{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:56:54Z","timestamp":1781053014107,"version":"3.54.1"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"Telithromycin has been reported to possess robust in vitro<\/jats:italic> antibacterial activity against many species of gram-positive bacteria, and telithromycin is also effective against Staphylococcus aureus<\/jats:italic> biofilms. However, the in vitro<\/jats:italic> antimicrobial susceptibility of telithromycin against clinical enterococci isolates in China is rarely reported and the impacts of telithromycin on the biofilm formation and eradication of enterococci remain elusive. Therefore, this study aimed to explore the inhibitory effects of telithromycin on planktonic cells and biofilms of Enterococcus<\/jats:italic> strains. A total of 280 Enterococcus faecalis<\/jats:italic> and 122 Enterococcus faecium<\/jats:italic> isolates were collected from individual inpatients in China. The 50% minimum inhibitory concentration (MIC50<\/jats:sub>) values of telithromycin against the E. faecalis<\/jats:italic> and E. faecium<\/jats:italic> strains carrying erythromycin-resistant methylase (erm<\/jats:italic>) genes such as the ermA<\/jats:italic>, ermB<\/jats:italic>, or ermC<\/jats:italic>, were 2 and 4 \u03bcg\/mL, respectively. In addition, these isolates were typed using multilocus sequence typing (MLST) based on housekeeping genes. The predominant sequence types (STs) of E. faecalis<\/jats:italic> were ST16, ST30, and ST179, and the main STs of E. faecium<\/jats:italic> isolates were ST18, ST78, and ST80. Among these major STs, 87.1% (135\/158) of E. faecalis<\/jats:italic> and 80.4% (41\/51) of E. faecium<\/jats:italic> carried erm<\/jats:italic> genes. Furthermore, at the subinhibitory concentrations (1\/4 and 1\/8 \u00d7 MIC) of telithromycin, the biofilm formation of 16 E. faecalis<\/jats:italic> isolates were inhibited by approximately 35%. Moreover, treatment with 8 \u00d7 MIC of telithromycin or ampicillin led to an almost 40% reduction in the established biofilms of E. faecalis<\/jats:italic> isolates, whereas vancomycin or linezolid with 8 \u00d7 MIC had minimal effects. The combination of telithromycin and ampicillin resulted in an almost 70% reduction in the established biofilms of E. faecalis<\/jats:italic>. In conclusion, these results revealed that telithromycin significantly decreased the planktonic cells of both E. faecalis<\/jats:italic> and E. faecium<\/jats:italic>. In addition, the data further demonstrated that telithromycin has the robust ability to inhibit E. faecalis<\/jats:italic> biofilms and the combination of telithromycin and ampicillin improved antibiofilm activity. These in vitro<\/jats:italic> antibacterial and antibiofilm activities suggest that telithromycin could be a potential candidate for the treatment of enterococcal infections.<\/jats:p>","DOI":"10.3389\/fmicb.2020.616797","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T19:00:02Z","timestamp":1610650802000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["The Antibacterial and Antibiofilm Activity of Telithromycin Against Enterococcus spp. Isolated From Patients in China"],"prefix":"10.3389","volume":"11","author":[{"given":"Yanpeng","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1093\/jac\/dkg123","article-title":"Drugs of the 21st century: telithromycin (HMR 3647)\u2013the first ketolide.","volume":"51","author":"Ackermann","year":"2003","journal-title":"J. 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