{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:51:35Z","timestamp":1776156695067,"version":"3.50.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601745"],"award-info":[{"award-number":["81601745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671989"],"award-info":[{"award-number":["81671989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471924"],"award-info":[{"award-number":["81471924"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903670"],"award-info":[{"award-number":["81903670"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2020.01648","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T14:16:00Z","timestamp":1594908960000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Dectin-1 Facilitates IL-18 Production for the Generation of Protective Antibodies Against Candida albicans"],"prefix":"10.3389","volume":"11","author":[{"given":"Hui","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuetian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan-Juan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Tong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-Ran","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Da","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangjing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Ying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao-Mao","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/MCC.0b013e32833e84d2","article-title":"Epidemiology of invasive candidiasis.","volume":"16","author":"Arendrup","year":"2010","journal-title":"Curr. Opin. Crit. Care"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1016\/j.vaccine.2010.01.012","article-title":"Beta-glucan-CRM197 conjugates as candidates antifungal vaccines.","volume":"28","author":"Bromuro","year":"2010","journal-title":"Vaccine"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/403121","article-title":"Human monoclonal antibody-based therapy in the treatment of invasive candidiasis.","volume":"2013","author":"Bugli","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"B4","first-page":"397","article-title":"Update on management of invasive candidiasis.","volume":"30","author":"Candel","year":"2017","journal-title":"Rev. Esp. Quimioter."},{"key":"B5","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1128\/MMBR.00032-07","article-title":"Candida albicans cell wall proteins.","volume":"72","author":"Chaffin","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity.","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1093\/cid\/cit006","article-title":"Finding the \u201cmissing 50%\u201d of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care.","volume":"56","author":"Clancy","year":"2013","journal-title":"Clin. Infect Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1128\/JCM.02018-07","article-title":"Immunoglobulin G responses to a panel of Candida albicans antigens as accurate and early markers for the presence of systemic candidiasis.","volume":"46","author":"Clancy","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007934","article-title":"The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus.","volume":"15","author":"de Castro-Jorge","year":"2019","journal-title":"PLoS Pathog."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019620","article-title":"Innate defense against fungal pathogens.","volume":"5","author":"Drummond","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2423-8","article-title":"Epidemiology of Candida albicans and non-C.albicans of neonatal candidemia at a tertiary care hospital in western China.","volume":"17","author":"Fu","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1128\/MMBR.00012-16","article-title":"The expanding landscape of moonlighting proteins in yeasts.","volume":"80","author":"Gancedo","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1038\/sj.emboj.7600594","article-title":"Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.","volume":"24","author":"Gantner","year":"2005","journal-title":"EMBO J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/ni.1692","article-title":"Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.","volume":"10","author":"Gringhuis","year":"2009","journal-title":"Nat. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/nature04926","article-title":"Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.","volume":"442","author":"Gross","year":"2006","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1101\/gad.1228704","article-title":"Signaling to NF-kappaB.","volume":"18","author":"Hayden","year":"2004","journal-title":"Genes Dev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/cmi.2015.56","article-title":"IL-17C is required for lethal inflammation during systemic fungal infection.","volume":"13","author":"Huang","year":"2016","journal-title":"Cell Mol. Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"19614","DOI":"10.1074\/jbc.M401873200","article-title":"Glycosylphosphatidylinositol (GPI) proteins of Saccharomyces cerevisiae contain ethanolamine phosphate groups on the alpha1,4-linked mannose of the GPI anchor.","volume":"279","author":"Imhof","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/imr.12616","article-title":"Interleukin-18: biological properties and role in disease pathogenesis.","volume":"281","author":"Kaplanski","year":"2018","journal-title":"Immunol. Rev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.chom.2015.01.006","article-title":"Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection.","volume":"17","author":"Karki","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06607-1","article-title":"The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.","volume":"9","author":"Kasper","year":"2018","journal-title":"Nat. Commun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.4049\/jimmunol.1402321","article-title":"IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection.","volume":"194","author":"Ketelut-Carneiro","year":"2015","journal-title":"J. Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1056\/NEJMra1315399","article-title":"Invasive candidiasis.","volume":"373","author":"Kullberg","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5526","DOI":"10.1016\/j.vaccine.2011.05.030","article-title":"Immunisation with the glycolytic enzyme enolase confers effective protection against Candida albicans infection in mice.","volume":"29","author":"Li","year":"2011","journal-title":"Vaccine"},{"key":"B25","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1021\/bc500575a","article-title":"Synthesis and immunological studies of linear oligosaccharides of beta-glucan as antigens for antifungal vaccine development.","volume":"26","author":"Liao","year":"2015","journal-title":"Bioconjug. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1021\/acsinfecdis.5b00104","article-title":"6-O-branched oligo-beta-glucan-based antifungal glycoconjugate vaccines.","volume":"2","author":"Liao","year":"2016","journal-title":"ACS Infect. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jconrel.2011.01.016","article-title":"Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged antigens: preparation, structural study and immune response towards rHsp90.","volume":"151","author":"Masek","year":"2011","journal-title":"J. Control Release"},{"key":"B28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.idc.2015.10.013","article-title":"Invasive candidiasis.","volume":"30","author":"McCarty","year":"2016","journal-title":"Infect. Dis. Clin. North Am."},{"key":"B29","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/jcp.21765","article-title":"Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation.","volume":"220","author":"Mineva","year":"2009","journal-title":"J. Cell Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/wsbm.1331","article-title":"Signaling via the NFkappaB system.","volume":"8","author":"Mitchell","year":"2016","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00763","article-title":"Unique action of Interleukin-18 on T cells and other immune cells.","volume":"9","author":"Nakanishi","year":"2018","journal-title":"Front. Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1086\/503428","article-title":"A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis.","volume":"42","author":"Pachl","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3109\/13693786.2012.686673","article-title":"Candida albicans and non-Candida albicans fungemia in an institutional hospital during a decade.","volume":"51","author":"Parmeland","year":"2013","journal-title":"Med. Mycol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nri2735","article-title":"How are T(H)2-type immune responses initiated and amplified?","volume":"10","author":"Paul","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.chom.2012.06.006","article-title":"Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.","volume":"12","author":"Quintin","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B36","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1046\/j.1365-2958.2002.02926.x","article-title":"Complete glycosylphosphatidylinositol anchors are required in Candida albicans for full morphogenesis, virulence and resistance to macrophages.","volume":"44","author":"Richard","year":"2002","journal-title":"Mol. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1128\/EC.00297-06","article-title":"Comprehensive analysis of glycosylphosphatidylinositol-anchored proteins in Candida albicans.","volume":"6","author":"Richard","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.immuni.2005.03.004","article-title":"Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.","volume":"22","author":"Rogers","year":"2005","journal-title":"Immunity"},{"key":"B39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.micpath.2015.10.001","article-title":"Moonlight-like proteins of the cell wall protect sessile cells of Candida from oxidative stress.","volume":"90","author":"Serrano-Fujarte","year":"2016","journal-title":"Microb. Pathog."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1128\/IAI.00097-15","article-title":"Abolishing cell wall Glycosylphosphatidylinositol-Anchored proteins in Candida albicans enhances recognition by host Dectin-1.","volume":"83","author":"Shen","year":"2015","journal-title":"Infect. Immun."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001181","article-title":"Host cell invasion and virulence mediated by Candida albicans Ssa1.","volume":"6","author":"Sun","year":"2010","journal-title":"PLoS Pathog."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1093\/infdis\/jiz322","article-title":"Candidalysin is required for neutrophil recruitment and virulence during systemic Candida albicans infection.","volume":"220","author":"Swidergall","year":"2019","journal-title":"J. Infect. Dis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/ni1408","article-title":"Dectin-1 is required for beta-glucan recognition and control of fungal infection.","volume":"8","author":"Taylor","year":"2007","journal-title":"Nat. Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.immuni.2009.02.006","article-title":"The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.","volume":"30","author":"Thomas","year":"2009","journal-title":"Immunity"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1182\/blood-2005-03-1239","article-title":"Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.","volume":"106","author":"Underhill","year":"2005","journal-title":"Blood"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019612","article-title":"Adaptive immunity to fungi.","volume":"5","author":"Verma","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.18388\/abp.2015_1153","article-title":"Interleukin 18 (IL-18) as a target for immune intervention.","volume":"63","author":"Wawrocki","year":"2016","journal-title":"Acta Biochim. Pol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000227","article-title":"Dynamic, morphotype-specific Candida albicans beta-glucan exposure during infection and drug treatment.","volume":"4","author":"Wheeler","year":"2008","journal-title":"PLoS Pathog."},{"key":"B49","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1021\/acschembio.6b00751","article-title":"Targeting NF-kappaB p65 with a helenalin inspired bis-electrophile.","volume":"12","author":"Widen","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1128\/CVI.05215-11","article-title":"Vaccine and monoclonal antibody that enhance mouse resistance to candidiasis.","volume":"18","author":"Xin","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"13526","DOI":"10.1073\/pnas.0803195105","article-title":"Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis.","volume":"105","author":"Xin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B52","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/s41590-018-0112-4","article-title":"CARD9(S12N) facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses.","volume":"19","author":"Xu","year":"2018","journal-title":"Nat. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s10096-010-1103-z","article-title":"CARD9 Syk-dependent and Raf-1 Syk-independent signaling pathways in target recognition of Candida albicans by Dectin-1.","volume":"30","author":"Yang","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007830","article-title":"Epidemiology, clinical characteristics, and risk factors for mortality of early- and late-onset invasive candidiasis in intensive care units in China.","volume":"96","author":"Yang","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005617","article-title":"Mnn10 Maintains pathogenicity in Candida albicans by extending alpha-1,6-mannose backbone to evade host Dectin-1 mediated antifungal immunity.","volume":"12","author":"Zhang","year":"2016","journal-title":"PLoS Pathog."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01648\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T14:16:03Z","timestamp":1594908963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01648\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,16]]},"references-count":55,"alternative-id":["10.3389\/fmicb.2020.01648"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.01648","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,16]]},"article-number":"1648"}}