{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:44:22Z","timestamp":1790502262737,"version":"4.1.0"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2020.01546","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T07:32:58Z","timestamp":1594711978000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["T-Bet Controls Susceptibility of Mice to Coxiella burnetii Infection"],"prefix":"10.3389","volume":"11","author":[{"given":"Soraya","family":"Mezouar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Lepidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Omar Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Gorvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Mege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassina","family":"Bechah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S189","DOI":"10.1086\/429994","article-title":"Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis.","volume":"41","author":"Algood","year":"2005","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.1128\/iai.71.8.4717-4723.2003","article-title":"SCID mouse model for lethal Q fever.","volume":"71","author":"Andoh","year":"2003","journal-title":"Infect. Immun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1128\/IAI.01767-06","article-title":"T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice.","volume":"75","author":"Andoh","year":"2007","journal-title":"Infect. Immun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1128\/iai.61.7.2872-2878.1993","article-title":"Endogenous gamma interferon is essential in granuloma formation induced by glycolipid-containing mycolic acid in mice.","volume":"61","author":"Asano","year":"1993","journal-title":"Infect. Immun."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008547","article-title":"Adipose tissue serves as a reservoir for recrudescent Rickettsia prowazekii infection in a mouse model.","volume":"5","author":"Bechah","year":"2010","journal-title":"PLoS One"},{"key":"B6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cimid.2016.11.009","article-title":"Transmission of Coxiella burnetii to cage mates using murine animal model.","volume":"50","author":"Bechah","year":"2017","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097503","article-title":"Persistence of Coxiella burnetii, the agent of Q fever, in murine adipose tissue.","volume":"9","author":"Bechah","year":"2014","journal-title":"PLoS One"},{"key":"B8","first-page":"6078","article-title":"Subversion of monocyte functions by Coxiella burnetii: impairment of the cross-talk between alphavbeta3 integrin and CR3.","volume":"163","author":"Capo","year":"1999","journal-title":"J. Immunol. Baltim. MD"},{"key":"B9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/978-94-007-4315-1_14","article-title":"Role of innate and adaptive immunity in the control of Q fever","author":"Capo","year":"2012","journal-title":"Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09816-4","article-title":"Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma.","volume":"10","author":"Carow","year":"2019","journal-title":"Nat. Commun."},{"key":"B11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jim.2010.06.008","article-title":"3D reconstruction of granulomas from transmitted light images implemented for long-time microscope applications.","volume":"360","author":"Delaby","year":"2010","journal-title":"J. Immunol. Methods"},{"key":"B12","first-page":"2259","article-title":"IFN-gamma-mediated control of Coxiella burnetii survival in monocytes: the role of cell apoptosis and TNF.","volume":"1950","author":"Dellacasagrande","year":"1999","journal-title":"J. Immunol. Baltim. MD"},{"key":"B13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1128\/CMR.00045-16","article-title":"From Q fever to Coxiella burnetii infection: a paradigm change.","volume":"30","author":"Eldin","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00172","article-title":"Granulomatous response to Coxiella burnetii, the agent of Q fever: the lessons from gene expression analysis.","volume":"4","author":"Faugaret","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1128\/IAI.00411-16","article-title":"Murine alveolar macrophages are highly susceptible to replication of Coxiella burnetii phase II in vitro.","volume":"84","author":"Fernandes","year":"2016","journal-title":"Infect. Immun."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099420","article-title":"Intracellular bacteria interfere with dendritic cell functions: role of the type I interferon pathway.","volume":"9","author":"Gorvel","year":"2014","journal-title":"PLoS One"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1016\/j.celrep.2019.02.103","article-title":"Limitation of TCA cycle intermediates represents an oxygen-independent nutritional antibacterial effector mechanism of macrophages.","volume":"26","author":"Hayek","year":"2019","journal-title":"Cell Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1128\/iai.64.3.796-809.1996","article-title":"Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis.","volume":"64","author":"Heinzen","year":"1996","journal-title":"Infect. Immun."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-511063","article-title":"Multiple \u201cdoughnut\u201d granulomas in Coxiella burnetii infection (Q fever).","volume":"122","author":"Herndon","year":"2013","journal-title":"Blood"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1128\/IAI.69.4.2596-2603.2001","article-title":"Mycobacterium bovis BCG-induced granuloma formation depends on gamma interferon and CD40 ligand but does not require CD28.","volume":"69","author":"Hogan","year":"2001","journal-title":"Infect. Immun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1086\/368129","article-title":"Dysregulation of cytokines in acute Q fever: role of interleukin-10 and tumor necrosis factor in chronic evolution of Q fever.","volume":"187","author":"Honstettre","year":"2003","journal-title":"J. Infect. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1128\/IAI.74.3.1800-1808.2006","article-title":"Role for the CD28 molecule in the control of Coxiella burnetii infection.","volume":"74","author":"Honstettre","year":"2006","journal-title":"Infect. Immun."},{"key":"B23","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.micinf.2004.02.005","article-title":"T-box transcription-factor-deficient mice display increased joint pathology and failure of infection control during Staphylococcal arthritis.","volume":"6","author":"Hultgren","year":"2004","journal-title":"Microb. Infect."},{"key":"B24","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/j.1365-2249.1993.tb08226.x","article-title":"Variation in interferon-gamma responses to Coxiella burnetii antigens with lymphocytes from vaccinated or naturally infected subjects.","volume":"94","author":"Izzo","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00070","article-title":"Coxiella burnetii induces inflammatory interferon-like signature in Plasmacytoid dendritic cells: a new feature of immune response in Q fever.","volume":"6","author":"Ka","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.it.2017.02.003","article-title":"Transcription factor T-bet orchestrates lineage development and function in the immune system.","volume":"38","author":"Kallies","year":"2017","journal-title":"Trends Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1210\/me.2004-0489","article-title":"Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract.","volume":"19","author":"Kawana","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.jinf.2016.01.004","article-title":"Altered interferon-\u03b3 response in patients with Q-fever fatigue syndrome.","volume":"72","author":"Keijmel","year":"2016","journal-title":"J. Infect."},{"key":"B29","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.cell.2014.03.030","article-title":"Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.","volume":"157","author":"Klose","year":"2014","journal-title":"Cell"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00165","article-title":"MyD88 is required for efficient control of Coxiella burnetii infection and dissemination.","volume":"10","author":"Kohl","year":"2019","journal-title":"Front. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.jaci.2004.02.004","article-title":"Sustained T-bet expression confers polarized human Th2 cells with Th1-like cytokine production and migratory capacities.","volume":"113","author":"Lametschwandtner","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1574-695X.2011.00898.x","article-title":"Detecting and measuring small numbers of viable Coxiella burnetii.","volume":"64","author":"Lockhart","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-244","article-title":"Coxiella burnetii Nine Mile II proteins modulate gene expression of monocytic host cells during infection.","volume":"10","author":"Mahapatra","year":"2010","journal-title":"BMC Microbiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.4049\/jimmunol.1302258","article-title":"Role of Th1\/Th17 balance regulated by T-bet in a mouse model of Mycobacterium avium complex disease.","volume":"1950","author":"Matsuyama","year":"2014","journal-title":"J. Immunol. Baltim. MD"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040023","article-title":"Persistent Coxiella burnetii infection in mice overexpressing IL-10: an efficient model for chronic Q fever pathogenesis.","volume":"4","author":"Meghari","year":"2008","journal-title":"PLoS Pathog."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1128\/IAI.00108-16","article-title":"Mouse model of Coxiella burnetii aerosolization.","volume":"84","author":"Melenotte","year":"","journal-title":"Infect. Immun."},{"key":"B37","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1182\/blood-2015-04-639617","article-title":"B-cell non-Hodgkin lymphoma linked to Coxiella burnetii.","volume":"127","author":"Melenotte","year":"","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1128\/IAI.01545-13","article-title":"T-bet regulates immunity to Francisella tularensis live vaccine strain infection, particularly in lungs.","volume":"82","author":"Melillo","year":"2014","journal-title":"Infect. Immun."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02434","article-title":"Full-term human placental macrophages eliminate Coxiella burnetii through an IFN-\u03b3 autocrine loop.","volume":"10","author":"Mezouar","year":"","journal-title":"Front. Microbiol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01947","article-title":"Tumor necrosis factor-alpha antagonist interferes with the formation of granulomatous multinucleated giant cells: new insights into Mycobacterium tuberculosis infection.","volume":"10","author":"Mezouar","year":"","journal-title":"Front. Immunol."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00219","article-title":"High concentrations of serum soluble E-cadherin in patients with Q fever.","volume":"9","author":"Mezouar","year":"","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02669-18","article-title":"Mast cell cytonemes as a defense mechanism against Coxiella burnetii.","volume":"10","author":"Mezouar","year":"","journal-title":"mBio"},{"key":"B43","doi-asserted-by":"publisher","first-page":"5545","DOI":"10.1073\/pnas.082114899","article-title":"T-bet regulates IgG class switching and pathogenic autoantibody production.","volume":"99","author":"Peng","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B44","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/infdis\/155.3.570","article-title":"Q fever endocarditis in the south of France.","volume":"155","author":"Raoult","year":"1987","journal-title":"J. Infect. Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"4603","DOI":"10.4049\/jimmunol.175.7.4603","article-title":"Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection.","volume":"175","author":"Ravindran","year":"2005","journal-title":"J. Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1128\/IAI.00101-10","article-title":"Role of CD4+ and CD8+ T cells in clearance of primary pulmonary infection with Coxiella burnetii.","volume":"78","author":"Read","year":"2010","journal-title":"Infect. Immun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1111\/j.1462-5822.2006.00838.x","article-title":"The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell.","volume":"9","author":"Romano","year":"2007","journal-title":"Cell. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1093\/cid\/cit129","article-title":"Specific interferon \u03b3 detection for the diagnosis of previous Q fever.","volume":"56","author":"Schoffelen","year":"2013","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"B49","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.diagmicrobio.2014.12.008","article-title":"Early cytokine and antibody responses against Coxiella burnetii in aerosol infection of BALB\/c mice.","volume":"81","author":"Schoffelen","year":"2015","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/1469-0691.12423","article-title":"A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever.","volume":"20","author":"Schoffelen","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"B51","doi-asserted-by":"publisher","first-page":"209.e9","DOI":"10.1016\/j.cmi.2016.11.008","article-title":"Intact interferon-\u03b3 response against Coxiella burnetii by peripheral blood mononuclear cells in chronic Q fever.","volume":"23","author":"Schoffelen","year":"2017","journal-title":"Clin. Microbiol. Infect. Off. Publ. Eur. Soc."},{"key":"B52","doi-asserted-by":"publisher","first-page":"8722","DOI":"10.1073\/pnas.0501863102","article-title":"Virulent Coxiella burnetii does not activate human dendritic cells: role of lipopolysaccharide as a shielding molecule.","volume":"102","author":"Shannon","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1128\/IAI.73.4.2469-2477.2005","article-title":"Q fever pneumonia: virulence of Coxiella burnetii pathovars in a murine model of aerosol infection.","volume":"73","author":"Stein","year":"2005","journal-title":"Infect. Immun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.4049\/jimmunol.175.7.4593","article-title":"Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production.","volume":"1950","author":"Sullivan","year":"2005","journal-title":"J. Immunol. Baltim. MD"},{"key":"B55","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1126\/science.1065543","article-title":"Distinct effects of T-bet in Th1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.","volume":"295","author":"Szabo","year":"2002","journal-title":"Science"},{"key":"B56","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/s0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment.","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/S1473-3099(09)70255-5","article-title":"Genetic deficiencies of innate immune signalling in human infectious disease.","volume":"9","author":"van de Vosse","year":"2009","journal-title":"Lancet Infect. Dis."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00025","article-title":"The SCID mouse model for identifying virulence determinants in Coxiella burnetii.","volume":"7","author":"van Schaik","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jneuroim.2013.12.001","article-title":"IFN-\u03b3 inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms.","volume":"267","author":"Yeh","year":"2014","journal-title":"J. Neuroimmunol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01546\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T07:33:02Z","timestamp":1594711982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01546\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,14]]},"references-count":59,"alternative-id":["10.3389\/fmicb.2020.01546"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.01546","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,14]]},"article-number":"1546"}}