{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:18:58Z","timestamp":1787026738300,"version":"build-2736575974"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Recycling waste into new materials and energy is becoming a major challenge in the context of the future circular economy, calling for advanced methods of waste treatment. For instance, microbially-mediated anaerobic digestion is widely used for conversion of sewage sludge into biomethane, fertilizers and other products, yet the efficiency of microbial digestion is limited by the occurrence of antibiotics in sludges, originating from drug consumption for human and animal health. Here we present antibiotic levels in Chinese wastewater, then we review the effects of antibiotics on hydrolysis, acidogenesis and methanogenesis, with focus on macrolides, tetracyclines, \u03b2-lactams and antibiotic mixtures. We detail effects of antibiotics on fermentative bacteria and methanogenic archaea. Most results display adverse effects of antibiotics on anaerobic digestion, yet some antibiotics promote hydrolysis, acidogenesis and methanogenesis.<\/jats:p>","DOI":"10.3389\/fmicb.2020.611613","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:07:40Z","timestamp":1611792460000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":62,"title":["Effect of Antibiotics on the Microbial Efficiency of Anaerobic Digestion of Wastewater: A Review"],"prefix":"10.3389","volume":"11","author":[{"given":"Leilei","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lichtfouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenkai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Senthil","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.126113","article-title":"Fenton-like catalyst based on a reticulated porous perovskite material: activity and stability for the on-site removal of pharmaceutical micropollutans in a hospital wastewater.","volume":"401","author":"Alamo","year":"2020","journal-title":"Chem. Eng. J."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105144","article-title":"Behavior of ionophore antibiotics in aquatic environments in Argentina: the distribution on different scales in water courses and the role of wetlands in depuration.","volume":"133","author":"Alonso","year":"2019","journal-title":"Environ. Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"8581","DOI":"10.1016\/j.biortech.2010.06.075","article-title":"The effect and fate of antibiotics during the anaerobic digestion of pig manure.","volume":"101","author":"Alvarez","year":"2010","journal-title":"Bioresour. Technol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.1021\/es060428j","article-title":"Influence of the antibiotic erythromycin on anaerobic treatment of a pharmaceutical wastewater.","volume":"40","author":"Amin","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1016\/j.procbio.2006.03.010","article-title":"The fate and effect of oxytetracycline during the anaerobic digestion of manure from therapeutically treated calves.","volume":"41","author":"Arikan","year":"2006","journal-title":"Process Biochem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/1758-2229.12735","article-title":"Understanding antimicrobial discovery and resistance from a metagenomic and metatranscriptomic perspective: advances and applications.","volume":"11","author":"Asante","year":"2019","journal-title":"Environ. Microbiol. Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.chemosphere.2014.09.045","article-title":"Inhibitory effects of antibiotic combinations on syntrophic bacteria, homoacetogens and methanogens.","volume":"120","author":"Aydin","year":"","journal-title":"Chemosphere"},{"key":"B8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.watres.2015.02.043","article-title":"Application of real-time PCR to determination of combined effect of antibiotics on Bacteria. Methanogenic Archaea. Archaea in anaerobic sequencing batch reactors.","volume":"76","author":"Aydin","year":"","journal-title":"Water Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.biortech.2013.01.032","article-title":"The combined effect of cefazolin and oxytertracycline on biogas production from thermophilic anaerobic digestion of dairy manure.","volume":"133","author":"Beneragama","year":"2013","journal-title":"Bioresour. Technol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.foodpol.2010.05.007","article-title":"Policies and practices for aquaculture food safety in China.","volume":"35","author":"Broughton","year":"2010","journal-title":"Food Policy"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/j.wasman.2012.04.016","article-title":"The effects of substrate pre-treatment on anaerobic digestion systems: a review.","volume":"32","author":"Carlsson","year":"2012","journal-title":"Waste Manage."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121888","article-title":"Acidogenesis is a key step in the anaerobic biotransformation of organic micropollutants.","volume":"389","author":"Carneiro","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"B13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.chemosphere.2014.12.004","article-title":"Acute effect of erythromycin on metabolic transformations of volatile fatty acid mixture under anaerobic conditions.","volume":"124","author":"Cetecioglu","year":"2015","journal-title":"Chemosphere"},{"key":"B14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.biortech.2012.03.020","article-title":"Acute inhibitory impact of antimicrobials on acetoclastic methanogenic activity.","volume":"114","author":"Cetecioglu","year":"2012","journal-title":"Bioresour. Technol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.2166\/wst.2011.222","article-title":"Tolerance of the antibiotic Tylosin on treatment performance of an Up-flow Anaerobic Stage Reactor (UASR).","volume":"63","author":"Chelliapan","year":"2011","journal-title":"Water Sci. Technol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1080\/19443994.2013.854037","article-title":"Impact of hydraulic retention time on the performance and archaea populations of an anaerobic reactor treating synthetic Tylosin wastewater.Desalin.","volume":"52","author":"Chelliapan","year":"2014","journal-title":"Water Treat."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.122570","article-title":"Influence of roxithromycin as antibiotic residue on volatile fatty acids recovery in anaerobic fermentation of waste activated sludge.","volume":"394","author":"Chen","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envint.2016.03.026","article-title":"Long-term field application of sewage sludge increases the abundance of antibiotic resistance genes in soil.","volume":"9","author":"Chen","year":"2016","journal-title":"Environ. Int."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4044","DOI":"10.1016\/j.biortech.2007.01.057","article-title":"Inhibition of anaerobic digestion process: a review.","volume":"99","author":"Chen","year":"2008","journal-title":"Bioresour. Technol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.biortech.2018.05.010","article-title":"Problematic effects of antibiotics on anaerobic treatment of swine wastewater.","volume":"263","author":"Cheng","year":"2018","journal-title":"Bioresour. Technol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1897\/05-415r.1","article-title":"Ecotoxicity of mixtures of antibiotics used in aquacultures.","volume":"25","author":"Christensen","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/s1002-0160(18)60052-9","article-title":"Importance of hydrogenotrophic, aceticlastic and methylotrophic methanogenesis for methane production in terrestrial, aquatic and other anoxic environments: a mini review.","volume":"30","author":"Conrad","year":"2020","journal-title":"Pedosphere."},{"key":"B23","doi-asserted-by":"publisher","first-page":"9128","DOI":"10.1021\/es102765a","article-title":"Effect of temperature on the fate of genes encoding tetracycline resistance and the integrase of class 1 integrons within anaerobic and aerobic digesters treating municipal wastewater solids.","volume":"44","author":"Diehl","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/jps.2600830422","article-title":"Photoisomerization kinetics of cefuroxime axetil and related-compounds.","volume":"83","author":"Fabre","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"445","DOI":"10.2166\/wst.2015.507","article-title":"Tylosin effect on methanogenesis in an anaerobic biomass from swine wastewater treatment.","volume":"73","author":"Garcia-Sanchez","year":"2016","journal-title":"Water Sci. Technol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1469-0691.2012.03868.x","article-title":"Metagenomics and antibiotics.","volume":"18","author":"Garmendia","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1016\/j.biotechadv.2018.06.001","article-title":"Pre-treatments to enhance the biodegradability of waste activated sludge: elucidating the rate limiting step.","volume":"36","author":"Gonzalez","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"B28","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.scitotenv.2013.12.008","article-title":"Occurrence and fate of antibiotic, analgesic\/anti-inflammatory, and antifungal compounds in five wastewater treatment processes.","volume":"473","author":"Guerra","year":"2014","journal-title":"Sci. Total Environ."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105667","article-title":"Platforms for elucidating antibiotic resistance in single genomes and complex metagenomes.","volume":"138","author":"Gupta","year":"2020","journal-title":"Environ. Int."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.137532","article-title":"Manure anaerobic digestion effects and the role of pre- and post-treatments on veterinary antibiotics and antibiotic resistance genes removal efficiency.","volume":"721","author":"Gurmessa","year":"2020","journal-title":"Sci. Total Environ."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.aambs.2016.09.001","article-title":"Biologically produced methane as a renewable energy source.","volume":"97","author":"Holmes","year":"2016","journal-title":"Adv. Appl. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.cej.2018.01.149","article-title":"Treatment of pharmaceutical wastewater containing beta-lactams antibiotics by a pilot-scale anaerobic membrane bioreactor (AnMBR).","volume":"341","author":"Huang","year":"2018","journal-title":"Chem. Eng. J."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2019.121598","article-title":"Effect of clarithromycin on the production of volatile fatty acids from waste activated sludge anaerobic fermentation.","volume":"288","author":"Huang","year":"2019","journal-title":"Bioresour. Technol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.watres.2015.11.071","article-title":"Antibiotic resistance genes and human bacterial pathogens: Co-occurrence, removal, and enrichment in municipal sewage sludge digesters.","volume":"91","author":"Ju","year":"2016","journal-title":"Water Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","article-title":"A common mechanism of cellular death induced by bactericidal antibiotics.","volume":"130","author":"Kohanski","year":"2007","journal-title":"Cell"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.126351","article-title":"Occurrence and toxicity of antibiotics in the aquatic environment: a review.","volume":"251","author":"Kovalakova","year":"2020","journal-title":"Chemosphere"},{"key":"B37","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/j.1747-0285.2011.01142.x","article-title":"Interaction between the antibiotic tetracycline and the elongation factor 1 alpha from the archaeon Sulfolobus solfataricus.","volume":"78","author":"Lamberti","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"B38","doi-asserted-by":"publisher","first-page":"9543","DOI":"10.1021\/es202775r","article-title":"Tertiary-treated municipal wastewater is a significant point source of antibiotic resistance genes into duluth-superior harbor.","volume":"45","author":"LaPara","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1126\/science.347.6223.704","article-title":"Pharmaceuticals China\u2019s lakes of pig manure spawn antibiotic resistance.","volume":"347","author":"Larson","year":"2015","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.esd.2018.03.009","article-title":"Influence of cefazolin contamination on performance of two-stage and single stage anaerobic batch digesters.","volume":"44","author":"Lateef","year":"2018","journal-title":"Energy Sustain. Dev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.cej.2017.02.123","article-title":"Effect of two-step thermo-disintegration on the enhancing solubilization and anaerobic biodegradability of excess waste sludge.","volume":"317","author":"Lee","year":"2017","journal-title":"Chem. Eng. J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.scitotenv.2018.06.271","article-title":"A new insight into the strategy for methane production affected by conductive carbon cloth in wetland soil: Beneficial to acetoclastic methanogenesis instead of CO2 reduction.","volume":"643","author":"Li","year":"2018","journal-title":"Sci. Total Environ."},{"key":"B43","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.scitotenv.2016.12.188","article-title":"Partition and fate analysis of fluoroquinolones in sewage sludge during anaerobic digestion with thermal hydrolysis pretreatment.","volume":"581","author":"Li","year":"2017","journal-title":"Sci. Total Environ."},{"key":"B44","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.scitotenv.2012.12.050","article-title":"Occurrence, distribution and potential affecting factors of antibiotics in sewage sludge of wastewater treatment plants in China.","volume":"445","author":"Li","year":"2013","journal-title":"Sci. Total Environ."},{"key":"B45","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.envint.2018.05.023","article-title":"Large-scale biogeographical patterns of bacterial antibiotic resistome in the waterbodies of China.","volume":"117","author":"Liu","year":"2018","journal-title":"Environ. Int."},{"key":"B46","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.biortech.2014.07.056","article-title":"Long-term effect of the antibiotic cefalexin on methane production during waste activated sludge anaerobic digestion.","volume":"169","author":"Lu","year":"2014","journal-title":"Bioresour. Technol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.583995","article-title":"Differences in tetracycline antibiotic resistance genes and microbial community structure during aerobic composting and anaerobic digestion.","volume":"11","author":"Luo","year":"2020","journal-title":"Front. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/s0960-8524(00)00046-8","article-title":"Effect of antibiotics on psychrophilic anaerobic digestion of swine manure slurry in sequencing batch reactors.","volume":"75","author":"Masse","year":"2000","journal-title":"Bioresour. Technol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/s0960-8524(00)00023-7","article-title":"Anaerobic digestion of organic solid wastes, An overview of research achievements and perspectives.","volume":"74","author":"Mata-Alvarez","year":"2000","journal-title":"Bioresour. Technol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.biortech.2018.04.030","article-title":"Co-digestion of food waste and sewage sludge for methane production: Current status and perspective.","volume":"265","author":"Mehariya","year":"2018","journal-title":"Bioresour. Technol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.chemosphere.2017.05.171","article-title":"The long-term impact of cefalexin on organic substrate degradation and microbial community structure in EGSB system.","volume":"184","author":"Meng","year":"2017","journal-title":"Chemosphere"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.537783","article-title":"Effects of sulfamethoxazole on the microbial community dynamics during the anaerobic digestion process.","volume":"11","author":"Miritana","year":"2020","journal-title":"Front. Microbiol."},{"key":"B53","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00159-11","article-title":"Potential for direct interspecies electron transfer in methanogenic wastewater digester aggregates.","volume":"2","author":"Morita","year":"2011","journal-title":"mBio"},{"key":"B54","doi-asserted-by":"publisher","first-page":"5323","DOI":"10.1007\/s00253-018-9003-8","article-title":"Seeking key microorganisms for enhancing methane production in anaerobic digestion of waste sewage sludge.","volume":"102","author":"Mustapha","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"9355","DOI":"10.1007\/s00253-016-7767-2","article-title":"Impact of different antibiotics on methane production using waste-activated sludge: mechanisms and microbial community dynamics.","volume":"100","author":"Mustapha","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134899","article-title":"Impact of roxithromycin on waste activated sludge anaerobic digestion: methane production, carbon transformation and antibiotic resistance genes.","volume":"703","author":"Ni","year":"2020","journal-title":"Sci. Total Environ."},{"key":"B57","doi-asserted-by":"publisher","first-page":"6230","DOI":"10.1007\/s11356-014-3841-4","article-title":"Acute effects of various antibiotic combinations on acetoclastic methanogenic activity.","volume":"22","author":"Ozbayram","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bej.2013.10.002","article-title":"Chronic effect of erythromycin on substrate biodegradation kinetics of activated sludge.","volume":"81","author":"Pala-Ozkok","year":"2013","journal-title":"Biochem. Eng. J."},{"key":"B59","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.biortech.2015.05.079","article-title":"Effect of ultrasonic and ozone pre-treatments on pharmaceutical waste activated sludge\u2019s solubilisation, reduction, anaerobic biodegradability and acute biological toxicity.","volume":"192","author":"Pei","year":"2015","journal-title":"Bioresour. Technol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.envint.2017.10.016","article-title":"Review of antibiotic resistance in China and its environment.","volume":"110","author":"Qiao","year":"2018","journal-title":"Environ. Int."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/clen.201900281","article-title":"Individual and synergistic effects of metronidazole, amoxicillin, and ciprofloxacin on methane fermentation with sewage sludge.","volume":"48","author":"Rusanowska","year":"2020","journal-title":"Clean Soil Air Water."},{"key":"B62","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s002530050865","article-title":"The action of antibiotics on the anaerobic digestion process.","volume":"46","author":"Sanz","year":"1996","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/bit.22934","article-title":"Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor.","volume":"108","author":"Shimada","year":"2011","journal-title":"Biotechnol. Bioeng."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.123510","article-title":"Determining the composition of bacterial community and relative abundance of specific antibiotics resistance genes via thermophilic anaerobic digestion of sewage sludge.","volume":"311","author":"Shin","year":"2020","journal-title":"Bioresour. Technol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.chemosphere.2010.10.026","article-title":"Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures.","volume":"82","author":"Sim","year":"2011","journal-title":"Chemosphere"},{"key":"B66","doi-asserted-by":"publisher","first-page":"4740","DOI":"10.1016\/j.watres.2009.08.005","article-title":"Effect of antimicrobial compounds tylosin and chlortetracycline during batch anaerobic swine manure digestion.","volume":"43","author":"Stone","year":"2009","journal-title":"Water Res."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105156","article-title":"Responses of antibiotics, antibiotic resistance genes, and mobile genetic elements in sewage sludge to thermal hydrolysis pre-treatment and various anaerobic digestion conditions.","volume":"133","author":"Sun","year":"2019","journal-title":"Environ. Int."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121363","article-title":"The effects of thiosulfinates on methane production from anaerobic co-digestion of waste activated sludge and food waste and mitigate method.","volume":"384","author":"Tao","year":"2020","journal-title":"J. Hazard. Mater"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.envpol.2018.02.023","article-title":"Chronic impacts of oxytetracycline on mesophilic anaerobic digestion of excess sludge: Inhibition of hydrolytic acidification and enrichment of antibiotic resistome.","volume":"238","author":"Tian","year":"2018","journal-title":"Environ. Pollut."},{"key":"B70","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1073\/pnas.1503141112","article-title":"Global trends in antimicrobial use in food animals.","volume":"112","author":"Van Boeckel","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/aac.45.1.1-12.2001","article-title":"Macrolide resistance conferred by base substitutions in 23S rRNA.","volume":"45","author":"Vester","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"B72","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/0922-338x(89)90067-6","article-title":"Influence of penicillin on the stabilization of anaerobic-digestion of rain tree kernels for methane generation.","volume":"68","author":"Viswanath","year":"1989","journal-title":"J. Ferment. Bioeng."},{"key":"B73","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/35021219","article-title":"Molecular mechanisms that confer antibacterial drug resistance.","volume":"406","author":"Walsh","year":"2000","journal-title":"Nature"},{"key":"B74","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.scitotenv.2017.10.128","article-title":"Occurrence and diversity of antibiotic resistance in untreated hospital wastewater.","volume":"621","author":"Wang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/j.chemosphere.2010.11.067","article-title":"Occurrence of veterinary antibiotics in animal wastewater and surface water around farms in Jiangsu Province, China.","volume":"82","author":"Wei","year":"2011","journal-title":"Chemosphere"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/j.bbabio.2013.12.002","article-title":"Bioenergetics and anaerobic respiratory chains of aceticlastic methanogens.","volume":"1837","author":"Welte","year":"2014","journal-title":"Bioenergetics"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124977","article-title":"Augmentation of chloramphenicol degradation by Geobacter-based biocatalysis and electric field.","volume":"409","author":"Xiao","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.soilbio.2020.107938","article-title":"Carbon nanotubes accelerate acetoclastic methanogenesis: From pure cultures to anaerobic soils.","volume":"150","author":"Xiao","year":"","journal-title":"Soil Biol. Biochem."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.124469","article-title":"Methane production by acetate dismutation stimulated by Shewanella oneidensis and carbon materials: an alternative to classical CO2 reduction.","volume":"389","author":"Xiao","year":"","journal-title":"Chem. Eng. J."},{"key":"B80","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1039\/c7en00577f","article-title":"Nano-Fe3O4 particles accelerating electromethanogenesis on an hour-long timescale in wetland soil.","volume":"5","author":"Xiao","year":"2018","journal-title":"Environ. Sci. Nano"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1007\/s10311-019-00863-3","article-title":"Biochar promotes methane production at high acetate concentrations in anaerobic soils.","volume":"17","author":"Xiao","year":"","journal-title":"Environ. Chem. Lett."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.122229","article-title":"Simultaneous intensification of direct acetate cleavage and CO2 reduction to generate methane by bioaugmentation and increased electron transfer.","volume":"378","author":"Xiao","year":"","journal-title":"Chem. Eng. J."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.catena.2019.104081","article-title":"A potential contribution of a Fe(III)-rich red clay horizon to methane release: biogenetic magnetite-mediated methanogenesis.","volume":"181","author":"Xiao","year":"","journal-title":"Catena"},{"key":"B84","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.scitotenv.2017.03.279","article-title":"Stimulation of long-term ammonium nitrogen deposition on methanogenesis by Methanocellaceae in a coastal wetland.","volume":"595","author":"Xiao","year":"2017","journal-title":"Sci. Total Environ."},{"key":"B85","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/b978-0-12-819722-6.00009-2","article-title":"Present scenario of antibiotic use in veterinary practice: importance of wastewater microbiology.","volume":"9","author":"Yadav","year":"2020","journal-title":"Curr. Dev. Biotechnol. Bioeng."},{"key":"B86","doi-asserted-by":"crossref","DOI":"10.1002\/clen.201700653","article-title":"Antibiotic inhibition on anaerobic digestion of animal manure and controlling strategies: a short review.","volume":"47","author":"Yang","year":"2019","journal-title":"Clean Soil Air Water."},{"key":"B87","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.cej.2016.04.120","article-title":"Establishment of a pretreatment method for tetracycline production wastewater using enhanced hydrolysis.","volume":"300","author":"Yi","year":"2016","journal-title":"Chem. Eng. J."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.125355","article-title":"Deciphering the role of calcium peroxide on the fate of antibiotic resistance genes and mobile genetic elements during bioelectrochemically-assisted anaerobic composting of excess dewatered sludge.","volume":"397","author":"Yu","year":"2020","journal-title":"Chem. Eng. J."},{"key":"B89","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1111\/1365-2745.13164","article-title":"Spartina alterniflora invasion drastically increases methane production potential by shifting methanogenesis from hydrogenotrophic to methylotrophic pathway in a coastal marsh.","volume":"107","author":"Yuan","year":"2019","journal-title":"J. Ecol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","article-title":"Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source Analysis, multimedia modeling, and linkage to bacterial resistance.","volume":"49","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.biortech.2018.01.100","article-title":"Variation of antibiotics in sludge pretreatment and anaerobic digestion processes: degradation and solid-liquid distribution.","volume":"255","author":"Zhang","year":"2018","journal-title":"Bioresour. Technol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.cej.2018.11.050","article-title":"Antibiotic residues may stimulate or suppress methane yield and microbial activity during high-solid anaerobic digestion.","volume":"359","author":"Zhi","year":"2019","journal-title":"Chem. Eng. J."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2020.611613\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:07:43Z","timestamp":1611792463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2020.611613\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,28]]},"references-count":92,"alternative-id":["10.3389\/fmicb.2020.611613"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2020.611613","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,28]]},"article-number":"611613"}}