{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:18:06Z","timestamp":1787167086654,"version":"build-2736575974"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2020.01504","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T01:28:56Z","timestamp":1594690136000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Verbascoside Protects Mice From Clostridial Gas Gangrene by Inhibiting the Activity of Alpha Toxin and Perfringolysin O"],"prefix":"10.3389","volume":"11","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lining","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1046\/j.1432-1327.2000.01588.x","article-title":"Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.","volume":"267","author":"Alape-Giron","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1093\/infdis\/jiu101","article-title":"Opioid analgesics stop the development of clostridial gas gangrene.","volume":"210","author":"Anjana","year":"2014","journal-title":"J. Infect. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1365-2958.1995.tb02234.x","article-title":"Virulence studies on chromosomal alpha-toxin and theta-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of alpha-toxin in Clostridium perfringens-mediated gas gangrene.","volume":"15","author":"Awad","year":"1995","journal-title":"Mol. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01613","article-title":"Prevalence of antimicrobial resistance and virulence gene elements of Salmonella serovars from ready-to-eat (RTE) shrimps.","volume":"10","author":"Beshiru","year":"2019","journal-title":"Front. Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1128\/iai.64.1.358-362.1996","article-title":"Phospholipase C and perfringolysin O from Clostridium perfringens upregulate endothelial cell-leukocyte adherence molecule 1 and intercellular leukocyte adherence molecule 1 expression and induce interleukin-8 synthesis in cultured human umbilical vein endothelial cells.","volume":"64","author":"Bryant","year":"1996","journal-title":"Infect. Immun."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-011-0155-3","article-title":"Management of gas gangrene in Wenchuan earthquake victims.","volume":"31","author":"Chen","year":"2011","journal-title":"J. Huazhong Univ. Sci. Technol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4013","article-title":"Comparative pharmacokinetics of acteoside from total glycoside extracted from leaves of Rehmannia and Dihuangye total glycoside capsule in normal and diabetic nephropathy rats.","volume":"31","author":"Dai","year":"2017","journal-title":"Biomed. Chromatogr."},{"key":"B8","first-page":"521","article-title":"Teratogenic effect of verbascoside, main constituent of Lippia citriodora leaves, in mice.","volume":"15","author":"Etemad","year":"2016","journal-title":"Iran. J. Pharm. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4408","DOI":"10.1002\/jssc.201800545","article-title":"Simultaneous determination of savaside A, acteoside, and isoacteoside in rat plasma by UHPLC-MS\/MS: comparative pharmacokinetic and bioavailability characteristics of Monochasma savatieri via different routes of administration.","volume":"41","author":"Feng","year":"2018","journal-title":"J. Separ. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1099\/00222615-8-2-251","article-title":"The production of neuraminidase by food poisoning strains of Clostridium welchii (C. perfringens).","volume":"8","author":"Fraser","year":"1975","journal-title":"J. Med. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.toxicon.2017.12.043","article-title":"Combined therapy with gas gangrene antitoxin and recombinant human soluble thrombomodulin for Clostridium perfringens sepsis in a rat model.","volume":"141","author":"Hifumi","year":"2018","journal-title":"Toxicon"},{"key":"B12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/978-94-017-8881-6_5","article-title":"Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysins.","volume":"80","author":"Johnson","year":"2014","journal-title":"Sub Cell. Biochem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ejphar.2011.02.022","article-title":"Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation.","volume":"658","author":"Kostyuk","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"B14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1128\/MMBR.00062-12","article-title":"Toxin plasmids of Clostridium perfringens.","volume":"77","author":"Li","year":"2013","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.fitote.2016.11.012","article-title":"Inhibition of listeriolysin O oligomerization by lutein prevents Listeria monocytogenes infection.","volume":"116","author":"Liu","year":"2017","journal-title":"Fitoterapia"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00473-18","article-title":"Concurrent host-pathogen transcriptional responses in a Clostridium perfringens murine myonecrosis infection.","volume":"9","author":"Low","year":"2018","journal-title":"mBio"},{"key":"B17","doi-asserted-by":"publisher","first-page":"5268","DOI":"10.3390\/toxins7124880","article-title":"Membrane-binding mechanism of clostridium perfringens alpha-toxin.","volume":"7","author":"Masataka","year":"2015","journal-title":"Toxins"},{"key":"B18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00210-009-0400-5","article-title":"Effects of verbascoside biotechnologically produced by Syringa vulgaris plant cell cultures in a rodent model of colitis.","volume":"380","author":"Mazzon","year":"2009","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"841","DOI":"10.20506\/rst.32.2.2212","article-title":"Antibiotic resistance of Clostridium perfringens isolates from broiler chickens in Egypt.","volume":"32","author":"Osman","year":"2013","journal-title":"Rev Sci Tech Oie."},{"key":"B20","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00203-010-0605-5","article-title":"Phenotypic and genotypic characterization of tetracycline and minocycline resistance in Clostridium perfringens.","volume":"192","author":"Park","year":"2010","journal-title":"Arch. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ijscr.2018.06.028","article-title":"Successful treatment of hepatic gas gangrene by open drainage: a case report and review of the Japanese literature.","volume":"49","author":"Ryohei","year":"2018","journal-title":"Int. J. Surg. Case Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1177\/003591577606900504","article-title":"Hyperbaric oxygen therapy in anaerobic infections: gas gangrene.","volume":"69","author":"Slack","year":"1976","journal-title":"Proc. R. Soc. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1111\/jcmm.13179","article-title":"Epigallocatechin gallate inhibits Streptococcus pneumoniae virulence by simultaneously targeting pneumolysin and sortase A.","volume":"21","author":"Song","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1002\/ptr.3173","article-title":"Antiinflammatory effects in THP-1 cells treated with verbascoside.","volume":"24","author":"Speranza","year":"2010","journal-title":"Phytother. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"6697","DOI":"10.1007\/s00253-017-8417-z","article-title":"Lysionotin attenuates Staphylococcus aureus pathogenicity by inhibiting alpha-toxin expression.","volume":"101","author":"Teng","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1099\/mic.0.28248-0","article-title":"Gas gangrene: an open and closed case.","volume":"151","author":"Titball","year":"2005","journal-title":"Microbiology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.vetmic.2015.02.013","article-title":"Animal models to study the pathogenesis of human and animal Clostridium perfringens infections.","volume":"179","author":"Uzal","year":"2015","journal-title":"Vet. Microbiol."},{"key":"B28","first-page":"343","article-title":"Clostridium perfringens septicaemia with massive intravascular haemolysis: a case report and review of the literature.","volume":"68","author":"van Bunderen","year":"2010","journal-title":"Netherlands J. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.3390\/toxins7051702","article-title":"Perfringolysin O: the underrated Clostridium perfringens toxin?","volume":"7","author":"Verherstraeten","year":"2015","journal-title":"Toxins"},{"key":"B30","doi-asserted-by":"publisher","first-page":"7068","DOI":"10.3390\/molecules16087068","article-title":"Activity and stability studies of verbascoside, a novel antioxidant, in dermo-cosmetic and pharmaceutical topical formulations.","volume":"16","author":"Vertuani","year":"2011","journal-title":"Molecules"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00009","article-title":"Phloretin attenuates listeria monocytogenes virulence both in vitro and in vivo by simultaneously targeting listeriolysin O and sortase A.","volume":"7","author":"Wang","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1093\/infdis\/jiu520","article-title":"Fisetin inhibits Listeria monocytogenes virulence by interfering with the oligomerization of listeriolysin O.","volume":"211","author":"Wang","year":"2015","journal-title":"J. Infect. Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"974","DOI":"10.3201\/eid1606.091523","article-title":"Causes of infection after earthquake, China, 2008.","volume":"16","author":"Wang","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1124\/mol.115.100610","article-title":"Verbascoside alleviates pneumococcal pneumonia by reducing pneumolysin oligomers.","volume":"89","author":"Zhao","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00574","article-title":"Curcumin promotes the clearance of listeria monocytogenes both in vitro and in vivo by reducing Listeriolysin O Oligomers.","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Immun."},{"key":"B36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neulet.2016.01.042","article-title":"Central anti-fatigue activity of verbascoside.","volume":"616","author":"Zhu","year":"2016","journal-title":"Neurosci. Lett."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01504\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T01:29:00Z","timestamp":1594690140000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01504\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,14]]},"references-count":36,"alternative-id":["10.3389\/fmicb.2020.01504"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.01504","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,14]]},"article-number":"1504"}}