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Microbiol."],"abstract":"<jats:p>Autoimmune diseases are increasingly linked to aberrant gut microbiome and relevant metabolites. However, the association between vitiligo and the gut microbiome remains to be elucidated. Thus, we conducted a case-control study through 16S rRNA sequencing and serum untargeted-metabolomic profiling based on 30 vitiligo patients and 30 matched healthy controls. In vitiligo patients, the microbial composition was distinct from that of healthy controls according to the analysis on \u03b1- and \u03b2-diversity (<jats:italic>P<\/jats:italic> &amp;lt; 0.05), with a characteristic decreased <jats:italic>Bacteroidetes: Firmicutes<\/jats:italic> ratio. Meanwhile, the levels of 23 serum metabolites (including taurochenodeoxycholate and L-NG-monomethyl-arginine) in the vitiligo patients were different from those in the healthy individuals and showed significant correlations with some microbial markers. We found that <jats:italic>Corynebacterium 1<\/jats:italic>, <jats:italic>Ruminococcus 2<\/jats:italic>, <jats:italic>Jeotgalibaca<\/jats:italic> and <jats:italic>Psychrobacter<\/jats:italic> were correlated significantly with disease duration and serum IL-1\u03b2 level in vitiligo patients. And <jats:italic>Psychrobacter<\/jats:italic> was identified as the most predictive features for vitiligo by machine learning analysis (\u201cimportance\u201d = 0.0236). Finally, combining multi-omics data and joint prediction models with accuracies up to 0.929 were established with dominant contribution of <jats:italic>Corynebacterium 1<\/jats:italic> and <jats:italic>Psychrobacter<\/jats:italic>. Our findings replenished the previously unknown relationship between gut dysbiosis and vitiligo circulating metabolome and enrolled the gut-skin axis into the understanding of vitiligo pathogenesis.<\/jats:p>","DOI":"10.3389\/fmicb.2020.592248","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T06:12:25Z","timestamp":1607926345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":52,"title":["Gut Microbial Dysbiosis and Plasma Metabolic Profile in Individuals With Vitiligo"],"prefix":"10.3389","volume":"11","author":[{"given":"Qingrong","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhubiao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianru","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"W537","DOI":"10.1093\/nar\/gky379","article-title":"The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update.","volume":"46","author":"Afgan","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00191-16","article-title":"Deblur rapidly resolves single-nucleotide community sequence patterns.","volume":"2","author":"Amir","year":"2017","journal-title":"mSystems"},{"key":"B3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1442-9993.2001.01070.pp.x","article-title":"A new method for non-parametric multivariate analysis of variance.","volume":"26","author":"Anderson","year":"2001","journal-title":"Austral Ecol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1093\/bioinformatics\/btv287","article-title":"Tax4Fun: predicting functional profiles from metagenomic 16S rRNA data.","volume":"31","author":"Asshauer","year":"2015","journal-title":"Bioinformatics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/bjd.15560","article-title":"Factors affecting quality of life in patients with vitiligo: a nationwide study.","volume":"178","author":"Bae","year":"2018","journal-title":"Br. 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