{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:17:27Z","timestamp":1787026647187,"version":"build-2736575974"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2020.573586","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:53:47Z","timestamp":1599094427000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of Lactobacillus fermentum CQPC04 on Lipid Reduction in C57BL\/6J Mice"],"prefix":"10.3389","volume":"11","author":[{"given":"Ruokun","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianrong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiping","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhennai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-016-0278-4","article-title":"The role of gut microbiota in the development of obesity and diabetes.","volume":"15","author":"Baothman","year":"2016","journal-title":"Lipids Health Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1159\/000336672","article-title":"Targets for medical therapy in obesity.","volume":"30","author":"Bareti\u00e6","year":"2012","journal-title":"Dig. Dis."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-2956-5","article-title":"Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature.","volume":"18","author":"Boumis","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.sge_brooks_intro","article-title":"Prebiotics and probiotics: methodology, efficacy, and potential health considerations.","volume":"95","author":"Brooks","year":"2012","journal-title":"J. AOAC Int."},{"key":"B5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s11154-013-9278-0","article-title":"Central mechanisms of obesity and related metabolic diseases.","volume":"14","author":"Cai","year":"2013","journal-title":"Rev. Endocr. Metab. Dis."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090863","article-title":"Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats.","volume":"9","author":"Carrier","year":"2014","journal-title":"PLoS One"},{"key":"B7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0308-8146(89)90036-8","article-title":"Superoxide dismutases in foods. A review.","volume":"33","author":"Donnelly","year":"1989","journal-title":"Food Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0958-6946(99)00044-8","article-title":"Prebiotics, probiotics and human gut microbiology.","volume":"9","author":"Fooks","year":"1999","journal-title":"Int. Dairy J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0168-1605(97)00136-0","article-title":"Probiotics.","volume":"39","author":"Guarner","year":"1998","journal-title":"Int. J. Food Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1053\/j.gastro.2009.08.042","article-title":"High-fat diet determines the composition of the murine gut microbiome independently of obesity.","volume":"137","author":"Hildebrandt","year":"2009","journal-title":"Gastroenterology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24183231","article-title":"Cyanate induces oxidative stress injury and abnormal lipid metabolism in liver through Nrf2\/HO-1.","volume":"24","author":"Hu","year":"2019","journal-title":"Molecules"},{"key":"B12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3945\/ajcn.110.010132","article-title":"Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans.","volume":"94","author":"Jumpertz","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"B13","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jnutbio.2007.05.007","article-title":"Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss.","volume":"19","author":"Jung","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ejim.2015.01.005","article-title":"Drug treatment of obesity: current status and future prospects.","volume":"26","author":"Kakkar","year":"2015","journal-title":"Eur. J. Int. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.crvi.2012.03.003","article-title":"Obesity, insulin resistance and diabetes in the sand rat exposed to a hypercaloric diet; possible protective effect for IL1-\u03b2.","volume":"335","author":"Khalkhal","year":"2012","journal-title":"C. R. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.7861\/clinmed.cme.20.1.2","article-title":"Cardiovascular prevention: frontiers in lipid guidelines","volume":"20","author":"Kim","year":"2020","journal-title":"Clin. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"397","DOI":"10.4014\/jmb.1802.02005","article-title":"Anti-obesity effect of red radish coral sprout extract by inhibited triglyceride accumulation in a microbial evaluation system and in high-fat diet-induced obese mice.","volume":"28","author":"Lee","year":"2018","journal-title":"J. Microbiol. Biotechnol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/16546628.2017.1348866","article-title":"Effect of dietary copper addition on lipid metabolism in rabbits.","volume":"61","author":"Lei","year":"2017","journal-title":"Food Nutr. Res."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8090381","article-title":"Antioxidant effects of Apocynum venetum tea extracts on d-galactose-induced aging model in mice.","volume":"8","author":"Li","year":"2019","journal-title":"Antioxidants"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9781914","article-title":"Inhibitory effect of Lactobacillus plantarum CQPC02 isolated from Chinese Sichuan pickles (Paocai) on constipation in mice.","volume":"2019","author":"Liu","year":"2019","journal-title":"J. Food Qual."},{"key":"B21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2147\/DMSO.S232279","article-title":"DHA protects against hepatic steatosis by activating sirt1 in a high fat diet-induced nonalcoholic fatty liver disease mouse model.","volume":"13","author":"Luo","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209565","article-title":"Changes in lipid droplets morphometric features in mammary epithelial cells upon exposure to non-esterified free fatty acids compared with VLDL.","volume":"13","author":"Mesilati-Stahy","year":"2018","journal-title":"PLoS One"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13813455.2020.1740742","article-title":"Astragalin, (3-O-glucoside of kaempferol), isolated from Moringa oleifera leaves modulates leptin, adiponectin secretion and inhibits adipogenesis in 3T3-L1 adipocytes.","volume":"2020","author":"Muni Swamy","year":"2020","journal-title":"Arch. Physiol. Biochem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1039\/c9fo02975c","article-title":"Bok-choy promotes growth performance, lipid metabolism and related gene expression in Syrian golden hamsters fed with a high-fat diet.","volume":"11","author":"Naseri","year":"2020","journal-title":"Food Funct."},{"key":"B25","doi-asserted-by":"publisher","first-page":"200","DOI":"10.2169\/internalmedicine1962.22.200","article-title":"Studies on the phenotyping system of hyperlipoproteinemias. Evaluation of a new method by enzymic staining of lipids in serum lipoproteins separated by electrophoresis on agarose.","volume":"22","author":"Ohno","year":"1983","journal-title":"Jpn. J. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.nutres.2019.09.008","article-title":"Severe calcium deficiency increased visceral fat accumulation, down-regulating genes associated with fat oxidation, and increased insulin resistance while elevating serum parathyroid hormone in estrogen-deficient rats.","volume":"73","author":"Park","year":"2020","journal-title":"Nutr. Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1530\/JOE-17-0592","article-title":"Lactobacillus acidophilus NS1 attenuates diet-induced obesity and fatty liver.","volume":"237","author":"Park","year":"2018","journal-title":"J. Endocrinol."},{"key":"B28","first-page":"341","article-title":"Dynamic changes of IL-17, occludin, and ZO-1 in mice with post-infectious irritable bowel syndrome.","volume":"39","author":"Peng","year":"2018","journal-title":"J. Sun Yat-sen Univ."},{"key":"B29","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3920\/BM2018.0066","article-title":"Mechanisms and immunomodulatory properties of pre- and probiotics.","volume":"10","author":"Peters","year":"2019","journal-title":"Benef. Microbes"},{"key":"B30","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.metabol.2017.01.034","article-title":"Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE).","volume":"70","author":"Pickens","year":"2017","journal-title":"Metabolism"},{"key":"B31","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.molmet.2019.08.019","article-title":"PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease.","volume":"29","author":"Rana","year":"2019","journal-title":"Mol. Metab."},{"key":"B32","doi-asserted-by":"publisher","first-page":"16767","DOI":"10.1073\/pnas.0808567105","article-title":"Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor. Gpr41.","volume":"105","author":"Samuel","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B33","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1080\/14787210.2019.1645597","article-title":"A successful history: probiotics and their potential as antimicrobials.","volume":"17","author":"Santacroce","year":"2019","journal-title":"Expert Rev. Anti-infect. Ther."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/829101","article-title":"Insights into the roles of gut microbes in obesity.","volume":"2008","author":"Sanz","year":"2008","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-2835-7","article-title":"Structural modulation of gut microbiota during alleviation of non-alcoholic fatty liver disease with Gynostemma pentaphyllum in rats.","volume":"20","author":"Shen","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072612","article-title":"Trace elements, PPARs, and metabolic syndrome.","volume":"21","author":"Shi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00403-019-01932-x","article-title":"Alterations in IL-4, IL-10 and IFN-\u03b3 levels synergistically decrease lipid content and protein expression of FAS and mature SREBP-1 in human sebocytes.","volume":"311","author":"Shin","year":"2019","journal-title":"Arch. Dermatol. Res."},{"key":"B38","article-title":"Obesity treatment.","volume":"84","author":"Stern","year":"1984","journal-title":"J. Am. Diet. Assoc."},{"key":"B39","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.imbio.2018.07.014","article-title":"Szczepankiewicz A. Interleukin 4 affects lipid metabolism and the expression of pro-inflammatory factors in mature rat adipocytes.","volume":"223","author":"Szczepankiewicz","year":"2018","journal-title":"Immunobiology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/MED.0b013e328308dbfb","article-title":"Microecology, obesity, and probiotics.","volume":"15","author":"Tennyson","year":"2008","journal-title":"Curr. Opin. Endocrinol. Diabetes. Obes."},{"key":"B41","first-page":"1558","article-title":"Research progress of rhein in treating diabetic nephropathy.","volume":"29","author":"Tong","year":"2017","journal-title":"Clin. J. Tradit. Chinese Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest.","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"B43","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jphs.2020.01.009","article-title":"Aqueous extracts of Lindera aggregate (Sims) Kosterm leaves regulate serum\/hepatic lipid and liver function in normal and hypercholesterolemic mice.","volume":"143","author":"Wang","year":"2020","journal-title":"J. Pharmacol. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"374","DOI":"10.11842\/wst.2016.03.008","article-title":"Effect of herb-partition moxibustion on protein and mRNA expressions of TLR4 and TNF-a in rats with ulcerative colitis.","volume":"18","author":"Wang","year":"2016","journal-title":"World Sci. Technol. Mod. Tradit. Chinese Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1136\/bmj.315.7114.997","article-title":"Obesity treatment.","volume":"315","author":"Wilding","year":"1997","journal-title":"Br. Med. J."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00223","article-title":"Effect of berberine on atherosclerosis and gut microbiota modulation and their correlation in high-fat diet-fed ApoE-\/- mice.","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600858","article-title":"Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation.","volume":"61","author":"Wu","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S1875-5364(20)30018-2","article-title":"Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice.","volume":"18","author":"Yi","year":"2020","journal-title":"Chinese J. Nat. Med."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7110530","article-title":"Isolation and identification of Lactobacillus plantarum HFY05 from natural fermented yak yogurt and its effect on alcoholic liver injury in mice.","volume":"7","author":"Yi","year":"2019","journal-title":"Microorganisms"},{"key":"B50","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3969\/j.issn.1000-484X.2019.05.004","article-title":"Effects of T lymphocytes on intestinal inflammation induced by high-fat diet.","volume":"35","author":"Yu","year":"2019","journal-title":"Chinese J. Immunol."},{"key":"B51","first-page":"393","article-title":"Palmitate triggers inflammatory response by upregulating fatty acid translocase in THP-1 macrophages.","volume":"34","author":"Zhang","year":"2018","journal-title":"Chinese J. Pathophysiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3136\/fstr.25.413","article-title":"Preventive effects of Lactobacillus plantarum CQPC07 on colitis induced by dextran sodium sulfate in mice.","volume":"25","author":"Zhang","year":"2019","journal-title":"Food Sci. Technol. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.biopha.2018.03.158","article-title":"Effects of shenling baizhu powder herbal formula on intestinal microbiota in high-fat diet-induced NAFLD rats.","volume":"102","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B54","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3969\/j.issn.1006-2157.2018.02.007","article-title":"Lipid-lowering ingredients in Chinese medicinals based on PPAR\u03b3-LXR\u03b1-ABCA1 pathway.","volume":"41","author":"Zhao","year":"2018","journal-title":"J.Beijing Univ. Tradit. Chinese Med."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/biom9090407","article-title":"Lactobacillus plantarum CQPC02 prevents obesity in mice through the PPAR-\u03b1 signaling pathway.","volume":"9","author":"Zhao","year":"2019","journal-title":"Biomolecules"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8110524","article-title":"White Peony (fermented Camellia sinensis) polyphenols help prevent alcoholic liver injury via antioxidation.","volume":"8","author":"Zhou","year":"2019","journal-title":"Antioxidants"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7070194","article-title":"Anti-obesity effects of Lactobacillus fermentum CQPC05 isolated from Sichuan pickle in high-fat diet-induced obese mice through PPAR-\u03b1 signaling pathway.","volume":"7","author":"Zhu","year":"2019","journal-title":"Microorganisms"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.573586\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:53:53Z","timestamp":1599094433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmicb.2020.573586\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":57,"alternative-id":["10.3389\/fmicb.2020.573586"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.573586","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,3]]},"article-number":"573586"}}