{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:30:51Z","timestamp":1769153451637,"version":"3.49.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST NSC 104-2321-B-002 -017"],"award-info":[{"award-number":["MOST NSC 104-2321-B-002 -017"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST NSC 103-2321-B-002 -059"],"award-info":[{"award-number":["MOST NSC 103-2321-B-002 -059"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.02942","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T23:30:06Z","timestamp":1579563006000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of Influenza A Virus Infection in Mouse Pulmonary Stem\/Progenitor Cells"],"prefix":"10.3389","volume":"10","author":[{"given":"Tai-Ling","family":"Chao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sing-Yi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pi-Han","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Tien","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thai-Yen","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sui-Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1006\/viro.2001.1107","article-title":"Functional analysis of the influenza A virus cRNA promoter and construction of an ambisense transcription system.","volume":"289","author":"Azzeh","year":"2001","journal-title":"Virology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1172\/JCI68782","article-title":"Type 2 alveolar cells are stem cells in adult lung.","volume":"123","author":"Barkauskas","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1159\/000356034","article-title":"Vascular endothelial growth factor in acute lung injury and acute respiratory distress syndrome.","volume":"87","author":"Barratt","year":"2014","journal-title":"Respiration"},{"key":"B4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1126\/science.aad7969","article-title":"Pulmonary neuroendocrine cells function as airway sensors to control lung immune response.","volume":"351","author":"Branchfield","year":"2016","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1080\/01926230701302558","article-title":"Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A\/PR\/8\/34 in C57BL\/6 mice.","volume":"35","author":"Buchweitz","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-102","article-title":"Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells.","volume":"10","author":"Chan","year":"2009","journal-title":"Respir. Res."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-135","article-title":"Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells.","volume":"6","author":"Chan","year":"2005","journal-title":"Respir. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"17629","DOI":"10.1074\/jbc.271.30.17629","article-title":"The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis.","volume":"271","author":"Clauss","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/nrmicro3367","article-title":"At the centre: influenza a virus ribonucleoproteins.","volume":"13","author":"Eisfeld","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors.","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.2353\/ajpath.2009.090339","article-title":"Spread of infection and lymphocyte depletion in mice depends on polymerase of influenza virus.","volume":"175","author":"Gabriel","year":"2009","journal-title":"Am. J. Pathol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"13917","DOI":"10.18632\/oncotarget.7285","article-title":"Acquisition of tumorigenic potential and enhancement of angiogenesis in pulmonary stem\/progenitor cells through Oct-4 hyperexpression.","volume":"7","author":"Gu","year":"2016","journal-title":"Oncotarget"},{"key":"B13","doi-asserted-by":"publisher","first-page":"422","DOI":"10.15252\/emmm.201506154","article-title":"OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia.","volume":"8","author":"Hirano","year":"2016","journal-title":"Embo Mol. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6108","DOI":"10.1073\/pnas.100133697","article-title":"A DNA transfection system for generation of influenza A virus from eight plasmids.","volume":"97","author":"Hoffmann","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B15","doi-asserted-by":"publisher","first-page":"6949","DOI":"10.1016\/j.vaccine.2015.08.044","article-title":"Sex differences in H7N9 influenza A virus pathogenesis.","volume":"33","author":"Hoffmann","year":"2015","journal-title":"Vaccine"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000462","article-title":"Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication.","volume":"5","author":"Jorba","year":"2009","journal-title":"PLoS Pathog."},{"key":"B17","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/nbt.1638","article-title":"Identification of influenza A nucleoprotein as an antiviral target.","volume":"28","author":"Kao","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.virusres.2013.04.008","article-title":"Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory viruses.","volume":"175","author":"Kebaabetswe","year":"2013","journal-title":"Virus Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"6427","DOI":"10.1128\/JVI.00341-312","article-title":"Oct4+ stem\/progenitor swine lung epithelial cells are targets for influenza virus replication.","volume":"86","author":"Khatri","year":"2012","journal-title":"J. Virol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.dci.2009.12.008","article-title":"Isolation and characterization of chicken lung mesenchymal stromal cells and their susceptibility to avian influenza virus.","volume":"34","author":"Khatri","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cell.2005.03.032","article-title":"Identification of bronchioalveolar stem cells in normal lung and lung cancer.","volume":"121","author":"Kim","year":"2005","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"S137","DOI":"10.1148\/radiographics.22.suppl-1.g02oc15s137","article-title":"Viral pneumonias in adults: radiologic and pathologic findings.","volume":"22","author":"Kim","year":"2002","journal-title":"Radiographics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"9880","DOI":"10.1128\/Jvi.00909-908","article-title":"NF-kappa B Signaling Differentially Regulates Influenza Virus RNA Synthesis.","volume":"82","author":"Kumar","year":"2008","journal-title":"J. Virol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.cell.2011.10.001","article-title":"Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection.","volume":"147","author":"Kumar","year":"2011","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation.","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"14177","DOI":"10.1074\/jbc.R700052200","article-title":"Molecular mechanisms of soluble cytokine receptor generation.","volume":"283","author":"Levine","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"9530","DOI":"10.1073\/pnas.0510232103","article-title":"Identification of pulmonary Oct-4+ stem\/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro.","volume":"103","author":"Ling","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5660","DOI":"10.1016\/j.biomaterials.2014.03.074","article-title":"Differentiation of lung stem\/progenitor cells into alveolar pneumocytes and induction of angiogenesis within a 3D gelatin - Microbubble scaffold.","volume":"35","author":"Ling","year":"2014","journal-title":"Biomaterials"},{"key":"B29","first-page":"97","article-title":"Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice.","volume":"12","author":"Lowder","year":"2006","journal-title":"Exerc. Immunol. Rev."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006851","article-title":"Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.","volume":"14","author":"Luo","year":"2018","journal-title":"PLoS Pathog."},{"key":"B31","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s10237-010-0285-288","article-title":"Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation.","volume":"10","author":"Maul","year":"2011","journal-title":"Biomech. Model. Mechanobiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1039\/c000442a","article-title":"Regulating microenvironmental stimuli for stem cells and cancer cells using microsystems.","volume":"2","author":"Park","year":"2010","journal-title":"Integr. Biol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005544","article-title":"Influenza virus infects epithelial stem\/progenitor cells of the distal lung: impact on fgfr2b-driven epithelial repair.","volume":"12","author":"Quantius","year":"2016","journal-title":"PLoS Pathog."},{"key":"B34","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1099\/vir.0.058438-58430","article-title":"Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model.","volume":"95","author":"Rosenberger","year":"2014","journal-title":"J. Gen. Virol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1089\/vim.2010.0118","article-title":"Responses of mouse airway epithelial cells and alveolar macrophages to virulent and avirulent strains of influenza a virus.","volume":"24","author":"Tate","year":"2011","journal-title":"Viral Immunol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-7-8","article-title":"Lung epithelial stem cells and their niches: Fgf10 takes center stage.","volume":"7","author":"Volckaert","year":"2014","journal-title":"Fibrogenesis Tissue Repair"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1099\/vir.0.043406-43400","article-title":"Permissive and restricted virus infection of murine embryonic stem cells.","volume":"93","author":"Wash","year":"2012","journal-title":"J. Gen. Virol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ni.3045","article-title":"Respiratory epithelial cells orchestrate pulmonary innate immunity.","volume":"16","author":"Whitsett","year":"2015","journal-title":"Nat. Immunol."},{"key":"B39","year":"2017","journal-title":"Influenza (Seasonal)."},{"key":"B40","doi-asserted-by":"publisher","first-page":"E4238","DOI":"10.1073\/pnas.1315068110","article-title":"Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus.","volume":"110","author":"York","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6844","DOI":"10.1128\/JVI.02200-2210","article-title":"Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses.","volume":"85","author":"Yu","year":"2011","journal-title":"J. Virol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3966","DOI":"10.1128\/JVI.03137-3115","article-title":"Host protein Moloney leukemia virus 10 (MOV10) acts as a restriction factor of influenza a virus by inhibiting the nuclear import of the viral nucleoprotein.","volume":"90","author":"Zhang","year":"2016","journal-title":"J. Virol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048451","article-title":"Regeneration of alveolar type I and II cells from Scgb1a1-expressing cells following severe pulmonary damage induced by bleomycin and influenza.","volume":"7","author":"Zheng","year":"2012","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"5822","DOI":"10.1128\/JVI.00015-15","article-title":"Phosphorylation controls the nuclear-cytoplasmic shuttling of influenza A virus nucleoprotein.","volume":"89","author":"Zheng","year":"2015","journal-title":"J. Virol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nature13903","article-title":"p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.","volume":"517","author":"Zuo","year":"2015","journal-title":"Nature"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.02942\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T23:30:11Z","timestamp":1579563011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.02942\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,21]]},"references-count":45,"alternative-id":["10.3389\/fmicb.2019.02942"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.02942","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,21]]},"article-number":"2942"}}