{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:29:04Z","timestamp":1789180144801,"version":"build-2803163510"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The study investigated the impact of dietary montmorillonite on the growth performance, intestinal mucosal barrier, and microbial community in weaned piglets with control group (CON) and dietary supplementation of 0.2% montmorillonite (0.2% M). Compared with the CON group, 0.2% M feed in the diet increased the average daily gain (ADG) on days 15\u201335 and day 1\u201335 and the average daily feed intake on days 1\u201335 (ADFI) (0.05 &amp;lt; <jats:italic>P<\/jats:italic> &amp;lt; 0.1). Besides, higher villus height of the duodenum and jejunum and lower crypt depth of duodenum and colon were revealed in the 0.2% M group than in the CON group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Moreover, the V\/C (ratio of the villus height and crypt depth) in the 0.2% M group was increased compared to that in the CON group both from the duodenum and ileum (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The relative mRNA expression of <jats:italic>mucin-1<\/jats:italic>, <jats:italic>ITGB1<\/jats:italic> (<jats:italic>\u03b21-integrins<\/jats:italic>), and <jats:italic>PKC<\/jats:italic> (<jats:italic>protein kinase C<\/jats:italic>) of ileum in the 0.2% M group were upregulated (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) compared to that in the CON group. The digesta sample of ileum from piglets in the 0.2% M group contained greater (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) intestinal bacterial diversity and abundances of probiotics, such as <jats:italic>Streptococcus<\/jats:italic>, <jats:italic>Eubacterium_rectale_group<\/jats:italic>, and <jats:italic>Lactobacillus<\/jats:italic>, which could promote the synthesis of carbon-containing biomolecules. Overall, dietary supplementation of 0.2% M was shown to have a tendency to improve the growth performance of weaned piglets and may enhance their intestinal mucosal barrier function via altering the gut microbiota.<\/jats:p>","DOI":"10.3389\/fmicb.2020.593056","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T04:46:19Z","timestamp":1606279579000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Dietary Montmorillonite Improves the Intestinal Mucosal Barrier and Optimizes the Intestinal Microbial Community of Weaned Piglets"],"prefix":"10.3389","volume":"11","author":[{"given":"Han","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunxi","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenju","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/ismej.2015.151","article-title":"Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants.","volume":"10","author":"Berni Canani","year":"2016","journal-title":"Isme J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.cis.2007.12.008","article-title":"Adsorption of a few heavy metals on natural and modified kaolinite and montmorillonite: A review.","volume":"140","author":"Bhattacharyya","year":"2008","journal-title":"Adv. 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