{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:26:54Z","timestamp":1780633614383,"version":"3.54.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY14C060005"],"award-info":[{"award-number":["LY14C060005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ17H190001"],"award-info":[{"award-number":["LQ17H190001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500109"],"award-info":[{"award-number":["31500109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["80215049"],"award-info":[{"award-number":["80215049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570013"],"award-info":[{"award-number":["81570013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.02732","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T05:42:33Z","timestamp":1574746953000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["OXA-830, a Novel Chromosomally Encoded Extended-Spectrum Class D \u03b2-Lactamase in Aeromonas simiae"],"prefix":"10.3389","volume":"10","author":[{"given":"Qianqian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangxiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changrui","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhewei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1128\/AAC.00570-08","article-title":"Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania.","volume":"52","author":"Adams-Haduch","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"B2","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41587-019-0036-z","article-title":"SignalP 5.0 improves signal peptide predictions using deep neural networks.","volume":"37","author":"Almagro Armenteros","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"B3","first-page":"185","article-title":"Analysis of 16S rRNA gene mutations in a subset of aeromonas strains and their impact in species delineation.","volume":"11","author":"Alperi","year":"2008","journal-title":"Int. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1093\/jac\/dkv181","article-title":"OXA-372, a novel carbapenem-hydrolysing class D \u03b2-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant.","volume":"70","author":"Antonelli","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"B5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.syapm.2015.02.005","article-title":"Aeromonas aquatica sp. nov., Aeromonas finlandiensis sp. nov. and Aeromonas lacus sp. nov. isolated from Finnish waters associated with cyanobacterial blooms.","volume":"38","author":"Beaz-Hidalgo","year":"2015","journal-title":"Syst. Appl. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1093\/jac\/dkx184","article-title":"OXA-427, a new plasmid-borne carbapenem-hydrolysing class D beta-lactamase in Enterobacteriaceae.","volume":"72","author":"Bogaerts","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"B7","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of beta-lactamases.","volume":"54","author":"Bush","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1128\/aac.39.6.1211","article-title":"A functional classification scheme for beta-lactamases and its correlation with molecular structure.","volume":"39","author":"Bush","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"B9","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ijfoodmicro.2012.09.008","article-title":"Phylogenetic diversity, antibiotic resistance and virulence traits of Aeromonas spp. from untreated waters for human consumption.","volume":"159","author":"Carvalho","year":"2012","journal-title":"Int. J. Food Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.jmii.2012.08.008","article-title":"Complexity of beta-lactamases among clinical aeromonas isolates and its clinical implications.","volume":"45","author":"Chen","year":"2012","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"B11","year":"2019","journal-title":"Performance Standards for Antimicrobial Susceptibility Testing, CLSI Supplement M100"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1093\/bioinformatics\/btp163","article-title":"Biopython: freely available Python tools for computational molecular biology and bioinformatics.","volume":"25","author":"Cock","year":"2009","journal-title":"Bioinformatics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1099\/00207713-36-3-473","article-title":"Proposal to recognize the family Aeromonadaceae fam. nov.","volume":"36","author":"Colwell","year":"1986","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1128\/AAC.01132-06","article-title":"Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii.","volume":"51","author":"Corvec","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1128\/aac.43.6.1362","article-title":"OXA-17, a further extended-spectrum variant of OXA-10 \u03b2-lactamase, isolated from Pseudomonas aeruginosa.","volume":"43","author":"Danel","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"B16","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1093\/bioinformatics\/btm009","article-title":"Identifying bacterial genes and endosymbiont DNA with Glimmer.","volume":"23","author":"Delcher","year":"2007","journal-title":"Bioinformatics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.chembiol.2009.04.010","article-title":"Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases.","volume":"16","author":"Docquier","year":"2009","journal-title":"Chem. Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1128\/AAC.00522-11","article-title":"OXA-198, an acquired carbapenem-hydrolyzing class D beta-lactamase from Pseudomonas aeruginosa.","volume":"55","author":"El Garch","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B19","year":"2019","journal-title":"Breakpoint Tables for Interpretation of MICs and Zone Diameters, Version 9.0."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1093\/bioinformatics\/btv271","article-title":"kSNP3.0: snp detection and phylogenetic analysis of genomes without genome alignment or reference genome.","volume":"31","author":"Gardner","year":"2015","journal-title":"Bioinformatics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1128\/aac.37.8.1637","article-title":"OXA-11, an extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from Pseudomonas aeruginosa.","volume":"37","author":"Hall","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"B22","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1099\/ijs.0.02786-0","article-title":"Aeromonas simiae sp. nov., isolated from monkey faeces.","volume":"54","author":"Harf-Monteil","year":"2004","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1128\/CMR.00039-09","article-title":"The genus Aeromonas: taxonomy, pathogenicity, and infection.","volume":"23","author":"Janda","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability.","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1101\/gr.215087.116","article-title":"Canu: scalable and accurate long-read assembly via adaptive k-mer weighting and repeat separation.","volume":"27","author":"Koren","year":"2017","journal-title":"Genome Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets.","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1021\/ar300327a","article-title":"Class D beta-lactamases: a reappraisal after five decades.","volume":"46","author":"Leonard","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1093\/bioinformatics\/btp105","article-title":"INTEGRALL: a database and search engine for integrons, integrases and gene cassettes.","volume":"25","author":"Moura","year":"2009","journal-title":"Bioinformatics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1128\/aac.42.12.3113","article-title":"Novel OXA-10-derived extended-spectrum \u03b2-lactamases selected in vivo or in vitro.","volume":"42","author":"Mugnier","year":"1998","journal-title":"Antimicrobial. Agents Chemother."},{"key":"B31","doi-asserted-by":"crossref","first-page":"865","DOI":"10.2174\/1381612805666230112185101","article-title":"OXA-type beta-lactamases.","volume":"5","author":"Naas","year":"1999","journal-title":"Curr. Pharm. Design"},{"key":"B32","article-title":"Crystal structure of the class D \u03b2-lactamase OXA-10.","volume":"7","author":"Paetzel","year":"2000","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1128\/aac.38.4.767","article-title":"Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important beta-lactamases.","volume":"38","author":"Payne","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1093\/bioinformatics\/btq588","article-title":"Interactive microbial genome visualization with GView.","volume":"26","author":"Petkau","year":"2010","journal-title":"Bioinformatics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1128\/AAC.01512-08","article-title":"Diversity, epidemiology, and genetics of class D beta-lactamases.","volume":"54","author":"Poirel","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1128\/AAC.50.4.1442-1448.2006","article-title":"Genetic structures at the origin of acquisition and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-58 in Acinetobacter baumannii.","volume":"50","author":"Poirel","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1128\/aac.38.9.2078","article-title":"Cloning and expression of a cloxacillin-hydrolyzing enzyme and a cephalosporinase from aeromonas sobria AER 14M in Escherichia coli: requirement for an E. coli chromosomal mutation for efficient expression of the class D enzyme.","volume":"38","author":"Rasmussen","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1099\/ijs.0.64351-0","article-title":"Updated phylogeny of the genus Aeromonas.","volume":"56","author":"Saavedra","year":"2006","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01260-17","article-title":"Dissemination and characteristics of a novel plasmid-encoded carbapenem-hydrolyzing class D beta-Lactamase, OXA-436, found in isolates from four patients at six different hospitals in denmark.","volume":"62","author":"Samuelsen","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"B40","doi-asserted-by":"publisher","first-page":"D32","DOI":"10.1093\/nar\/gkj014","article-title":"ISfinder: the reference centre for bacterial insertion sequences.","volume":"34","author":"Siguier","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"37292","DOI":"10.1074\/jbc.M111.280115","article-title":"Hydrolytic mechanism of OXA-58 enzyme, a carbapenem-hydrolyzing class D beta-lactamase from Acinetobacter baumannii.","volume":"286","author":"Verma","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B42","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/jac\/36.1.41","article-title":"Sequence analysis of two chromosomally mediated inducible \u03b2-lactamases from Aeromonas sobria, strain 163a, one a class D penicillinase, the other an AmpC cephalosporinase.","volume":"36","author":"Walsh","year":"1995","journal-title":"J. Antimicrob. Chemother."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1093\/jac\/dks261","article-title":"Identification of acquired antimicrobial resistance genes.","volume":"67","author":"Zankari","year":"2012","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.02732\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T10:02:02Z","timestamp":1695463322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.02732\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,26]]},"references-count":43,"alternative-id":["10.3389\/fmicb.2019.02732"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.02732","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,26]]},"article-number":"2732"}}