{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:09:16Z","timestamp":1792591756313,"version":"4.5.0"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2020.02108","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T04:42:27Z","timestamp":1598503347000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":62,"title":["Acellular Pertussis Vaccines Induce Anti-pertactin Bactericidal Antibodies Which Drives the Emergence of Pertactin-Negative Strains"],"prefix":"10.3389","volume":"11","author":[{"given":"Elodie","family":"Lesne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breeze E.","family":"Cavell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Freire-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby","family":"Persaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Matheson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile A. C. M.","family":"van Els","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Gorringe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/IAI.00004-18","article-title":"Characterization of individual human antibodies that bind pertussis toxin stimulated by acellular immunization.","volume":"86","author":"Acquaye-Seedah","year":"2018","journal-title":"Infect. Immun."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0382-8","article-title":"Asymptomatic transmission and the resurgence of Bordetella pertussis.","volume":"13","author":"Althouse","year":"2015","journal-title":"BMC Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.molimm.2010.11.015","article-title":"Interactions between Bordetella pertussis and the complement inhibitor factor H.","volume":"48","author":"Amdahl","year":"2011","journal-title":"Mol. Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femspd\/ftv050","article-title":"Seroprevalence studies of pertussis: what have we learned from different immunized populations.","volume":"73","author":"Barkoff","year":"2015","journal-title":"Pathog. Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2807\/1560-7917.ES.2019.24.7.1700832","article-title":"Pertactin-deficient Bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015.","volume":"24","author":"Barkoff","year":"2019","journal-title":"Eurosurveillance"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1128\/IAI.69.5.3067","article-title":"BrkA protein of Bordetella pertussis inhibits the classical pathway of complement after C1 deposition.","volume":"69","author":"Barnes","year":"2001","journal-title":"Infect. Immun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1128\/IAI.70.1.403-406.2002","article-title":"Growth phase influences complement resistance of Bordetella pertussis.","volume":"70","author":"Barnes","year":"2002","journal-title":"Infect. Immun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.01074-14","article-title":"Global population structure and evolution of Bordetella pertussis and their relationship with vaccination.","volume":"5","author":"Bart","year":"","journal-title":"mBio"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e1301","DOI":"10.1128\/genomeA.01301-14","article-title":"Complete genome sequences of Bordetella pertussis isolates B1917 and B1920, representing two predominant global lineages.","volume":"2","author":"Bart","year":"","journal-title":"Genome Announc."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftv064","article-title":"Bordetella pertussis evolution in the (functional) genomics era.","volume":"73","author":"Belcher","year":"2015","journal-title":"Pathog. Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1002\/1521-4141(200109)31:9<2771::aid-immu2771>3.0.co;2-0","article-title":"Bordetella pertussis binds to human C4b-binding protein (C4BP) at a site similar to that used by the natural ligand C4b.","volume":"31","author":"Bergg\u00e5rd","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1042\/BST0300978","article-title":"Structural and functional studies of complement inhibitor C4b-binding protein.","volume":"30","author":"Blom","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"B13","doi-asserted-by":"publisher","first-page":"751","DOI":"10.3390\/vaccines3030751","article-title":"New data on vaccine antigen deficient Bordetella pertussis isolates.","volume":"3","author":"Bouchez","year":"2015","journal-title":"Vaccines"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0084-3","article-title":"Bordetella pertussis isolates vary in their interactions with human complement components article.","volume":"7","author":"Brookes","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"B15","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jim.2013.02.007","article-title":"Development of a large scale human complement source for use in bacterial immunoassays.","volume":"391","author":"Brookes","year":"2013","journal-title":"J. Immunol. Methods"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1128\/IAI.73.5.2698","article-title":"Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of.","volume":"73","author":"Carbonetti","year":"2005","journal-title":"Infect. Immun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1128\/IAI.72.6.3350-3358.2004","article-title":"Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein.","volume":"72","author":"Carbonetti","year":"2004","journal-title":"Infect. Immun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/CIRCULATIONAHA.110.956839","article-title":"The Bps polysaccharide of Bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin.","volume":"23","author":"Conover","year":"2010","journal-title":"Mol. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1172\/JCI121309","article-title":"Th1\/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters.","volume":"128","author":"da Silva Antunes","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105011","article-title":"Proteomics-identified Bvg-activated autotransporters protect against Bordetella pertussis in a mouse model.","volume":"9","author":"De Gouw","year":"2014","journal-title":"PLoS One"},{"key":"B21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1574-6976.2010.00257.x","article-title":"Pertussis: a matter of immune modulation.","volume":"35","author":"de Gouw","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1016\/S1473-3099(18)30646-7","article-title":"PERISCOPE: road towards effective control of pertussis.","volume":"19","author":"Diavatopoulos","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01344","article-title":"Pertussis prevention : reasons for resurgence, and differences in the current acellular pertussis vaccines.","volume":"10","author":"Esposito","year":"2019","journal-title":"Front. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"4727","DOI":"10.1128\/iai.62.11.4727-4738.1994","article-title":"Cloning and sequencing of a Bordetella pertussis serum resistance locus.","volume":"62","author":"Fernandez","year":"1994","journal-title":"Infect. Immun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1080\/21645515.2019.1593082","article-title":"A review of complement sources used in serum bactericidal assays for evaluating immune responses to meningococcal ACWY conjugate vaccines.","volume":"15","author":"Findlow","year":"2019","journal-title":"Hum. Vaccines Immunother."},{"key":"B26","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/j.1365-2958.1995.tb02425.x","article-title":"Tracheal colonization factor: a Bordetella pertussis secreted virulence determinant.","volume":"16","author":"Finn","year":"1995","journal-title":"Mol. Microbiol."},{"key":"B27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4049\/jimmunol.24.4.273","article-title":"Influenzal meningitis the relation of age incidence to the bactericidal power of blood against the causal organism.","volume":"24","author":"Fothergill","year":"1933","journal-title":"J. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1111\/cmi.12264","article-title":"The Bordetella pertussis Bps polysaccharide enhances lung colonization by conferring protection from complement-mediated killing.","volume":"16","author":"Ganguly","year":"2014","journal-title":"Cell. Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1586\/14760584.2014.944901","article-title":"Importance of (antibody-dependent) complement-mediated serum killing in protection against Bordetella pertussis.","volume":"13","author":"Geurtsen","year":"2014","journal-title":"Expert Rev. Vaccines"},{"key":"B30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/jid.2014.371","article-title":"Correlation between serum bactericidal activity against Neisseria meningitidis serogroups A, C, W-135 and Y measured using human versus rabbit serum as the complement source.","volume":"30","author":"Gill","year":"2011","journal-title":"Vaccine"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1084\/jem.129.6.1307","article-title":"Human immunity to the meningococcus. I. The role of humoral antibodies.","volume":"129","author":"Goldschneider","year":"1969","journal-title":"J. Exp. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1128\/iai.61.5.2211-2215.1993","article-title":"Biochemical and immunological properties of two forms of pertactin, the 69,000-molecular-weight outer membrane protein of Bordetella pertussis.","volume":"61","author":"Gotto","year":"1993","journal-title":"Infect. Immun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1056\/NEJM199602083340602","article-title":"A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine.","volume":"334","author":"Gustafsson","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"6597","DOI":"10.1016\/j.vaccine.2014.09.068","article-title":"Pertactin deficient Bordetella pertussis present a better fitness in mice immunized with an acellular pertussis vaccine.","volume":"32","author":"Hegerle","year":"2014","journal-title":"Vaccine"},{"key":"B35","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1086\/377283","article-title":"Crucial role of antibodies to pertactin in Bordetella pertussis immunity.","volume":"188","author":"Hellwig","year":"2003","journal-title":"J. Infect. Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/mi.2012.54","article-title":"Immunity to the respiratory pathogen Bordetella pertussis.","volume":"5","author":"Higgs","year":"2012","journal-title":"Mucosal Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3201\/eid2304.161575","article-title":"Significant decrease in pertactin-deficient Bordetella pertussis isolates.","volume":"23","author":"Hiramatsu","year":"2017","journal-title":"Jpn. Emerg. Infect. Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-30558-8","article-title":"Detection of opsonizing antibodies directed against a recently circulating Bordetella pertussis strain in paired plasma samples from symptomatic and recovered pertussis patients.","volume":"8","author":"Hovingh","year":"2018","journal-title":"Sci. Rep."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006531","article-title":"Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface.","volume":"13","author":"Hovingh","year":"2017","journal-title":"PLoS Pathog."},{"key":"B40","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s00109-015-1259-1","article-title":"Complement evasion by Bordetella pertussis: implications for improving current vaccines.","volume":"93","author":"Jongerius","year":"2015","journal-title":"J. Mol. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/infdis\/jiy022","article-title":"Maternal vaccination with a monocomponent pertussis toxoid vaccine is sufficient to protect infants in a baboon model of whooping cough.","volume":"217","author":"Kapil","year":"2018","journal-title":"J. Infect. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1172\/JCI24609.3594","article-title":"Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis.","volume":"115","author":"Kirimanjeswara","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3326","article-title":"Waning Tdap effectiveness in adolescents.","volume":"137","author":"Klein","year":"2016","journal-title":"Pediatrics"},{"key":"B44","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1073\/pnas.1100782108","article-title":"Oligosaccharide conjugates of Bordetella pertussis and bronchiseptica induce bactericidal antibodies, an addition to pertussis vaccine.","volume":"108","author":"Kubler-Kielb","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1093\/cid\/civ695","article-title":"Antibody responses after primary immunization in infants born to women receiving a Pertussis-containing vaccine during pregnancy: single arm observational study with a historical comparator.","volume":"61","author":"Ladhani","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3201\/eid2004.131478","article-title":"Rapid increase in pertactin-deficient Bordetella pertussis isolates.","volume":"20","author":"Lam","year":"2014","journal-title":"Australia. Emerg. Infect. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1146\/annurev.micro.51.1.311","article-title":"Interaction of antigens and antibodies at mucosal surfaces.","volume":"51","author":"Lamm","year":"1997","journal-title":"Annu. Rev. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S1369-5274(00)00169-7","article-title":"Bordetella pertussis, molecular pathogenesis under multiple aspects.","volume":"4","author":"Locht","year":"2001","journal-title":"Curr. Opin. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.vaccine.2019.10.062","article-title":"Surfaceome analysis of Australian epidemic Bordetella pertussis reveals potential vaccine antigens.","volume":"38","author":"Luu","year":"2020","journal-title":"Vaccine"},{"key":"B50","doi-asserted-by":"publisher","first-page":"4306","DOI":"10.1016\/j.vaccine.2008.06.017","article-title":"Protective activity of the Bordetella pertussis BrkA autotransporter in the murine lung colonization model.","volume":"26","author":"Marr","year":"2008","journal-title":"Vaccine"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020585","article-title":"Bordetella pertussis autotransporter Vag8 binds human C1 esterase inhibitor and confers serum resistance.","volume":"6","author":"Marr","year":"2011","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/cid\/ciu788","article-title":"Pertactin-negative bordetella pertussis strains: evidence for a possible selective advantage.","volume":"60","author":"Martin","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"B53","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0882-4010(92)90115-5","article-title":"Construction and analysis of Bordetella pertussis mutants defective in the production of fimbriae.","volume":"12","author":"Mooi","year":"1992","journal-title":"Microb. Pathog."},{"key":"B54","doi-asserted-by":"publisher","first-page":"5316","DOI":"10.1128\/iai.60.12.5316-5318.1992","article-title":"A bactericidal monoclonal antibody specific for the lipooligosaccharide of Bordetella pertussis reduces colonization of the respiratory tract of mice after aerosol infection with B. pertussis.","volume":"60","author":"Mountzouros","year":"1992","journal-title":"Infect. Immun."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/sciadv.aay9258","article-title":"Neutralization of pertussis toxin by a single antibody prevents clinical pertussis in neonatal baboons.","volume":"6","author":"Nguyen","year":"2020","journal-title":"Sci. Adv."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1016\/B978-0-12-397169-2.00085-8","article-title":"Bordetella pertussis.","volume":"3","author":"Nieves","year":"2016","journal-title":"Mol. Med. Microbiol. Second Ed."},{"key":"B57","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.micpath.2011.04.004","article-title":"BapC autotransporter protein is a virulence determinant of Bordetella pertussis.","volume":"51","author":"Noofeli","year":"2011","journal-title":"Microb. Pathog."},{"key":"B58","doi-asserted-by":"publisher","first-page":"S288","DOI":"10.1086\/322564","article-title":"How to make sense of pertussis immunogenicity data.","volume":"33","author":"Olin","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"B59","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0264-410X(01)00269-9","article-title":"Antibodies to BrkA augment killing of Bordetella pertussis.","volume":"20","author":"Oliver","year":"2001","journal-title":"Vaccine"},{"key":"B60","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1365-2222.1991.tb00799.x","article-title":"Plasma exudation as a first line respiratory mucosal defence.","volume":"21","author":"Persson","year":"1991","journal-title":"Clin. Exp. Allergy"},{"key":"B61","doi-asserted-by":"publisher","first-page":"S114","DOI":"10.1016\/S0163-4453(17)30201-3","article-title":"Pertussis disease and transmission and host responses: insights from the baboon model of pertussis.","volume":"74","author":"Pinto","year":"2017","journal-title":"J. Infect."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1016\/j.vaccine.2019.10.046","article-title":"Updates on immunologic correlates of vaccine-induced protection.","volume":"38","author":"Plotkin","year":"2020","journal-title":"Vaccine"},{"key":"B63","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.micres.2015.03.006","article-title":"Structural and functional studies of BapC protein of Bordetella pertussis.","volume":"174","author":"Riaz","year":"2015","journal-title":"Microbiol. Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0264-410X(92)90418-J","article-title":"Recombinant P.69\/pertactin: immunogenicity and protection of mice against Bordetella pertussis infection.","volume":"10","author":"Roberts","year":"1992","journal-title":"Vaccine"},{"key":"B65","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1574-695X.2005.00001.x","article-title":"Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies.","volume":"46","author":"Rodr\u00edguez","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003264","article-title":"Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine.","volume":"9","author":"Ross","year":"2013","journal-title":"PLoS Pathog."},{"key":"B67","doi-asserted-by":"publisher","first-page":"6277","DOI":"10.1016\/j.vaccine.2015.09.064","article-title":"Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model.","volume":"33","author":"Safarchi","year":"2015","journal-title":"Vaccine"},{"key":"B68","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1128\/CDLI.8.3.616-623.2001","article-title":"Importance of complement source in measuring meningococcal bactericidal titers.","volume":"8","author":"Santos","year":"2001","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1586\/14760584.2014.944900","article-title":"Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines.","volume":"13","author":"Sebo","year":"2014","journal-title":"Expert Rev. Vaccines"},{"key":"B70","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1016\/j.vaccine.2011.02.086","article-title":"A comprehensive analysis of Bordetella pertussis surface proteome and identification of new immunogenic proteins.","volume":"29","author":"Tefon","year":"2011","journal-title":"Vaccine"},{"key":"B71","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0168-1656(99)00155-8","article-title":"Rational medium design for Bordetella pertussis: basic metabolism.","volume":"75","author":"Thalen","year":"1999","journal-title":"J. Biotechnol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"5178","DOI":"10.1016\/j.vaccine.2013.08.034","article-title":"Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults-A review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience.","volume":"31","author":"Thierry-Carstensen","year":"2013","journal-title":"Vaccine"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00777","article-title":"Development and standardization of a high-throughput Bordetella pertussis growth-inhibition assay.","volume":"11","author":"Thiriard","year":"2020","journal-title":"Front. Microbiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/bit.22326","article-title":"Gene-expression-based quality scores indicate optimal harvest point in Bordetella pertussis cultivation for vaccine production.","volume":"103","author":"Van De Waterbeemd","year":"2009","journal-title":"Biotechnol. Bioeng."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1128\/iai.67.3.1056-1062.1999","article-title":"Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract.","volume":"67","author":"Van Den Berg","year":"1999","journal-title":"Infect. Immun."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00051","article-title":"Whole-cell or acellular pertussis primary immunizations in infancy determines adolescent cellular immune profiles.","volume":"9","author":"van der Lee","year":"2018","journal-title":"Front. Immunol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1574-695X.2007.00291.x","article-title":"Characterization of Bordetella pertussis clinical isolates that do not express the tracheal colonization factor.","volume":"51","author":"Van Gent","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1128\/JCM.40.6.1994-2001.2002","article-title":"Multilocus sequence typing of Bordetella pertussis based on surface protein genes.","volume":"40","author":"Van Loo","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/srep40328","article-title":"Impact of age and vaccination history on long-Term serological responses after symptomatic B. Pertussis infection, a high dimensional data analysis.","volume":"7","author":"Van Twillert","year":"2017","journal-title":"Sci. Rep."},{"key":"B80","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.1074\/jbc.M114.585281","article-title":"The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies.","volume":"290","author":"Wang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B81","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1073\/pnas.1314688110","article-title":"Acellular pertussis vaccines protect against disease butfail to prevent infection and transmission ina nonhuman primate model.","volume":"111","author":"Warfel","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B82","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1128\/IAI.00869-17","article-title":"Screening and genomic characterization of filamentous hemagglutinin-deficient Bordetella pertussis.","volume":"86","author":"Weigand","year":"2018","journal-title":"Infect. Immun."},{"key":"B83","doi-asserted-by":"publisher","first-page":"7175","DOI":"10.1128\/IAI.68.12.7175-7179.2000","article-title":"Characterization of bactericidal immune responses following vaccination with acellular pertussis vaccines in adults.","volume":"68","author":"Weingart","year":"","journal-title":"Infect. Immun."},{"key":"B84","doi-asserted-by":"publisher","first-page":"7152","DOI":"10.1128\/IAI.68.12.7152-7155.2000","article-title":"Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils.","volume":"68","author":"Weingart","year":"","journal-title":"Infect. Immun."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1128\/iai.67.3.1424-1431.1999","article-title":"Characterization of human bactericidal antibodies to Bordetella pertussis.","volume":"67","author":"Weiss","year":"1999","journal-title":"Infect. Immun."},{"key":"B86","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/22221751.2018.1564630","article-title":"Immunization with whole cell but not acellular pertussis vaccines primes CD4 TRM cells that sustain protective immunity against nasal colonization with Bordetella pertussis.","volume":"8","author":"Wilk","year":"2019","journal-title":"Emerg. Microbes Infect."},{"key":"B87","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3201\/eid2202.151332","article-title":"Bordetella pertussis strain lacking pertactin and pertussis toxin.","volume":"22","author":"Williams","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1093\/cid\/cit046","article-title":"Reduced risk of pertussis among persons ever vaccinated with whole cell pertussis vaccine compared to recipients of acellular pertussis vaccines in a large US cohort.","volume":"56","author":"Witt","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep12888","article-title":"Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.","volume":"5","author":"Xu","year":"2015","journal-title":"Sci. Rep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/S1473-3099(17)30390-0","article-title":"An update of the global burden of pertussis in children younger than 5 years: a modeling study.","volume":"17","author":"Yeung","year":"2017","journal-title":"Lancet Infect. Dis."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.02108\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T10:14:35Z","timestamp":1696587275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.02108\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":90,"alternative-id":["10.3389\/fmicb.2020.02108"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.02108","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]},"article-number":"2108"}}