{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:53:27Z","timestamp":1791302007612,"version":"4.1.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2019.03150","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T05:14:08Z","timestamp":1579583648000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":86,"title":["The Antifungal Peptide MCh-AMP1 Derived From Matricaria chamomilla Inhibits Candida albicans Growth via Inducing ROS Generation and Altering Fungal Cell Membrane Permeability"],"prefix":"10.3389","volume":"10","author":[{"given":"Sima Sadat","family":"Seyedjavadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soghra","family":"Khani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Eslamifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila","family":"Ajdary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheleh","family":"Halabian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Zare-Zardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Ali","family":"Imani Fooladi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jafar","family":"Amani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Razzaghi-Abyaneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1159\/000104753","article-title":"The antifungal activity of RsAFP2, a plant defensin from Raphanus sativus, involves the induction of reactive oxygen species in Candida albicans.","volume":"13","author":"Aerts","year":"2007","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"B2","article-title":"Electron microscopy: principles and techniques for biologists","author":"Bozzola","year":"1999"},{"key":"B3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1574-6968.1990.tb04174.x","article-title":"An automated quantitative assay for fungal growth inhibition.","volume":"69","author":"Broekaert","year":"1990","journal-title":"FEMS Microbiol. Lett."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1098","article-title":"Antimicrobial peptides: pore formers or metabolic inhibitors inbacteria?","volume":"3","author":"Brogden","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1016\/j.biochi.2011.07.011","article-title":"Oxidative stress by antimicrobial peptide pleurocidin triggers apoptosis in Candida albicans.","volume":"93","author":"Cho","year":"2011","journal-title":"Biochimie"},{"key":"B6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4155\/fmc.13.189","article-title":"Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms.","volume":"6","author":"Delattin","year":"2014","journal-title":"Future Med. Chem."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nri1180","article-title":"Defensins: antimicrobial peptides of innate immunity.","volume":"3","author":"Ganz","year":"2003","journal-title":"Nat. rev. immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1742-4658.2005.05042.x","article-title":"Antifungal effects and mechanism of action of viscotoxin A3.","volume":"273","author":"Giudici","year":"2006","journal-title":"FEBS. J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"7286","DOI":"10.1074\/jbc.274.11.7286","article-title":"The cellular target of histatin 5 on Candida albicans is the energized mitochondrion.","volume":"274","author":"Helmerhorst","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/nbt1113","article-title":"High-throughput generation of small antibacterial peptides with improved activity.","volume":"23","author":"Hilpert","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1016\/j.peptides.2011.05.023","article-title":"Inhibitory effects and mechanisms of physiological conditions on the activity of enantiomeric forms of an \u03b1-helical antibacterial peptide against bacteria.","volume":"32","author":"Huang","year":"2011","journal-title":"Peptides"},{"key":"B12","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bbrc.2011.03.125","article-title":"Induction of yeast apoptosis by an antimicrobial peptide, Papiliocin.","volume":"408","author":"Hwang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1128\/CMR.00056-05","article-title":"Peptide antimicrobial agents.","volume":"19","author":"Jenssen","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2019.170195","article-title":"Effects of the antifungal peptide Skh-AMP1 derived from Satureja khuzistanica on cell membrane permeability, ROS production, and cell morphology of conidia and hyphae of Aspergillus fumigatus.","volume":"123","author":"Khani","year":"2020","journal-title":"Peptides"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1128\/EC.00250-13","article-title":"Cell wall-related bionumbers and bioestimates of Saccharomyces cerevisiae and Candida albicans.","volume":"13","author":"Klis","year":"2014","journal-title":"Eukaryot. Cell"},{"key":"B16","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.bbamem.2014.11.024","article-title":"Fungicidal mechanisms of the antimicrobial peptide Bac8c.","volume":"1848","author":"Lee","year":"2015","journal-title":"Biochim. Biophys. Acta. Biomembr."},{"key":"B17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.etap.2014.05.015","article-title":"Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway.","volume":"38","author":"Li","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.3892\/etm.2015.2838","article-title":"Antiproliferative effect and characterization of a novel antifungal peptide derived from human Chromogranin A.","author":"Li","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.peptides.2012.07.001","article-title":"Overview on the recent study of antimicrobial peptides: origins, functions, relative mechanisms and application.","volume":"37","author":"Li","year":"2012","journal-title":"Peptides"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086364","article-title":"Antimicrobial properties and membrane-active mechanism of a potential \u03b1-helical antimicrobial derived from cathelicidin PMAP-36.","volume":"9","author":"Lv","year":"2014","journal-title":"PloS one"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/srep27258","article-title":"Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida.","volume":"6","author":"Lyu","year":"2016","journal-title":"Sci. Rep."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00194","article-title":"Antimicrobial peptides: an emerging category of therapeutic agents.","volume":"6","author":"Mahlapuu","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"14942","DOI":"10.1074\/jbc.273.24.14942","article-title":"Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase.","volume":"273","author":"Mandala","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B24","first-page":"337","article-title":"Antifungal peptides: exploiting non-lytic mechanisms and cell penetration properties","author":"Marcos","year":"2012","journal-title":"Small wonders: peptides for disease control"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1016\/j.peptides.2011.06.003","article-title":"Antifungal activity of novel synthetic peptides by accumulation of reactive oxygen species (ROS) and disruption of cell wall against Candida albicans.","volume":"32","author":"Maurya","year":"2011","journal-title":"Peptides"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-010-9847-3","article-title":"The antifungal activity of PvD1, a plant seed defensin of Phaseolus vulgaris, involves plasma membrane permeabilization, inhibition of medium acidification and induction of reactive oxygen species in yeast cells.","volume":"62","author":"Mello","year":"2011","journal-title":"Curr. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1126\/science.3961484","article-title":"Solid phase synthesis.","volume":"232","author":"Merrifield","year":"1986","journal-title":"Science"},{"key":"B28","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.bbrc.2010.02.138","article-title":"Melittin induces apoptotic features in Candida albicans.","volume":"394","author":"Park","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.toxicon.2009.07.040","article-title":"Two novel antimicrobial peptides from centipede venoms.","volume":"55","author":"Peng","year":"2010","journal-title":"Toxicon"},{"key":"B30","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.coph.2013.08.008","article-title":"Antifungal therapy with an emphasis on biofilms.","volume":"13","author":"Pierce","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"B31","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1128\/JCM.35.9.2320-2324.1997","article-title":"Rapid flow cytometric susceptibility testing of Candida albicans.","volume":"35","author":"Ramani","year":"1997","journal-title":"J. Clin. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01351","article-title":"Candida infections and therapeutic strategies: mechanisms of action for traditional and alternative agents.","volume":"9","author":"Santos","year":"2018","journal-title":"Front. Microbial."},{"key":"B33","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/cbdd.13500","article-title":"Isolation, functional characterization and biological properties of MCh\u2212AMP 1, a novel antifungal peptide from Matricaria chamomilla L.","volume":"93","author":"Seyedjavadi","year":"2019","journal-title":"Chem. Biol. Drug Des."},{"key":"B34","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3390\/ph8040711","article-title":"Antimicrobial peptides from plants.","volume":"8","author":"Tam","year":"2015","journal-title":"Pharmaceuticals"},{"key":"B35","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.foodcont.2014.01.010","article-title":"Citral inhibits mycelial growth of Penicillium italicum by a membrane damage mechanism.","volume":"41","author":"Tao","year":"2014","journal-title":"Food Control"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2011.12.005","article-title":"Role of lipids in the interaction of antimicrobial peptides with membranes.","volume":"51","author":"Teixeira","year":"2012","journal-title":"Prog. Lipid. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"37513","DOI":"10.1074\/jbc.M110.134882","article-title":"Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall-dependent process.","volume":"285","author":"van der Weerden","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1016\/j.bbamem.2015.07.008","article-title":"Antimicrobial peptide protonectin disturbs the membrane integrity and induces ROS production in yeast cells.","volume":"1848","author":"Wang","year":"2015","journal-title":"Biochim. Biophys. Acta. Biomembr"},{"key":"B39","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/psc.2835","article-title":"Antifungal effect and action mechanism of antimicrobial peptide polybia\u2212CP.","volume":"22","author":"Wang","year":"2016","journal-title":"J. Pept. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms.","author":"Zasloff","year":"2002","journal-title":"Nature"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.03150\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T05:14:10Z","timestamp":1579583650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2019.03150\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,21]]},"references-count":40,"alternative-id":["10.3389\/fmicb.2019.03150"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2019.03150","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,21]]},"article-number":"3150"}}