{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:21:17Z","timestamp":1790882477730,"version":"4.1.0"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T00:00:00Z","timestamp":1580774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2020.00067","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T05:13:31Z","timestamp":1580793211000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Resistome in Lake Bolonha, Brazilian Amazon: Identification of Genes Related to Resistance to Broad-Spectrum Antibiotics"],"prefix":"10.3389","volume":"11","author":[{"given":"Jorianne","family":"Alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackeline","family":"Mateus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Gra\u00e7as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rommel","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Seldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Henriques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Folador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00426","article-title":"Seawater is a reservoir of multi-resistant Escherichia coli, including strains hosting plasmid-mediated quinolones resistance and extended-spectrum beta-lactamases genes.","volume":"5","author":"Alves","year":"2014","journal-title":"Front. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1590\/S1678-91992005000400002","article-title":"Clostridial toxins: potent poisons, potent medicines.","volume":"11","author":"Baldassi","year":"2005","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/ajcp\/45.4_ts.493","article-title":"Antibiotic susceptibility testing by a standardized single disc method.","volume":"45","author":"Bauer","year":"1966","journal-title":"Am. J. Clin. Pathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1006\/anae.1997.0101","article-title":"Distribution of Clostridium perfringens in polluted lake environments.","volume":"3","author":"Bezirtzoglou","year":"1997","journal-title":"Anaerobe"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4172\/2325-9590.1000134","article-title":"Analysis of virulence associated and antibiotic resistance genes of microbes in subclinical mastitis affected cattle milk by pyrosequencing approach.","volume":"3","author":"Bhatt","year":"2014","journal-title":"J. Vet. Sci. Med. Diagnosis"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025239","article-title":"\u03b2-lactamases: a focus on current challenges.","volume":"7","author":"Bonomo","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1128\/CMR.14.4.933","article-title":"Extended-spectrum \u03b2-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.","volume":"14","author":"Bradford","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"B9","year":"2005","journal-title":"Minist\u00e9rio do Desenvolvimento Urbano e Meio Ambiente. Conselho Nacional do Meio Ambiente \u2013 CONAMA. Resolu\u00e7\u00e3o n\u00b0 357, de 17 de mar\u00e7o de 2005."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2010.05872.x","article-title":"The coming of age of antibiotics: discovery and therapeutic value.","volume":"1213","author":"Bush","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of beta-lactamases.","volume":"54","author":"Bush","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01283","article-title":"Tetracycline and sulfonamide antibiotic resistance genes in soils from nebraska organic farming operations.","volume":"9","author":"Cadena","year":"2018","journal-title":"Front. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193957","article-title":"Newly identified colistin resistance genes, mcr-4 and mcr-5, from upper and lower alimentary tract of pigs and poultry in China.","volume":"13","author":"Chen","year":"2018","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1128\/MMBR.65.2.232","article-title":"Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance.","volume":"65","author":"Chopra","year":"2001","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B15","year":"2017","journal-title":"Performance Standard for Antimicrobial Susceptibility Testing - Document Approved Standard M100-S27."},{"key":"B16","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3201\/eid1402.070350","article-title":"Dissemination of clonally related Escherichia coli strains expressing ESBL CTX-M-15.","volume":"14","author":"Coque","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1099\/mic.0.000613","article-title":"Stress responses, outer membrane permeability control and antimicrobial resistance in Enterobacteriaceae.","volume":"164","author":"Dam","year":"2018","journal-title":"Microbiology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.ijmm.2013.02.008","article-title":"CTX-M-type \u03b2-lactamases: a successful story of antibiotic resistance.","volume":"303","author":"D\u2019Andrea","year":"2013","journal-title":"Int. J. Med. Microbiol."},{"key":"B19","article-title":"Uma contribui\u00e7\u00e3o \u00e0 geografi a dos recursos h\u00eddricos","author":"de Lima","year":"2016","journal-title":"Brasil : Uma Vis\u00e3o Geogr\u00e1fica e Ambiental no In\u00edcio do S\u00e9culo XXI"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1038\/ismej.2011.197","article-title":"Structure, fluctuation and magnitude of a natural grassland soil metagenome.","volume":"6","author":"Delmont","year":"2012","journal-title":"ISME J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jgar.2018.07.013","article-title":"Carbapenem resistance in bacteria isolated from soil and water environments in Algeria.","volume":"15","author":"Djenadi","year":"2018","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"B22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1021\/np400466j","article-title":"Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis.","volume":"77","author":"Farnaes","year":"2014","journal-title":"J. Nat. Prod."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00364","article-title":"Extended spectrum gram-negative bacteria recovered from an Amazonian Lake near the city of Bel\u00e9m, Brazil.","volume":"10","author":"Freitas","year":"2019","journal-title":"Front. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.femsec.2005.02.005","article-title":"Effects of the inoculant strain Pseudomonas putida KT2442 (pNF142) and of naphthalene contamination on the soil bacterial community.","volume":"54","author":"Gomes","year":"2005","journal-title":"FEMS Microbiol. Ecol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1023\/B:EMAS.0000031719.83065.68","article-title":"Temperature correction coefficients of electrical conductivity and of density measurements for saline groundwater.","volume":"96","author":"Hayashi","year":"2004","journal-title":"Environ. Monit. Assess."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1128\/aem.63.8.3233-3241.1997","article-title":"Analysis of actinomycete communities by specific amplification of genes encoding 16S rRNA and Gel-electrophoretic separation in denaturing gradients.","volume":"63","author":"Heuer","year":"1997","journal-title":"Appl. Environ. Microbiol."},{"key":"B27","first-page":"177","article-title":"Bacterial community profiling using DGGE or TGGE analysis","author":"Heuer","year":"2001","journal-title":"Environmental Molecular Microbiology: Protocols and Applications"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-119","article-title":"Prodigal: prokaryotic gene recognition and translation initiation site identification.","volume":"11","author":"Hyatt","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"B29","first-page":"2327","article-title":"Molecular detection of metallo-\u03b2-lactamase and putative virulence genes in environmental isolates of Pseudomonas species.","volume":"23","author":"Igbinosa","year":"2014","journal-title":"Pol. J. Environ. Stud."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1004","article-title":"CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database.","volume":"45","author":"Jia","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.scitotenv.2013.04.038","article-title":"Prevalence of antibiotic resistance genes and their relationship with antibiotics in the Huangpu River and the drinking water sources, Shanghai, China.","volume":"45","author":"Jiang","year":"2013","journal-title":"Sci. Total Environ."},{"key":"B32","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.tim.2017.09.005","article-title":"Antibiotic-resistance genes in waste water.","volume":"26","author":"Karkman","year":"2018","journal-title":"Trends Microbiol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00586","article-title":"Antibiotic resistance patterns of Pseudomonas spp. isolated from the river Danube.","volume":"7","author":"Kittinger","year":"2016","journal-title":"Front. Microbiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.scitotenv.2004.01.015","article-title":"Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions.","volume":"328","author":"Kolpin","year":"2004","journal-title":"Sci. Total Environ"},{"key":"B35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.mimet.2004.01.002","article-title":"Significance test for comparing complex microbial community fingerprints using pairwise similarity measures.","volume":"57","author":"Kropf","year":"2004","journal-title":"J. Microbiol. Methods"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01826","article-title":"The microbiota of recreational freshwaters and the implications for environmental and public health.","volume":"7","author":"Lee","year":"2016","journal-title":"Front. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1751-7915.2008.00061","article-title":"Indole and 7-hydroxyindole diminish Pseudomonas aeruginosa virulence.","volume":"1","author":"Lee","year":"2009","journal-title":"Microb. Biotechnol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"30191","DOI":"10.1007\/s11356-018-2913-2","article-title":"Dynamic transport of antibiotics and antibiotic resistance genes under different treatment processes in a typical pharmaceutical wastewater treatment plant.","volume":"25","author":"Li","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"8201","DOI":"10.1128\/AEM.71.12.8201","article-title":"Distribution of typical freshwater bacterial groups is associated with pH, temperature, and lake water retention time.","volume":"71","author":"Lindstr\u00f6m","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/nar\/gkt1178","article-title":"The carbohydrate-active enzymes database (CAZy) in 2013.","volume":"42","author":"Lombard","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1139\/W07-104","article-title":"Diversity of tet resistance genes in tetracycline-resistant bacteria isolated from a swine lagoon with low antibiotic impact.","volume":"53","author":"Macauley","year":"2007","journal-title":"Can. J. Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"291","DOI":"10.4103\/0974-777X.68538","article-title":"Multidrug resistant Acinetobacter.","volume":"2","author":"Manchanda","year":"2010","journal-title":"J. Glob. Infect. Dis."},{"key":"B43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.5935\/1676-2444.20150028","article-title":"Molecular characterization of Enterobacteriaceae resistant to carbapenem antimicrobials.","volume":"51","author":"Marques","year":"2015","journal-title":"J. Bras. Patol. Med. Lab."},{"key":"B44","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/978-94-011-0351-0_20","article-title":"Bacterial community fingerprinting of amplified 16S and 16-23S ribosomal DNA gene sequences and restriction endonuclease analysis (ARDRA).","volume":"4","author":"Massol-Deya","year":"1995","journal-title":"Mol. Microb. Ecol. Man."},{"key":"B45","doi-asserted-by":"publisher","first-page":"432","DOI":"10.2134\/jeq2015.06.0317","article-title":"Culture-based methods for detection of antibiotic resistance in agroecosystems: advantages, challenges, and gaps in knowledge.","volume":"45","author":"McLain","year":"2016","journal-title":"J. Environ. Qual."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-386","article-title":"The metagenomics RAST server \u2013 a public resource for the automatic phylogenetic and functional analysis of metagenomes.","volume":"9","author":"Meyer","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"B47","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/978-3-319-78723-7_36","article-title":"Improving metagenomic assemblies through data partitioning: a GC content approach","author":"Miranda","year":"2018","journal-title":"Proceedings of the Bioinformatics and Biomedical Engineering, 6th International Work-Conference, IWBBIO 2018"},{"key":"B48","first-page":"2","article-title":"Molecular detection of metallo-\u03b2-lactamase genes, blaIMP\u20131, blaVIM\u20132.","volume":"7","author":"Moosavian","year":"2015","journal-title":"Iran. J. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.jgar.2014.10.001","article-title":"bla\n            TEM and vanA as indicator genes of antibiotic resistance contamination in a hospital-urban wastewater treatment plant system.","volume":"2","author":"Narciso-Da-Rocha","year":"2014","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"B50","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/j.1469-0691.2012.03795.x","article-title":"Carbapenemase-producing Enterobacteriaceae: a call for action !","volume":"18","author":"Nordmann","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"B51","doi-asserted-by":"publisher","first-page":"5636","DOI":"10.1128\/jb.178.19.5636-5643.1996","article-title":"Sequence heterogeneities of genes enconding 16S rRNA in Paenibacillus polymyxa detected by temperature gradient gel electrophoresis.","volume":"178","author":"N\u00fcbel","year":"1996","journal-title":"J. Bacteriol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15071365","article-title":"Characterization of bacterial communities and their antibiotic resistance profiles in wastewaters obtained from pharmaceutical facilities in lagos and Ogun states, Nigeria.","volume":"15","author":"Obayiuwana","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B53","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/935842","article-title":"The Occurrence of blaCTX\u2013M, blaSHV, and blaTEM genes in extended-spectrum \u03b2 -lactamase-positive strains of Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis in Poland.","volume":"2014","author":"Ojdana","year":"2014","journal-title":"Int. J. Antibiot."},{"key":"B54","doi-asserted-by":"publisher","first-page":"10818","DOI":"10.1007\/s11356-016-6221-4","article-title":"Prevalence of plasmid-mediated multidrug resistance determinants in fluoroquinolone-resistant bacteria isolated from sewage and surface water.","volume":"23","author":"Osi\u00f1ska","year":"","journal-title":"Environ. Sci. Pollut. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.scitotenv.2016.10.203","article-title":"The prevalence and characterization of antibiotic-resistant and virulent Escherichia coli strains in the municipal wastewater system and their environmental fate.","volume":"577","author":"Osi\u00f1ska","year":"","journal-title":"Sci. Total Environ."},{"key":"B56","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/bs.ampbs.2017.02.001","article-title":"Metal resistance and its association with antibiotic resistance.","volume":"70","author":"Pal","year":"2017","journal-title":"Adv. Microb. Physiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1128\/AEM.67.7.3325-3327","article-title":"Incidence of Klebsiella species in surface waters and their expression of virulence factors.","volume":"67","author":"Podschun","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1093\/jac\/dks196","article-title":"Bacterial stress responses as determinants of antimicrobial resistance.","volume":"67","author":"Poole","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"B59","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2174\/1874285801711010203","article-title":"Genetic investigation of beta-lactam associated antibiotic resistance among strains isolated from water sources.","volume":"11","author":"Ranjbar","year":"2017","journal-title":"Open Microbiol. J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s10482-016-0665-x","article-title":"High mycobacterial diversity in recreational lakes.","volume":"109","author":"Roguet","year":"2016","journal-title":"Antonie van Leeuwenhoek"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01650","article-title":"Resistance to antibiotics, biocides, preservatives and metals in bacteria isolated from seafoods: co-selection of strains resistant or tolerant to different classes of compounds.","volume":"8","author":"Romero","year":"2017","journal-title":"Front. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/ismej.2012.162","article-title":"In situ substrate preferences of abundant bacterioplankton populations in a prealpine freshwater lake.","volume":"7","author":"Salcher","year":"2013","journal-title":"ISME J."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01183-14","article-title":"The draft genome sequence of Sphingomonas sp. strain FukuSWIS1, obtained from acidic Lake Grosse Fuchskuhle, indicates photoheterotrophy and a potential for humic matter degradation.","volume":"2","author":"Salka","year":"2014","journal-title":"Genome Announc."},{"key":"B64","first-page":"1707","article-title":"Novel bioactive actinomycetes from a niche biotope, Loktak Lake, in Manipur, India.","volume":"4","author":"Sanasam","year":"2011","journal-title":"J. Pharm. Res."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01450-16","article-title":"Metagenome sequencing of prokaryotic microbiota collected from rivers in the upper Amazon Basin.","volume":"5","author":"Santos-J\u00fanior","year":"2017","journal-title":"Genome Announc."},{"key":"B66","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S1995-7645(11)60046-1","article-title":"bla\n            CTX\u2013M, blaTEM, and blaSHV in Enterobacteriaceae from North-Indian tertiary hospital: high occurrence of combination genes.","volume":"4","author":"Shahid","year":"2011","journal-title":"Asian Pac. J. Trop. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.7860\/JCDR\/2013\/7759.3747","article-title":"bla\n            KPC gene detection in clinical isolates of carbapenem resistant Enterobacteriaceae in a tertiary care hospital.","volume":"7","author":"Shanmugam","year":"2013","journal-title":"J. Clin. Diagn. Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"7372","DOI":"10.1128\/AEM.70.12.7372-7377.2004","article-title":"Quantification of tetracycline resistance genes in feedlot lagoons by real-time PCR.","volume":"70","author":"Smith","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.emcon.2015.07.001","article-title":"Occurrence, sources and fate of pharmaceuticals and personal care products in the groundwater: a review.","volume":"1","author":"Sui","year":"2015","journal-title":"Emerg. Contam."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/AAC.02569-16","article-title":"Occurrence of blaKPC\u20132, blaCTX\u2013M, and mcr-1 in Enterobacteriaceae from well water in rural China.","volume":"61","author":"Sun","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"B71","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.1128\/AEM.00359-12","article-title":"Resistance to broad-spectrum antibiotics in aquatic systems : anthropogenic activities modulate the dissemination of blaCTX\u2013M -Like Genes.","volume":"78","author":"Tac\u00e3o","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1089\/mdr.2015.0072","article-title":"Low Prevalence of Carbapenem-Resistant Bacteria in River Water.","volume":"21","author":"Tac\u00e3o","year":"2015","journal-title":"Microb. Drug Resist."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.3201\/eid2308.170162","article-title":"mcr-1 and blaKPC\u20133 in Escherichia coli sequence type 744 after meropenem and colistin therapy, Portugal.","volume":"23","author":"Tac\u00e3o","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"B74","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.marpolbul.2016.06.086","article-title":"Antibiotic and metal resistance in a ST395 Pseudomonas aeruginosa environmental isolate: a genomics approach.","volume":"110","author":"Teixeira","year":"2016","journal-title":"Mar. Pollut. Bull."},{"key":"B75","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00467-009-1431-3","article-title":"Risk factors in community-acquired urinary tract infections caused by ESBL-producing bacteria in children.","volume":"25","author":"Topaloglu","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1128\/genomeA.01440-16","article-title":"Metagenomics analysis of microorganisms in freshwater lakes of the Amazon Basin.","volume":"4","author":"Toyama","year":"2016","journal-title":"Genome Announc."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1007\/s11356-012-1099-2","article-title":"Seasonal variation of pharmaceutically active compounds in surface (Tagus River) and tap water (Central Spain).","volume":"20","author":"Valc\u00e1rcel","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.scitotenv.2012.03.046","article-title":"Diversity and antibiotic resistance in Pseudomonas spp. from drinking water.","volume":"426","author":"Vaz-Moreira","year":"2012","journal-title":"Sci. Total Environ."},{"key":"B79","year":"2014","journal-title":"Antimicrobial Resistance: Global Report on Surveillance."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2.4.1","DOI":"10.1002\/0471142727.mb0204s56","article-title":"Preparation of genomic DNA from bacteria.","volume":"56","author":"Wilson","year":"2001","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"4207","DOI":"10.1021\/jo400236f.Overcoming","article-title":"Overcoming resistance to \u03b2-lactam antibiotics.","volume":"78","author":"Worthington","year":"2014","journal-title":"J. Org. Chem."},{"key":"B82","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.mib.2010.08.005","article-title":"Antibiotic resistance in the environment: a link to the clinic?","volume":"13","author":"Wright","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156383","article-title":"Prevalence and fate of carbapenemase genes in a wastewater treatment plant in northern China.","volume":"11","author":"Yang","year":"2016","journal-title":"PLoS One"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3892\/etm.2017.5485","article-title":"Mechanism for carbapenem resistance of clinical Enterobacteriaceae isolates.","volume":"15","author":"Ye","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B85","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1128\/genomeA.01683-16","article-title":"Complete genome sequence of carbendazim-degrading Mycobacterium sp. Strain djl-10.","volume":"5","author":"Zhang","year":"2017","journal-title":"Genome Announc."},{"key":"B86","article-title":"Evaluation of a new detection and quantification method of total coliforms and Escherichia coli in water.","volume":"2","author":"Zhurbenko","year":"2017","journal-title":"Enliven Microb. Microb. Tech"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-018-0912-0","article-title":"Bioprospection of actinobacteria derived from freshwater sediments for their potential to produce antimicrobial compounds.","volume":"17","author":"Zothan","year":"2018","journal-title":"Microb. Cell Fact."},{"key":"B88","first-page":"136","article-title":"Molecular characterization of actinomycetes isolated from Tuichang river and their biosynthetic potential.","volume":"15","author":"Zothan","year":"2015","journal-title":"Sci. Vis."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.00067\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T05:13:41Z","timestamp":1580793221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.00067\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,4]]},"references-count":88,"alternative-id":["10.3389\/fmicb.2020.00067"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.00067","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,4]]},"article-number":"67"}}