{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:33:22Z","timestamp":1787625202187,"version":"build-2736575974"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2020.01972","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T15:37:51Z","timestamp":1597419471000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Pasteurella multocida Pm0442 Affects Virulence Gene Expression and Targets TLR2 to Induce Inflammatory Responses"],"prefix":"10.3389","volume":"11","author":[{"given":"Fang","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rendong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Hardwidge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengzhang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1128\/iai.68.6.3463-3468.2000","article-title":"The capsule is a virulence determinant in the pathogenesis of Pasteurella multocida M1404 (B:2).","volume":"68","author":"Boyce","year":"2000","journal-title":"Infect. Immun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/s0168-1656(00)00309-6","article-title":"Pasteurella multocida capsule: composition, function and genetics.","volume":"83","author":"Boyce","year":"2000","journal-title":"J. Biotechnol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"7187","DOI":"10.1128\/aem.71.11.7187-7195.2005","article-title":"Generation and molecular characterization of new temperature-sensitive plasmids intended for genetic engineering of Pasteurellaceae.","volume":"71","author":"Briggs","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1177\/0022034510381264","article-title":"TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.","volume":"90","author":"Brown","year":"2011","journal-title":"J. Dent. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1096\/fj.11-199588","article-title":"Mycobacterium tuberculosis Rv0577, a novel TLR2 agonist, induces maturation of dendritic cells and drives Th1 immune response.","volume":"26","author":"Byun","year":"2012","journal-title":"FASEB J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"668","DOI":"10.4049\/jimmunol.1102177","article-title":"Recombinant MPT83 derived from Mycobacterium tuberculosis induces cytokine production and upregulates the function of mouse macrophages through TLR2.","volume":"188","author":"Chen","year":"2012","journal-title":"J. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1128\/iai.69.4.2487-2492.2001","article-title":"Role of capsule in the pathogenesis of fowl cholera caused by Pasteurella multocida serogroup A.","volume":"69","author":"Chung","year":"2001","journal-title":"Infect. Immun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1099\/mic.0.026765-0","article-title":"Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization in a strain-specific manner.","volume":"155","author":"Cron","year":"2009","journal-title":"Microbiology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1017\/s1466252307001399","article-title":"Pasteurella multocida and bovine respiratory disease.","volume":"8","author":"Dabo","year":"2007","journal-title":"Anim. Health Res. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/nsmb.1869","article-title":"Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.","volume":"17","author":"Drage","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"4627","DOI":"10.3892\/mmr.2017.7153","article-title":"Two novel crossprotective antigens for bovine Pasteurella multocida.","volume":"16","author":"Du","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s10753-015-0259-1","article-title":"Anti-inflammatory activity of tanshinone IIA in LPS-stimulated RAW264.7 Macrophages via miRNAs and TLR4-NF-kappaB Pathway.","volume":"39","author":"Fan","year":"2016","journal-title":"Inflammation"},{"key":"B13","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.vetmic.2019.03.019","article-title":"NLRP3 inflammasome plays an important role in caspase-1 activation and IL-1beta secretion in macrophages infected with Pasteurella multocida.","volume":"231","author":"Fang","year":"2019","journal-title":"Vet. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2020.108646","article-title":"High- and low-virulent bovine Pasteurella multocida induced differential NLRP3 inflammasome activation and subsequent IL-1\u03b2 secretion.","volume":"243","author":"Fang","year":"2020","journal-title":"Vet. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.4049\/jimmunol.173.7.4635","article-title":"Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus.","volume":"173","author":"Giambartolomei","year":"2004","journal-title":"J. Immunol."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9080254","article-title":"The Myriad Properties of Pasteurella multocida Lipopolysaccharide.","volume":"9","author":"Harper","year":"2017","journal-title":"Toxins"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1574-6968.2006.00442.x","article-title":"Pasteurella multocida pathogenesis: 125 years after pasteur.","volume":"265","author":"Harper","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"B18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/82_2012_202","article-title":"The key surface components of Pasteurella multocida: capsule and lipopolysaccharide.","volume":"361","author":"Harper","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.vetmic.2011.05.022","article-title":"Pasteurella multocida lipopolysaccharide: the long and the short of it.","volume":"153","author":"Harper","year":"2011","journal-title":"Vet. Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetmic.2010.01.027","article-title":"Outer membrane proteins of Pasteurella multocida.","volume":"144","author":"Hatfaludi","year":"2010","journal-title":"Vet. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00677-19","article-title":"L-serine lowers the inflammatory responses during Pasteurella multocida infection.","volume":"87","author":"He","year":"2019","journal-title":"Infect. Immun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1074\/jbc.M510014200","article-title":"The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization.","volume":"281","author":"Hermans","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"5408","DOI":"10.1021\/bi100058w","article-title":"Leptospiral outer membrane lipoprotein LipL32 binding on toll-like receptor 2 of renal cells as determined with an atomic force microscope.","volume":"49","author":"Hsu","year":"2010","journal-title":"Biochemistry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1099\/13500872-140-2-263","article-title":"Modulation of Pasteurella multocida capsular polysaccharide during growth under iron-restricted conditions and in vivo.","volume":"140","author":"Jacques","year":"1994","journal-title":"Microbiology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1110\/ps.0303703","article-title":"Prediction of lipoprotein signal peptides in Gram-negative bacteria.","volume":"12","author":"Juncker","year":"2003","journal-title":"Protein Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1128\/iai.00682-10","article-title":"Lipoproteins of bacterial pathogens.","volume":"79","author":"Kovacs-Simon","year":"2011","journal-title":"Infect. Immun."},{"key":"B28","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.vetmic.2016.10.017","article-title":"High and low-virulent bovine Pasteurella multocida capsular type A isolates exhibit different virulence gene expression patterns in vitro and in vivo.","volume":"196","author":"Li","year":"2016","journal-title":"Vet. Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3892\/mmr.2017.6617","article-title":"Toxic proteins from Croton tiglium L. exert a proinflammatory effect by inducing release of proinflammatory cytokines and activating the p38-MAPK signaling pathway.","volume":"16","author":"Liu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation.","volume":"2","author":"Liu","year":"2017","journal-title":"Signal. Transduct. Target. Ther."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1073\/pnas.051634598","article-title":"Complete genomic sequence of Pasteurella multocida, Pm70.","volume":"98","author":"May","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1128\/iai.00122-16","article-title":"The RNA-binding chaperone Hfq is an important global regulator of gene expression in Pasteurella multocida and plays a crucial role in production of a number of virulence factors, including hyaluronic acid capsule.","volume":"84","author":"M\u00e9groz","year":"2016","journal-title":"Infect. Immun."},{"key":"B33","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.4049\/jimmunol.158.10.4838","article-title":"Borrelia burgdorferi outer surface protein A (OspA) activates and primes human neutrophils.","volume":"158","author":"Morrison","year":"1997","journal-title":"J. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"422","DOI":"10.4049\/jimmunol.177.1.422","article-title":"Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.","volume":"177","author":"Pecora","year":"2006","journal-title":"J. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.gene.2016.01.041","article-title":"Genomic characterization of Pasteurella multocida HB01, a serotype A bovine isolate from China.","volume":"581","author":"Peng","year":"2016","journal-title":"Gene"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00014-19","article-title":"Pasteurella multocida: genotypes and genomics.","volume":"83","author":"Peng","year":"2019","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179420","article-title":"Genome wide host gene expression analysis in mice experimentally infected with Pasteurella multocida.","volume":"12","author":"Priya","year":"2017","journal-title":"Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/advances\/nmy084","article-title":"Glutamine metabolism in macrophages: a novel target for obesity\/type 2 diabetes.","volume":"10","author":"Ren","year":"2019","journal-title":"Adv. Nutr."},{"key":"B39","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.vetmic.2006.12.013","article-title":"The response of Mannheimia haemolytica to iron limitation: implications for the acquisition of iron in the bovine lung.","volume":"121","author":"Roehrig","year":"2007","journal-title":"Vet. Microbiol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(19)30953-5","article-title":"Dog licks baby. Baby gets Pasteurella multocida meningitis.","volume":"393","author":"Ryan","year":"2019","journal-title":"Lancet"},{"key":"B41","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.immuni.2009.11.008","article-title":"TLR2 looks at lipoproteins.","volume":"31","author":"Schenk","year":"2009","journal-title":"Immunity"},{"key":"B42","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1128\/iai.67.2.871-878.1999","article-title":"Lmb, a protein with similarities to the LraI adhesin family, mediates attachment of Streptococcus agalactiae to human laminin.","volume":"67","author":"Spellerberg","year":"1999","journal-title":"Infect. Immun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1099\/mic.0.27046-0","article-title":"Molecular cloning of haemoglobin-binding protein HgbA in the outer membrane of Actinobacillus pleuropneumoniae.","volume":"150","author":"Srikumar","year":"2004","journal-title":"Microbiology"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000750","article-title":"Fis is essential for capsule production in Pasteurella multocida and regulates expression of other important virulence factors.","volume":"6","author":"Steen","year":"2010","journal-title":"PLoS Pathog."},{"key":"B45","doi-asserted-by":"publisher","first-page":"14.12.1","DOI":"10.1002\/0471142735.im1412s109","article-title":"Toll-like receptors.","volume":"109","author":"Takeda","year":"2015","journal-title":"Curr. Protoc. Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1128\/iai.70.2.993-997.2002","article-title":"Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells.","volume":"70","author":"Terao","year":"2002","journal-title":"Infect. Immun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1128\/jcm.39.3.924-929.2001","article-title":"Genetic organization of Pasteurella multocida cap Loci and development of a multiplex capsular PCR typing system.","volume":"39","author":"Townsend","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00251","article-title":"Transcriptomic analysis on responses of murine lungs to Pasteurella multocida infection.","volume":"7","author":"Wu","year":"2017","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12547","article-title":"Melatonin in macrophage biology: current understanding and future perspectives.","volume":"66","author":"Xia","year":"2019","journal-title":"J. Pineal Res."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02670","article-title":"Betaine inhibits interleukin-1beta production and release: potential mechanisms.","volume":"9","author":"Xia","year":"2018","journal-title":"Front. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s00011-015-0863-4","article-title":"NZ suppresses TLR4\/NF-kappaB signalings and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophages.","volume":"64","author":"Xiang","year":"2015","journal-title":"Inflamm. Res."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019631","article-title":"Genomic characterization of Haemophilus parasuis SH0165, a highly virulent strain of serovar 5 prevalent in China.","volume":"6","author":"Xu","year":"2011","journal-title":"PLoS One"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001450","article-title":"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China.","volume":"3","author":"Xu","year":"2008","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.imbio.2008.02.005","article-title":"TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity.","volume":"213","author":"Zahringer","year":"2008","journal-title":"Immunobiology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.intimp.2015.02.028","article-title":"Tp17 membrane protein of Treponema pallidum activates endothelial cells in vitro.","volume":"25","author":"Zhang","year":"2015","journal-title":"Int. Immunopharmacol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01972\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:44:18Z","timestamp":1696535058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.01972\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":55,"alternative-id":["10.3389\/fmicb.2020.01972"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.01972","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"article-number":"1972"}}