interleukin-37: a crucial cytokine with multiple roles in disease and potentially clinical therapy","volume":"15","author":"Wang","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.4049\/jimmunol.1700397","article-title":"Aging impairs alveolar macrophage phagocytosis and increases influenza-induced mortality in mice","volume":"199","author":"Wong","year":"2017","journal-title":"J. Immunol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.cjca.2019.04.007","article-title":"Role of IL-37 in cardiovascular disease inflammation","volume":"35","author":"Yang","year":"2019","journal-title":"Can. J. Cardiol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"21775","DOI":"10.18632\/oncotarget.4887","article-title":"IL-37 restrains autoimmune diseases","volume":"6","author":"Ye","year":"2015","journal-title":"Oncotarget"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1073\/pnas.1619667114","article-title":"Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice","volume":"114","author":"Zeng","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"6922","DOI":"10.1038\/s41598-019-43364-7","article-title":"IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.02482\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T04:38:38Z","timestamp":1572410318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.02482\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":38,"alternative-id":["10.3389\/fmicb.2019.02482"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.02482","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,30]]},"article-number":"2482"}}