{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:45:03Z","timestamp":1787957103113,"version":"build-2784847793"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2020.602057","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:38:56Z","timestamp":1605055136000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Evaluation of Staphylococcal Bacteriophage Sb-1 as an Adjunctive Agent to Antibiotics Against Rifampin-Resistant Staphylococcus aureus Biofilms"],"prefix":"10.3389","volume":"11","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamta","family":"Tkhilaishvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Trampuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Gonzalez Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1128\/aac.02073-12","article-title":"Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.","volume":"57","author":"Abdelhady","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8030103","article-title":"Synergistic action of phage and antibiotics: parameters to enhance the killing efficacy against mono and dual-species biofilms.","volume":"8","author":"Akturk","year":"2019","journal-title":"Antibiotics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.1007\/s00253-019-09810-2","article-title":"Peculiarities of Staphylococcus aureus phages and their possible application in phage therapy.","volume":"103","author":"Azam","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1128\/aac.00181-13","article-title":"A combined pharmacodynamic quantitative and qualitative model reveals the potent activity of daptomycin and delafloxacin against Staphylococcus aureus biofilms.","volume":"57","author":"Bauer","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B5","author":"Berbari","year":"2020","journal-title":"Prosthetic Joint Infection: Treatment UpToDate."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00572","article-title":"Differential activity of the combination of vancomycin and amikacin on planktonic vs. biofilm-growing Staphylococcus aureus bacteria in a hollow fiber infection model.","volume":"9","author":"Broussou","year":"2018","journal-title":"Front. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6413982","article-title":"Efficacy of linezolid and fosfomycin in catheter-related biofilm infection caused by methicillin-resistant Staphylococcus aureus.","volume":"2016","author":"Chai","year":"2016","journal-title":"BioMed Res. Int."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2842-6","article-title":"Daptomycin treatment in patients with resistant staphylococcal periprosthetic joint infection.","volume":"17","author":"Chang","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168615","article-title":"Synergy and order effects of antibiotics and phages in killing Pseudomonas aeruginosa biofilms.","volume":"12","author":"Chaudhry","year":"2017","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.1128\/aac.01811-09","article-title":"Unpredictable effects of rifampin as an adjunctive agent in elimination of rifampin-susceptible and -resistant Staphylococcus aureus strains grown in biofilms.","volume":"54","author":"Croes","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B11","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1302\/2058-5241.4.180095","article-title":"Implant materials and prosthetic joint infection: the battle with the biofilm.","volume":"4","author":"Davidson","year":"2019","journal-title":"EFORT Open Rev."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1101\/358879","article-title":"Adjunct phage treatment enhances the effectiveness of low antibiotic concentration against Staphylococcus aureus biofilms in vitro.","author":"Dickey","year":"2018","journal-title":"BioRxiv"},{"key":"B13","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jinf.2008.04.003","article-title":"Clinical failures of appropriately-treated methicillin-resistant Staphylococcus aureus infections.","volume":"57","author":"Dombrowski","year":"2008","journal-title":"J. Infect."},{"key":"B14","year":"2020","journal-title":"Breakpoint tables for interpretation of MICs and zone diameters. Version 10.0."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03227","article-title":"The ability of lytic staphylococcal podovirus vB_SauP_phiAGO1.3 to coexist in equilibrium with its host facilitates the selection of host mutants of attenuated virulence but does not preclude the phage antistaphylococcal activity in a nematode infection model.","volume":"9","author":"G\u0142owacka-Rutkowska","year":"2019","journal-title":"Front. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1093\/jac\/dkz174","article-title":"In vitro antimicrobial activity against Abiotrophia defectiva and Granulicatella elegans biofilms.","volume":"74","author":"Gonzalez Moreno","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"B17","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.cmi.2014.10.024","article-title":"ESCMID guideline for the diagnosis and treatment of biofilm infections 2014.","author":"Hoiby","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"key":"B18","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1302\/2058-5241.4.180092","article-title":"Periprosthetic joint infection: current concepts and outlook.","volume":"4","author":"Izakovicova","year":"2019","journal-title":"EFORT Open Rev."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118557","article-title":"Isolation of phages for phage therapy: a comparison of spot tests and efficiency of plating analyses for determination of host range and efficacy.","volume":"10","author":"Khan Mirzaei","year":"2015","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00127","article-title":"Does treatment order matter? Investigating the ability of bacteriophage to augment antibiotic activity against Staphylococcus aureus biofilms.","volume":"9","author":"Kumaran","year":"2018","journal-title":"Front. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.medmal.2008.06.023","article-title":"Phage therapy experience at the Eliava Institute.","volume":"38","author":"Kutateladze","year":"2008","journal-title":"Med. Mal. Infect."},{"key":"B22","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1751-7915.2011.00259.x","article-title":"Evaluation of lytic activity of staphylococcal bacteriophage Sb-1 against freshly isolated clinical pathogens.","volume":"4","author":"Kvachadze","year":"2011","journal-title":"Microb. Biotechnol."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.27.967034","article-title":"Phage-antibiotic synergy is driven by a unique combination of antibacterial mechanism of action and stoichiometry.","author":"Liu","year":"2020","journal-title":"BioRxiv"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00051","article-title":"The factors affecting effectiveness of treatment in phages therapy.","volume":"5","author":"Ly-Chatain","year":"2014","journal-title":"Front. Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1128\/aac.02420-12","article-title":"High activity of Fosfomycin and Rifampin against methicillin-resistant Staphylococcus aureus biofilm in vitro and in an experimental foreign-body infection model.","volume":"58","author":"Mihailescu","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1128\/aac.00317-09","article-title":"Inoculum effect with cefazolin among clinical isolates of methicillin-susceptible Staphylococcus aureus: frequency and possible cause of cefazolin treatment failure.","volume":"53","author":"Nannini","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"B27","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1139\/cjm-2015-0855","article-title":"Effects of vancomycin, daptomycin, and tigecycline on coagulase-negative Staphylococcus biofilm and bacterial viability within biofilm: an in vitro biofilm model.","volume":"62","author":"Ozturk","year":"2016","journal-title":"Can. J. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00134-016-4572-4","article-title":"Treatment of severe MRSA infections: current practice and further development.","volume":"43","author":"Paiva","year":"2017","journal-title":"Intensive Care Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/510015a","article-title":"Phage therapy gets revitalized.","volume":"510","author":"Reardon","year":"2014","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1574-695x.2012.00977.x","article-title":"Synergistic phage-antibiotic combinations for the control of Escherichia coli biofilms in vitro.","volume":"65","author":"Ryan","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1080\/17453670710015418","article-title":"Risk factors associated with acute hip prosthetic joint infections and outcome of treatment with a rifampin-based regimen.","volume":"79","author":"Sendi","year":"2008","journal-title":"Acta Orthop."},{"key":"B32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.cmi.2016.10.002","article-title":"The use of rifampin in staphylococcal orthopaedic-device-related infections.","volume":"23","author":"Sendi","year":"2017","journal-title":"Clin. Microbiol. Infect."},{"key":"B33","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ijantimicag.2008.08.029","article-title":"Comparison of biofilm-associated cell survival following in vitro exposure of meticillin-resistant Staphylococcus aureus biofilms to the antibiotics clindamycin, daptomycin, linezolid, tigecycline and vancomycin.","volume":"33","author":"Smith","year":"2009","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B34","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1128\/AAC.45.3.649-659.2001","article-title":"Bacteriophage therapy.","volume":"45","author":"Sulakvelidze","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"B35","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bjid.2019.05.006","article-title":"Daptomycin to bone and joint infections and prosthesis joint infections: a systematic review.","volume":"23","author":"Telles","year":"2019","journal-title":"Braz. J. Infect. Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.ijantimicag.2018.09.006","article-title":"Bacteriophage Sb-1 enhances antibiotic activity against biofilm, degrades exopolysaccharide matrix and targets persisters of Staphylococcus aureus.","volume":"52","author":"Tkhilaishvili","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B37","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1128\/cmr.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1111\/j.1365-2672.2011.04989.x","article-title":"Isolation and characterization of lytic bacteriophages against enterohaemorrhagic Escherichia coli.","volume":"110","author":"Viazis","year":"2011","journal-title":"J. Appl. Microbiol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-019-1573-9","article-title":"Evolution of resistance mechanisms and biological characteristics of rifampicin-resistant Staphylococcus aureus strains selected in vitro.","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Microbiol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02522","article-title":"Synergistic activity of fosfomycin, ciprofloxacin, and gentamicin against Escherichia coli and Pseudomonas aeruginosa biofilms.","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Microbiol."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00934","article-title":"SLPW: a virulent bacteriophage targeting methicillin-resistant Staphylococcus aureus in vitro and in vivo.","volume":"7","author":"Wang","year":"2016","journal-title":"Front. Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/jac\/14.suppl_d.7","article-title":"Mode of action and in-vitro activity of vancomycin.","volume":"14","author":"Watanakunakorn","year":"1984","journal-title":"J. Antimicrob. Chemother."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01746-18","article-title":"Role of rifampin against staphylococcal biofilm infections in vitro, in animal models, and in orthopedic-device-related infections.","volume":"63","author":"Zimmerli","year":"2019","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2020.602057\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:38:58Z","timestamp":1605055138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2020.602057\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":43,"alternative-id":["10.3389\/fmicb.2020.602057"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.602057","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,11]]},"article-number":"602057"}}