{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:35:57Z","timestamp":1788514557238,"version":"build-2803163510"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2020.01919","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T12:52:37Z","timestamp":1597668757000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Synergistic Potential of Antimicrobial Combinations Against Methicillin-Resistant Staphylococcus aureus"],"prefix":"10.3389","volume":"11","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Liang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Tong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ping","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.34172\/jsums.2019.10","article-title":"Antibacterial effects of vancomycin in combination with methicillin against methicillin-resistant and methicillinsensitive Staphylococcus aureus.","volume":"21","author":"Abdolahi","year":"2019","journal-title":"J. Shahrekord Univ. Med. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.ijantimicag.2005.10.008","article-title":"Characterisation of laboratory-generated vancomycin intermediate resistant Staphylococcus aureus strains.","volume":"27","author":"Bhateja","year":"2006","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1039\/c7pp00079k","article-title":"How do fluorescence spectroscopy and multimodal fluorescence imaging help to dissect the enhanced efficiency of the vancomycin-rifampin combination against: Staphylococcus aureus infections?","volume":"16","author":"Boudjemaa","year":"2017","journal-title":"Photochem. Photobiol. Sci."},{"key":"B4","year":"2018","journal-title":"Performance Standards for Antimicrobial Susceptibility Testing, M100"},{"key":"B5","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.eimc.2018.05.009","article-title":"Clinical efficacy of fosfomycin combinations against a variety of gram-positive cocci.","volume":"37","author":"Coronado-\u00c1lvarez","year":"2019","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s15010-013-0430-2","article-title":"The first case report of non-nosocomial healthcare-associated infective endocarditis due to methicillin-resistant Staphylococcus aureus USA400 in Rio de Janeiro, Brazil.","volume":"41","author":"Damasco","year":"2013","journal-title":"Infection"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02633-17","article-title":"The combination of daptomycin and fosfomycin has synergistic, potent, and rapid bactericidal activity against methicillin-resistant Staphylococcus aureus in a rabbit model of experimental endocarditis.","volume":"62","author":"Garcia-de-la-Maria","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8030128","article-title":"Staphylococcus aureus infections in Malaysia: a review of antimicrobial resistance and characteristics of the clinical isolates, 1990\u20132017.","volume":"8","author":"Hamzah","year":"2019","journal-title":"Antibiotics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.2147\/DDDT.S164515","article-title":"Linezolid: a review of its properties, function, and use in critical care.","volume":"12","author":"Hashemian","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1128\/CMR.00042-09","article-title":"Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications.","volume":"23","author":"Howden","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00503","article-title":"Occurrence and characterization of methicillin resistant Staphylococcus aureus in processed raw foods and ready-to-eat foods in an urban setting of a developing country.","volume":"10","author":"Islam","year":"2019","journal-title":"Front. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-018-0331-3","article-title":"Prevalence and molecular characterization of Staphylococcus aureus from human stool samples.","volume":"7","author":"Kates","year":"2018","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"B13","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/jcpt.12743","article-title":"Treatment strategies for persistent methicillin-resistant Staphylococcus aureus bacteraemia.","volume":"43","author":"Lewis","year":"2018","journal-title":"J. Clin. Pharm. Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1128\/AAC.00534-07","article-title":"Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.","volume":"52","author":"Neoh","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1128\/AAC.02354-12","article-title":"Novel combinations of vancomycin plus ceftaroline or oxacillin against methicillin-resistant vancomycin-intermediate Staphylococcus aureus (VISA) and Heterogeneous VISA.","volume":"57","author":"Pharmaceuticals","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B16","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1128\/AAC.00315-11","article-title":"Activity of ceftaroline and epidemiologic trends in Staphylococcus aureus isolates collected from 43 Medical Centers in the United States in 2009.","volume":"55","author":"Richter","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01344","article-title":"Detection and characterization of Staphylococcus aureus and methicillin-resistant S. aureus in foods confiscated in EU borders.","volume":"8","author":"Rodr\u00edguez-L\u00e1zaro","year":"2017","journal-title":"Front. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ijantimicag.2014.01.018","article-title":"Daptomycin activity tested against 164 457 bacterial isolates from hospitalised patients: summary of 8 years of a Worldwide Surveillance Programme (2005-2012).","volume":"43","author":"Sader","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B19","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.jiph.2019.03.014","article-title":"Antimicrobial consumption and bacterial resistance pattern in patients admitted in I.C.U at a tertiary care center.","volume":"12","author":"Saxena","year":"2019","journal-title":"J. Infect. Public Health"},{"key":"B20","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1099\/jmm.0.000649","article-title":"In vitro and in vivo activity of fosfomycin alone and in combination with rifampin and tigecycline against Grampositive cocci isolated from surgical wound infections.","volume":"67","author":"Simonetti","year":"2018","journal-title":"J. Med. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1590\/0037-8682-0373-2017","article-title":"Molecular analysis, biofilm formation, and susceptibility of methicillin-resistant Staphylococcus aureus strains causing community-and health care-associated infections in central venous catheters.","volume":"51","author":"Sohail","year":"2018","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"B22","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1089\/fpd.2018.2585","article-title":"Detection and molecular characterization of Staphylococci from eggs of household chickens.","volume":"16","author":"Syed","year":"2019","journal-title":"Foodborne Pathog. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/AAC.01554-17","article-title":"Outcomes of vancomycin plus a-lactam versus vancomycin only for treatment of methicillin-resistant Staphylococcus aureus bacteremia.","volume":"62","author":"Truong","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"B24","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.jinf.2014.12.016","article-title":"Comparative activities of vancomycin, tigecycline and rifampin in a rat model of methicillin-resistant Staphylococcus aureus osteomyelitis.","volume":"70","author":"Vergidis","year":"2015","journal-title":"J. Infect."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.02163","article-title":"Novel mutation sites in the development of vancomycin- intermediate resistance in Staphylococcus aureus.","volume":"7","author":"Wang","year":"2017","journal-title":"Front. Microbiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1093\/jac\/dkz003","article-title":"Genomic characterization of inpatient evolution of MRSA resistant to daptomycin, vancomycin and ceftaroline.","volume":"74","author":"W\u00fcthrich","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"B27","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/ng1755","article-title":"Functional classification of drugs by properties of their pairwise interactions.","volume":"38","author":"Yeh","year":"2006","journal-title":"Nat. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/jac\/dky413","article-title":"Novel partners with colistin to increase its in vivo therapeutic effectiveness and prevent the occurrence of colistin resistance in NDM- and MCR-co-producing Escherichia coli in a murine infection model.","volume":"74","author":"Yu","year":"2019","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01919\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T12:52:40Z","timestamp":1597668760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01919\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,17]]},"references-count":28,"alternative-id":["10.3389\/fmicb.2020.01919"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.01919","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,17]]},"article-number":"1919"}}